AutismKB 2.0

Annotation Detail for IL4R


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Basic Information Top
Gene Symbol:IL4R ( CD124,IL4RA )
Gene Full Name: interleukin 4 receptor
Band: 16p12.1
Quick LinksEntrez ID:3566; OMIM: 147781; Uniprot ID:IL4RA_HUMAN; ENSEMBL ID: ENSG00000077238; HGNC ID: 6015
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200018IL4-mediated signaling events
Pathway IDPathway Name
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00079Asthma
Immune system diseases
Allergies and autoimmune diseases
Desease IDDesease Name
1774Necrotizing enterocolitis
1807Autoimmune disease
1845Psoriasis
1904Diabetes mellitus
1970Virus disease
2038Gastritis
2074Asthma
2090Hamman-Rich syndrome
2106Pancreas cancer
2146Lupus erythematosus
2214Malignant glioma
2220Dermatitis
2257Hemolytic-Uremic syndrome
Desease Name
rheumatoid arthritis
Total serum IgE
Atopy (IgE)
eczema
AGING
CARDIOVASCULAR
diabetes, type 1
multiple sclerosis(PPmultiple sclerosis)
CANCER
Hyper-IgE syndrome. severe eczema. atopy
PHARMACOGENOMIC
adult atopic dermatitis
Dermatitis, Atopic
Asthma
allergic reaction, betalactam
vascular disease
Graves' disease IgE
allele frequency/ normal
IL-4
IMMUNE
Normal volunteers
Hodgkin lymphoma
Atopic Eczema
atopy
METABOLIC
osteoarthritis
Lymphoma, Large B-Cell, Diffuse
asthma bronchodilator response IgE lung function
obesity
Crohn's disease
HIV
atopy and influence the signal transduction
hyper-IgE syndrome and severe eczema. atopy
increasing risk and a poor prognosis of renal cell carcinoma
Allergic asthma
INFECTION
No data
Desease Name
Atopy, susceptibility to
AIDS, slow progression to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C099681 allergovit allergovit results in decreased expression of IL4R proteindecreases expression 12239597
C006632 arsenic trioxide arsenic trioxide results in decreased expression of IL4R mRNAdecreases expression 12243866
D001554 Benzene Benzene results in increased expression of IL4R mRNAincreases expression 15929907
D001554 Benzene Benzene results in increased expression of IL4R proteinincreases expression 14673790
D019819 Budesonide Budesonide results in decreased expression of IL4R proteindecreases expression 15679716
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of IL4R mRNAincreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of IL4R mRNAincreases expression 16644059
C014347 decitabine decitabine affects the expression of IL4R mRNAaffects expression 17145863
D002945 Cisplatin Cisplatin promotes the reaction [[TP73 protein binds to IL4R intron] which results in increased expression of IL4R mRNA]affects binding|increases expression|increases reaction 14678968
D002945 Cisplatin Cisplatin results in increased expression of IL4R mRNAincreases expression 14678968
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of IL4R mRNAincreases expression 12807726
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of IL4R mRNAincreases expression 19371625
D002117 Calcitriol Calcitriol results in increased expression of IL4R mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in increased expression of IL4R mRNAincreases expression 12469912
D015025 Zearalenone Zearalenone results in increased expression of IL4R mRNAincreases expression 19371625
D019833 Genistein Genistein results in decreased expression of IL4R mRNAdecreases expression 16705744
D017313 Fenretinide Fenretinide results in decreased expression of IL4R mRNAdecreases expression 16570282
D008775 Methylprednisolone Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]decreases reaction|increases expression 11997017
D008775 Methylprednisolone Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]decreases reaction|increases expression 11997017
D008775 Methylprednisolone Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein]decreases reaction|increases phosphorylation 11997017
D009151 Mustard Gas Mustard Gas results in decreased expression of IL4R mRNAdecreases expression 16173061
D009151 Mustard Gas Mustard Gas results in decreased expression of IL4R mRNAdecreases expression 18988085
D010406 Penicillins IL4R gene polymorphism results in increased susceptibility to Penicillinsincreases response to substance 15969687
D011794 Quercetin Quercetin results in decreased expression of IL4R mRNAdecreases expression 15309432
D020849 Raloxifene Raloxifene affects the expression of IL4R mRNAaffects expression 14699072
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of IL4R mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in increased expression of IL4R mRNAincreases expression 19244175
D020123 Sirolimus [Sirolimus binds to FKBP1A protein] which results in decreased expression of IL4R mRNAaffects binding|decreases expression 12531798
D020123 Sirolimus [Sirolimus binds to FKBP1A protein] which results in decreased expression of IL4R proteinaffects binding|decreases expression 12531798
D013629 Tamoxifen Tamoxifen affects the expression of IL4R mRNAaffects expression 14699072
C015559 trimellitic anhydride trimellitic anhydride results in increased expression of IL4R proteinincreases expression 15922011
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of IL4R mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of IL4R mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D058186 Acute Kidney Injury Cisplatin 3.7917670903 15814532 12690470
MESH:D000230 Adenocarcinoma arsenic trioxide 13.0519825857 11798837
MESH:D000230 Adenocarcinoma Cisplatin 13.0517638652 11798837
MESH:D000230 Adenocarcinoma Estradiol 13.0511473722
MESH:D000230 Adenocarcinoma Fenretinide 13.0510697514
MESH:D000230 Adenocarcinoma Genistein 13.0511473722
MESH:D000236 Adenoma Diethylnitrosamine 2.7410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 3.7117162532 17620307 16434500 18056438 19052882 19061943
MESH:D000419 Albuminuria Raloxifene 4.4117451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5015800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3015469931
MESH:D000741 Anemia, Aplastic Benzene 4.2217661222 11369114 14761424
MESH:D000743 Anemia, Hemolytic Quercetin 4.0717084956
MESH:D001249 Asthma Budesonide 8.0115136378 10893010 12113382 18489783 20004779 15572850 12604023
MESH:D001249 Asthma Mustard Gas 8.0110378619
MESH:D001249 Asthma trimellitic anhydride 8.0116141432
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7815336622
MESH:D001321 Autistic Disorder Sirolimus 3.2221115397
MESH:D001327 Autoimmune Diseases Quercetin 4.2219761891
MESH:D001768 Blister Mustard Gas 4.9719167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.5016206674
MESH:D001855 Bone Marrow Diseases Benzene 5.0416183116
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6914601052
MESH:D001930 Brain Injuries Raloxifene 4.2916580743
MESH:D001932 Brain Neoplasms Fenretinide 4.1816187019
MESH:D001943 Breast Neoplasms Benzene 9.4811921183 17162533
MESH:D001943 Breast Neoplasms Calcitriol 9.4811237771
MESH:D001943 Breast Neoplasms Cisplatin 9.4819526202 18382427
MESH:D001943 Breast Neoplasms decitabine 9.4819208741 18320071
MESH:D001943 Breast Neoplasms Diethylnitrosamine 9.4817474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 9.4815324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 9.4817261762 17289903 17018787 12948864 14630087 16675129 19861407 18497071
MESH:D001943 Breast Neoplasms Fenretinide 9.4816601279
MESH:D001943 Breast Neoplasms Genistein 9.4816873071 16541309 17200150
MESH:D001943 Breast Neoplasms Quercetin 9.4818628248
MESH:D001943 Breast Neoplasms Raloxifene 9.4816837676 15758505 17242785 16912660 17595753 17893378 17049068 15572757 17440819 17952589 15775269 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 9.4821138602 19084267 20065188 20544844 20005174 19189212 19410462 18629630 18821012 19155303 18425577 19011961 16873071 20135344 20390343 15668708 17440819 15565566 20859285 18815881 17242785 11161223 19289846 19221464 16818667 19189210 21152245 17893378 19059307 19115204 19244106 18351453 18984771 18855134 17261762 16202921 18997820 19142967 19288272 19103187 17049068 19200415 19066611 16273361 19487384
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7817687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.1511589617
MESH:D002105 Cadmium Poisoning Quercetin 5.3516962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.3016097048 15673190 10355542 16227642 16011737 15721981 16192424 15700767 16124888 3786805 18705752 16050911
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.3016050911
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 25.4815553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 25.4818788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 25.4817982673
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 25.4810672840 18056438 16569478 16698587 17138121 11831363 19701751 16779866 19539802 19335982 18393292 3581430 16502159 18971187 18210153 18665156 18506893 10737359 19394651 18978308 20084675 16540662 19919837 19822196 20514400 20512989 17173139 20007298 20214788 19418558 19519916 20101231 3084413 17162532 17055752 19107877 18788625 19383236 17761372 16830150 19208518 18494052 16935385 20432363 16288022 21159647 16878318 18691550 19052882 16681979 16328049 20935162 20727157 20524982 17978847 17428255 19171122 18785209 16807293
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 25.4815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 25.4816924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 25.4817159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Genistein 25.4816924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 25.4819519916 12508355
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 25.4819335982
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 25.4816924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9716685392 12023789
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7717234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.6819014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.9512490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 13.7911237771
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 13.7917066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell decitabine 13.7919215824
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 13.7916274795
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 13.7919435901
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.9417572228
MESH:D006332 Cardiomegaly Quercetin 3.2119794523
MESH:D002318 Cardiovascular Diseases Genistein 7.0716332659
MESH:D002318 Cardiovascular Diseases Raloxifene 7.0715775269
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 6.2617174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.2618566989
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.2816154183
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.5219052882
MESH:D003072 Cognition Disorders Raloxifene 4.4315800139
MESH:D003092 Colitis Selenium 3.5917936198
MESH:D003110 Colonic Neoplasms decitabine 5.6917616700
MESH:D003110 Colonic Neoplasms Genistein 5.6917182828
MESH:D003110 Colonic Neoplasms Quercetin 5.6911134977 17148506 17191121 19056647 19440933 16640504 15741050
MESH:D015179 Colorectal Neoplasms arsenic trioxide 6.2920501625
MESH:D015179 Colorectal Neoplasms Cisplatin 6.2915273666
MESH:D015179 Colorectal Neoplasms decitabine 6.2918981723
MESH:D015179 Colorectal Neoplasms Fenretinide 6.2917273769
MESH:D015179 Colorectal Neoplasms Quercetin 6.2918095365 18852136
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.8110525206
MESH:D019465 Craniofacial Abnormalities Benzene 3.8115643154
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8119769572
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3716002989 12952375
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9215213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0017474826
MESH:D003872 Dermatitis Benzene 4.5815902427
MESH:D003882 Dermatomyositis Methylprednisolone 6.2120191521
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5819496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.3616647724
MESH:D003928 Diabetic Nephropathies Estradiol 14.0919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.0917308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0919279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.9419336974 21278145 10092053 16227642 11566570 17522070 7179309 7440962 7120509 10915739 3786805 16177239 6623471 4309450 6884620 19085960 3732212 15968718 15027814 9327722 15998439 2869522
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.9419107877
MESH:D056486 Drug-Induced Liver Injury Selenium 5.9415131321
MESH:D004362 Drug Toxicity Cisplatin 3.7212649298 19839026 12231392 15033597
MESH:D004417 Dyspnea Budesonide 5.3520016425
MESH:C538011 Eales disease Vitamin E 4.519068938
MESH:D004487 Edema Mustard Gas 6.639260866 11402378 11428647 11428631
MESH:D004487 Edema Raloxifene 6.6315860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 14.3815138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 14.3815845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.3819031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9219294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.2516402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.2516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.7815700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 16.7818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 16.7811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.7819155303 17893378 20544844 16202921
MESH:D004890 Erythema Mustard Gas 4.979357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.5512903497
MESH:D004938 Esophageal Neoplasms Cisplatin 4.5515464296 17638652 15173087 16785472 16481741
MESH:D005234 Fatty Liver arsenic trioxide 22.8215073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 22.8212795759 17595544 15959796 19224547 12631006 16045604 61145 16239168
MESH:D005234 Fatty Liver Diethylnitrosamine 22.8220387270 21071580
MESH:D005234 Fatty Liver Raloxifene 22.8217473493
MESH:D005234 Fatty Liver Tamoxifen 22.8214986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.8316534752 16611131 16002989 16513791 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.8316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3218705752
MESH:D005355 Fibrosis Quercetin 8.3219474275
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.0816904648
MESH:D005739 Gas Poisoning Budesonide 5.7320016425
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7516452187
MESH:D005909 Glioblastoma Fenretinide 11.3416187019
MESH:D005909 Glioblastoma Genistein 11.3416598420
MESH:D005909 Glioblastoma Quercetin 11.3419804834
MESH:D005910 Glioma Quercetin 2.9817643826
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.4515102660 15464296
MESH:D006258 Head and Neck Neoplasms decitabine 12.4519215824
MESH:D006258 Head and Neck Neoplasms Sirolimus 12.4519435901
MESH:D034381 Hearing Loss Cisplatin 4.1319898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2615464296
MESH:D006330 Heart Defects, Congenital Vitamin E 2.8916080930
MESH:D006331 Heart Diseases Raloxifene 3.4011110106
MESH:D006333 Heart Failure Selenium 2.9617162251
MESH:D006402 Hematologic Diseases Benzene 4.4816183116
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4119110552 19900420
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6416863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D006689 Hodgkin Disease Cisplatin 3.4416170182 16200630
MESH:D019584 Hot Flashes Estradiol 9.4117088409
MESH:D019584 Hot Flashes Vitamin E 9.4114716179
OMIM:609423 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO marker/mechanism
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006943 Hyperglycemia Quercetin 3.8611834736 18262572
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2514722030 12960047
MESH:D006973 Hypertension Benzene 8.4217940673
MESH:D006973 Hypertension Quercetin 8.4218356687
MESH:D006973 Hypertension Raloxifene 8.4215787275 17577099
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D006984 Hypertrophy Sirolimus 5.0619211884
MESH:D007021 Hypospadias Diethylstilbestrol 4.3916002989
OMIM:147050 IgE RESPONSIVENESS, ATOPIC marker/mechanism
MESH:D007246 Infertility Diethylstilbestrol 4.1715036965
MESH:D007248 Infertility, Male decitabine 3.0817581917
MESH:D007249 Inflammation Diethylnitrosamine 7.8218785209
MESH:D007249 Inflammation Mustard Gas 7.828975870 16001271 17524151 11428631 11428620 11428647 9260866 9357497 11402378
MESH:D007249 Inflammation Tamoxifen 7.8219457130
MESH:D007251 Influenza, Human Quercetin 17.5016624496
MESH:D007251 Influenza, Human Selenium 17.5016624496
MESH:D007251 Influenza, Human Vitamin E 17.5016624496
MESH:D007333 Insulin Resistance Estradiol 2.8416627594 16393666
MESH:D007627 Keloid Quercetin 4.7717086741
MESH:D007673 Kidney Cortex Necrosis Cisplatin 4.9515464296
MESH:D007674 Kidney Diseases Cisplatin 13.6118289764 12649298 12231392 15190930 19839026
MESH:D007674 Kidney Diseases Estradiol 13.6115618244
MESH:D007674 Kidney Diseases Quercetin 13.6116962696
MESH:D007674 Kidney Diseases Vitamin E 13.6112488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.7116518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.5715003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 11.5715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.5718625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.6011231351
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8717184923
MESH:D007889 Leiomyoma Raloxifene 4.3216973256
MESH:D007938 Leukemia arsenic trioxide 18.7115070760
MESH:D007938 Leukemia Benzene 18.7118335105 17119257 14694614 15935818
MESH:D007938 Leukemia decitabine 18.7119235587 18980019
MESH:D007938 Leukemia Genistein 18.7118980019 17468513
MESH:D007938 Leukemia Quercetin 18.7117468513
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Methylprednisolone 4.8014551737
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1116972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 15.0819077051
MESH:D007951 Leukemia, Myeloid Benzene 15.0817506065
MESH:D007951 Leukemia, Myeloid decitabine 15.0818454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 6.0217050201 16467208 20471514 19850784 16968895
MESH:D015470 Leukemia, Myeloid, Acute Benzene 6.0219478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 6.0219387464 19010910 18704418 17679729 18206229 18460780
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2718055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0912712474 11161223 17107899 17712046 17649720 15336539 15213294 17869043 16823087 19225113 9834237 12018890 16112521 15748426 19642359 16330433 11468182 15622746 19035177 17217047 19075265 16331271 16891316 16966277 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.1716882451
