AutismKB 2.0

Annotation Detail for IMPDH2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IMPDH2 ( IMPD2,IMPDH-II )
Gene Full Name: IMP (inosine 5'-monophosphate) dehydrogenase 2
Band: 3p21.31
Quick LinksEntrez ID:3615; OMIM: 146691; Uniprot ID:IMDH2_HUMAN; ENSEMBL ID: ENSG00000178035; HGNC ID: 6053
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-841purine nucleotides de novo biosynthesis II
PWY-6353purine nucleotides degradation II (aerobic)
Pathway IDPathway Name
hsa00230Purine metabolism
hsa00983Drug metabolism - other enzymes
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of nucleotides
No data
Pathway IDPathway Name
P02738De novo purine biosynthesis
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1904Diabetes mellitus
2251Osteosarcoma
No data
No data
Desease Name
IMPDH2 enzyme activity, variation in
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of IMPDH2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of IMPDH2 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of IMPDH2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of IMPDH2 mRNAaffects expression 17562736
C006780 bisphenol A bisphenol A results in increased expression of IMPDH2 mRNAincreases expression 19371625
C010052 bredinin bredinin results in increased expression of IMPDH2 mRNAincreases expression 11145582
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of IMPDH2 mRNAdecreases expression 17557909
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of IMPDH2 mRNAincreases expression 17108234
D015025 Zearalenone Zearalenone results in increased expression of IMPDH2 mRNAincreases expression 19371625
D005472 Fluorouracil Fluorouracil results in increased expression of IMPDH2 mRNAincreases expression 19219653
D019833 Genistein Genistein results in increased expression of IMPDH2 mRNAincreases expression 19371625
D006151 Guanosine Guanosine results in decreased expression of IMPDH2 mRNAdecreases expression 11145582
D009173 Mycophenolic Acid Mycophenolic Acid results in increased expression of IMPDH2 mRNAincreases expression 11145582
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of IMPDH2 mRNAdecreases expression 17616710
C016340 o,p'-DDT o,p'-DDT results in increased expression of IMPDH2 mRNAincreases expression 19371625
C006253 pirinixic acid pirinixic acid results in decreased expression of IMPDH2 mRNAdecreases expression 17426115
C059514 resveratrol resveratrol results in increased expression of IMPDH2 mRNAincreases expression 19371625
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of IMPDH2 mRNAaffects binding|increases expression 16214954
D014212 Tretinoin Tretinoin results in increased expression of IMPDH2 mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.367525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3615322242 11752688 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D058186 Acute Kidney Injury resveratrol 3.8116538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0514692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.0517638652
MESH:D000230 Adenocarcinoma Genistein 7.0511473722
MESH:D000236 Adenoma resveratrol 3.2915688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000544 Alzheimer Disease resveratrol 2.5616183991 16162502
MESH:D000740 Anemia Fluorouracil 8.5515504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.5511748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 12.1215885639
MESH:D001169 Arthritis, Experimental resveratrol 12.1217115116
MESH:D001169 Arthritis, Experimental Tretinoin 12.1216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D050197 Atherosclerosis resveratrol 3.2516873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.0419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.0412125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.0416206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001862 Bone Resorption bisphenol A 3.8211985600
MESH:D002545 Brain Ischemia resveratrol 4.2517600658
MESH:D001943 Breast Neoplasms bisphenol A 2.9417123778
MESH:D001943 Breast Neoplasms Fluorouracil 2.9418357371 15136595 16110121 19217205 16595493 16557594 18608205
MESH:D001943 Breast Neoplasms Genistein 2.9416541309 16873071 17200150
MESH:D001943 Breast Neoplasms resveratrol 2.9417651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9420435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9416873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002276 Carcinoid Tumor Fluorouracil 4.6416051944
MESH:D002277 Carcinoma Fluorouracil 8.0617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 14.0016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 14.0016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.003084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.0016332177 18930000 17045692 17971768 17088986 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 14.0016924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 14.0019321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 14.001917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.9517123778
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.5616675471
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0018695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 7.5418986760 16757204 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.5416227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.5416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 7.4116332659
MESH:D002318 Cardiovascular Diseases resveratrol 7.4115458977
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.2314694615
MESH:D002386 Cataract Acetaminophen 12.2310977129
MESH:D002386 Cataract Tretinoin 12.2317460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.746135515
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6317333356 17681005 17110522 16105132 15861022 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 7.6319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7015340226 8697196 16354765 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 5.709407595
MESH:D003092 Colitis resveratrol 9.4916474422
MESH:D003092 Colitis Tretinoin 9.4917035595
MESH:D003110 Colonic Neoplasms Fluorouracil 5.8617287894 16510598 17018589 15001691 17169374 17725105 18772588 16340194 17172411 17016597
MESH:D003110 Colonic Neoplasms Genistein 5.8617182828
MESH:D003110 Colonic Neoplasms resveratrol 5.8616338953
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6718949393 20501625 17255274 18509181 17094418 15148649 18288408 16524972 16391804 17401013 17016601 17695437 15289873 16331619 17594712 17454858 14970324 16303861 18448328 18383874 16282729 18802399
MESH:D015179 Colorectal Neoplasms resveratrol 2.6716550006
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.0615095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.0614669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.7216507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4315322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4314991402 17551590 9211117 16925845 9142499 10589399 9664655 9125849 8800419 9224671
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.7618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.7618551238
MESH:D007644 Darier Disease Fluorouracil 4.7616733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.7316873680
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2916647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2917107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.9216286809
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.8821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.8818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 11.8821346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.8819164858 10915739 19923254 16781746 11529661 17906064 16485898 11461765 19370779 19416960 2444490 19085960 14550746 15968718 19420014 12958197 18713872 14986274 12594235 18071297 15619225 14725611 12153990 16109766 16393943 16081117 10774834 16227642 10663392 12705907 12392966 11834606 11739529 11287661 17562736 19739265 11743745 16177239 12540782 11421492 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.8820420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004487 Edema pirinixic acid 11.2012083418
MESH:D004487 Edema resveratrol 11.208985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.2012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8515322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.9912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.9917872969
MESH:D004714 Endometrial Hyperplasia Genistein 4.5516402032
MESH:D016889 Endometrial Neoplasms Genistein 7.4611473722
MESH:D016889 Endometrial Neoplasms Tretinoin 7.4616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.8117923197
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7316337965 16785472 15173087 16481741 17638652
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7315623463 16510608 16704527 15264214 15547721 15547733 16805852 15878914 15150132
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.729664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.4115345470
MESH:D005234 Fatty Liver pirinixic acid 7.4119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4920067830
MESH:D005355 Fibrosis Tretinoin 8.4917994277
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005909 Glioblastoma Genistein 7.1116598420
MESH:D005909 Glioblastoma Tretinoin 7.1117312396
MESH:D005910 Glioma Fluorouracil 2.8516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.6915102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.6916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.469664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.1316221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1315340226 12621046 16120746
MESH:D006561 Herpes Simplex resveratrol 4.1416876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.5016870215
MESH:D006930 Hyperalgesia Tretinoin 7.5016870215
MESH:D006937 Hypercholesterolemia resveratrol 3.9617188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006949 Hyperlipidemias resveratrol 3.9916873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2617488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.6117600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation resveratrol 4.9916366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.9912878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.5216624496
MESH:D007333 Insulin Resistance bisphenol A 7.2216393666
MESH:D007333 Insulin Resistance pirinixic acid 7.2216306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8015992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.1712587719 15629191
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.2316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.2316705839
MESH:D007680 Kidney Neoplasms Fluorouracil 12.2316985049
MESH:D007938 Leukemia Genistein 6.3418980019 17468513
MESH:D007938 Leukemia Tretinoin 6.3417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.6716087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.6717339181 16140955 17107899 16331271 17712046 19225113 19035177 15748426 17361223 17301526 17294898 12679006 16891316 16766008 16823087 16935935 16788101 17217047 17649720 17368321 9834237 19029980 19642359 17506722 19075265
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.8917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8916248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6219460945 16611625 12969438 16610002 19784758 12587719 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.077678174
MESH:D008113 Liver Neoplasms Fluorouracil 14.0718383874 17045692 15113037 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 14.0720007298 15890375 16377806
MESH:D008113 Liver Neoplasms resveratrol 14.0719812893 20405173 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.0716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.642876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6412151625
MESH:D008175 Lung Neoplasms Fluorouracil 2.3315246190
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3319555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7615086387
MESH:D016393 Lymphoma, B-Cell resveratrol 4.2617088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.8314749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.2115688416
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.1912929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 6.198985016 11606380
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma resveratrol 3.4417992120
MESH:D008545 Melanoma Tretinoin 3.4416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008659 Metabolic Diseases resveratrol 4.3417112576
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6018986760 16757204
MESH:D009101 Multiple Myeloma resveratrol 3.4317164350 17049120 14749477 16490592 16267019 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.8317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D009203 Myocardial Infarction Genistein 9.3917141266
MESH:D009203 Myocardial Infarction pirinixic acid 9.3919151258
MESH:D009203 Myocardial Infarction resveratrol 9.3916456233 16317513 17015251 17125593 17188708 16525036
MESH:D017202 Myocardial Ischemia resveratrol 8.8917125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8912213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.2717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2716411023
MESH:D009205 Myocarditis resveratrol 4.7217322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.2318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.237678174 18551238
MESH:D009369 Neoplasms Fluorouracil 8.1216928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 8.1217405874
MESH:D009369 Neoplasms Tretinoin 8.1216594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 3.968985016
MESH:D009421 Nervous System Malformations bisphenol A 23.1311399458 16427766
MESH:D009421 Nervous System Malformations Genistein 23.1316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 23.1314600291
MESH:D009421 Nervous System Malformations Tretinoin 23.139125849
MESH:D009436 Neural Tube Defects Tretinoin 3.029142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2318514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.2317652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.3617929310
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4116436463
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.9316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.9316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.9314694615
MESH:D010024 Osteoporosis Genistein 3.2219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 10.0216169203
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 10.0217513867
MESH:D010049 Ovarian Diseases bisphenol A 4.9511985600
MESH:D010051 Ovarian Neoplasms Genistein 4.9019005980
MESH:D010051 Ovarian Neoplasms Tretinoin 4.9016936753
MESH:D010146 Pain Acetaminophen 6.4616870215
MESH:D010146 Pain Tretinoin 6.4616870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.2915113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.0910548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 16.0916679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.0911118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1720887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.1316740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1318626508 19082440
MESH:D011471 Prostatic Neoplasms Genistein 2.1315256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms resveratrol 2.1315767336 17675339 16731767 17636462 17718901 17804756
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D011629 Puberty, Precocious bisphenol A 4.7510548101
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9716160472 18286688 15538739 18722050
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.5516325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.5019058328
MESH:D015427 Reperfusion Injury resveratrol 6.5017520802 16314181 15827377 16317513 17058453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616116481 16283617
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.7718551238
MESH:D012878 Skin Neoplasms resveratrol 9.3615837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3616192470
MESH:D012878 Skin Neoplasms Tretinoin 9.3616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4417522103 15786421 18396642 16951190 16424979 18567086 17172411 19084572 17498489 19015929
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.4417575124 12958204
MESH:D013274 Stomach Neoplasms Tretinoin 3.4417261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.4416321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.9516684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9916026305 17045167
MESH:D014062 Tongue Neoplasms Fluorouracil 16.3616280240
MESH:D014062 Tongue Neoplasms resveratrol 16.3616227395
MESH:D014062 Tongue Neoplasms Tretinoin 16.3616051514
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.9516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.9516049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.8710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.8710091137
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 15.6816803524
MESH:D002583 Uterine Cervical Neoplasms resveratrol 15.6817473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 15.6816129372
MESH:D014591 Uterine Diseases bisphenol A 4.9814652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.3614692618
MESH:D014594 Uterine Neoplasms resveratrol 9.3617044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.2617488730
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
Pathway ID Pathway Name
KEGG:00983 Drug metabolism - other enzymes
KEGG:01100 Metabolic pathways
REACT:1698 Metabolism of nucleotides
KEGG:00230 Purine metabolism
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29863
    • No data
    Releated disease ID Related disease Name
    PA447247liver transplantation
    PA446116Inflammatory Bowel Diseases
    PA443434Arthritis, Rheumatoid
    PA133888799Organ Transplantation
    PA134850491Transplantation
    Releated drug ID Related drug Name
    PA164748728mycophenolic acid
    PA450566mycophenolate mofetil
    PA448515azathioprine
    PA449692folic acid
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00157 - NADH Dietary supplement;Micronutrient
    DB00688 antagonist Mycophenolate mofetil Antineoplastic Agents;Enzyme Inhibitors;Dermatologic Agents;Immunosuppressive Agents
    DB01024 inhibitor Mycophenolic acid Enzyme Inhibitors;Antibiotics, Antineoplastic
    DB01693 - Ribavirin Monophosphate
    DB01907 - Nicotinamide-Adenine-Dinucleotide
    DB03055 - Ester
    DB03070 - Selenazole-4-Carboxyamide-Adenine Dinucleotide
    DB03948 - 6-Chloropurine Riboside, 5'-Monophosphate
    DB04566 - Inosinic Acid
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved