AutismKB 2.0

Annotation Detail for ZBTB41


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Basic Information Top
Gene Symbol:ZBTB41 ( DKFZp686C06120,FLJ36199,FRBZ1,RP11-469L3.1,ZNF924 )
Gene Full Name: zinc finger and BTB domain containing 41
Band: 1q31.3
Quick LinksEntrez ID:360023; OMIM: NA; Uniprot ID:ZBT41_HUMAN; ENSEMBL ID: ENSG00000177888; HGNC ID: 24819
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of ZBTB41 mRNAdecreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of ZBTB41 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ZBTB41 proteinaffects expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of ZBTB41 mRNAincreases expression 20106945
D007213 Indomethacin Indomethacin results in decreased expression of ZBTB41 mRNAdecreases expression 16984733
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ZBTB41 mRNAdecreases expression 17101203
C025643 vinclozolin vinclozolin affects the expression of ZBTB41 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2415322242 14514962 11752688
MESH:D000230 Adenocarcinoma Indomethacin 2.8416537180
MESH:D000236 Adenoma Indomethacin 3.5911497255
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D016301 Alveolar Bone Loss Indomethacin 5.8117225004
MESH:D000544 Alzheimer Disease Indomethacin 2.7517627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8619015723
MESH:D001014 Aortic Aneurysm Indomethacin 5.1810231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 5.2310388637
MESH:D018771 Arthralgia Indomethacin 5.612160914
MESH:D001172 Arthritis, Rheumatoid Indomethacin 2.8711248219
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001477 Bartter Syndrome Indomethacin 5.3410684365
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001929 Brain Edema Indomethacin 5.4711481608
MESH:D002545 Brain Ischemia Indomethacin 4.8112524144
MESH:D001943 Breast Neoplasms Indomethacin 2.1617401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1620435547
MESH:D002056 Burns Indomethacin 5.0610459503
MESH:D002100 Cachexia Indomethacin 5.4011239499 15625704 16537180 15141370
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.893084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8921507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 6.8916391822
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 5.1211053908
MESH:D018276 Carcinoma, Medullary Indomethacin 5.7511352223 18791128 14736730
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.4817341418
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 2.9115482327 12636206
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5016120746 18850075 18670907
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.196135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1912371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002764 Cholecystitis Indomethacin 5.6111181007
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2012621046 15668235 15340226 8697196 16354765
MESH:D003110 Colonic Neoplasms Indomethacin 2.6315786552 11260862 15936596 15625704 15963497 15637740
MESH:D015179 Colorectal Neoplasms Indomethacin 2.3618059344 12606626 17054584 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3114669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 6.1617302372
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2620055451 10048152 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.6714966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D003967 Diarrhea Indomethacin 4.127237001 7907874
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5212392966 11743745 15619225 19420014 11421492 16393943 15968718 11739529 16177239 14550746 17522070 11529661 19085960 11287661 10774834 14986274 16109766 16485898 11834606 18713872 16081117 11461765 16227642 12153990 12958197 16781746 12594235 18071297 19370779 12540782 19923254 2444490 17906064 19416960 12705907 19739265 10663392 14725611 17562736 10915739 19164858
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 5.5517190690 16326151 18043480 16133044 18446180 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 4.4617329845 17202747 17045617 10671773 11535926 11595431 11595415 11991626 17151854 16699067 17351913
MESH:D004487 Edema Indomethacin 7.867990266 16100529 8985016 19703484 8273558 7907874 10653021
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.8611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3518230668 16714409 15322242
MESH:D004715 Endometriosis Indomethacin 9.9615652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.9610568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.9018509659
MESH:D004751 Enteritis Indomethacin 5.1910567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 5.3417980183
MESH:D004802 Eosinophilia Indomethacin 4.4111298111
MESH:D004938 Esophageal Neoplasms Indomethacin 2.8611005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005334 Fever Indomethacin 4.3817627676 10431976 11852909
MESH:D005354 Fibrosarcoma Indomethacin 5.2910962813
MESH:D005355 Fibrosis Cyclosporine 17.0012639820 12168785
MESH:D005355 Fibrosis Indomethacin 17.0017994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.0020067830
MESH:D005499 Folliculitis Indomethacin 5.6111298111
MESH:D005756 Gastritis Acetaminophen 12.6716983495
MESH:D005756 Gastritis Indomethacin 12.6715046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.3316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.7416417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D005909 Glioblastoma Indomethacin 3.7312870263
MESH:D005910 Glioma Indomethacin 3.3118371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 4.5111849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006073 Gout Indomethacin 5.7511248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.9215482327
