AutismKB 2.0

Annotation Detail for INSR


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:INSR ( CD220,HHF5 )
Gene Full Name: insulin receptor
Band: 19p13.2
Quick LinksEntrez ID:3643; OMIM: 147670; Uniprot ID:INSR_HUMAN; ENSEMBL ID: ENSG00000171105; HGNC ID: 6091
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04910Insulin signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa04520Adherens junction
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Signaling by Insulin receptor
Signaling by FGFR
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200012Insulin Pathway
200065Signaling events mediated by TCPTP
200168Insulin-mediated glucose transport
Pathway IDPathway Name
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00048PI3 kinase pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Pathway IDPathway Name
500506Insulin receptor recycling
500492Signaling by Insulin receptor
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1784Choriocarcinoma
1818Systemic scleroderma
1856Obesity
1859Ovarian cancer
1894Abortion
1909Migraine
1944Breast cancer
2091Hypertension
2040Hyperglycemia
2053Colon cancer
2102Polycystic ovary syndrome
2115Muscular dystrophies
Desease Name
Diastolic blood pressure
diabetes
polycystic ovary syndrome
CARDIOVASCULAR
myocardial infarct
Leanness
gestational diabetes mellitus
hypertension
Hyperandrogenism
hyperlipidemia
METABOLIC
Glucose Intolerance
migraine
triglycerides
obesity
insulin
decreased levels of insulin-receptor messenger ribonucleic acid
leprechaunism
Insulin-resistant diabetes
polycystic ovarian disease
Insulin Resistance
typical migraine
No data
Desease Name
Rabson-Mendenhall syndrome
Hyperinsulinemic hypoglycemia, familial, 5
Diabetes mellitus, insulin-resistant, with acanthosis nigricans
Leprechaunism
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of INSR proteinaffects expression 20106945
C103303 alitretinoin alitretinoin results in increased phosphorylation of INSR proteinincreases phosphorylation 18063688
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]affects activity|affects phosphorylation|decreases reaction 19345745
C015001 arsenite [arsenite co-treated with Benzo(a)pyrene] results in increased expression of INSR mRNAaffects cotreatment|increases expression 15894712
C015001 arsenite arsenite results in increased expression of INSR mRNAincreases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of INSR mRNAdecreases expression 17879257
D001564 Benzo(a)pyrene [arsenite co-treated with Benzo(a)pyrene] results in increased expression of INSR mRNAaffects cotreatment|increases expression 15894712
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of INSR mRNAdecreases expression 15894712
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of INSR mRNAdecreases expression 20382639
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased phosphorylation of INSR proteinaffects cotreatment|decreases phosphorylation 19509184
D002857 Chromium Chromium promotes the reaction [INS1 protein results in increased phosphorylation of INSR protein]increases phosphorylation|increases reaction 16842748
D017608 Chromium Compounds Chromium Compounds promotes the reaction [INS1 protein results in increased phosphorylation of INSR protein]increases phosphorylation|increases reaction 16842748
C503589 cis-9, trans-11-conjugated linoleic acid cis-9, trans-11-conjugated linoleic acid affects the expression of INSR proteinaffects expression 17327424
D016572 Cyclosporine Cyclosporine results in decreased expression of INSR mRNAdecreases expression 20106945
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of INSR mRNAdecreases expression 17490981
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased phosphorylation of INSR proteinaffects cotreatment|decreases phosphorylation 19509184
D004052 Diethylnitrosamine Diethylnitrosamine affects the expression of INSR mRNAaffects expression 20387270
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of INSR proteindecreases expression 19542621
D004958 Estradiol Estradiol affects the phosphorylation of INSR proteinaffects phosphorylation 17068109
D004958 Estradiol Estradiol affects the reaction [Streptozocin affects the expression of INSR protein]affects expression|affects reaction 17068109
D000431 Ethanol Ethanol results in decreased phosphorylation of INSR proteindecreases phosphorylation 18377926
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of INSR geneincreases mutagenesis 18056790
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased phosphorylation of INSR proteinaffects cotreatment|decreases phosphorylation 19509184
D005632 Fructose [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNAaffects cotreatment|decreases expression 14633139
D005632 Fructose [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR proteinaffects cotreatment|decreases expression 14633139
D005632 Fructose Fructose results in decreased expression of INSR mRNAdecreases expression 14573337
D005632 Fructose Fructose results in decreased expression of INSR proteindecreases expression 14573337
D005947 Glucose Glucose results in decreased degradation of INSR mRNAdecreases degradation 7826318
D005947 Glucose Glucose results in increased expression of INSR mRNAincreases expression 7826318
D005947 Glucose Glucose results in increased phosphorylation of INSR proteinincreases phosphorylation 7826318
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of INSR proteinincreases expression 16237195
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of INSR proteinincreases expression 16237195
D009151 Mustard Gas Mustard Gas results in increased expression of INSR mRNAincreases expression 18955075
C488250 oleoylethanolamide anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]affects activity|affects phosphorylation|decreases reaction 19345745
C488250 oleoylethanolamide MAPK8 protein promotes the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]affects activity|affects phosphorylation|increases reaction 19345745
C488250 oleoylethanolamide oleoylethanolamide affects the phosphorylation of and affects the activity of INSR proteinaffects activity|affects phosphorylation 19345745
C488250 oleoylethanolamide [oleoylethanolamide binds to and results in increased activity of PPARA protein] which results in decreased activity of INSR proteinaffects binding|decreases activity|increases activity 19345745
C488250 oleoylethanolamide SB 203580 inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]affects activity|affects phosphorylation|decreases reaction 19345745
D011374 Progesterone Progesterone affects the reaction [Streptozocin affects the expression of INSR protein]affects expression|affects reaction 17068109
D011374 Progesterone Progesterone results in decreased phosphorylation of INSR proteindecreases phosphorylation 17068109
C093642 SB 203580 SB 203580 inhibits the reaction [oleoylethanolamide affects the phosphorylation of and affects the activity of INSR protein]affects activity|affects phosphorylation|decreases reaction 19345745
D017673 Sodium Chloride, Dietary [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR mRNAaffects cotreatment|decreases expression 14633139
D017673 Sodium Chloride, Dietary [Fructose co-treated with Sodium Chloride, Dietary deficiency] results in decreased expression of INSR proteinaffects cotreatment|decreases expression 14633139
D017673 Sodium Chloride, Dietary Sodium Chloride, Dietary results in decreased expression of INSR mRNAdecreases expression 14633139
D017673 Sodium Chloride, Dietary Sodium Chloride, Dietary results in decreased expression of INSR proteindecreases expression 14633139
D013311 Streptozocin Estradiol affects the reaction [Streptozocin affects the expression of INSR protein]affects expression|affects reaction 17068109
D013311 Streptozocin Progesterone affects the reaction [Streptozocin affects the expression of INSR protein]affects expression|affects reaction 17068109
D013311 Streptozocin Streptozocin affects the expression of INSR proteinaffects expression 17068109
D013739 Testosterone Testosterone results in increased expression of INSR mRNAincreases expression 17618942
D013739 Testosterone Testosterone affects the expression of INSRaffects expression 17162844
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR mRNA]affects reaction|decreases expression 20181658
D013749 Tetrachlorodibenzodioxin MAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]affects reaction|decreases expression 20181658
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of INSR mRNAdecreases expression 20181658
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of INSR proteindecreases expression 20181658
D013749 Tetrachlorodibenzodioxin TNF protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]affects reaction|decreases expression 20181658
D013749 Tetrachlorodibenzodioxin TNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]affects reaction|decreases expression 20181658
D013749 Tetrachlorodibenzodioxin U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]decreases expression|decreases reaction 20181658
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of INSR mRNAaffects expression 15977195
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with LEP protein] affects the expression of INSR mRNAaffects cotreatment|affects expression 15977195
C113580 U 0126 U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of INSR protein]decreases expression|decreases reaction 20181658
D014638 Vanadates Vanadates promotes the reaction [INS1 protein results in increased phosphorylation of INSR protein]increases phosphorylation|increases reaction 16842748
D014638 Vanadates Vanadates results in increased expression of INSR proteinincreases expression 17874149
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.4918926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.4914514962 15322242 11752688
MESH:D000138 Acidosis Ethanol 4.2011192467
MESH:D000168 Acrocephalosyndactylia U 0126 5.1817694057
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.7111473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 6.7115113128 15688392
MESH:D000236 Adenoma Benzo(a)pyrene 10.266695378
MESH:D000236 Adenoma Diethylnitrosamine 10.2610737359 6695378
MESH:D000236 Adenoma Ethylnitrosourea 10.266695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.0718056438 19052882 16434500 19061943 17162532 17620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.0716835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0215451039 15451040
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 3.7920157255
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6911748828
MESH:D000853 Anophthalmos Ethanol 4.5315513904
MESH:D000855 Anorexia oleoylethanolamide 5.6915879057
MESH:D000987 Antisocial Personality Disorder Testosterone 5.557506515
MESH:D001008 Anxiety Disorders Ethanol 3.7711141031
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 9.7315552841
MESH:D001161 Arteriosclerosis Dietary Fats 9.7315238619
MESH:D001249 Asthma Mustard Gas 2.6210378619
MESH:D001768 Blister Mustard Gas 4.8619167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.6214991843
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0417868700
MESH:D001930 Brain Injuries Progesterone 3.9715380490 15665606 15845082
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.0415144691 16436596 16651633 16357521 18412241
MESH:D001943 Breast Neoplasms alitretinoin 7.9316344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.9320146248 17474063
MESH:D001943 Breast Neoplasms Chromium 7.9315986119
MESH:D001943 Breast Neoplasms Dietary Fats 7.9320435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.9317474063
MESH:D001943 Breast Neoplasms Estradiol 7.9317289903 17261762 12948864 19861407 17018787 14630087 16675129 18497071
MESH:D001943 Breast Neoplasms Hexachlorobenzene 7.9312709520 15061365
MESH:D001943 Breast Neoplasms Methylnitrosourea 7.9314633655 11306469 16253758
MESH:D001943 Breast Neoplasms Progesterone 7.9315562024 17614352 16175315
MESH:D001943 Breast Neoplasms Testosterone 7.9317261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.9320435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6817687719 10378619
MESH:D002056 Burns Ethanol 4.3616374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002276 Carcinoid Tumor Streptozocin 5.3016051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.3512619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 8.3519418558
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.3520214788 16807293 18788625 18056438 17138121 20512989 3084413 18785209 19171122 18494052 16328049 18971187 17055752 18978308 18506893 19394651 16569478 19335982 16502159 3581430 19701751 16681979 17173139 20084675 19208518 19107877 20727157 10737359 19822196 19519916 16935385 16698587 19919837 20432363 17761372 19418558 19052882 20935162 19539802 18691550 10672840 16878318 17978847 11831363 18210153 17428255 20514400 20101231 16288022 19383236 18393292 16830150 16779866 16540662 20007298 18665156 21159647 20524982 17162532
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.3516924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 8.3515289165 15763234 18788625
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 1.9720419170
MESH:D006332 Cardiomegaly Ethanol 6.3019332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3016120746 18670907 18850075
MESH:D002386 Cataract Methylnitrosourea 3.8212484553
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 23.7520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 23.7512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 23.7517174075 7505956 2727394 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 23.7518566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 23.7516003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 23.757505956 2727394
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.6817160924
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.5720678186
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D002779 Cholestasis Cyclosporine 2.7019486331
MESH:D002971 Cleft Lip Ethanol 3.4315513904
MESH:D002972 Cleft Palate Ethanol 5.5315513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5312621046 8697196 15668235 15340226 16354765
MESH:D003110 Colonic Neoplasms arsenite 2.5415037631
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8114669216 17141729
MESH:D003327 Coronary Disease Fructose 4.2918504504
MESH:D019465 Craniofacial Abnormalities Ethanol 2.5415451039 15451040 19302082 15513904 10194807 11198716 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5415322242 10048152 20055451
MESH:D003920 Diabetes Mellitus Streptozocin 4.4816285004
MESH:D003921 Diabetes Mellitus, Experimental Fructose 8.3118603373
MESH:D003921 Diabetes Mellitus, Experimental Streptozocin 8.317637645 19496084 19960420 16286809 12083368 15862027 18715473 16684804 17442507 2177838 12644472 12446591 11260395 18603373 19586609 19298542 11055810 6379147 17874149 12093613 15831366 8740154 15298345 1374869
OMIM:610549 DIABETES MELLITUS, INSULIN-RESISTANT, WITH ACANTHOSIS NIGRICANS marker/mechanism
MESH:D003922 Diabetes Mellitus, Type 1 Streptozocin 3.5418603373
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 9.6820387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 9.6818603373
MESH:D003924 Diabetes Mellitus, Type 2 Streptozocin 9.6819586609 19647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.6817107852
MESH:D058065 Diabetic Cardiomyopathies Streptozocin 5.4316025228
MESH:D003928 Diabetic Nephropathies Estradiol 8.4619279558
MESH:D003928 Diabetic Nephropathies Streptozocin 8.4619682444 19960420
MESH:D003929 Diabetic Neuropathies Progesterone 4.2017187935
MESH:D003930 Diabetic Retinopathy Streptozocin 5.1417662242
MESH:D056731 Donohue Syndrome marker/mechanism 18411068
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 5.7319107877
MESH:D056486 Drug-Induced Liver Injury Ethanol 5.7311566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.7320420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2418367378
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.6818357618
MESH:D004487 Edema Mustard Gas 5.9811428647 9260866 11428631 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.5017692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.7911473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 8.0816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.0810568697 9294722
MESH:D004890 Erythema Mustard Gas 4.869357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7920426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7916530937
MESH:D004938 Esophageal Neoplasms Ethanol 6.7916704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver arsenite 27.3018296743
MESH:D005234 Fatty Liver Cyclosporine 27.3019224547
MESH:D005234 Fatty Liver Dietary Fats 27.3017967931 19551842 19004024 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 27.3021071580 20387270
MESH:D005234 Fatty Liver Ethanol 27.3016409862 19236843 18620774
MESH:D005234 Fatty Liver Fructose 27.3018395287 18641190 19196556
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3617920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0016946407 15513904 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.9411555667
MESH:D005355 Fibrosis arsenite 24.6818296743
MESH:D005355 Fibrosis Cyclosporine 24.6812639820 12168785
MESH:D005355 Fibrosis Dietary Fats 24.6818296743
MESH:D005355 Fibrosis Fructose 24.6818504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.6820067830
MESH:D005391 Firesetting Behavior Testosterone 5.557506515
MESH:D005756 Gastritis Ethanol 4.3915046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma Ethylnitrosourea 7.1716436596
MESH:D005909 Glioblastoma Testosterone 7.1717162496
MESH:D005910 Glioma Ethylnitrosourea 6.2016651633 18412241 16357521
MESH:D005910 Glioma Methylnitrosourea 6.209825942
MESH:D018149 Glucose Intolerance marker/mechanism 10949030
MESH:D018149 Glucose Intolerance Fructose 5.0519165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.9320471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9311294989 10048152
MESH:D006331 Heart Diseases Streptozocin 4.0712093613
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6115340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D006628 Hirsutism Testosterone 5.3517019078
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7515340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Ethanol 3.4918783367
MESH:D017588 Hyperandrogenism Testosterone 5.0117019078
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 8.8110876104
MESH:D006937 Hypercholesterolemia Dietary Fats 8.8121332399
MESH:D006943 Hyperglycemia marker/mechanism 18056790
OMIM:609968 HYPERINSULINEMIC HYPOGLYCEMIA, FAMILIAL, 5 marker/mechanism
MESH:D006946 Hyperinsulinism marker/mechanism 18411068 10949030
MESH:D006946 Hyperinsulinism Fructose 4.6518360027 19008412 18563319 14757778 15752949
MESH:D006949 Hyperlipidemias Dietary Fats 14.2621332399
MESH:D006949 Hyperlipidemias Fructose 14.2615752949
MESH:D006949 Hyperlipidemias oleoylethanolamide 14.2615910890
MESH:D006973 Hypertension Cyclosporine 11.5510903974
MESH:D006973 Hypertension Fructose 11.5516843071 19008412 14633139 14568997 14573337
MESH:D006973 Hypertension Sodium Chloride, Dietary 11.5518524855
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.5518850075 18670907
MESH:D015228 Hypertriglyceridemia Fructose 4.8219342510 19799862
MESH:D007006 Hypogonadism Testosterone 4.3812002444
MESH:D007018 Hypopituitarism Testosterone 5.9017426086
MESH:D007174 Impulse Control Disorders Testosterone 5.557506515
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1115869954
MESH:D007248 Infertility, Male Methylnitrosourea 3.607193160
MESH:D007249 Inflammation Dietary Fats 14.2120412841
MESH:D007249 Inflammation Diethylnitrosamine 14.2118785209
MESH:D007249 Inflammation Mustard Gas 14.2111428620 11402378 8975870 9357497 17524151 16001271 9260866 11428647 11428631
MESH:D007249 Inflammation Progesterone 14.2115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.2112878042 12200463
MESH:D007333 Insulin Resistance marker/mechanism 10949030
MESH:D007333 Insulin Resistance Dietary Fats 11.4018457598 11836018
MESH:D007333 Insulin Resistance Estradiol 11.4016393666 16627594
MESH:D007333 Insulin Resistance Fructose 11.4018057795 19008412 14573337 14757778 19342510 17133782 14633139 19799862 18563319 18981581 19586609
MESH:D007569 Jaw Abnormalities Ethanol 9.2415513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.3416144296
MESH:D007674 Kidney Diseases Chromium 13.1517934191
MESH:D007674 Kidney Diseases Cyclosporine 13.1510903974 18776723 8314463
MESH:D007674 Kidney Diseases Estradiol 13.1515618244
MESH:D007674 Kidney Diseases Streptozocin 13.1512093613
MESH:D007680 Kidney Neoplasms Cyclosporine 11.1212371664
MESH:D007680 Kidney Neoplasms Estradiol 11.1215610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 11.1217379185
MESH:D007859 Learning Disorders Ethanol 3.9215451040
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 11.1616972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 11.1616972261
MESH:D017880 Limb Deformities, Congenital Ethanol 7.9517676605
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 7.9515526292
MESH:D008103 Liver Cirrhosis arsenite 14.4718296743
MESH:D008103 Liver Cirrhosis Dietary Fats 14.4718296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 14.4718522880 18407596 20032147 19638242 18665156
MESH:D008103 Liver Cirrhosis Ethanol 14.4715289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8018295389
MESH:D008106 Liver Cirrhosis, Experimental cis-9, trans-11-conjugated linoleic acid 4.7517869086
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.7518166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7512878042
MESH:D008107 Liver Diseases Diethylnitrosamine 2.0317034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3617207112 17347304
MESH:D008113 Liver Neoplasms Aflatoxin B1 9.7315890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 9.7320195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 9.7312771043 15885732 20452335 21071580 19690152 21047994 18648771 21167192 19499222 2422723 15175105 19642983 18977376 2862719 19638242 20118626 19254457 10737359 21278145 20492335 18754104 20405173 18644402 19256749 12112319 20501860 19812893 20434301 19426721 19090486 19294768 20583210 20101389 19255062 20137499 19551842 19833225 9163691 19427195 19996281 19073162 19850985 16942905 18978307
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 9.7316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.658603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.6519009564 17174075 18544905 19519916 19539802 16842330 18775883 18308698 16267830 2563599 18079962 9362446 19126423 3124819 18093689 17854601 17942915 18282651 21159647 18164116 18253720 19004024
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 12.651423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.6512151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.1716080182
MESH:D008171 Lung Diseases Mustard Gas 3.2518702808 18161513
MESH:D008175 Lung Neoplasms Aflatoxin B1 14.6314755239
MESH:D008175 Lung Neoplasms alitretinoin 14.6316413115
MESH:D008175 Lung Neoplasms arsenite 14.6316809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.6318569708 20135361 18816296 18520028 20464547 17053015 20869020 6695378 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 14.6320970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Ethylnitrosourea 14.636695378 16271038 17703301 16019985
MESH:D008175 Lung Neoplasms Methylnitrosourea 14.6318062963
MESH:D008175 Lung Neoplasms Mustard Gas 14.633148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.6319555203 11884234
MESH:D008223 Lymphoma Ethylnitrosourea 7.4315790496
MESH:D008223 Lymphoma Methylnitrosourea 7.4316257854 11418001
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.5014633661
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.7615375218
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.8011408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 12.8010767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 12.8011751437 17020996 11807958 12931682 15113128 16944150 16619500 15688392 15313902 14999141 10767621 16051031 17131329 19196723 14633655 16827153 10838139
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 12.8017203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008545 Melanoma Glucose 3.0314993021
MESH:D008569 Memory Disorders Ethanol 3.9115451040 18411066
MESH:D008579 Meningioma Ethylnitrosourea 5.6817943659
MESH:D024821 Metabolic Syndrome X Fructose 4.5818497449 17261469 16815490 19165636 17098227
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9716381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0616810080
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.453581430 9029167
MESH:D009369 Neoplasms alitretinoin 7.6316946489
MESH:D009369 Neoplasms Benzo(a)pyrene 7.6311141357
MESH:D009369 Neoplasms Methylnitrosourea 7.6315533788
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 8.7116707424
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.7112696579
MESH:D009389 Neovascularization, Pathologic arsenite 9.1715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.1717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0419348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.5316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5314600291
MESH:D009442 Neurilemmoma Ethylnitrosourea 12.3016651423 16003739 17160924
MESH:D009442 Neurilemmoma Methylnitrosourea 12.3011555667
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.1020387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009503 Neutropenia Mustard Gas 3.7016761898 7688884
MESH:D009765 Obesity Dietary Fats 7.4220132043 21332399 11836018 17217161 19632207 18674790 20518802 16723640 18457598
MESH:D009765 Obesity Fructose 7.4218585860 17707055
MESH:D009765 Obesity oleoylethanolamide 7.4215910890
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.6817160924
MESH:D010051 Ovarian Neoplasms Estradiol 7.4619401270
MESH:D010051 Ovarian Neoplasms Progesterone 7.4617393432 16525653
MESH:D010051 Ovarian Neoplasms U 0126 7.4616211241
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1516540662
MESH:D010190 Pancreatic Neoplasms Ethanol 8.1512384795
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 8.1516965848
MESH:D010300 Parkinson Disease Cholesterol, Dietary 4.0619014385
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D011041 Poisoning Mustard Gas 3.5315727166
MESH:D017499 Porokeratosis alitretinoin 5.7016144296
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 10.179918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.1718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.122563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9011118676 11896295 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9820887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 9.9820887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7217292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.7216740699
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.7212376480 15682402
MESH:D011537 Pruritus Mustard Gas 3.8018058305
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8117720292 17620002 17266442 10334151 17894541
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.1918172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.1911555667
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7518045962
MESH:D012640 Seizures Ethanol 2.989754883
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 5.9016631401
MESH:D012871 Skin Diseases Mustard Gas 2.6416961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.7210029692 19755658
MESH:D012878 Skin Neoplasms Glucose 8.7214993021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.7216192470
MESH:D013119 Spinal Cord Injuries Progesterone 3.9816503802 15862959
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.5120155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.5118456281
MESH:D013274 Stomach Neoplasms Ethanol 4.5118456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.5116257854 18593901 15930296
MESH:D013276 Stomach Ulcer Ethanol 3.2817918041 9211565 16755016 17189318 11906479 9562338
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.009754883
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 11.3115790496
MESH:D013953 Thymus Neoplasms Methylnitrosourea 11.3111418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.777505956
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 6.773078959 7505956
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.0717053015
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D015430 Weight Gain Dietary Fats 3.4916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
KEGG:04520 Adherens junction
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:04910 Insulin signaling pathway
REACT:9470 Signaling by FGFR
REACT:498 Signaling by Insulin receptor
KEGG:04930 Type II diabetes mellitus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA202
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449773glucose
    PA451365sirolimus
    PA451096prednisolone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00030 agonist Insulin recombinant Hypoglycemic Agents
    DB00046 agonist Humalog Mix75/25 Hypoglycemic Agents;Antidiabetic
    DB00047 agonist Insulin Glargine Hypoglycemic Agents;Antidiabetic
    DB00071 binder Insulin, porcine Hypoglycemic Agents
    DB01277 - Mecasermin
    DB01306 agonist NovoMix 30 Hypoglycemic Agents;Antidiabetic
    DB01307 agonist Insulin Detemir Hypoglycemic Agents;Antidiabetic
    DB01309 agonist Insulin Glulisine Hypoglycemic Agents;Antidiabetic
    DB03909 - Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
    DB08513 - [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved