AutismKB 2.0

Annotation Detail for IGHM


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Basic Information Top
Gene Symbol:IGHM ( AGM1,DKFZp686I15196,DKFZp686I15212,FLJ00385,MGC104996,MGC52291,MU,VH )
Gene Full Name: immunoglobulin heavy constant mu
Band: 14q32.33
Quick LinksEntrez ID:3507; OMIM: 147020; Uniprot ID:; ENSEMBL ID: ; HGNC ID: 5541
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C430898 AGN 194204 AGN 194204 results in increased expression of IGHM mRNAincreases expression 16339527
D015081 2-Naphthylamine 2-Naphthylamine results in decreased expression of IGHM mRNAdecreases expression 18247414
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IGHM mRNAdecreases expression 18247414
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of IGHM proteinincreases expression 15166399
D009538 Nicotine Nicotine results in decreased expression of IGHM mRNAdecreases expression 18247414
D010634 Phenobarbital Phenobarbital results in increased expression of IGHM mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in decreased expression of IGHM mRNAdecreases expression 17426115
D012643 Selenium Selenium results in increased expression of IGHM mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of IGHM mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.726195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.0916434500
MESH:D000361 Agammaglobulinemia marker/mechanism
MESH:D000544 Alzheimer Disease Nicotine 3.3116627626
MESH:D000686 Amyloidosis Diethylstilbestrol 4.7215469931
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.2120146248 17474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.2117129689 15324884
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 3.2815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.281701930 17173139 6705139 20935162 20007298
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D003092 Colitis Selenium 4.0417936198
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7912952375 16002989
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2215131321
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D020821 Dystonic Disorders Nicotine 6.2117881519
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004487 Edema pirinixic acid 2.6812083418
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.9816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5916804899 15700306
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005234 Fatty Liver pirinixic acid 2.9719236843 20131406
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7716513791 15751030 16611131 16534752 16002989
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.2316452187
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0220471113
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0216080930
MESH:D006333 Heart Failure pirinixic acid 7.3520558911
MESH:D006333 Heart Failure Selenium 7.3517162251
MESH:D006529 Hepatomegaly Phenobarbital 9.3616109766
MESH:D006529 Hepatomegaly pirinixic acid 9.3618467677 16221962 19772884 19176532
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6914722030 12960047
MESH:D007021 Hypospadias Diethylstilbestrol 4.8416002989
MESH:D007246 Infertility Diethylstilbestrol 4.5915036965
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.6315003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.3217184923
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0021047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4316169303
MESH:D008107 Liver Diseases Phenobarbital 2.2119363144
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2821137059 20195826
MESH:D008113 Liver Neoplasms Diethylstilbestrol 11.2816712894 15890375
MESH:D008113 Liver Neoplasms Phenobarbital 11.2819812893 19073162 21047994 8742319 15975961 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 11.2820007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.822563599 1399818 18308698 17172636 6150874
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.4717053015 18569708 18520028 20464547 20064080 18816296 20869020 6695378 20135361
MESH:D008175 Lung Neoplasms Vitamin E 2.4711062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.4315166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.8316002989
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8815318939
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009369 Neoplasms Benzo(a)pyrene 12.6911141357
MESH:D009369 Neoplasms Diethylstilbestrol 12.6915313581
MESH:D009369 Neoplasms Nicotine 12.6916365874
MESH:D009369 Neoplasms pirinixic acid 12.6917405874
MESH:D009389 Neovascularization, Pathologic Nicotine 5.2816365874
MESH:D009421 Nervous System Malformations Diethylstilbestrol 4.3711399458
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5516965848
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.9315687265 16977796
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D011230 Precancerous Conditions Phenobarbital 3.802563599
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.4017184923
MESH:D011471 Prostatic Neoplasms AGN 194204 2.1116000583
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1117136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Vitamin E 2.1115084515
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012640 Seizures Nicotine 6.8417873105
MESH:D012640 Seizures Phenobarbital 6.843137016 11442880 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013088 Spermatocele Diethylstilbestrol 5.0316002989 16709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.211399818
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.8716785264 11259349 16720336
MESH:D014029 Tobacco Use Disorder Nicotine 5.7117979512 18041664 15735609 18305452
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 8.9411144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.9417053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.9416452187 16712894 17306315
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.2316175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.4914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.3115809267 16690809
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6916002989 16513791
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29730
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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