AutismKB 2.0

Annotation Detail for IRF2BP2


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Basic Information Top
Gene Symbol:IRF2BP2 ( MGC72189 )
Gene Full Name: interferon regulatory factor 2 binding protein 2
Band: 1q42.3
Quick LinksEntrez ID:359948; OMIM: NA; Uniprot ID:I2BP2_HUMAN; ENSEMBL ID: ENSG00000168264; HGNC ID: 21729
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of IRF2BP2 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IRF2BP2 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of IRF2BP2 mRNA]affects reaction|increases expression 18038451
D004041 Dietary Fats Dietary Fats results in decreased expression of IRF2BP2 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of IRF2BP2 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IRF2BP2 mRNAaffects binding|increases activity|increases expression 19710929
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.3115238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2015673190 16124888 15721981 16192424 15700767 16097048 16227642 3786805 18705752 10355542 16050911 16011737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 2.9618788625
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9320889678
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9911529661 11834606 12540782 19416960 12153990 10915739 11739529 12958197 18713872 18071297 14550746 16781746 10774834 11287661 16485898 15968718 2444490 16227642 12594235 12705907 19370779 16177239 17562736 19739265 16393943 16109766 19923254 11461765 19164858 11421492 10663392 19085960 11743745 14986274 15619225 17522070 12392966 16081117 19420014 17906064 14725611
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.9915027814 19085960 7179309 10915739 19336974 16177239 3786805 9327722 15998439 15968718 11566570 21278145 6884620 16227642 3732212 7440962 6623471 17522070 7120509 4309450 10092053 2869522
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6718367378
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1320426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 15.0716045604 12795759 16239168 61145 17595544 15959796 12631006 19224547
MESH:D005234 Fatty Liver Dietary Fats 15.0717967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver pirinixic acid 15.0719236843 20131406
MESH:D005355 Fibrosis Carbon Tetrachloride 10.2418705752
MESH:D005355 Fibrosis Dietary Fats 10.2418296743
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9719110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 3.4119176532 16221962 19772884 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9916899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9221332399
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.9721332399
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5015338365
MESH:D007249 Inflammation Dietary Fats 2.5720412841
MESH:D007333 Insulin Resistance Dietary Fats 7.8911836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.8916306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3615629191 12587719
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.1516221502 11408273 17334410 16943688 17174718 17157831 11903743 21278145 16239168
MESH:D008103 Liver Cirrhosis Dietary Fats 7.1518296743
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.4017565644 15673190 15123356 17805973 15362042 12445418 15650968 18395914 16116963 17708605 15057751 18412020 18187930 18376398 18418968 18277467 10355542 12667390 15052691 18251166 13678700 17714472 18420326 16248980 17631135 15338365 18395095 15730626 18279442 12632514 12741479 18210741 12445421 18054572 15931870 18472332 12609069 17761835 12958196 14716496 14716833 17557913 16097048 15818738 18156304 12546737 18481824 12666154 15893842 17823541 18705752 14748882 16027843 12898905 17944888 16015684 11481614 17481882 18339082 12649538 15996030 14620537 16011737 17698563 16192424 16638106 20821823 14512876 18429990 18472094 15876570 17869086 17976157 18006644 12632512 16136751 18317297 15925388 17525996 17922224 18263696 12389079 18166357 15370692 17900296 17640975 14724832 12586293 16033810 15959796 17766677 17721639 18205269
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4015474484
MESH:D008107 Liver Diseases Acetaminophen 4.1212587719 19784758 16610002 19014921 11587558 12969438 16611625 19460945
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1215720792 16964402 15830285 16246199 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.4416871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.4416899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.7619294768
MESH:D008113 Liver Neoplasms pirinixic acid 4.7615890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7915583823 12014681
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms pirinixic acid 2.0817405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009765 Obesity Dietary Fats 4.6418674790 17217161 19632207 21332399 18457598 20132043 16723640 11836018 20518802
MESH:D009765 Obesity pirinixic acid 4.6420558911
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D015430 Weight Gain Dietary Fats 4.0216723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134947294
    • No data
    No data
    Releated drug ID Related drug Name
    PA449014cisplatin
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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