AutismKB 2.0

Annotation Detail for FOXK2


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Basic Information Top
Gene Symbol:FOXK2 ( ILF,ILF-1,ILF1 )
Gene Full Name: forkhead box K2
Band: 17q25.3
Quick LinksEntrez ID:3607; OMIM: 147685; Uniprot ID:FOXK2_HUMAN; ENSEMBL ID: ENSG00000141568; HGNC ID: 6036
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of FOXK2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of FOXK2 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of FOXK2 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of FOXK2 mRNAincreases expression 20106945
D012176 Retinoids RARA protein promotes the reaction [Retinoids results in increased expression of FOXK2 mRNA]increases expression|increases reaction 12075115
D012176 Retinoids Retinoids results in increased expression of FOXK2 mRNAincreases expression 12075115
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Retinoids 4.0317491551 17368321 19340624
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 2.9516705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.953084413
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.3512371664
MESH:D002779 Cholestasis Cyclosporine 3.1719486331
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.5018551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 3.9921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9916485898 17522070 18713872 12705907 11739529 16081117 19370779 11421492 15619225 18071297 17562736 14725611 10663392 15968718 11743745 16109766 16393943 19416960 11529661 12958197 12392966 10915739 12540782 11287661 19420014 16781746 10774834 17906064 12153990 19085960 14550746 16177239 11834606 19739265 16227642 11461765 19164858 12594235 19923254 2444490 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D015785 Eye Diseases, Hereditary Retinoids 6.3216968212
MESH:D005234 Fatty Liver Cyclosporine 3.2319224547
MESH:D005355 Fibrosis Cyclosporine 3.6212639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.768708960
MESH:D006258 Head and Neck Neoplasms Retinoids 5.2017368321
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.9615720958
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Cyclosporine 2.2010903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.0515604871
MESH:D007674 Kidney Diseases Acetaminophen 6.4112587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.4110903974 8314463 18776723
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.3016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.3012371664
MESH:D007951 Leukemia, Myeloid Retinoids 5.8616482212
MESH:D008107 Liver Diseases Acetaminophen 1.6911587558 16610002 19784758 16611625 12587719 12969438 19014921 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008415 Mastocytosis Retinoids 7.1316953078
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.4016801185
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.4018551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.0517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6119348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.7816049721 12819281
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.5512371664
MESH:D011471 Prostatic Neoplasms Retinoids 4.9516724957 16166285
MESH:D011565 Psoriasis Cyclosporine 2.3216882103
MESH:D012640 Seizures 2,4-dinitrotoluene 2.7618551238
MESH:D012878 Skin Neoplasms Retinoids 4.5417538947
MESH:D013964 Thyroid Neoplasms Retinoids 5.0916940797
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 2.3916049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D014605 Uveitis Cyclosporine 4.591336536
MESH:D014985 Xerophthalmia Cyclosporine 5.0517120751
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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