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.8515633222
MESH:D019698 Hepatitis C, Chronic Indomethacin 5.0115135802
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2512621046 16120746 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.498697196 16354765 15340226 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 8.5816870215
MESH:D006930 Hyperalgesia Indomethacin 8.5812727271
MESH:D034321 Hyperamylasemia Indomethacin 6.1617883296
MESH:D006940 Hyperemia Indomethacin 5.4012524144
MESH:D006949 Hyperlipidemias Indomethacin 4.4717546600
MESH:D006973 Hypertension Cyclosporine 5.2410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.2418670907 18850075
MESH:D007077 Ileal Diseases Indomethacin 5.4718306037 10574470
MESH:D007079 Ileitis Indomethacin 5.7510647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 5.8116133044
MESH:D007248 Infertility, Male vinclozolin 3.2116467254
MESH:D007249 Inflammation Indomethacin 5.553291741 7812673 12568917
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.5512878042 12200463
MESH:D007410 Intestinal Diseases Indomethacin 4.6811855677 17994277 15831440 11713966 11686837 17329856 15610444 10210152 18236018
MESH:D019586 Intracranial Hypertension Indomethacin 5.8115241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007579 Jejunal Diseases Indomethacin 5.4710574470 16133968 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Acetaminophen 10.9212587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.928314463 18776723 10903974
MESH:D007674 Kidney Diseases Indomethacin 10.9217190690
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 4.1411703811 12228301 10320625
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 4.1316572323 10785260 15631656
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 2.6718360721
MESH:D007964 Leukocytosis Indomethacin 5.8116537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 6.1617980183
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1316417039
MESH:D008101 Liver Abscess, Amebic Indomethacin 6.1611479899
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 2.5818194892
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6819784758 16610002 19460945 16611625 12969438 11587558 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.927678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.9215890375 18177683 9163691 2125692
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.9216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.752876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.758603461
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.7512151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.6114755239
MESH:D008175 Lung Neoplasms Indomethacin 3.6116537180 11497255 11053908
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6111884234 19555203
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D008881 Migraine Disorders Indomethacin 3.8611903285
MESH:D009062 Mouth Neoplasms Indomethacin 4.2012636206
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009362 Neoplasm Metastasis Indomethacin 3.2616537180 11239499 11053908
MESH:D009374 Neoplasms, Experimental Indomethacin 4.4915625704 10663608
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5414600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 9.1918514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 9.1912349958
MESH:D007752 Obstetric Labor, Premature Indomethacin 5.616374098
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010003 Osteoarthritis Indomethacin 3.827009135
MESH:D010146 Pain Acetaminophen 7.5816870215
MESH:D010146 Pain Indomethacin 7.583291741 17627676 13679232 17440234
MESH:D010149 Pain, Postoperative Indomethacin 5.1218702446 12538197
MESH:D010195 Pancreatitis Indomethacin 4.2215028970 17883296
MESH:D010257 Paraneoplastic Syndromes Indomethacin 6.1616537180
MESH:D020734 Parkinsonian Disorders Indomethacin 4.3812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 6.1611903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010437 Peptic Ulcer Indomethacin 5.5511148446
MESH:D010518 Periodontitis Indomethacin 5.3617225004
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D047928 Premature Birth Indomethacin 5.4917000239
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.8411118676 11222880 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.8418220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.3318220299
MESH:D011472 Prostatitis vinclozolin 5.3318629315
MESH:D011507 Proteinuria Indomethacin 4.4711849393
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013272 Stomach Diseases Indomethacin 4.8116113693 10486359 17638125 16280098 15472012 10192188 15038085 18209964 18545984 17160473 17207306 10215738 16184426
MESH:D013274 Stomach Neoplasms Indomethacin 2.3615609394
MESH:D013276 Stomach Ulcer Indomethacin 3.8618181030 15255614 11595431 17135157 15138204 18431645 1323529 11729361 12077510 16252198 18193104 11523592 10423059 12498302 17895592 11595415 16631530 12500499 12787963 18299717 17918041 18237397 18726076 18543354 11906479 16755016 18209962 18087811 16934674 11145282 16150113 17627676 15104355 10750652 17657623 17977527 17654042 12467913 10878458 14567935 16169175 16397915
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013964 Thyroid Neoplasms Indomethacin 3.7918791128 14736730 11352223
MESH:D014456 Ulcer Indomethacin 5.2910574470 17380554
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.3816049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D014839 Vomiting Indomethacin 5.1911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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