AutismKB 2.0

Annotation Detail for INPP4A


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Basic Information Top
Gene Symbol:INPP4A ( INPP4,TVAS1 )
Gene Full Name: inositol polyphosphate-4-phosphatase, type I, 107kDa
Band: 2q11.2
Quick LinksEntrez ID:3631; OMIM: 600916; Uniprot ID:INP4A_HUMAN; ENSEMBL ID: ENSG00000040933; HGNC ID: 6074
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-63683-phosphoinositide degradation
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2074Asthma
Desease Name
Asthma
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of INPP4A mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of INPP4A mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of INPP4A mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.3018287403
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7916705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.566135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.5612371664
MESH:D002779 Cholestasis Cyclosporine 3.2419486331
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.6718551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 2.0618551238 21346803
MESH:D005234 Fatty Liver Cyclosporine 3.3419224547
MESH:D005355 Fibrosis Cyclosporine 3.7912639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.968708960
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.1615720958
MESH:D006973 Hypertension Cyclosporine 2.2310903974
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.3115604871
MESH:D007674 Kidney Diseases Cyclosporine 2.5618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.5916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.5912371664
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.287678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.792876784 2876786 6135515
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.6516801185
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.6018551238 7678174
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.7019348381 18481113
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.8816049721
MESH:D011230 Precancerous Conditions Cyclosporine 3.6412371664
MESH:D011565 Psoriasis Cyclosporine 2.3416882103
MESH:D012640 Seizures 2,6-dinitrotoluene 2.8218551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4216049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 5.0610091137
MESH:D014605 Uveitis Cyclosporine 4.851336536
MESH:D014985 Xerophthalmia Cyclosporine 5.3117120751
Pathway ID Pathway Name
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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