AutismKB 2.0

Annotation Detail for IL7


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Basic Information Top
Gene Symbol:IL7 ( IL-7 )
Gene Full Name: interleukin 7
Band: 8q21.13
Quick LinksEntrez ID:3574; OMIM: 146660; Uniprot ID:IL7_HUMAN; ENSEMBL ID: ENSG00000104432; HGNC ID: 6023
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
No data
Pathway IDPathway Name
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1704Common variable immunodeficiency
1767Immunologic deficiency syndrome
1776Lymphopenia
1781Rheumatoid arthritis
1859Ovarian cancer
1918Atherosclerosis
2025Polyarthritis
2051Leukemia
2081Pulmonary fibrosis
2257Hemolytic-Uremic syndrome
No data
Desease Name
Longevity
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C029955 2-nitrotoluene 2-nitrotoluene results in increased expression of IL7 mRNAincreases expression 15612046
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of IL7 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IL7 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of IL7 mRNAdecreases expression 20064835
20106945
D003436 Croton Oil Croton Oil results in decreased expression of IL7 mRNAdecreases expression 18242016
D016572 Cyclosporine Cyclosporine results in increased expression of IL7 mRNAincreases expression 20106945
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in decreased expression of IL7 mRNAdecreases expression 18242016
D004391 Dust Dust results in increased expression of IL7 proteinincreases expression 17805423
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of IL7 exonincreases mutagenesis 17151827
17179092
D005472 Fluorouracil Fluorouracil affects the expression of IL7 mRNAaffects expression 18344199
D007213 Indomethacin Indomethacin results in decreased expression of IL7 mRNAdecreases expression 16984733
D008345 Manganese Manganese results in increased expression of IL7 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of IL7 mRNAincreases expression 17175027
C036868 methyl carbamate methyl carbamate results in increased expression of IL7 mRNAincreases expression 15612046
D009538 Nicotine Nicotine results in increased expression of and results in increased secretion of IL7 proteinincreases expression|increases secretion 18082304
D010081 Oxazolone Oxazolone results in decreased expression of IL7 mRNAdecreases expression 18242016
D010081 Oxazolone Oxazolone results in increased expression of IL7 mRNAincreases expression 11379042
D010100 Oxygen Oxygen deficiency results in increased expression of IL7 mRNAincreases expression 17175027
C008776 pelargonic acid pelargonic acid results in increased expression of IL7 mRNAincreases expression 11379042
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IL7 mRNAaffects binding|decreases expression|increases activity 19710929
C025299 polyphenols polyphenols results in decreased expression of IL7 mRNAdecreases expression 16293270
C017947 sodium arsenite sodium arsenite results in increased expression of IL7 mRNAincreases expression 12760830
D013629 Tamoxifen Tamoxifen results in decreased expression of IL7 mRNAdecreases expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IL7 mRNAincreases expression 12167310
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of IL7 mRNAdecreases expression 18242016
D001335 Vehicle Emissions Vehicle Emissions results in increased expression of IL7 mRNAincreases expression 19465080
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6614514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3718287403
MESH:D055371 Acute Lung Injury Oxygen 8.6316759491
MESH:D055371 Acute Lung Injury pirinixic acid 8.6318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8920127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 6.8917638652
MESH:D000230 Adenocarcinoma Indomethacin 6.8916537180
MESH:D000236 Adenoma Benzo(a)pyrene 10.706695378
MESH:D000236 Adenoma Ethylnitrosourea 10.706695378
MESH:D000236 Adenoma Indomethacin 10.7011497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7117306315 16712894
MESH:D016301 Alveolar Bone Loss Indomethacin 5.1817225004
MESH:D000544 Alzheimer Disease Indomethacin 4.5917627676 15579461
MESH:D000544 Alzheimer Disease Nicotine 4.5916627626
MESH:D000740 Anemia Fluorouracil 8.1317963324 15504547 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.1311748828
MESH:D000756 Anemia, Sideroblastic Manganese 10.4516910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.4516910769
MESH:D000860 Anoxia Oxygen 4.8620872349
MESH:D001014 Aortic Aneurysm Indomethacin 4.6610231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 11.0819183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 11.0810388637
MESH:D018771 Arthralgia Indomethacin 4.982160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.7811248219
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 3.4415590891 18394133 3040596 15855793 17015710 10797510 170078 6091945 10934080 12585506 15590890 8156442 7684630 11742282 19187332 20032816 12684321 12762349 11077013 16792590 11467998 16210060 6091946
MESH:D050197 Atherosclerosis Oxygen 3.6916391483
MESH:D001477 Bartter Syndrome Indomethacin 4.7910684365
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.7114991843
MESH:D001929 Brain Edema Indomethacin 4.8311481608
MESH:D002545 Brain Ischemia Indomethacin 4.2312524144
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.1218412241 16651633 16436596 15144691 16357521
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.6517474063 20146248
MESH:D001943 Breast Neoplasms Fluorouracil 3.6516595493 19217205 18357371 15136595 18608205 16110121 16557594
MESH:D001943 Breast Neoplasms Indomethacin 3.6517401462
MESH:D001943 Breast Neoplasms Oxygen 3.6517263869
MESH:D001943 Breast Neoplasms Tamoxifen 3.6517440819 19221464 20859285 19189210 16873071 18629630 19103187 11161223 19410462 16202921 21152245 19084267 17261762 19115204 16273361 19189212 19200415 17893378 21138602 19155303 18997820 19142967 19059307 19011961 18821012 18855134 20005174 18351453 18984771 20135344 16818667 20544844 20390343 15668708 17049068 15565566 19288272 18815881 18425577 19066611 19289846 20065188 19487384 19244106 17242785
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.6520435547
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 3.6511921183
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.3915590891 8156442 12507178
MESH:D002056 Burns Indomethacin 4.5210459503
MESH:D002100 Cachexia Indomethacin 4.8115141370 16537180 11239499 15625704
MESH:D002276 Carcinoid Tumor Fluorouracil 4.4816051944
MESH:D002277 Carcinoma Fluorouracil 7.6917121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.6916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.5521507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.5517045692 17971768 16332177 16799960 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 8.5516391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 8.5515276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.5516924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.5311053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.1611352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.4618695887
MESH:D002292 Carcinoma, Renal Cell Indomethacin 6.4617341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.3520419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.3516757204 17066447 16280240 18986760
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 10.3515482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.3518572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2616120746 18670907 18850075
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.5014688030
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.5512371664
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 10.5516003739
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.5519524636 20056578
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.7917160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0016835633
MESH:D002764 Cholecystitis Indomethacin 4.9811181007
MESH:D002779 Cholestasis Cyclosporine 7.2919486331
MESH:D002779 Cholestasis pirinixic acid 7.2919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 8697196 15668235 15340226 16354765
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.7919159591 17373747
MESH:D003110 Colonic Neoplasms Fluorouracil 5.7517725105 17169374 16510598 17172411 15001691 16340194 18772588 17018589 17287894 17016597
MESH:D003110 Colonic Neoplasms Indomethacin 5.7515786552 11260862 15625704 15936596 15963497 15637740
MESH:D003110 Colonic Neoplasms polyphenols 5.7516293270
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6818383874 18949393 16524972 17255274 18509181 18288408 16303861 18448328 17454858 17094418 20501625 17594712 16331619 16391804 17401013 15289873 15148649 14970324 18802399 17016601 16282729 17695437
MESH:D015179 Colorectal Neoplasms Indomethacin 2.6812606626 18059344 17054584 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9014669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.5217302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D007644 Darier Disease Fluorouracil 4.6016733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 7.1915491423
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 7.1912956900 15491423 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003877 Dermatitis, Contact Oxazolone 9.5915944321 12811023
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 9.5917010967
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3219279558
MESH:D003967 Diarrhea Indomethacin 3.617237001 7907874
MESH:D056486 Drug-Induced Liver Injury polyphenols 3.8019370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.9618043480 12774134 18446180 16133044 16326151 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 3.9517151854 11991626 17329845 11595415 17045617 10671773 11535926 16699067 17202747 11595431 17351913
MESH:D004417 Dyspnea Oxygen 4.6420016425
MESH:D020821 Dystonic Disorders Nicotine 5.7317881519
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.7918357618
MESH:D004487 Edema Indomethacin 10.457907874 8985016 16100529 19703484 10653021 8273558 7990266
MESH:D004487 Edema pirinixic acid 10.4512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.4511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7118230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.3619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9216202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Indomethacin 8.5115652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.5110568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.3118509659
MESH:D004751 Enteritis Croton Oil 11.498982514
MESH:D004751 Enteritis Indomethacin 11.4910567023 17763956 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.7917980183
MESH:D004802 Eosinophilia Indomethacin 8.7611298111
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 8.768156442
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.0316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 7.0317638652 16481741 16785472 16337965 15173087
MESH:D004938 Esophageal Neoplasms Indomethacin 7.0311005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.5518447907
MESH:D005234 Fatty Liver Cyclosporine 12.0519224547
MESH:D005234 Fatty Liver pirinixic acid 12.0519236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 12.0514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005334 Fever Indomethacin 3.9517627676 11852909 10431976
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005354 Fibrosarcoma Indomethacin 4.7010962813
MESH:D005355 Fibrosis Cyclosporine 13.7012168785 12639820
MESH:D005355 Fibrosis Indomethacin 13.7017994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.7020067830
MESH:D005499 Folliculitis Indomethacin 4.9811298111
MESH:D005739 Gas Poisoning Oxygen 5.0320016425
MESH:D005756 Gastritis Indomethacin 4.5515046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4916452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005909 Glioblastoma Ethylnitrosourea 11.4516436596
MESH:D005909 Glioblastoma Indomethacin 11.4512870263
MESH:D005909 Glioblastoma Manganese 11.4517043766
MESH:D005910 Glioma Ethylnitrosourea 9.6216651633 16357521 18412241
MESH:D005910 Glioma Fluorouracil 9.6216145905
MESH:D005910 Glioma Indomethacin 9.6218371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.1311849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006073 Gout Indomethacin 5.1611248219
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.5715162350 15102660 18337622
MESH:D006258 Head and Neck Neoplasms Indomethacin 7.5715482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 4.9113678655
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.4015633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.5015135802
MESH:D006529 Hepatomegaly pirinixic acid 7.6316221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6312621046 16120746 15340226
MESH:D006689 Hodgkin Disease sodium arsenite 3.0012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8518606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Indomethacin 3.6212727271
MESH:D034321 Hyperamylasemia Indomethacin 5.5217883296
MESH:D006940 Hyperemia Indomethacin 4.8112524144
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006949 Hyperlipidemias Indomethacin 3.9817546600
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.4311019492 10880147
MESH:D006973 Hypertension Cyclosporine 4.7010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7018670907 18850075
MESH:D007077 Ileal Diseases Indomethacin 4.8310574470 18306037
MESH:D007079 Ileitis Indomethacin 5.1610647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.1816133044
MESH:D007248 Infertility, Male sodium arsenite 2.8612646999 15346721
MESH:D007249 Inflammation Indomethacin 11.1912568917 3291741 7812673
MESH:D007249 Inflammation polyphenols 11.1916366677
MESH:D007249 Inflammation Tamoxifen 11.1919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.1912878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.5116306350
MESH:D007410 Intestinal Diseases Indomethacin 4.1411855677 11713966 11686837 17329856 17994277 15831440 18236018 10210152 15610444
MESH:D019586 Intracranial Hypertension Indomethacin 5.1815241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007579 Jejunal Diseases Indomethacin 4.8310574470 18306037 16133968
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Cyclosporine 9.528314463 10903974 18776723
MESH:D007674 Kidney Diseases Indomethacin 9.5217190690
MESH:D007674 Kidney Diseases sodium arsenite 9.5220008137
MESH:D007680 Kidney Neoplasms Cyclosporine 16.5312371664
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 16.5317379185
MESH:D007680 Kidney Neoplasms Fluorouracil 16.5316985049
MESH:D007680 Kidney Neoplasms Tamoxifen 16.5318625569
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.7512228301 11703811 10320625
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.7810785260 16572323 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6018360721
MESH:D007964 Leukocytosis Indomethacin 5.1816537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.5217980183
MESH:D008064 Lipidoses Tamoxifen 3.0215342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.5211479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.7518194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.7515474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.7518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7512878042
MESH:D008107 Liver Diseases polyphenols 2.7416698588
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.792125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.7920195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 20.7917045692 16603448 18383874 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 20.7920007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 20.7916712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 20.7916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.7916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 5.428603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.4212151625
MESH:D008171 Lung Diseases sodium arsenite 3.0519095001
MESH:D055370 Lung Injury Oxygen 4.3218339021
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.9614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.9618816296 17053015 18569708 18520028 6695378 20869020 20135361 20064080 20464547
MESH:D008175 Lung Neoplasms Ethylnitrosourea 14.9616271038 6695378 16019985 17703301
MESH:D008175 Lung Neoplasms Fluorouracil 14.9615246190
MESH:D008175 Lung Neoplasms Indomethacin 14.9616537180 11497255 11053908
MESH:D008175 Lung Neoplasms sodium arsenite 14.9615276417 17306315 19931552 16712894 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 14.9618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.9619555203 11884234
MESH:D008175 Lung Neoplasms Vehicle Emissions 14.969255578
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6015086387
MESH:D008223 Lymphoma Ethylnitrosourea 3.8115790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.8615375218
MESH:D008231 Lymphopenia marker/mechanism 17151827
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 5.9210838139 10767621 18041768
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9216827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Manganese 12.3816551646 16568477 19453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.3819453300
MESH:D008545 Melanoma Dinitrochlorobenzene 5.0617334785 12202904
MESH:D008545 Melanoma sodium arsenite 5.0616487513 19082730
MESH:D008545 Melanoma Tamoxifen 5.0612393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008579 Meningioma Ethylnitrosourea 5.7917943659
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D008881 Migraine Disorders Indomethacin 3.5411903285
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 13.5816381670
MESH:D009062 Mouth Neoplasms Fluorouracil 13.5816757204 18986760
MESH:D009062 Mouth Neoplasms Indomethacin 13.5812636206
MESH:D009069 Movement Disorders Manganese 4.8316551646
MESH:D009103 Multiple Sclerosis marker/mechanism 17660816
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.4913678655
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8016411023
MESH:D009362 Neoplasm Metastasis Indomethacin 5.7011239499 16537180 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.7411141357
MESH:D009369 Neoplasms Fluorouracil 14.7418600527 16928823 18239605
MESH:D009369 Neoplasms Nicotine 14.7416365874
MESH:D009369 Neoplasms pirinixic acid 14.7417405874
MESH:D009369 Neoplasms sodium arsenite 14.7411559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 20.2916707424
MESH:D009374 Neoplasms, Experimental Indomethacin 20.2910663608 15625704
MESH:D009374 Neoplasms, Experimental sodium arsenite 20.2920056578
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 20.291670384
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Nicotine 4.8016365874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009410 Nerve Degeneration Manganese 4.1316551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0314600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0212854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.2216003739 17160924 16651423
MESH:D019636 Neurodegenerative Diseases Indomethacin 3.7912349958
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3116436463
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.986374098
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 4.5512585506 3040596 11077013 18394133 6091946 8156442 6091945
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.7917160924
MESH:D010003 Osteoarthritis Indomethacin 3.557009135
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.3815276417 17306315
MESH:D010146 Pain Indomethacin 3.313291741 17440234 17627676 13679232
MESH:D010149 Pain, Postoperative Indomethacin 4.4918702446 12538197
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6016500647 16929163 15113037 19003803
MESH:D010195 Pancreatitis Indomethacin 3.7417883296 15028970
MESH:D010212 Papilloma Croton Oil 5.6016517061
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.5216537180
MESH:D010300 Parkinson Disease Manganese 3.3011181820
MESH:D020734 Parkinsonian Disorders Indomethacin 8.9712349958
MESH:D020734 Parkinsonian Disorders Manganese 8.9716140633
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.5211903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010437 Peptic Ulcer Indomethacin 4.9611148446
MESH:D010518 Periodontitis Indomethacin 4.7217225004
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0612371664
MESH:D047928 Premature Birth Indomethacin 4.9417000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0011896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1017292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1019082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1016039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1015067354
MESH:D011507 Proteinuria Indomethacin 3.9811849393
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.4314606601
MESH:D012004 Rectal Neoplasms Fluorouracil 3.8518722050 16160472 18286688 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.3317627322 18339021
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.317692837 20219652 16940033
MESH:D012135 Respiratory Sounds Vehicle Emissions 5.0318950799
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 4.9318447907
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.4119050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.0812617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.3219075512
MESH:D012640 Seizures Nicotine 3.6717873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.9210029692 19755658
MESH:D012878 Skin Neoplasms Croton Oil 12.9216517061
MESH:D012878 Skin Neoplasms sodium arsenite 12.9218572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.9216192470
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.3219050374 19075512
MESH:D013088 Spermatocele Tamoxifen 4.1016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8519457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6512854658
MESH:D013272 Stomach Diseases Indomethacin 4.2316280098 15472012 17638125 15038085 10192188 17207306 16113693 18209964 18545984 10215738 16184426 10486359 17160473
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.332093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.3317522103 15786421 16424979 17172411 18396642 19015929 17498489 16951190 19084572 18567086
MESH:D013274 Stomach Neoplasms Indomethacin 3.3315609394
MESH:D013276 Stomach Ulcer Indomethacin 3.4217918041 12498302 1323529 12787963 16755016 16252198 17977527 17657623 17135157 15255614 17627676 11595431 15104355 18193104 18431645 18726076 18543354 18237397 11906479 11595415 10750652 11729361 16150113 12467913 15138204 16169175 17895592 18209962 12077510 18087811 16397915 18181030 16631530 18299717 10423059 14567935 10878458 11523592 12500499 11145282 17654042 16934674
MESH:D013398 Sudden Infant Death Oxygen 5.3512563064
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.0617997062
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.9715790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms Indomethacin 3.4411352223 18791128 14736730
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.5916785264 16720336 11259349
MESH:D014029 Tobacco Use Disorder Nicotine 5.2615735609 18041664 17979512 18305452
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8216280240
MESH:D014456 Ulcer Indomethacin 4.7017380554 10574470
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.3817053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 11.3816712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.3816712894 17572228 8653321
MESH:D001749 Urinary Bladder Neoplasms Vehicle Emissions 11.3811144890
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.9316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.9311813266
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D014839 Vomiting Indomethacin 4.5511897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04640 Hematopoietic cell lineage
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29839
    • No data
    Releated disease ID Related disease Name
    PA444987Multiple Sclerosis
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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