AutismKB 2.0

Annotation Detail for IL15RA


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IL15RA ( MGC104179 )
Gene Full Name: interleukin 15 receptor, alpha
Band: 10p15.1
Quick LinksEntrez ID:3601; OMIM: 601070; Uniprot ID:I15RA_HUMAN; ENSEMBL ID: ENSG00000134470; HGNC ID: 5978
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04672Intestinal immune network for IgA production
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
No data
No data
Pathway IDPathway Name
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1848Embryoma
2239Lymphoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of IL15RA mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of IL15RA mRNAincreases expression 20106945
D004139 Dinitrofluorobenzene IL15RA protein results in increased susceptibility to Dinitrofluorobenzeneincreases response to substance 15719370
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of IL15RA mRNA]decreases reaction|increases expression 12072388
C002950 methylformamide methylformamide analog results in decreased expression of IL15RA mRNAdecreases expression 17040096
C002950 methylformamide methylformamide results in decreased expression of IL15RA mRNAdecreases expression 17040096
D010634 Phenobarbital Phenobarbital results in increased expression of IL15RA mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of IL15RA mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.836195326
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4816434500
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416124888 15673190 16192424 16227642 18705752 15700767 16097048 15721981 3786805 16011737 16050911 10355542
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1518788625
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.151701930 17173139 20935162 20007298 6705139
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7112371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D002779 Cholestasis Cyclosporine 14.5419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.5416105132 17110522 17681005 11677210 16919318 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 14.5419176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.106623471 21278145 10092053 10915739 6884620 7440962 19336974 19085960 11566570 16227642 3732212 16177239 15027814 2869522 7120509 17522070 15998439 9327722 3786805 15968718 7179309 4309450
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.2112795759 16239168 12631006 16045604 15959796 19224547 17595544 61145
MESH:D005234 Fatty Liver Cyclosporine 21.2119224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 21.2115345470
MESH:D005234 Fatty Liver pirinixic acid 21.2120131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 9.8918705752
MESH:D005355 Fibrosis Cyclosporine 9.8912639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 9.7016109766
MESH:D006529 Hepatomegaly pirinixic acid 9.7019176532 16221962 19772884 18467677
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007674 Kidney Diseases Cyclosporine 2.488314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9712371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0911903743 16943688 16239168 11408273 17174718 21278145 17334410 17157831 16221502
MESH:D008103 Liver Cirrhosis Phenobarbital 7.0921047994
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3912632514 14724832 16136751 15893842 15730626 18429990 17698563 14716833 18376398 18263696 18277467 15057751 15673190 15959796 16248980 15996030 17823541 16027843 12649538 18420326 14716496 20821823 12898905 18395095 17481882 15876570 12546737 12609069 18210741 17976157 15925388 12445421 18251166 18481824 12445418 16011737 18412020 12667390 14748882 11481614 17805973 17525996 15818738 16116963 18395914 17565644 18006644 18418968 15931870 18205269 15338365 12741479 18472094 18279442 12666154 16033810 18054572 17721639 14512876 12586293 17761835 16097048 15370692 10355542 12389079 18339082 17557913 18317297 14620537 17944888 17869086 17900296 16638106 15362042 16015684 18705752 18472332 17640975 17714472 15052691 17922224 18166357 15650968 18156304 17708605 15123356 16192424 12632512 18187930 12958196 17766677 17631135 13678700
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3915474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.2916964402 17285989 16246199 15720792 15830285
MESH:D008107 Liver Diseases Phenobarbital 4.2919363144
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9514706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.9419294768
MESH:D008113 Liver Neoplasms Phenobarbital 7.9419073162 19812893 15975961 8742319 21047994 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 7.9420007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.5215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.5218308698 17172636 6150874 1399818 2563599
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D011230 Precancerous Conditions Cyclosporine 9.8112371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.812563599
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012640 Seizures Phenobarbital 2.8711442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04672 Intestinal immune network for IgA production
KEGG:04630 Jak-STAT signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved