AutismKB 2.0

Annotation Detail for INPP1


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Basic Information Top
Gene Symbol:INPP1 ( MGC110984 )
Gene Full Name: inositol polyphosphate-1-phosphatase
Band: 2q32.2
Quick LinksEntrez ID:3628; OMIM: 147263; Uniprot ID:INPP_HUMAN; ENSEMBL ID: ENSG00000151689; HGNC ID: 6071
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
PWY-6363D-myo-inositol (1,4,5)-trisphosphate degradation
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
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Related Diseases/Disorders Top
No data
Desease IDDesease Name
2045Bipolar disorder
No data
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No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of INPP1 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of INPP1 proteinaffects expression 20106945
D000499 Allylamine Allylamine results in increased expression of INPP1 mRNAincreases expression 15910882
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of INPP1 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in increased expression of INPP1 mRNAincreases expression 20106945
D003907 Dexamethasone Dexamethasone results in increased expression of INPP1 mRNAincreases expression 12782123
D004041 Dietary Fats Dietary Fats results in increased expression of INPP1 mRNAincreases expression 18042831
C002950 methylformamide methylformamide analog results in decreased expression of INPP1 mRNAdecreases expression 17040096
C002950 methylformamide methylformamide results in decreased expression of INPP1 mRNAdecreases expression 17040096
C041786 palm oil palm oil results in increased expression of INPP1 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of INPP1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of INPP1 mRNAincreases expression 18301758
C079198 S 1 (combination) INPP1 protein results in increased susceptibility to S 1 (combination)increases response to substance 16734730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D001169 Arthritis, Experimental Dexamethasone 3.6217659584
MESH:D001321 Autistic Disorder marker/mechanism 14627686
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0920146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.0920435547
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.0916705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.0912907637 21507988 12619106
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 4.1118212800 18347146
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 5.2620419170
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 5.2615984520
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.896135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8912371664
MESH:D002779 Cholestasis Cyclosporine 8.1019486331
MESH:D002779 Cholestasis pirinixic acid 8.1019176532
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5115824018
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.2917728286
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1918551238
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.5812438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003967 Diarrhea Dexamethasone 3.867237001
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0021346803 18551238
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004485 Eczema Dexamethasone 4.6212438553
MESH:D004487 Edema Dexamethasone 7.3819703484
MESH:D004487 Edema pirinixic acid 7.3812083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver Cyclosporine 13.8919224547
MESH:D005234 Fatty Liver Dietary Fats 13.8917967931 18296743 19551842 19004024
MESH:D005234 Fatty Liver pirinixic acid 13.8919236843 20131406
MESH:D005355 Fibrosis Cyclosporine 9.2912639820 12168785
MESH:D005355 Fibrosis Dietary Fats 9.2918296743
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 5.9219093184
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.418708960
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 4.8418607998 15984520
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7220471113
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6215720958
MESH:D006529 Hepatomegaly pirinixic acid 3.1716221962 19772884 19176532 18467677
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.117520565
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Cyclosporine 5.4810903974
MESH:D006973 Hypertension Dexamethasone 5.4817042910
MESH:D007249 Inflammation Dexamethasone 5.528960868 11099482
MESH:D007249 Inflammation Dietary Fats 5.5220412841
MESH:D007333 Insulin Resistance Dietary Fats 7.5418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.418314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms Cyclosporine 7.6712371664
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.5516718785
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5515474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.097678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.092125692 15890375 9163691 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 11.0916377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.242876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.248603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5714755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5718816296 6695378 20464547 18520028 20135361 20869020 17053015 18569708 20064080
MESH:D008175 Lung Neoplasms Dexamethasone 3.5711195469 15824018
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0116801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009101 Multiple Myeloma Dexamethasone 3.6015744524 15867202 16118317
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.619809623
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.057678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4119348381 18481113
MESH:D009765 Obesity Dietary Fats 4.5411836018 18674790 20132043 18457598 17217161 16723640 21332399 20518802 19632207
MESH:D009765 Obesity pirinixic acid 4.5420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5616049721
MESH:D011230 Precancerous Conditions Cyclosporine 3.3512371664
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6221297632
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011565 Psoriasis Cyclosporine 2.2716882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.1618379247 11700416
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6218551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4319755658 10029692
MESH:D013272 Stomach Diseases Dexamethasone 4.5115472012
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.952093021 20155912
MESH:D013274 Stomach Neoplasms S 1 (combination) 2.9518506536 16557585 18553229
MESH:D013276 Stomach Ulcer Dexamethasone 3.6215138204
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.1416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1417053015
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.5110091137
MESH:D014605 Uveitis Cyclosporine 12.511336536
MESH:D014605 Uveitis Dexamethasone 12.511336536
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
MESH:D014985 Xerophthalmia Cyclosporine 4.6617120751
Pathway ID Pathway Name
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29880
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA447199Bipolar Disorder
    Releated drug ID Related drug Name
    PA450243lithium
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01356 inhibitor Lithium
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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