AutismKB 2.0

Annotation Detail for ACADSB


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Basic Information Top
Gene Symbol:ACADSB ( 2-MEBCAD,ACAD7,SBCAD )
Gene Full Name: acyl-CoA dehydrogenase, short/branched chain
Band: 10q26.13
Quick LinksEntrez ID:36; OMIM: 600301; Uniprot ID:ACDSB_HUMAN; ENSEMBL ID: ENSG00000196177; HGNC ID: 91
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
VALDEG-PWYvaline degradation I
ILEUDEG-PWYisoleucine degradation I
Pathway IDPathway Name
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of amino acids and derivatives
No data
No data
Pathway IDPathway Name
500780Branched-chain amino acid catabolism
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
hypertension
No data
Desease Name
2-methylbutyrylglycinuria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene results in decreased expression of ACADSB mRNAdecreases expression 16917068
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ACADSB mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACADSB mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ACADSB mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ACADSB mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ACADSB mRNAaffects expression 16483693
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in increased expression of ACADSB mRNAincreases expression 18178546
D003010 Clorgyline Clorgyline results in increased expression of ACADSB mRNAincreases expression 19691856
D016572 Cyclosporine Cyclosporine results in decreased expression of ACADSB mRNAdecreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNAaffects cotreatment|increases expression 18313992
C045651 epigallocatechin gallate epigallocatechin gallate results in decreased expression of ACADSB mRNAdecreases expression 16988119
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ACADSB mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ACADSB mRNAincreases expression 17942748
C027185 indirubin indirubin results in decreased expression of ACADSB mRNAdecreases expression 15056799
D015741 Metribolone Metribolone results in decreased expression of ACADSB proteindecreases expression 17152098
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of ACADSB mRNAdecreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of ACADSB mRNA]decreases expression|increases reaction 18467677
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ACADSB mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ACADSB mRNAdecreases expression 18467677
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ACADSB mRNA]decreases expression|increases reaction 18467677
D012402 Rotenone Rotenone results in decreased expression of ACADSB mRNAdecreases expression 19013527
D013629 Tamoxifen Tamoxifen affects the expression of ACADSB mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACADSB mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ACADSB mRNAdecreases expression 18796159
D013752 Tetracycline Tetracycline results in increased expression of ACADSB mRNAincreases expression 16917069
C052342 topiramate topiramate results in increased expression of ACADSB mRNAincreases expression 16979414
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of ACADSB mRNAaffects cotreatment|increases expression 18313992
D015032 Zinc Zinc results in increased expression of ACADSB mRNAincreases expression 17074742
D019287 Zinc Sulfate Zinc Sulfate results in increased expression of ACADSB mRNAincreases expression 17074742
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
OMIM:610006 2-METHYLBUTYRYL-CoA DEHYDROGENASE DEFICIENCY marker/mechanism
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4014745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 10.1118287403
MESH:D000138 Acidosis Zinc Sulfate 10.117265320
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7917505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.679612607
MESH:D000169 Acrodermatitis Zinc 5.2517202136 17190629 16889938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9718653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.7814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.673712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.3916835633
MESH:D000437 Alcoholism topiramate 4.9119331489 17925516 18552399
MESH:D000544 Alzheimer Disease Zinc 2.7217119284 16580781 16325427 16410023
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.7516916123
MESH:D000799 Angioedema Acetaminophen 3.6910982225
MESH:D000860 Anoxia Zinc Sulfate 4.877265320
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.3111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5715885639
MESH:D001249 Asthma epigallocatechin gallate 5.3016516891
MESH:D001249 Asthma Zinc 5.3017085522
MESH:D001321 Autistic Disorder marker/mechanism 17883863
MESH:D001321 Autistic Disorder Acetaminophen 1.4318445737
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 4.9119761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8711289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.3119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.3112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6715746008
MESH:D001930 Brain Injuries Zinc 4.5417109824
MESH:D001943 Breast Neoplasms Tamoxifen 1.9917440819 19155303 19103187 11161223 17049068 16202921 19487384 20135344 19066611 20005174 20065188 18351453 18997820 19142967 18821012 18425577 16273361 16818667 21138602 18855134 19059307 18984771 19410462 17242785 16873071 19289846 19244106 15565566 19115204 20859285 17261762 21152245 19288272 17893378 19084267 19189210 18629630 20390343 20544844 15668708 19011961 19221464 18815881 19189212 19200415
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3519066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.5916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.5916705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.593581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.593084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.5916924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.617296757
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.8616543248
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Zinc 3.5616936243
MESH:D002386 Cataract Acetaminophen 2.4910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.546135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 10.547505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.5412371664
MESH:D002659 Child Development Disorders, Pervasive topiramate 4.0415650499
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 18.2919486331 9022650
MESH:D002779 Cholestasis Cyclosporine 18.2919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 18.2917110522 11677210 15861022 16105132 17333356 16919318 17681005
MESH:D002779 Cholestasis pirinixic acid 18.2919176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.048697196 15340226 15668235 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Zinc 2.6319302082
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.3918551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.3918551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2119031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6612868966 8970840 8156756 11298694 18759878 11906362 2524372 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.353621924 2952479
MESH:D003920 Diabetes Mellitus Zinc 4.0716479319
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 7.1916988119
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.1917107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 7.1916979414
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 18.0018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.0018551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 18.0011289319 7440962 6482804 9022650 18648102 1440618 9653073 6679447 18692083 16192314 18289764 9328219 8291058
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.0016393943 19416960 19420014 11287661 11743745 18071297 11739529 12153990 18713872 11834606 19164858 14725611 16485898 12705907 12594235 14986274 19370779 16227642 19923254 12540782 2444490 14550746 17562736 10915739 17522070 17906064 16177239 16781746 12958197 11529661 19085960 11461765 15619225 19739265 12392966 10663392 16081117 10774834 15968718 16109766 11421492
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 18.0017851650
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.0020420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 18.0017522070
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9519426721
MESH:D004362 Drug Toxicity Lamivudine 13.2315040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.2311462148
MESH:D004362 Drug Toxicity Zidovudine 13.2315040536
MESH:D004487 Edema perfluorooctanoic acid 10.6612083418 17259670
MESH:D004487 Edema pirinixic acid 10.6612083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.6611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.4612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.4619031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.9517893378 16202921 20544844 19155303
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8910568697 9294722
MESH:D004827 Epilepsy topiramate 4.2519148780
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.1216499746
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.543581430
MESH:D004938 Esophageal Neoplasms Zinc 4.5416543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Cyclosporine 28.9219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.9215345470
MESH:D005234 Fatty Liver pirinixic acid 28.9220131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 28.9219224547 14986274
MESH:D005234 Fatty Liver Tetracycline 28.9216917069 19224547
MESH:D005234 Fatty Liver Zidovudine 28.9218299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.876705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0319069698
MESH:D005355 Fibrosis Cyclosporine 7.9812639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.9820067830
MESH:D005756 Gastritis Acetaminophen 10.6616983495
MESH:D005756 Gastritis Zinc 10.6617241300
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.897505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006130 Growth Disorders Zinc 3.8717217573
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2510048152 11294989
MESH:D006333 Heart Failure pirinixic acid 6.8420558911
MESH:D006333 Heart Failure Zinc 6.8417162251
MESH:D006335 Heart Injuries Zinc 5.6217074742
MESH:D016481 Helicobacter Infections Zinc 4.3917241300
MESH:D006402 Hematologic Diseases Zidovudine 4.5712579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.376705139
MESH:D006509 Hepatitis B Lamivudine 4.9617703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.9616476009 15309715 15274664 15631357 12044531
MESH:D006527 Hepatolenticular Degeneration Zinc 10.8117276780
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 10.8117063115
MESH:D006529 Hepatomegaly perfluorooctanoic acid 13.593609246
MESH:D006529 Hepatomegaly pirinixic acid 13.5919772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.5916120746 15340226 12621046
MESH:D015658 HIV Infections Lamivudine 6.809296927 11141242 17530837 20032539
MESH:D015658 HIV Infections Zidovudine 6.8011141242 11363243 17358032 20032539 11698656
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8916354765 8697196 16959395 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.4616870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.4612083418
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7915034207
MESH:D006968 Hypersensitivity, Delayed indirubin 5.7811275354
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6616945680 16569931
MESH:D007022 Hypotension Zinc Sulfate 4.337265320
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3917937319
MESH:D007249 Inflammation perfluorooctanoic acid 7.9012083418
MESH:D007249 Inflammation Tamoxifen 7.9019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9012200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5316306350
MESH:D007511 Ischemia Zinc 4.4816584753
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.879022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.5712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.5710903974 8314463 18776723
MESH:D007674 Kidney Diseases Zinc 9.5716960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.2816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 27.4916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 27.4916705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 27.496582329