MESH:D007972 Leukoplakia, Oral Fenretinide 5.8516707609
MESH:D008064 Lipidoses Tamoxifen 3.0217567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.2611408273 21278145 16943688 16221502 16239168 11903743 17334410 17157831 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2618522880 19638242 20032147 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.5615673190 15052691 12649538 15893842 17805973 15650968 12389079 10355542 18412020 17721639 18472332 15057751 12632514 18705752 12546737 15996030 16638106 16027843 16116963 14716833 18317297 18263696 17708605 14724832 17761835 15959796 15931870 17766677 17481882 12632512 17557913 18187930 17565644 12586293 18210741 15123356 17823541 18429990 16248980 18156304 15338365 17900296 18006644 17525996 15730626 17976157 18395914 12667390 18054572 12741479 17714472 12445421 15925388 18418968 18472094 15876570 18251166 15362042 15370692 17631135 17922224 16097048 18376398 16011737 12445418 18420326 16136751 18395095 14512876 18481824 17698563 12609069 12666154 16033810 12898905 18339082 18277467 16192424 14748882 18166357 14716496 18205269 15818738 13678700 17869086 11481614 14620537 12958196 16015684 17944888 20821823 18279442 17640975
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.5614659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.5617823541
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 10.5612741479
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 10.5617050028
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.5618564211
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.5616169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.9116246199 16964402 15830285 17285989 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9117034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5214706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 17.0514682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.0519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.0515885732 18977376 2422723 19294768 16942905 19499222 19073162 19254457 19090486 19638242 2862719 19812893 19850985 18644402 20434301 18754104 20583210 12112319 19551842 21278145 19255062 10737359 21071580 15175105 19996281 18648771 19642983 20101389 21047994 20405173 21167192 20452335 19833225 12771043 19427195 19690152 20501860 20492335 20118626 20137499 18978307 19426721 19256749 9163691
MESH:D008113 Liver Neoplasms Diethylstilbestrol 17.0516712894 15890375
MESH:D008113 Liver Neoplasms Quercetin 17.0518980244
MESH:D008113 Liver Neoplasms Tamoxifen 17.0516684651
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 17.4120377131
MESH:D008114 Liver Neoplasms, Experimental Benzene 17.4112562636
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 17.4115583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.4118079962 18093689 18544905 18282651 16267830 18308698 18775883 2563599 19539802 16842330 19009564 19519916 18253720 19126423 18164116 3124819 17942915 17174075 21159647 17854601 9362446 19004024
MESH:D008114 Liver Neoplasms, Experimental Quercetin 17.4119519916
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2115213294
MESH:D008171 Lung Diseases Mustard Gas 7.1218161513 18702808
MESH:D008171 Lung Diseases Vitamin E 7.1216863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6214698565
MESH:D008175 Lung Neoplasms arsenic trioxide 14.9619825857 11798837
MESH:D008175 Lung Neoplasms Benzene 14.9612562636
MESH:D008175 Lung Neoplasms Budesonide 14.9616885199 17163412 12117777
MESH:D008175 Lung Neoplasms Cisplatin 14.966189445 11798837 17225452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.9620512841 20970405 6695378 21163286
MESH:D008175 Lung Neoplasms Mustard Gas 14.963148597 8781369
MESH:D008175 Lung Neoplasms Quercetin 14.9616280456
MESH:D008175 Lung Neoplasms Tamoxifen 14.9618625569
MESH:D008175 Lung Neoplasms Vitamin E 14.9611062179
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9615166399
MESH:D008223 Lymphoma Benzene 11.8917584886 17119257
MESH:D008223 Lymphoma decitabine 11.8919470736
MESH:D008223 Lymphoma Diethylstilbestrol 11.8915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3216002989
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.4312562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.4319428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 22.0111921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 22.0111807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 22.0110697514
