AutismKB 2.0

Annotation Detail for ILF2


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Basic Information Top
Gene Symbol:ILF2 ( MGC8391,NF45,PRO3063 )
Gene Full Name: interleukin enhancer binding factor 2, 45kDa
Band: 1q21.3
Quick LinksEntrez ID:3608; OMIM: 603181; Uniprot ID:ILF2_HUMAN; ENSEMBL ID: ENSG00000143621; HGNC ID: 6037
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ILF2 mRNAaffects expression 21346803
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of ILF2 mRNAdecreases expression 12958071
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ILF2 mRNAaffects expression 21346803
C006780 bisphenol A bisphenol A results in increased expression of ILF2 mRNAincreases expression 16474171
C099555 CD 437 CD 437 results in decreased expression of ILF2 mRNAdecreases expression 12958071
D016572 Cyclosporine Cyclosporine results in increased expression of ILF2 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of ILF2 mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ILF2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ILF2 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in increased expression of ILF2 mRNAincreases expression 16474171
C027185 indirubin indirubin results in decreased expression of ILF2 mRNAdecreases expression 15056799
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of ILF2 mRNAincreases expression 16474171
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ILF2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.007525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0014514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1217505938
MESH:D000230 Adenocarcinoma Estradiol 7.2211473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.2214692618
MESH:D000230 Adenocarcinoma Genistein 7.2211473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.5316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7315885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9717123778
MESH:D001943 Breast Neoplasms Estradiol 1.9716675129 17289903 17261762 14630087 17018787 12948864 19861407 18497071
MESH:D001943 Breast Neoplasms Genistein 1.9716873071 16541309 17200150
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 4.7016705839
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.7016924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7016924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.3816332659
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6914694615
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8218566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0516105132 11677210 17681005 17110522 16919318 17333356 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1415340226 12621046 8697196 15668235 16354765
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.5215095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.5214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.1518551238
MESH:D003704 Dementia Polychlorinated Biphenyls 4.8116140633
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.4116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5119279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.4321346803
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3112538720
MESH:D004714 Endometrial Hyperplasia Genistein 4.7416402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.7411473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 7.7411473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 7.9519224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Genistein 3.3316598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0315340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 15340226 18606429 16959395 16354765
MESH:D006968 Hypersensitivity, Delayed indirubin 6.1111275354
MESH:D006973 Hypertension Cyclosporine 5.0710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 7.6716393666
MESH:D007333 Insulin Resistance Estradiol 7.6716393666 16627594
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 6.148314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.1415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D007680 Kidney Neoplasms Estradiol 12.9115610895
MESH:D007938 Leukemia Genistein 3.0718980019 17468513
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5417823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5412878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7516984957
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 6.341423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.3412151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3111807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.3114578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009203 Myocardial Infarction Genistein 2.9017141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.8016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.8017141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 4.0118551238
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 24.5616427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 24.5616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 24.5616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.5614600291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.4816049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.4814694615
MESH:D010024 Osteoporosis Genistein 3.3219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2016169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D010051 Ovarian Neoplasms CD 437 8.2117474084
MESH:D010051 Ovarian Neoplasms Estradiol 8.2119401270
MESH:D010051 Ovarian Neoplasms Genistein 8.2119005980
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8011578682
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4316702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.0310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.0311896295 11222880 11118676 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.9220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1216740699
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Genistein 2.1215378649 16925846 15256057
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.1215721890
MESH:D011537 Pruritus Ethinyl Estradiol 3.4716919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,4-dinitrotoluene 2.6018551238
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1216709447
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2515669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013978 Tibial Fractures Estradiol 4.8619048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.5516049721
MESH:D001749 Urinary Bladder Neoplasms CD 437 5.5516720286
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4710091137
MESH:D014591 Uterine Diseases bisphenol A 5.1814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4214692618
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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