AutismKB 2.0

Annotation Detail for IL6ST


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IL6ST ( CD130,CDW130,DKFZp564F053,GP130,IL-6RB )
Gene Full Name: interleukin 6 signal transducer (gp130, oncostatin M receptor)
Band: 5q11.2
Quick LinksEntrez ID:3572; OMIM: 600694; Uniprot ID:IL6RB_HUMAN; ENSEMBL ID: ENSG00000134352; HGNC ID: 6021
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
Pathway IDPathway Name
200124IL6-mediated signaling events
200023IL27-mediated signaling events
Pathway IDPathway Name
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1707Multiple myeloma
1770Melanoma
1779Cervical cancer
1822Infectious lung disease
1832Congenital abnormality
1848Embryoma
1856Obesity
1918Atherosclerosis
2008Liver disease
2066Lung cancer
2075Heart failure
2214Malignant glioma
2220Dermatitis
2230Alopecia
Desease Name
periodontitis
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of IL6ST mRNAdecreases expression 12419474
D000082 Acetaminophen Acetaminophen affects the expression of IL6ST mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in increased expression of IL6ST mRNAincreases expression 19420014
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IL6ST proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IL6ST mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of IL6ST mRNAdecreases expression 17103032
C006632 arsenic trioxide arsenic trioxide results in increased expression of IL6ST mRNAincreases expression 15073043
C416282 BAY 11-7085 BAY 11-7085 inhibits the reaction [TNF protein results in increased secretion of IL6ST protein]decreases reaction|increases secretion 16606632
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of IL6ST mRNAdecreases expression 12419474
D002087 Butyrates Butyrates results in decreased expression of IL6ST mRNAdecreases expression 14674679
D002211 Capsaicin Capsaicin results in decreased expression of IL6ST proteindecreases expression 19285962
D002251 Carbon Tetrachloride IL6ST protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein]affects reaction|increases activity 12830005
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL6ST mRNA]decreases reaction|increases expression 11007951
C014347 decitabine decitabine results in increased expression of IL6ST mRNAincreases expression 19223499
C044101 endotoxin, Escherichia coli endotoxin, Escherichia coli results in increased expression of IL6ST mRNAincreases expression 15919760
D004958 Estradiol Estradiol affects the expression of IL6ST mRNAaffects expression 19401270
D004958 Estradiol Estradiol affects the expression of IL6ST proteinaffects expression 19401270
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of IL6ST mRNAaffects cotreatment|increases expression 17404688
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of IL6ST mRNAincreases expression 15159207
D007213 Indomethacin Indomethacin results in decreased expression of IL6ST mRNAdecreases expression 16984733
C011890 kojic acid kojic acid results in decreased expression of IL6ST mRNAdecreases expression 16595896
C467567 lenalidomide lenalidomide results in decreased expression of IL6ST mRNAdecreases expression 15618473
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of IL6ST mRNAincreases expression 15919760
D010126 Ozone Ozone results in decreased expression of IL6ST mRNAdecreases expression 17460151
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of IL6ST mRNAaffects cotreatment|increases expression 17404688
D012643 Selenium Selenium results in decreased expression of IL6ST mRNAdecreases expression 19244175
D017632 Asbestos, Serpentine Asbestos, Serpentine results in increased expression of IL6ST mRNAincreases expression 16251409
C004648 testosterone enanthate testosterone enanthate affects the expression of IL6ST mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL6ST mRNA]decreases reaction|increases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IL6ST mRNAincreases expression 20106945
11007951
12377990
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IL6ST mRNAdecreases expression 16960034
D013792 Thalidomide Thalidomide results in decreased expression of IL6ST mRNAdecreases expression 15618473
D019284 Thapsigargin Thapsigargin results in decreased expression of IL6ST proteindecreases expression 19285962
C012589 trichostatin A trichostatin A results in increased expression of IL6ST mRNAincreases expression 19223499
C025643 vinclozolin vinclozolin affects the expression of IL6ST mRNAaffects expression 19015723
C025643 vinclozolin vinclozolin results in increased expression of IL6ST mRNAincreases expression 18629315
D015032 Zinc Zinc inhibits the reaction [TNF protein results in increased secretion of IL6ST protein]decreases reaction|increases secretion 16606632
D019287 Zinc Sulfate Zinc Sulfate inhibits the reaction [TNF protein results in increased secretion of IL6ST protein]decreases reaction|increases secretion 16606632
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of IL6ST mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 12.6918926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 12.6911752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Thalidomide 12.698333272
MESH:D000138 Acidosis Ammonium Chloride 9.5918287403
MESH:D000138 Acidosis Zinc Sulfate 9.597265320
MESH:D000169 Acrodermatitis Zinc 5.0917190629 17202136 16889938
MESH:D058186 Acute Kidney Injury Capsaicin 4.2718460982
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.7518653653 11850527
MESH:D000230 Adenocarcinoma arsenic trioxide 6.6819825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 6.6811473722
MESH:D000230 Adenocarcinoma Indomethacin 6.6816537180
MESH:D000236 Adenoma Indomethacin 3.2711497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0716835633
MESH:D000505 Alopecia Capsaicin 4.4917569567
MESH:D016301 Alveolar Bone Loss Indomethacin 5.0517225004
MESH:D000544 Alzheimer Disease Indomethacin 6.3117627676 15579461
MESH:D000544 Alzheimer Disease Ozone 6.3115513908
MESH:D000544 Alzheimer Disease Zinc 6.3116580781 16325427 16410023 17119284
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 12.4810965797
MESH:D000690 Amyotrophic Lateral Sclerosis lenalidomide 12.4816510725
MESH:D000690 Amyotrophic Lateral Sclerosis Thalidomide 12.4816510725
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6811748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.6116916123
MESH:D000799 Angioedema Acetaminophen 3.5310982225
MESH:D000860 Anoxia Zinc Sulfate 4.717265320
MESH:D001008 Anxiety Disorders vinclozolin 3.4019015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.5510231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.5710388637
MESH:D018771 Arthralgia Indomethacin 4.852160914
MESH:D001169 Arthritis, Experimental Thalidomide 4.039598899
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 20453842
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.6111248219
MESH:D001172 Arthritis, Rheumatoid Ozone 4.6115570426
MESH:D001195 Asbestosis Asbestos, Serpentine 5.3710751356
MESH:D001249 Asthma Ozone 4.8416373670 17854713
MESH:D001249 Asthma Zinc 4.8417085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001477 Bartter Syndrome Indomethacin 4.6810684365
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.0416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.0412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D001919 Bradycardia Capsaicin 4.7518207255
MESH:D001929 Brain Edema Indomethacin 4.7111481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0217868700
MESH:D001930 Brain Injuries Progesterone 10.0315380490 15665606 15845082
MESH:D001930 Brain Injuries Zinc 10.0317109824
MESH:D002545 Brain Ischemia Capsaicin 9.5719211983
MESH:D002545 Brain Ischemia Indomethacin 9.5712524144
MESH:D001943 Breast Neoplasms decitabine 2.8019208741 18320071
MESH:D001943 Breast Neoplasms Estradiol 2.8012948864 17261762 17289903 19861407 16675129 14630087 18497071 17018787
MESH:D001943 Breast Neoplasms Hexachlorobenzene 2.8012709520 15061365
MESH:D001943 Breast Neoplasms Indomethacin 2.8017401462
MESH:D001943 Breast Neoplasms Progesterone 2.8015562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8020435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4418417511 14754758 18315731 17626835 15516495 19059883 16777450
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0411589617
MESH:D002056 Burns Indomethacin 4.4010459503
MESH:D002100 Cachexia Indomethacin 11.3615141370 15625704 11239499 16537180
MESH:D002100 Cachexia Ozone 11.3616183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4818705752 16227642 16011737 16192424 10355542 15721981 16124888 15700767 16097048 15673190 16050911 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5616835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.233084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.2321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 13.2315553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 13.2318788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.2316924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 13.2316391822
MESH:D006528 Carcinoma, Hepatocellular Thalidomide 13.2316313753
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.4211053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.0418791128 14736730 11352223
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5619014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.2317341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8512490120
MESH:D002294 Carcinoma, Squamous Cell decitabine 7.1619215824
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 7.1612636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Zinc 7.1616543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2016120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Zinc 3.4516936243
MESH:D002386 Cataract Acetaminophen 2.4010977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.5618566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.9016835633
MESH:D018281 Cholangiocarcinoma Thalidomide 8.9018291259
MESH:D002764 Cholecystitis Indomethacin 4.8511181007
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9715340226 12621046 8697196 15668235 16354765
MESH:D003092 Colitis Selenium 8.9117936198
MESH:D003092 Colitis Thalidomide 8.9116680017
MESH:D003110 Colonic Neoplasms Butyrates 5.6615936596
MESH:D003110 Colonic Neoplasms decitabine 5.6617616700
MESH:D003110 Colonic Neoplasms Indomethacin 5.6615625704 15936596 15786552 15637740 15963497 11260862
MESH:D015179 Colorectal Neoplasms marker/mechanism 19223499
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.3520501625
MESH:D015179 Colorectal Neoplasms decitabine 3.3518981723
MESH:D015179 Colorectal Neoplasms Indomethacin 3.3518059344 12606626 11197048 17054584
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8014669216 17141729
MESH:D016510 Corneal Neovascularization Thalidomide 5.279301478
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8912609071
MESH:D018352 Coronavirus Infections Indomethacin 5.4017302372
MESH:D003371 Cough Capsaicin 4.8610350223
MESH:D003389 Cranial Nerve Diseases Thalidomide 5.999200351
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.1710525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1710048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Thalidomide 5.179200351
MESH:D019465 Craniofacial Abnormalities Zinc 5.1719302082
MESH:D003424 Crohn Disease Thalidomide 4.0116078585
MESH:D003456 Cryptorchidism vinclozolin 4.0514966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8115213294
MESH:D003920 Diabetes Mellitus Zinc 3.9516479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.5917107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1917187935
MESH:D003967 Diarrhea Indomethacin 3.517907874 7237001
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.132444490 18713872 14550746 10663392 19164858 15968718 10774834 18071297 12594235 16109766 11529661 12705907 19420014 17906064 11739529 11834606 12540782 19085960 15619225 11287661 19923254 10915739 12392966 19416960 11743745 16781746 12153990 12958197 16393943 11421492 17562736 16081117 19370779 14725611 16485898 19739265 16177239 14986274 11461765 17522070 16227642
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.137120509 2869522 7179309 17522070 19336974 16177239 6623471 15968718 10092053 19085960 15998439 21278145 6884620 16227642 3786805 7440962 15027814 4309450 3732212 9327722 11566570 10915739
MESH:D056486 Drug-Induced Liver Injury Selenium 8.1315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7819426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.8418043480 16133044 18446180 16326151 17190690 12774134
MESH:D004381 Duodenal Ulcer Capsaicin 8.6711535926 10671773
MESH:D004381 Duodenal Ulcer Indomethacin 8.6717151854 10671773 17045617 17351913 11535926 16699067 17329845 11595415 11991626 11595431 17202747
MESH:D004487 Edema Indomethacin 6.0116100529 7990266 7907874 8985016 8273558 19703484 10653021
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.0111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5916714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.4917692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 12.9719294695
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 12.9719294695
MESH:D016889 Endometrial Neoplasms Estradiol 2.7819148513 18566989 11473722
MESH:D004715 Endometriosis Indomethacin 13.7515652904
MESH:D004715 Endometriosis Progesterone 13.7516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.759294722 10568697
MESH:D019446 Endotoxemia endotoxin, Escherichia coli 15.9817637181 18509659
MESH:D019446 Endotoxemia Indomethacin 15.9818509659
MESH:D019446 Endotoxemia Lipopolysaccharides 15.9817637181 15328337 15821434
MESH:D004751 Enteritis Indomethacin 4.4317763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.6817980183
MESH:D004802 Eosinophilia Indomethacin 3.7511298111
MESH:D004935 Esophageal Diseases Capsaicin 5.3919566590
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.9212903497
MESH:D004938 Esophageal Neoplasms Indomethacin 6.9211005569
MESH:D004938 Esophageal Neoplasms Zinc 6.9216543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7811564622
MESH:D005234 Fatty Liver arsenic trioxide 6.9515073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 6.9516239168 15959796 17595544 12795759 19224547 12631006 16045604 61145
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D005334 Fever endotoxin, Escherichia coli 13.9316997862
MESH:D005334 Fever Indomethacin 13.9310431976 17627676 11852909
MESH:D005334 Fever Lipopolysaccharides 13.9311852909 9205823
MESH:D005354 Fibrosarcoma Indomethacin 4.5810962813
MESH:D005355 Fibrosis Carbon Tetrachloride 13.0818705752
MESH:D005355 Fibrosis Indomethacin 13.0817994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0820067830
MESH:D005499 Folliculitis Indomethacin 4.8511298111
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9716904648
MESH:D005756 Gastritis Acetaminophen 17.2416983495
MESH:D005756 Gastritis Indomethacin 17.2415046732
MESH:D005756 Gastritis Zinc 17.2417241300
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6216973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9816417039
MESH:D005871 Giant Lymph Node Hyperplasia Thalidomide 5.9912701121
MESH:D005909 Glioblastoma Capsaicin 11.0218405923
MESH:D005909 Glioblastoma Indomethacin 11.0212870263
MESH:D005909 Glioblastoma trichostatin A 11.0218801729
MESH:D005910 Glioma Indomethacin 6.1716487511 18371953
MESH:D005910 Glioma Thalidomide 6.1716327979
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.0411849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006073 Gout Indomethacin 5.0411248219
MESH:D006130 Growth Disorders Zinc 3.7617217573
MESH:D006258 Head and Neck Neoplasms decitabine 7.3419215824
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.3415482327
MESH:D006356 Heartburn Capsaicin 5.3919566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1710048152 11294989
MESH:D006333 Heart Failure Selenium 6.7117162251
MESH:D006333 Heart Failure Zinc 6.7117162251
MESH:D006335 Heart Injuries Zinc 5.4517074742
MESH:D016481 Helicobacter Infections Zinc 4.2517241300
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.1216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.2915633222
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3019900420 19110552
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.3915135802
MESH:D006527 Hepatolenticular Degeneration Zinc 10.3017276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.3017063115
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5912621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7215709030
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.4317440010
MESH:D019584 Hot Flashes Estradiol 3.4417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7316959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 11.8216870215
MESH:D006930 Hyperalgesia Capsaicin 11.8217434803 17043245
MESH:D006930 Hyperalgesia Indomethacin 11.8212727271
MESH:D034321 Hyperamylasemia Indomethacin 5.4017883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2216899240
MESH:D006940 Hyperemia Indomethacin 4.6912524144
MESH:D006949 Hyperlipidemias Indomethacin 3.8817546600
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7815338365
MESH:D007022 Hypotension Zinc Sulfate 4.197265320
MESH:D007077 Ileal Diseases Indomethacin 4.7118306037 10574470
MESH:D007079 Ileitis Indomethacin 5.0410651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.0516133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1015869954
MESH:D007248 Infertility, Male decitabine 6.2417581917
MESH:D007248 Infertility, Male vinclozolin 6.2416467254
MESH:D007249 Inflammation Capsaicin 17.8516956363
MESH:D007249 Inflammation Indomethacin 17.8512568917 3291741 7812673
MESH:D007249 Inflammation Lipopolysaccharides 17.8512878042 17963957 17237260 9205823 17255318
MESH:D007249 Inflammation Progesterone 17.8515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.8512878042 12200463
MESH:D007249 Inflammation Thalidomide 17.8516134734
MESH:D007251 Influenza, Human Selenium 3.8816624496
MESH:D007333 Insulin Resistance Estradiol 2.7716393666 16627594
MESH:D007410 Intestinal Diseases Indomethacin 4.0211713966 11855677 17329856 18236018 15831440 17994277 10210152 11686837 15610444
MESH:D019586 Intracranial Hypertension Indomethacin 5.0515241188
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3417255318
MESH:D007511 Ischemia Zinc 4.3316584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0616580747
MESH:D007579 Jejunal Diseases Indomethacin 4.7110574470 18306037 16133968
MESH:D007674 Kidney Diseases Acetaminophen 13.0012587719 15629191
MESH:D007674 Kidney Diseases Estradiol 13.0015618244
MESH:D007674 Kidney Diseases Indomethacin 13.0017190690
MESH:D007674 Kidney Diseases Zinc 13.0016960431
MESH:D007676 Kidney Failure, Chronic Selenium 9.1616518626
MESH:D007676 Kidney Failure, Chronic Zinc 9.1616518626
MESH:D007680 Kidney Neoplasms Estradiol 2.7315610895
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 7.9710320625 12228301 11703811
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 7.9715237267
MESH:D007898 Leishmaniasis, Visceral Thalidomide 4.1116514283
MESH:D007938 Leukemia arsenic trioxide 5.9315070760
MESH:D007938 Leukemia decitabine 5.9318980019 19235587
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.5212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.0016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.8014633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 7.8010785260 16572323 15631656
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.6619077051
MESH:D007951 Leukemia, Myeloid decitabine 8.6618454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 11.0519850784 16467208 20471514 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute decitabine 11.0518460780 18704418 18206229 19387464 19010910 17679729
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 11.0518360721
MESH:D015470 Leukemia, Myeloid, Acute Thalidomide 11.0518720364
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 11.0518206229
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1518055864
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.0117712046 12679006 17107899 16331271 15213294 15748426 12712474 19225113 16823087 16966277 19642359 17217047 17649720 16330433 16112521 11161223 9834237 12018890 11468182 17869043 16891316 15336539 19035177 15622746 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0616882451
MESH:D007964 Leukocytosis Indomethacin 5.0516537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.4017980183
MESH:D007970 Leukopenia Lipopolysaccharides 4.3915821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4216417039
MESH:D017880 Limb Deformities, Congenital Thalidomide 4.2310473037
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.4011479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4717174718 16943688 17157831 11408273 11903743 21278145 16221502 17334410 16239168
MESH:D008103 Liver Cirrhosis Thalidomide 6.4717174718 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.1914748882 18205269 12898905 18481824 16136751 18156304 12649538 16033810 12389079 20821823 18054572 16011737 17869086 15052691 18472332 11481614 17557913 16116963 16638106 18418968 15959796 17721639 17714472 15362042 18472094 18317297 17922224 18263696 18251166 17944888 18412020 12586293 12445418 15996030 18376398 15123356 17481882 15057751 12666154 12958196 17823541 15876570 14512876 18339082 15370692 16027843 18277467 12667390 15931870 17805973 16015684 10355542 15818738 12445421 14716496 18279442 14620537 18429990 12546737 12609069 18006644 16192424 15925388 18420326 18395914 18395095 17698563 17631135 15338365 17525996 15673190 18187930 16248980 14724832 18210741 12632512 15730626 18705752 12632514 12741479 17708605 13678700 17761835 17640975 17565644 15650968 15893842 16097048 17900296 14716833 17976157 17766677 18166357
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.1914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 8.1918194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.1912878042
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1912878042
MESH:D008106 Liver Cirrhosis, Experimental Thalidomide 8.1915465738
MESH:D008107 Liver Diseases Acetaminophen 6.1219460945 16611625 19014921 11587558 12969438 12587719 19784758 16610002
MESH:D008107 Liver Diseases Capsaicin 6.1216956363
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.1215720792 16246199 17285989 16964402 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8615123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.5216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.5214706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 9.6915890375 18177683 2125692 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 9.6914682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 9.6919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.6916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 20.868603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 20.8620377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 20.8612014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 20.861423854
MESH:D008114 Liver Neoplasms, Experimental kojic acid 20.8618544905
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 20.8612151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1215213294
MESH:D008171 Lung Diseases Asbestos, Serpentine 7.2617200189
MESH:D008171 Lung Diseases Ozone 7.268266340 19066396
MESH:D055370 Lung Injury Lipopolysaccharides 8.2321114838
MESH:D055370 Lung Injury Ozone 8.2320417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.0114755239
MESH:D008175 Lung Neoplasms arsenic trioxide 8.0111798837 19825857
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 8.0111198217
MESH:D008175 Lung Neoplasms Indomethacin 8.0116537180 11497255 11053908
MESH:D008175 Lung Neoplasms Ozone 8.018597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.0111884234 19555203
MESH:D008223 Lymphoma decitabine 3.2019470736
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.6611807958 17203775 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.6617203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Selenium 12.6615318939
MESH:D008325 Mammary Neoplasms, Experimental Zinc 12.6612773700
MESH:D020149 Manganese Poisoning Estradiol 4.1719453300
MESH:D008545 Melanoma decitabine 5.0516505122 17785578
MESH:D008545 Melanoma Thalidomide 5.0512829675 16098027 17089043
MESH:D008545 Melanoma trichostatin A 5.0516505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2619513568
MESH:D008654 Mesothelioma Selenium 2.6715107826
MESH:D008679 Metaplasia Ozone 4.7910496685
MESH:D008881 Migraine Disorders Indomethacin 3.4611903285
MESH:D009062 Mouth Neoplasms Indomethacin 3.7512636206
MESH:D009101 Multiple Myeloma arsenic trioxide 25.4319417148 19549372 14977855 11468182 15949261
MESH:D009101 Multiple Myeloma Capsaicin 25.4317505005
MESH:D009101 Multiple Myeloma decitabine 25.4318172295
MESH:D009101 Multiple Myeloma lenalidomide 25.4319112817 16118317 16433596
MESH:D009101 Multiple Myeloma Thalidomide 25.4315939924 19112817 15744524 17168659 19372569 15867202 15920492 19112201 15741222 16445831
MESH:D009101 Multiple Myeloma trichostatin A 25.4318172295
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3618349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 16.2616882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 16.2619010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes lenalidomide 16.2617076650
MESH:D009190 Myelodysplastic Syndromes Thalidomide 16.2618720364
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0516810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6716624393
MESH:D009362 Neoplasm Metastasis Indomethacin 3.0416537180 11239499 11053908
MESH:D009369 Neoplasms decitabine 2.5719116145 19470736 17925555
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 8.7011704859
MESH:D009374 Neoplasms, Experimental Indomethacin 8.7015625704 10663608
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4217289903
MESH:D009421 Nervous System Malformations Estradiol 14.7716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.7714600291
MESH:D009421 Nervous System Malformations Thalidomide 14.7716859833
MESH:D009436 Neural Tube Defects arsenic trioxide 2.9210525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5718514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.5712349958
MESH:D020078 Neurogenic Inflammation Capsaicin 4.8017961222
MESH:D009765 Obesity Capsaicin 3.3119056576
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.856374098
MESH:D010003 Osteoarthritis Indomethacin 3.487009135
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.5316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms decitabine 17.5319331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 17.5319401270
MESH:D010051 Ovarian Neoplasms Progesterone 17.5317393432 16525653
MESH:D010051 Ovarian Neoplasms Thalidomide 17.5316288038
MESH:D010051 Ovarian Neoplasms trichostatin A 17.5319331143
MESH:D010146 Pain Acetaminophen 9.9816870215
MESH:D010146 Pain Capsaicin 9.9817043245 19081190 17084039 17434803 18987195 16996476
MESH:D010146 Pain Indomethacin 9.9813679232 17440234 17627676 3291741
MESH:D010149 Pain, Postoperative Indomethacin 4.3618702446 12538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.0915580305
MESH:D010190 Pancreatic Neoplasms decitabine 8.0919294695
MESH:D010190 Pancreatic Neoplasms trichostatin A 8.0919294695
MESH:D010195 Pancreatitis Indomethacin 3.6415028970 17883296
MESH:D010235 Paraganglioma arsenic trioxide 3.8819927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.4016537180
MESH:D010291 Paresis Thalidomide 5.999200351
MESH:D020734 Parkinsonian Disorders Indomethacin 3.8512349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.4011903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010437 Peptic Ulcer Indomethacin 4.8411148446
MESH:D010518 Periodontitis Indomethacin 4.6017225004
MESH:D010538 Peritonitis Ozone 3.8316369182
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.1911550810
MESH:D010954 Plasmacytoma Selenium 4.5715087411
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.3910923243
MESH:D011014 Pneumonia Lipopolysaccharides 10.0712224865 11605937
MESH:D011014 Pneumonia Ozone 10.0718381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 10.129918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.1218163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Thalidomide 4.0617031469
MESH:D011225 Pre-Eclampsia Zinc 3.9417114810
MESH:D047928 Premature Birth Indomethacin 4.8217000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.4511399792 11222880 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 8.4519015723 18220299 18042343
MESH:D055728 Primary Myelofibrosis decitabine 11.4117616702
MESH:D055728 Primary Myelofibrosis trichostatin A 11.4117616702
MESH:D011469 Prostatic Diseases vinclozolin 4.6218220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6120887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9319131511
MESH:D011471 Prostatic Neoplasms Estradiol 1.9316740699
MESH:D011471 Prostatic Neoplasms Thalidomide 1.9316729912
MESH:D011471 Prostatic Neoplasms trichostatin A 1.9318798265 19789329
MESH:D011471 Prostatic Neoplasms Zinc 1.9316700911 12429649 16606632 16517595
MESH:D011472 Prostatitis vinclozolin 4.6218629315
MESH:D011507 Proteinuria Indomethacin 3.8811849393
MESH:D011536 Prurigo Thalidomide 5.9912755975
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 3.7115511213 18569384
MESH:D015427 Reperfusion Injury Capsaicin 3.8119211983 18460982
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5310835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012162 Retinal Degeneration Zinc 3.9016584753
MESH:D012208 Rhabdomyosarcoma decitabine 4.1219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7418045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6716646077
MESH:D019873 Schnitzler Syndrome Thalidomide 5.6316096327
MESH:D012772 Shock, Septic endotoxin, Escherichia coli 5.3218063050
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.108532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1016192470
MESH:D013119 Spinal Cord Injuries Progesterone 3.9715862959 16503802
MESH:D013272 Stomach Diseases Indomethacin 4.1116113693 15038085 16184426 15472012 18545984 10215738 17638125 17207306 16280098 17160473 18209964 10486359 10192188
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3117007042
MESH:D013274 Stomach Neoplasms decitabine 3.3119037991
MESH:D013274 Stomach Neoplasms Indomethacin 3.3115609394
MESH:D013276 Stomach Ulcer Indomethacin 6.9117135157 14567935 16755016 12498302 18543354 12467913 16150113 11523592 17895592 16169175 16397915 18209962 10878458 18181030 12077510 17657623 17918041 15255614 15104355 18299717 10423059 17654042 17977527 12787963 16631530 18193104 18431645 12500499 17627676 16252198 10750652 18726076 15138204 11595415 1323529 16934674 11906479 11145282 18087811 18237397 11595431 11729361
MESH:D013276 Stomach Ulcer Thalidomide 6.9115138204
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.4117997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.9015821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 15.2819014326
MESH:D013964 Thyroid Neoplasms Butyrates 15.2817967635
MESH:D013964 Thyroid Neoplasms decitabine 15.2817967635
MESH:D013964 Thyroid Neoplasms Indomethacin 15.2811352223 14736730 18791128
MESH:D013978 Tibial Fractures Estradiol 4.3719048282
MESH:D014062 Tongue Neoplasms Zinc 4.1316543248
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6515213294
MESH:D014456 Ulcer Indomethacin 4.5810574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.8211780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms decitabine 4.8219087683 17616700
MESH:D014581 Urticaria Acetaminophen 2.6910982225
MESH:D014604 Uveal Neoplasms decitabine 4.6017785578
MESH:D014652 Vascular Diseases Thalidomide 5.1715741222
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D014839 Vomiting Indomethacin 4.4311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04630 Jak-STAT signaling pathway
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29837
    • No data
    Releated disease ID Related disease Name
    PA446629Adenoma, Liver Cell
    PA444660Job's Syndrome
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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