AutismKB 2.0

Annotation Detail for INPP5B


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Basic Information Top
Gene Symbol:INPP5B ( 5PTase,MGC65156,MGC71303 )
Gene Full Name: inositol polyphosphate-5-phosphatase, 75kDa
Band: 1p34.3
Quick LinksEntrez ID:3633; OMIM: 147264; Uniprot ID:I5P2_HUMAN; ENSEMBL ID: ENSG00000204084; HGNC ID: 6077
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
PWY-6363D-myo-inositol (1,4,5)-trisphosphate degradation
PWY-63621D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
PWY-63683-phosphoinositide degradation
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
Pathway IDPathway Name
Signaling by Rho GTPases
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006632 arsenic trioxide arsenic trioxide results in increased expression of INPP5B mRNAincreases expression 15761015
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of INPP5B mRNAdecreases expression 15336504
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3719825857 11798837
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.2216206674
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.9411589617
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 1.9915553829 14691202 11135700 16217749 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.9419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.6312490120
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8720501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.8612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.9010525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.7015213294
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.4012903497
MESH:D005234 Fatty Liver arsenic trioxide 3.8415073043
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.9416904648
MESH:D007938 Leukemia arsenic trioxide 3.0315070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.3512560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 5.1916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.3119077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1916467208 19850784 16968895 17050201 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.5117107899 16966277 19075265 15336539 16823087 17869043 12712474 15748426 19642359 11161223 17649720 17217047 17712046 19225113 16891316 12679006 15213294 12018890 19035177 16331271 11468182 15622746 9834237 16330433 16112521
MESH:D015458 Leukemia, T-Cell arsenic trioxide 5.0316882451
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4814682389
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 3.0120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.7315213294
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8719825857 11798837
MESH:D009101 Multiple Myeloma arsenic trioxide 3.4414977855 19417148 11468182 15949261 19549372
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.7418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3816105982 16882451
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.6316624393
MESH:D009436 Neural Tube Defects arsenic trioxide 3.4110525206
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5212452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6615580305
MESH:D010235 Paraganglioma arsenic trioxide 4.7719927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2019131511
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.6316646077
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.878532709
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.4719014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.8515213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.6212845720 20435036 12973940 11780464
Pathway ID Pathway Name
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03158 - D-Myo-Inositol-1,4-Bisphosphate
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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