MESH:D008325 Mammary Neoplasms, Experimental Genistein 22.0112929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Selenium 22.0115318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 22.0114580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.0019453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0019453300
MESH:D008545 Melanoma Cisplatin 9.4615577323 17023156 16809738 12883367 17761969 12374674 18505091 18332650 16248763 18176117 16432458 12393984 11135225
MESH:D008545 Melanoma decitabine 9.4617785578 16505122
MESH:D008545 Melanoma Fenretinide 9.4616270382
MESH:D008545 Melanoma Sirolimus 9.4619282848
MESH:D008545 Melanoma Tamoxifen 9.4612393984 19393235
MESH:D018328 Melanoma, Amelanotic Cisplatin 10.8715990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 10.8715990972
MESH:D008654 Mesothelioma Cisplatin 6.1117638057
MESH:D008654 Mesothelioma Selenium 6.1115107826
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3615863610
MESH:D009062 Mouth Neoplasms Fenretinide 8.8516274795
MESH:D009062 Mouth Neoplasms Sirolimus 8.8519435901
MESH:D009101 Multiple Myeloma arsenic trioxide 16.2019417148 19549372 15949261 14977855 11468182
MESH:D009101 Multiple Myeloma Benzene 16.2017119195
MESH:D009101 Multiple Myeloma decitabine 16.2018172295
MESH:D009101 Multiple Myeloma Raloxifene 16.2016497877
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.4818349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.1416882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 7.1419010910 16882708 19157545 18608210
MESH:D009203 Myocardial Infarction Genistein 5.7317141266
MESH:D009203 Myocardial Infarction Quercetin 5.7319595682
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.4416810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.4417141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 13.4419207477
MESH:D009232 Myxoma Raloxifene 5.3616343187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.7816624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.483581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Cisplatin 14.7716773208
MESH:D009369 Neoplasms decitabine 14.7719116145 17925555 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 14.7715313581
MESH:D009369 Neoplasms Fenretinide 14.7715958647 17353921
MESH:D009369 Neoplasms Quercetin 14.7715185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.3015464296
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.4211399458
MESH:D009421 Nervous System Malformations Estradiol 15.4211399458 16427766
MESH:D009421 Nervous System Malformations Genistein 15.4216427766
MESH:D009436 Neural Tube Defects arsenic trioxide 7.1210525206
MESH:D009436 Neural Tube Defects Benzene 7.1215643154
MESH:D009447 Neuroblastoma Cisplatin 3.358761367
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1920387270
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.518761367
MESH:D020078 Neurogenic Inflammation Quercetin 4.1817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4916303764
MESH:D009503 Neutropenia Mustard Gas 3.7916761898 7688884
MESH:D009784 Occupational Diseases Benzene 4.0117119257 15913788 17479406 15935809 15576619 16737584 17178637 15612468 15727169
MESH:D010024 Osteoporosis Genistein 6.9519401787
MESH:D010024 Osteoporosis Raloxifene 6.9517882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 15.8616169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 15.8619495926
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 15.8615758505 17823083 15579764 17893378
MESH:D010051 Ovarian Neoplasms arsenic trioxide 26.1112452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Benzene 26.1112562636
MESH:D010051 Ovarian Neoplasms Cisplatin 26.1117225452 19769630 15464296 6897625
MESH:D010051 Ovarian Neoplasms decitabine 26.1119259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 26.1119401270
MESH:D010051 Ovarian Neoplasms Fenretinide 26.1116133793
MESH:D010051 Ovarian Neoplasms Genistein 26.1119005980
MESH:D010051 Ovarian Neoplasms Quercetin 26.1119005980
MESH:D010149 Pain, Postoperative Methylprednisolone 6.0312538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 19.6215580305
MESH:D010190 Pancreatic Neoplasms Cisplatin 19.6219003803
MESH:D010190 Pancreatic Neoplasms decitabine 19.6219294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 19.6216540662
MESH:D010190 Pancreatic Neoplasms Fenretinide 19.6215580305
MESH:D010190 Pancreatic Neoplasms Quercetin 19.6216965848
MESH:D010235 Paraganglioma arsenic trioxide 3.9819927285
MESH:D010300 Parkinson Disease Sirolimus 3.6719682553
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1215464296
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4815687265 16977796
MESH:D010954 Plasmacytoma Selenium 4.7015087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.1517638057
MESH:D011041 Poisoning Mustard Gas 3.6215727166
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.692563599
MESH:D011230 Precancerous Conditions Quercetin 8.6919056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 3.9217184923
MESH:D055728 Primary Myelofibrosis decitabine 4.5417616702
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.5915572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.4819131511
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4812479363 16289102 16644109 18247401 15754350
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.4815846301 15046698 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 3.4816740699
MESH:D011471 Prostatic Neoplasms Fenretinide 3.4817024972
MESH:D011471 Prostatic Neoplasms Genistein 3.4815256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 3.4817292933 14715546
MESH:D011471 Prostatic Neoplasms Raloxifene 3.4816220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.4815067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.4815084515
MESH:D011537 Pruritus Mustard Gas 3.9018058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8617620002 17266442 10334151 17894541 17720292
MESH:D011693 Purpura Raloxifene 5.3615770314
MESH:D051437 Renal Insufficiency Cisplatin 4.2215464296
MESH:D012130 Respiratory Hypersensitivity trimellitic anhydride 4.7420219652
MESH:D012162 Retinal Degeneration Fenretinide 4.2616303925
MESH:D012208 Rhabdomyosarcoma decitabine 4.2219155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 9.7316646077
MESH:D012512 Sarcoma, Ewing's Cisplatin 9.7314601052
MESH:D012554 Schistosomiasis japonica Quercetin 5.3516862918
MESH:D012871 Skin Diseases Mustard Gas 4.8616961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin E 4.8618709164
MESH:D012878 Skin Neoplasms Fenretinide 5.8316467112
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.838532709
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1515464296
MESH:D013088 Spermatocele Diethylstilbestrol 11.2016709447 16002989
MESH:D013088 Spermatocele Tamoxifen 11.2016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 6.2117007042
MESH:D013274 Stomach Neoplasms Benzene 6.2112562636
MESH:D013274 Stomach Neoplasms Cisplatin 6.2118396642 15958060 17522103
MESH:D013274 Stomach Neoplasms decitabine 6.2119037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.2118456281
MESH:D020521 Stroke Raloxifene 8.2116837676
MESH:D020521 Stroke Vitamin E 8.2116517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.4517225452 15464296
MESH:D013953 Thymus Neoplasms Benzene 4.7610850423
MESH:D013964 Thyroid Neoplasms arsenic trioxide 11.1819014326
MESH:D013964 Thyroid Neoplasms decitabine 11.1817967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.187505956
MESH:D013978 Tibial Fractures Estradiol 13.0719048282
MESH:D013978 Tibial Fractures Raloxifene 13.0719048282
MESH:D016171 Torsades de Pointes arsenic trioxide 3.7715213294
MESH:D014402 Tuberous Sclerosis Sirolimus 5.3821115397 18495876
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 27.2520435036 12973940 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 27.2517225452 12973940 15464296
MESH:D001749 Urinary Bladder Neoplasms decitabine 27.2517616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 27.2516712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 27.2516720286
MESH:D001749 Urinary Bladder Neoplasms Quercetin 27.2516720314
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 27.2517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 27.2516712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 15.0916803524
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 15.0916175088
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 15.0916154183
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9814652134
MESH:D014594 Uterine Neoplasms Benzene 9.2412562636
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.2415809267 16690809
MESH:D014604 Uveal Neoplasms decitabine 4.7217785578
MESH:D014605 Uveitis Sirolimus 5.441336536
MESH:D014625 Vaginal Neoplasms Cisplatin 10.4515577323
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 10.4516002989 16513791
MESH:D054556 Venous Thromboembolism Raloxifene 5.0216837676
MESH:D014839 Vomiting Cisplatin 4.5311897121
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3616343187
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04640 Hematopoietic cell lineage
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29832
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA443450Asthma
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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