AutismKB 2.0

Annotation Detail for INSRR


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Basic Information Top
Gene Symbol:INSRR ( IRR )
Gene Full Name: insulin receptor-related receptor
Band: 1q23.1
Quick LinksEntrez ID:3645; OMIM: 147671; Uniprot ID:INSRR_HUMAN; ENSEMBL ID: ENSG00000027644; HGNC ID: 6093
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
hsa05215Prostate cancer
No data
No data
Pathway IDPathway Name
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2151Neuroblastoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of INSRR mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of INSRR mRNAaffects expression 16483693
C095105 bexarotene bexarotene results in increased expression of INSRR mRNAincreases expression 16648578
C055494 caffeic acid phenethyl ester [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of INSRR mRNAaffects cotreatment|increases expression 20360939
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of INSRR mRNAaffects cotreatment|increases expression 18636392
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of INSRR mRNAaffects cotreatment|increases expression 20360939
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of INSRR mRNAaffects cotreatment|increases expression 18636392
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury Chlorine 4.6320601635
MESH:D000236 Adenoma Diethylnitrosamine 2.9910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3018056438 19061943 17162532 17620307 16434500 19052882
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms bexarotene 2.4116818667 16344269
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.4117474063
MESH:D016535 Bronchial Hyperreactivity Ozone 3.9015516495 17626835 18417511 19059883 18315731 16777450 14754758
MESH:D002100 Cachexia Ozone 5.1416183385
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.963084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9621159647 16328049 11831363 16288022 20007298 17761372 19822196 20214788 19335982 19171122 19394651 20727157 3581430 19919837 20084675 17055752 16779866 18210153 19519916 16569478 18506893 18971187 18494052 17978847 20524982 17138121 18785209 16502159 16830150 19208518 16540662 19539802 19107877 19701751 19383236 20514400 16698587 16878318 16807293 16935385 17162532 18788625 20935162 10672840 17428255 3084413 20512989 19052882 20101231 17173139 18978308 18393292 20432363 19418558 16681979 18691550 18665156 18056438 10737359
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.3016247446
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0417174075 21159647 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9711834606 2444490 12705907 12392966 16081117 12594235 11287661 12153990 19739265 11739529 11421492 19164858 12958197 12540782 14986274 14550746 17522070 19923254 16227642 18713872 17906064 19420014 16109766 11743745 19085960 15619225 15968718 10663392 18071297 19370779 10915739 17562736 16177239 16393943 16781746 10774834 14725611 16485898 19416960 11529661 11461765
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9719107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004417 Dyspnea Chlorine 5.0720016425
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.4620387270 21071580
MESH:D005739 Gas Poisoning Chlorine 5.4520016425
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007249 Inflammation Diethylnitrosamine 2.5018785209
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.8510783313
MESH:D007674 Kidney Diseases Acetaminophen 6.7215629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 6.7215369732
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 4.1616766008
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9620032147 19638242 18665156 18407596 18522880
MESH:D008107 Liver Diseases Acetaminophen 4.1019014921 12969438 11587558 19784758 16610002 19460945 16611625 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 4.1017034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.3218754104 19073162 20452335 19255062 18644402 20434301 20101389 20492335 18977376 10737359 15175105 16942905 19812893 20405173 19638242 19850985 12771043 21047994 19254457 21071580 19499222 19996281 2422723 21167192 18648771 19642983 19426721 19256749 19294768 19833225 19090486 9163691 21278145 20583210 12112319 15885732 19690152 2862719 20137499 19427195 20501860 20118626 19551842 18978307
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7917942915 2563599 17854601 19004024 3124819 17174075 18308698 9362446 21159647 19519916 18253720 19009564 18164116 18544905 18282651 18775883 19126423 16267830 18093689 19539802 16842330 18079962
MESH:D008171 Lung Diseases Ozone 3.558266340 19066396
MESH:D055370 Lung Injury Ozone 4.2120417186
MESH:D008175 Lung Neoplasms bexarotene 3.7317849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.7321163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Ozone 3.738597069 7614698
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 5.5111161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 3.5719196723 15591091 19196722
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008679 Metaplasia Ozone 5.5510496685
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 5.2319196722
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.9720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D010538 Peritonitis Ozone 4.4916369182
MESH:D011014 Pneumonia Ozone 4.7918007984 18929643 18381685
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D012120 Respiration Disorders Chlorine 5.6518579056
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
KEGG:05215 Prostate cancer
KEGG:04810 Regulation of actin cytoskeleton
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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