MESH:D007680 Kidney Neoplasms Cyclosporine 27.4912371664
MESH:D007680 Kidney Neoplasms Tamoxifen 27.4918625569
MESH:D007680 Kidney Neoplasms Zidovudine 27.4912579204
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.1415237267
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.2720370541
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.088812269
MESH:D008064 Lipidoses Tamoxifen 3.0515342952 17567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.109327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 4.8217481882
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8215474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8212878042
MESH:D008107 Liver Diseases Acetaminophen 1.5919014921 16610002 19784758 16611625 12969438 11587558 19460945 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 13.637678174
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 13.6318709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 13.6316377806 15890375 20007298
MESH:D008113 Liver Neoplasms Tamoxifen 13.6316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.6316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.232876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.236587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2312151625
MESH:D008175 Lung Neoplasms Tamoxifen 3.3718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3719555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 3.3718800350
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9214580682 19196722 11731420 19196723 16827153
MESH:D008325 Mammary Neoplasms, Experimental Zinc 5.9212773700
MESH:D020149 Manganese Poisoning Tamoxifen 4.4019453300
MESH:D008545 Melanoma epigallocatechin gallate 3.5811746506 17992120
MESH:D008545 Melanoma Tamoxifen 3.5819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.4219513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.6917358032
MESH:D008881 Migraine Disorders topiramate 4.4716942474 18759728 18765137 18803445
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 5.3417962980
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.0819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8316411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.8418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.8418551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.493581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms pirinixic acid 1.8817405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8519196722 19189210 19200415
MESH:D009395 Nephritis, Interstitial Tetracycline 4.639884423
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1518481113 19348381
MESH:D009410 Nerve Degeneration Rotenone 3.7617356569 15790535 18619942
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.826679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.7518514411
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.809802331
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.2912819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.2916049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.296482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.873988306
MESH:D010146 Pain Acetaminophen 2.2716870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.337296757
MESH:D010300 Parkinson Disease Rotenone 2.9216140633 19232380 15451049 11445065 18191903 11535288 16412576 19114014 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 3.9415795934 15574749 18197244 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.2811026799
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.326228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0912371664
MESH:D011225 Pre-Eclampsia Zinc 4.0617114810
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 9.1617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.1611222880 11896295 11399792 11118676
MESH:D017096 Prion Diseases Tetracycline 5.2610903871
MESH:D011471 Prostatic Neoplasms Clorgyline 2.8219691856
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.8215067354
MESH:D011471 Prostatic Neoplasms Zinc 2.8216700911 12429649 16606632 16517595
MESH:D011537 Pruritus Ethinyl Estradiol 3.1616919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.3119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.633692021
MESH:D012162 Retinal Degeneration Zinc 8.6316584753
MESH:D012206 Rhabdomyolysis Lamivudine 5.389296927
MESH:D012640 Seizures 2,4-dinitrotoluene 9.4118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 9.4118551238
MESH:D012640 Seizures topiramate 9.4116499746
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0616709447
MESH:D013088 Spermatocele Tamoxifen 11.0616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8919457130
MESH:D013274 Stomach Neoplasms Zidovudine 2.4717696246
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.777505956 6582329 3712494 1399818 6587162
MESH:D014062 Tongue Neoplasms Zinc 4.2616543248
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 11.4216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 11.4216049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.428074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.4216712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.4810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.4810091137
MESH:D014581 Urticaria Acetaminophen 2.8310982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1514692618
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.6112579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4015869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
KEGG:00071 Fatty acid metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
KEGG:00280 Valine, leucine and isoleucine degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24427
    • No data
    Releated disease ID Related disease Name
    PA164925725Toxic liver disease
    Releated drug ID Related drug Name
    PA451846valproic acid
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00167 - L-Isoleucine Dietary supplement;Micronutrient;Essential Amino Acids
    DB00313 antagonist Valproic Acid Anticonvulsants;Enzyme Inhibitors;Antimanic Agents;GABA Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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