Annotation Detail for RBPJ
Basic Information
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| Gene Symbol: | RBPJ ( CBF1,IGKJRB,IGKJRB1,KBF2,MGC61669,RBP-J,RBPJK,RBPSUH,SUH,csl ) |
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| Gene Full Name: | recombination signal binding protein for immunoglobulin kappa J region |
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| Band: | 4p15.2 |
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| Quick Links | Entrez ID:3516; OMIM: 147183; Uniprot ID:SUH_HUMAN; ENSEMBL ID: ENSG00000168214; HGNC ID: 5724 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| hsa04330 | Notch signaling pathway |
| Pathway ID | Pathway Name |
|---|
| Gene Expression |
| Pathway ID | Pathway Name |
|---|
| 200013 | Notch signaling pathway |
| 200196 | Notch-mediated HES/HEY network |
| 200052 | Presenilin action in Notch and Wnt signaling |
| Pathway ID | Pathway Name |
|---|
| P00005 | Angiogenesis |
| P00004 | Alzheimer disease-presenilin pathway |
| P00045 | Notch signaling pathway |
| Desease ID | Desease Name |
|---|
| 2007 | Liver tumor |
| 2022 | Liver cancer |
| 2132 | Kaposi sarcoma |
| 2152 | Renal tubular acidosis |
| Desease Name |
|---|
| Rheumatoid arthritis |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D015123 |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RBPJ mRNA | decreases expression | 19150397
|
| D005472 |
Fluorouracil |
[Fluorouracil co-treated with irinotecan] results in decreased expression of RBPJ mRNA | affects cotreatment|decreases expression | 16391804
|
| C051890 |
irinotecan |
[Fluorouracil co-treated with irinotecan] results in decreased expression of RBPJ mRNA | affects cotreatment|decreases expression | 16391804
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000230 |
Adenocarcinoma |
|
Fluorouracil |
2.50 | 17638652 |
| MESH:D000740 |
Anemia |
|
Fluorouracil |
4.16 | 17963324 15504547 16511603 |
| MESH:D001172 |
Arthritis, Rheumatoid |
marker/mechanism |
|
| 20453842 |
| MESH:D001943 |
Breast Neoplasms |
|
Fluorouracil |
2.43 | 19217205 16557594 15136595 18608205 18357371 16595493 16110121 |
| MESH:D002276 |
Carcinoid Tumor |
|
Fluorouracil |
5.53 | 16051944 |
| MESH:D002277 |
Carcinoma |
|
Fluorouracil |
3.93 | 17121937 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
Fluorouracil |
2.12 | 16799960 17971768 17045692 18930000 16332177 17088986 |
| MESH:D002292 |
Carcinoma, Renal Cell |
|
Fluorouracil |
3.18 | 18695887 |
| MESH:D002294 |
Carcinoma, Squamous Cell |
|
Fluorouracil |
2.58 | 16757204 16280240 17066447 18986760 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
3.01 | 20889678 |
| MESH:D003110 |
Colonic Neoplasms |
|
Fluorouracil |
4.17 | 17287894 17725105 17018589 16340194 17169374 16510598 18772588 15001691 17172411 17016597 |
| MESH:D003110 |
Colonic Neoplasms |
|
irinotecan |
4.17 | 17725105 17287894 |
| MESH:D015179 |
Colorectal Neoplasms |
|
Fluorouracil |
2.81 | 18288408 17695437 18949393 18509181 16391804 14970324 18448328 20501625 17255274 17454858 16282729 18802399 17016601 16331619 17094418 16524972 17594712 16303861 18383874 15289873 15148649 17401013 |
| MESH:D015179 |
Colorectal Neoplasms |
|
irinotecan |
2.81 | 15273666 18259882 16391804 17159606 16303861 18509181 17454858 |
| MESH:D007644 |
Darier Disease |
|
Fluorouracil |
5.53 | 16733453 |
| MESH:D004938 |
Esophageal Neoplasms |
|
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide |
4.80 | 20426865 |
| MESH:D004938 |
Esophageal Neoplasms |
|
Fluorouracil |
4.80 | 15173087 16481741 16785472 16337965 17638652 |
| MESH:D005910 |
Glioma |
|
Fluorouracil |
3.00 | 16145905 |
| MESH:D006258 |
Head and Neck Neoplasms |
|
Fluorouracil |
3.67 | 18337622 15162350 15102660 |
| MESH:D007680 |
Kidney Neoplasms |
|
Fluorouracil |
3.69 | 16985049 |
| MESH:D008113 |
Liver Neoplasms |
|
Fluorouracil |
2.61 | 16603448 15113037 18383874 17045692 |
| MESH:D008175 |
Lung Neoplasms |
|
Fluorouracil |
2.01 | 15246190 |
| MESH:D008178 |
Lupus Erythematosus, Cutaneous |
|
Fluorouracil |
5.53 | 15086387 |
| MESH:D009062 |
Mouth Neoplasms |
|
Fluorouracil |
3.98 | 16757204 18986760 |
| MESH:D052016 |
Mucositis |
|
irinotecan |
5.75 | 17159606 |
| MESH:D009362 |
Neoplasm Metastasis |
|
irinotecan |
3.31 | 18259882 |
| MESH:D009369 |
Neoplasms |
|
Fluorouracil |
2.79 | 18600527 16928823 18239605 |
| MESH:D009447 |
Neuroblastoma |
|
irinotecan |
3.67 | 8761367 |
| MESH:D017599 |
Neuroectodermal Tumors |
|
irinotecan |
5.47 | 8761367 |
| MESH:D020258 |
Neurotoxicity Syndromes |
|
Fluorouracil |
3.72 | 16436463 |
| MESH:D010190 |
Pancreatic Neoplasms |
|
Fluorouracil |
2.78 | 19003803 16929163 15113037 16500647 |
| MESH:D011471 |
Prostatic Neoplasms |
|
Fluorouracil |
3.34 | 19082440 18626508 |
| MESH:D012004 |
Rectal Neoplasms |
|
Fluorouracil |
4.43 | 18722050 18286688 16160472 15538739 |
| MESH:D013274 |
Stomach Neoplasms |
|
Fluorouracil |
2.79 | 18567086 17522103 19015929 16424979 17172411 15786421 18396642 17498489 16951190 19084572 |
| MESH:D013274 |
Stomach Neoplasms |
|
irinotecan |
2.79 | 15723263 |
| MESH:D014062 |
Tongue Neoplasms |
|
Fluorouracil |
4.44 | 16280240 |
| MESH:D002583 |
Uterine Cervical Neoplasms |
|
Fluorouracil |
4.33 | 16803524 |
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