AutismKB 2.0

Annotation Detail for IGLL1


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Basic Information Top
Gene Symbol:IGLL1 ( 14.1,AGM2,CD179b,IGL1,IGL5,IGLJ14.1,IGLL,IGO,IGVPB,VPREB2 )
Gene Full Name: immunoglobulin lambda-like polypeptide 1
Band: 22q11.23
Quick LinksEntrez ID:3543; OMIM: 146770; Uniprot ID:IGLL1_HUMAN; ENSEMBL ID: ENSG00000128322; HGNC ID: 5870
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05340Primary immunodeficiency
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00085Agammaglobulinemias
Immune system diseases
Primary immunodeficiency
No data
Desease Name
height
DEVELOPMENTAL
No data
Desease Name
Agammaglobulinemia 2
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001554 Benzene Benzene results in decreased expression of IGLL1 mRNAdecreases expression 15120971
15122651
D003474 Curcumin Curcumin results in decreased expression of IGLL1 mRNAdecreases expression 17198877
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of IGLL1 mRNAaffects cotreatment|increases expression 17183730
D011374 Progesterone Progesterone results in decreased expression of IGLL1 mRNAdecreases expression 18070364
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IGLL1 mRNAaffects cotreatment|affects expression 16979875
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of IGLL1 mRNAaffects cotreatment|increases expression 17183730
D015032 Zinc Zinc affects the expression of IGLL1 mRNAaffects expression 16979875
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of IGLL1 mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000169 Acrodermatitis Zinc 5.8017202136 17190629 16889938
MESH:D019973 Alcohol-Related Disorders Curcumin 5.5217887948
MESH:D000544 Alzheimer Disease Curcumin 4.6915590663
MESH:D000544 Alzheimer Disease Zinc 4.6916410023 17119284 16580781 16325427
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000741 Anemia, Aplastic Benzene 4.5814761424 17661222 11369114
MESH:D000755 Anemia, Sickle Cell Zinc 5.2316916123
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7916807698
MESH:D001249 Asthma Zinc 3.0217085522
MESH:D050197 Atherosclerosis Curcumin 3.4718704882
MESH:D001321 Autistic Disorder Valproic Acid 1.9915238991 18775368 18558336 17688650 18985861 19460635 17507914 19232924 20603192 18177632 18316065 17157402 18396377 16609825 18940202
MESH:D001327 Autoimmune Diseases Curcumin 4.8519761891
MESH:D001714 Bipolar Disorder Valproic Acid 3.2017594078 20046352
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D001855 Bone Marrow Diseases Benzene 5.6716183116
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.7817868700
MESH:D001930 Brain Injuries Progesterone 12.2715665606 15380490 15845082
MESH:D001930 Brain Injuries Zinc 12.2717109824
MESH:D002545 Brain Ischemia Curcumin 4.7316770732
MESH:D001932 Brain Neoplasms Curcumin 4.2017596214
MESH:D001943 Breast Neoplasms Benzene 2.0817162533 11921183
MESH:D001943 Breast Neoplasms Curcumin 2.0818462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms Progesterone 2.0816175315 15562024 17614352
MESH:D002277 Carcinoma Curcumin 4.0618593918
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0518414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 8.1618462866
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 8.1618922899
MESH:D002294 Carcinoma, Squamous Cell Zinc 8.1616543248
MESH:D002318 Cardiovascular Diseases Zinc 3.8416936243
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D003092 Colitis Curcumin 4.5316804969 16782535 18200517
MESH:D003103 Coloboma Curcumin 4.8318809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5419359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.2618497527
MESH:D019465 Craniofacial Abnormalities Benzene 4.1415643154
MESH:D019465 Craniofacial Abnormalities Valproic Acid 4.148888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Zinc 4.1419302082
MESH:D003872 Dermatitis Benzene 5.1315902427
MESH:D003920 Diabetes Mellitus Zinc 4.4516479319
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7518403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.2618204486
MESH:D003929 Diabetic Neuropathies Progesterone 4.8517187935
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 2.231733752 19641884
MESH:D004381 Duodenal Ulcer Curcumin 4.3817351913
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004487 Edema Tetradecanoylphorbol Acetate 3.8911698051 9599246 15177302 8113982 16716910 7812673 8273558
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 4.1117692515
MESH:D004715 Endometriosis Progesterone 4.0316134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.513659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.3616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.847562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004938 Esophageal Neoplasms Zinc 2.9116543248
MESH:D005234 Fatty Liver Curcumin 9.0219297423
MESH:D005234 Fatty Liver Valproic Acid 9.0219224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D005355 Fibrosis Curcumin 4.3418705752
MESH:D005756 Gastritis Zinc 5.2417241300
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0518462866
MESH:D005909 Glioblastoma Curcumin 3.6417596214
MESH:D006130 Growth Disorders Zinc 4.1317217573
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8318462866 18829502
MESH:D006333 Heart Failure Zinc 3.7617162251
MESH:D006335 Heart Injuries Zinc 6.2117074742
MESH:D016481 Helicobacter Infections Zinc 4.8417241300
MESH:D006402 Hematologic Diseases Benzene 4.9616183116
MESH:D006527 Hepatolenticular Degeneration Zinc 5.0517276780
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.4017701891
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006937 Hypercholesterolemia Curcumin 4.3318704882
MESH:D006973 Hypertension Benzene 3.1717940673
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9816612254
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.7615869954
MESH:D007249 Inflammation Curcumin 9.3018403477 17151092 16956363
MESH:D007249 Inflammation Progesterone 9.3015869954
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 9.308273558 11698051 7812673 15177302 7562506
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3018200517 18596194
MESH:D007414 Intestinal Neoplasms Curcumin 4.4810783313
MESH:D007511 Ischemia Zinc 4.9916584753
MESH:D007674 Kidney Diseases Zinc 3.4616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.7016518626
MESH:D007889 Leiomyoma Curcumin 4.8818555241
MESH:D007938 Leukemia Benzene 7.1217119257 14694614 15935818 18335105
MESH:D007938 Leukemia Curcumin 7.1218462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4916106398
MESH:D007951 Leukemia, Myeloid Benzene 4.6017506065
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.2519478238
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 4.2516294345 17596541
MESH:D015458 Leukemia, T-Cell Curcumin 5.0916106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.2818705752 18006644 17355460
MESH:D008107 Liver Diseases Curcumin 2.6616956363
MESH:D008114 Liver Neoplasms, Experimental Benzene 3.4512562636
MESH:D017563 Lung Diseases, Interstitial Benzene 12.9114698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 12.9117228818
MESH:D008175 Lung Neoplasms Benzene 3.8412562636
MESH:D008175 Lung Neoplasms Curcumin 3.8419359593 18462866 16243823
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 3.8411807781
MESH:D008223 Lymphoma Benzene 8.5417584886 17119257
MESH:D008223 Lymphoma Curcumin 8.5418462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0516173963
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.8412562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 15.8011921183
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 15.8017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 15.808985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 15.8012773700
MESH:D008545 Melanoma Curcumin 2.4418462866 17885582
MESH:D008569 Memory Disorders Curcumin 4.4817263510
MESH:D008881 Migraine Disorders Valproic Acid 3.3818765137 18803445
MESH:D009101 Multiple Myeloma Benzene 8.2917119195
MESH:D009101 Multiple Myeloma Curcumin 8.2919372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.3117962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009361 Neoplasm Invasiveness Curcumin 4.7018495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9812497104
MESH:D009423 Nervous System Neoplasms Curcumin 6.0718462866
MESH:D009436 Neural Tube Defects Benzene 8.1015643154
MESH:D009436 Neural Tube Defects Valproic Acid 8.1016359493 8888407
MESH:D009765 Obesity Curcumin 2.8019297423
MESH:D009784 Occupational Diseases Benzene 4.4417178637 15576619 17479406 17119257 15913788 16737584 15612468 15727169 15935809
MESH:D010024 Osteoporosis Curcumin 3.6218719352
MESH:D010051 Ovarian Neoplasms Benzene 8.4812562636
MESH:D010051 Ovarian Neoplasms Curcumin 8.4819020741 18462866
MESH:D010051 Ovarian Neoplasms Progesterone 8.4816525653 17393432
MESH:D010190 Pancreatic Neoplasms Curcumin 5.9619401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.9615976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.6512065085 18922899 18404319 8330346
MESH:D011225 Pre-Eclampsia Zinc 4.3917114810
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D011471 Prostatic Neoplasms Curcumin 3.5818769126 11398177 10851300 12497104 18226269 18156803 15129424
MESH:D011471 Prostatic Neoplasms Zinc 3.5812429649 16700911 16517595 16606632
MESH:D019310 Pseudolymphoma Valproic Acid 4.9812752131 11422049
MESH:D011656 Pulmonary Emphysema Curcumin 4.7919168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.3310666014 18379247
MESH:D012162 Retinal Degeneration Zinc 4.3316584753
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9318045962
MESH:D012509 Sarcoma Curcumin 4.3818462866
MESH:D012559 Schizophrenia Valproic Acid 2.0919110320 15737665
MESH:D012640 Seizures Valproic Acid 2.9115475178 14763951 17978042 3137016 11738929 11044598 16876388 1511512
MESH:D018805 Sepsis Curcumin 4.3118389075
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 3.398985016 8330346 12065085 18404319 11807781
MESH:D013119 Spinal Cord Injuries Progesterone 4.6815862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms Benzene 2.4212562636
MESH:D013276 Stomach Ulcer Curcumin 3.7719188055 16631530
MESH:D013953 Thymus Neoplasms Benzene 5.3510850423
MESH:D014062 Tongue Neoplasms Zinc 4.6616543248
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms Curcumin 2.9818593936
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014565 Urogenital Neoplasms Curcumin 5.6618462866
MESH:D014594 Uterine Neoplasms Benzene 4.6612562636
Pathway ID Pathway Name
KEGG:05340 Primary immunodeficiency
Pharmacogenomics Knowledge Base Top
Drug Bank Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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