Annotation Detail for INPP5D
Basic Information Top
| Gene Symbol: | INPP5D ( MGC104855,MGC142140,MGC142142,SHIP,SHIP1,SIP-145,hp51CN ) |
|---|---|
| Gene Full Name: | inositol polyphosphate-5-phosphatase, 145kDa |
| Band: | 2q37.1 |
| Quick Links | Entrez ID:3635; OMIM: 601582; Uniprot ID:SHIP1_HUMAN; ENSEMBL ID: ENSG00000168918; HGNC ID: 6079 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Pathway ID | Pathway Name |
|---|---|
| PWY-6364 | D-myo-inositol (1,3,4)-trisphosphate biosynthesis |
| PWY-6358 | superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism |
| PWY-6362 | 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) |
| PWY-6368 | 3-phosphoinositide degradation |
| Pathway ID | Pathway Name |
|---|---|
| hsa04910 | Insulin signaling pathway |
| hsa04070 | Phosphatidylinositol signaling system |
| hsa04662 | B cell receptor signaling pathway |
| hsa04664 | Fc epsilon RI signaling pathway |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| Pathway ID | Pathway Name |
|---|---|
| Hemostasis | |
| Signaling in Immune system |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| 500307 | PECAM1 interactions |
| 500482 | Downstream TCR signaling |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of INPP5D mRNA | affects expression | 17562736 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of INPP5D mRNA | affects expression | 16483693 |
| D004610 | Ellagic Acid | Ellagic Acid results in increased expression of INPP5D mRNA | increases expression | 12002526 |
| D004997 | Ethinyl Estradiol | Ethinyl Estradiol results in increased expression of INPP5D mRNA | increases expression | 12655037 |
| C014707 | nitrosobenzylmethylamine | nitrosobenzylmethylamine results in increased expression of INPP5D mRNA | increases expression | 17616710 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 4.10 | 18287403 | |
| MESH:D000152 | Acne Vulgaris | Ethinyl Estradiol | 4.55 | 17505938 | |
| MESH:D000230 | Adenocarcinoma | Ethinyl Estradiol | 1.88 | 14692618 | |
| MESH:D000799 | Angioedema | Acetaminophen | 4.45 | 10982225 | |
| MESH:D001161 | Arteriosclerosis | Ethinyl Estradiol | 3.95 | 11256880 | |
| MESH:D001169 | Arthritis, Experimental | Ethinyl Estradiol | 2.86 | 15885639 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.40 | 18445737 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.40 | 3084413 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.77 | 10977129 | |
| MESH:D002779 | Cholestasis | Ethinyl Estradiol | 3.13 | 16105132 15861022 17681005 11677210 16919318 17110522 17333356 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.66 | 14986274 12594235 16781746 15619225 11421492 12540782 10915739 14550746 11287661 2444490 16081117 19923254 19085960 17562736 19739265 11529661 14725611 10774834 16109766 19370779 17906064 16485898 17522070 19420014 12958197 11739529 11461765 12392966 16227642 19164858 12705907 16393943 11834606 11743745 18071297 12153990 19416960 18713872 15968718 10663392 16177239 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.71 | 19426721 | |
| MESH:D004681 | Encephalomyelitis, Autoimmune, Experimental | Ethinyl Estradiol | 3.63 | 12538720 | |
| MESH:D004938 | Esophageal Neoplasms | nitrosobenzylmethylamine | 2.84 | 15547721 15878914 15150132 16510608 16704527 15547733 15623463 15264214 16805852 | |
| MESH:D005234 | Fatty Liver | Ethinyl Estradiol | 3.18 | 15345470 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.29 | 16983495 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 2.99 | 16870215 | |
| MESH:D007021 | Hypospadias | Ethinyl Estradiol | 4.29 | 16569931 16945680 | |
| MESH:D007247 | Infertility, Female | Ethinyl Estradiol | 3.87 | 12013081 | |
| MESH:D007248 | Infertility, Male | Ethinyl Estradiol | 2.71 | 17937319 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 2.38 | 12587719 15629191 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.69 | 19460945 11587558 19784758 16611625 12969438 12587719 19014921 16610002 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.58 | 17185352 16871587 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.05 | 19513568 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.18 | 18514411 | |
| MESH:D010146 | Pain | Acetaminophen | 2.69 | 16870215 | |
| MESH:D016584 | Panic Disorder | Ethinyl Estradiol | 4.09 | 11578682 | |
| MESH:D011537 | Pruritus | Ethinyl Estradiol | 3.85 | 16919318 15861022 | |
| MESH:D013088 | Spermatocele | Ethinyl Estradiol | 4.55 | 16709447 | |
| MESH:D013274 | Stomach Neoplasms | nitrosobenzylmethylamine | 2.33 | 12958204 17575124 | |
| MESH:D019851 | Thrombophilia | Ethinyl Estradiol | 4.02 | 11994571 | |
| MESH:D013927 | Thrombosis | Ethinyl Estradiol | 3.48 | 15669648 | |
| MESH:D014581 | Urticaria | Acetaminophen | 3.38 | 10982225 | |
| MESH:D014594 | Uterine Neoplasms | Ethinyl Estradiol | 3.74 | 14692618 | |
| MESH:D020246 | Venous Thrombosis | Ethinyl Estradiol | 3.91 | 14671159 15869587 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04662 | B cell receptor signaling pathway |
| KEGG:04664 | Fc epsilon RI signaling pathway |
| KEGG:04666 | Fc gamma R-mediated phagocytosis |
| REACT:604 | Hemostasis |
| KEGG:04910 | Insulin signaling pathway |
| KEGG:04070 | Phosphatidylinositol signaling system |
| REACT:6900 | Signaling in Immune system |
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