AutismKB 2.0

Annotation Detail for IL3RA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IL3RA ( CD123,IL3R,IL3RAY,IL3RX,IL3RY,MGC34174,hIL-3Ra )
Gene Full Name: interleukin 3 receptor, alpha (low affinity)
Band: Xp22.3 and Yp13.3
Quick LinksEntrez ID:3563; OMIM: 308385,430000; Uniprot ID:IL3RA_HUMAN; ENSEMBL ID: ENSG00000185291; HGNC ID: 6012
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
Pathway IDPathway Name
Signaling in Immune system
No data
Pathway IDPathway Name
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1998Enteritis
2051Leukemia
2069Schizophrenia
2201Myeloproliferative disease
Desease Name
PSYCH
schizophrenia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of IL3RA mRNAaffects expression 17562736
D015081 2-Naphthylamine 2-Naphthylamine results in decreased expression of IL3RA mRNAdecreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IL3RA mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in increased expression of IL3RA mRNAincreases expression 17103032
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IL3RA mRNAdecreases expression 18247414
D003907 Dexamethasone Dexamethasone results in increased expression of IL3RA mRNAincreases expression 11758170
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of IL3RA mRNAincreases expression 17555576
D008628 Mercury Mercury results in decreased expression of IL3RA mRNAdecreases expression 16823088
D009538 Nicotine Nicotine results in decreased expression of IL3RA mRNAdecreases expression 18247414
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of IL3RA mRNAdecreases expression 17616710
D018038 Sodium Selenite Sodium Selenite results in increased expression of IL3RA mRNAincreases expression 18175754
D015215 Zidovudine [IL3 protein co-treated with CSF2 protein] inhibits the reaction [Zidovudine results in decreased expression of IL3RA mRNA]affects cotreatment|decreases expression|decreases reaction 12084393
D015215 Zidovudine Zidovudine results in decreased expression of IL3RA mRNAdecreases expression 12084393
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.969612607
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2614692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D000544 Alzheimer Disease Nicotine 3.3016627626
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.5917659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.5915885639
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Mercury 2.1417497416
MESH:D001327 Autoimmune Diseases Mercury 5.0116634805
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.383084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002311 Cardiomyopathy, Dilated Mercury 3.4810334427
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9517681005 11677210 16105132 17110522 16919318 15861022 17333356
MESH:D019457 Chromosome Breakage Sodium Selenite 4.8915894690
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5115824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2817728286
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 7.8712438553
MESH:D017449 Dermatitis, Allergic Contact Mercury 7.8716823706
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.8716285004
MESH:D003967 Diarrhea Dexamethasone 3.827237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9310915739 16485898 12958197 11743745 12705907 19164858 16177239 17562736 11287661 19923254 11421492 2444490 17522070 12540782 19085960 12392966 18071297 19370779 15968718 11739529 16781746 10663392 14725611 15619225 16227642 12153990 11834606 12594235 16109766 19420014 16081117 14550746 17906064 18713872 14986274 10774834 11461765 11529661 19416960 16393943 19739265
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 3.9315131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Zidovudine 4.0815040536
MESH:D020821 Dystonic Disorders Nicotine 6.0817881519
MESH:D004485 Eczema Dexamethasone 4.5912438553
MESH:D004487 Edema Dexamethasone 3.5119703484
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.6916530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.6915547721 15623463 15150132 15264214 16805852 16510608 16704527 15878914 15547733
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.3315345470
MESH:D005234 Fatty Liver Zidovudine 8.3318299183
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006402 Hematologic Diseases Zidovudine 4.8312579204
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.107520565
MESH:D015658 HIV Infections Zidovudine 3.5411698656 11363243 20032539 17358032 11141242
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006973 Hypertension Dexamethasone 2.9717042910
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Dexamethasone 2.9311099482 8960868
MESH:D007333 Insulin Resistance Sodium Selenite 3.3414714311
MESH:D007674 Kidney Diseases Acetaminophen 6.4415629191 12587719
MESH:D007674 Kidney Diseases Mercury 6.4417934191
MESH:D007680 Kidney Neoplasms Zidovudine 3.8812579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5220370541
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.2716718785
MESH:D008107 Liver Diseases Acetaminophen 1.6516611625 12969438 11587558 19460945 16610002 19784758 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.0821137059 20195826
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6418816296 20464547 20135361 18569708 18520028 20869020 17053015 20064080 6695378
MESH:D008175 Lung Neoplasms Dexamethasone 3.6411195469 15824018
MESH:D008175 Lung Neoplasms Zidovudine 3.6418800350
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.1814737004
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.0117358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.5815744524 15867202 16118317
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.609809623
MESH:D009369 Neoplasms Benzo(a)pyrene 5.5811141357
MESH:D009369 Neoplasms Nicotine 5.5816365874
MESH:D009389 Neovascularization, Pathologic Nicotine 5.1516365874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6021297632
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2017292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.2018760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.4715861022 16919318
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.1318379247 11700416
MESH:D012640 Seizures Nicotine 3.8717873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D013272 Stomach Diseases Dexamethasone 4.4715472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.552093021 20155912
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.5512958204 17575124
MESH:D013274 Stomach Neoplasms Zidovudine 3.5517696246
MESH:D013276 Stomach Ulcer Dexamethasone 3.5915138204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.8116785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 5.5915735609 18305452 17979512 18041664
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 5.6311144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.6317053015
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Dexamethasone 4.991336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9012579204
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
Pathway ID Pathway Name
KEGG:04210 Apoptosis
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04640 Hematopoietic cell lineage
KEGG:04630 Jak-STAT signaling pathway
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00020 agonist Sargramostim Antineoplastic Agents;Immunomodulatory Agents;Anti-Infective Agents
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved