AutismKB 2.0

Annotation Detail for ITGA6


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ITGA6 ( CD49f,DKFZp686J01244,FLJ18737,ITGA6B,VLA-6 )
Gene Full Name: integrin, alpha 6
Band: 2q31.1
Quick LinksEntrez ID:3655; OMIM: 147556; Uniprot ID:ITA6_HUMAN; ENSEMBL ID: ENSG00000091409; HGNC ID: 6142
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05145Toxoplasmosis
hsa05222Small cell lung cancer
hsa04810Regulation of actin cytoskeleton
hsa04514Cell adhesion molecules (CAMs)
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Hemostasis
Cell junction organization
Integrin cell surface interactions
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200162a6b1 and a6b4 Integrin signaling
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500004Integrin cell surface interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1728Gastrointestinal tumor
1934Cancer
2052Infection
1925Pemphigoid, Bullous
2138Osteoporosis
Desease Name
prostate cancer
CANCER
Desease Name
Prostate cancer
Desease Name
Epidermolysis bullosa, junctional, with pyloric stenosis
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ITGA6 mRNAincreases expression 19933214
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ITGA6 mRNAdecreases expression 18648102
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of ITGA6 mRNAdecreases expression 12419474
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of ITGA6 mRNAincreases expression 17011747
D000082 Acetaminophen Acetaminophen affects the expression of ITGA6 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ITGA6 mRNAaffects expression 16483693
D016718 Arachidonic Acid Arachidonic Acid results in increased expression of ITGA6 mRNAincreases expression 16704987
C015001 arsenite arsenite results in increased expression of ITGA6 mRNAincreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ITGA6 mRNAdecreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ITGA6 mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ITGA6 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ITGA6 mRNAdecreases expression 12419474
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ITGA6 mRNAincreases expression 15003993
D004041 Dietary Fats Dietary Fats results in increased expression of ITGA6 mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ITGA6 mRNAincreases expression 19638242
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ITGA6 mRNAincreases expression 17011747
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ITGA6 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ITGA6 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ITGA6 mRNAincreases expression 17108234
D005492 Folic Acid Folic Acid affects the expression of ITGA6 mRNAaffects expression 16361273
C071834 glycidamide glycidamide results in decreased expression of ITGA6 mRNAdecreases expression 17822822
D019266 Iron, Dietary Iron, Dietary affects the expression of ITGA6 mRNAaffects expression 15637178
D015735 Mifepristone Mifepristone results in increased expression of ITGA6 mRNAincreases expression 17584828
D009151 Mustard Gas Mustard Gas affects the expression of [ITGA6 protein binds to ITGB4 protein]affects binding|affects expression 12880345
D009151 Mustard Gas Mustard Gas results in decreased expression of ITGA6 proteindecreases expression 12880345
D009151 Mustard Gas Mustard Gas affects the expression of ITGA6 proteinaffects expression 9285538
D009151 Mustard Gas Mustard Gas inhibits the reaction [ITGA6 protein binds to ITGB4 protein]affects binding|decreases reaction 18300329
D009151 Mustard Gas Mustard Gas results in decreased expression of ITGA6decreases expression 18300329
C041786 palm oil palm oil results in increased expression of ITGA6 mRNAincreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ITGA6 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of ITGA6 mRNAincreases expression 18301758
D011794 Quercetin Quercetin results in increased expression of ITGA6 mRNAincreases expression 15309432
C410733 scriptaid scriptaid affects the expression of ITGA6 mRNAaffects expression 18813790
D013629 Tamoxifen Tamoxifen affects the expression of ITGA6 mRNAaffects expression 17555576
C021751 tanshinone tanshinone results in decreased expression of ITGA6 mRNAdecreases expression 15849732
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITGA6 mRNAincreases expression 19933214
19465110
D013876 Thiophenes Thiophenes analog promotes the reaction [Tretinoin results in increased expression of ITGA6 mRNA]increases expression|increases reaction 16140955
D014212 Tretinoin Thiophenes analog promotes the reaction [Tretinoin results in increased expression of ITGA6 mRNA]increases expression|increases reaction 16140955
D014212 Tretinoin Tretinoin results in increased expression of ITGA6 mRNAincreases expression 16140955
16054129
C034613 triacsin C triacsin C results in increased expression of ITGA6 mRNAincreases expression 16704987
C025643 vinclozolin vinclozolin affects the expression of ITGA6 mRNAaffects expression 19015723
D002762 Cholecalciferol Cholecalciferol results in increased expression of ITGA6 mRNAincreases expression 17170073
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2314745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5415322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6317505938
MESH:D058186 Acute Kidney Injury Folic Acid 4.0516595132 16316344 17003819
MESH:D055371 Acute Lung Injury pirinixic acid 2.8318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.9020127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9014692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 14.513712494
MESH:D000236 Adenoma Benzo(a)pyrene 14.516695378
MESH:D000236 Adenoma Diethylnitrosamine 14.5110737359 6695378
MESH:D000236 Adenoma Folic Acid 14.5116963246
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.4719052882 16434500 17620307 17162532 19061943 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.4716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.4716835633
MESH:D000505 Alopecia Tretinoin 3.3715955085
MESH:D000544 Alzheimer Disease Folic Acid 2.9817116317
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1815469931
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9110965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6811748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.9617084956
MESH:D000799 Angioedema Acetaminophen 3.5310982225
MESH:D001008 Anxiety Disorders vinclozolin 3.4019015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7719183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.9015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.9011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.5715885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.5716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1916292516
MESH:D001249 Asthma Mustard Gas 4.6410378619
MESH:D001249 Asthma Tretinoin 4.6416456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.6715336622
MESH:D001321 Autistic Disorder Acetaminophen 2.2918445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2918582451
MESH:D001321 Autistic Disorder Folic Acid 2.2921388746
MESH:D001327 Autoimmune Diseases Cholecalciferol 10.0516142846
MESH:D001327 Autoimmune Diseases Quercetin 10.0519761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1116935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.701440618 11289319
MESH:D001768 Blister Mustard Gas 4.8519167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.6619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.6612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.6616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5715746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.6520146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 6.6520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.6517474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.6517129689 15324884
MESH:D001943 Breast Neoplasms Folic Acid 6.6516777985
MESH:D001943 Breast Neoplasms Quercetin 6.6518628248
MESH:D001943 Breast Neoplasms Tamoxifen 6.6519142967 16273361 16202921 18984771 20544844 18997820 19155303 17440819 18629630 19103187 18351453 19410462 15565566 19487384 15668708 20005174 20135344 19059307 19289846 19066611 19084267 20065188 19011961 19288272 18855134 18821012 11161223 21138602 18815881 20390343 19115204 17261762 17893378 20859285 19189212 16873071 19221464 19200415 16818667 18425577 17242785 19189210 21152245 19244106 17049068
MESH:D001943 Breast Neoplasms tanshinone 6.6515849732 19885617
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.6520435547
MESH:D001943 Breast Neoplasms Tretinoin 6.6516166294 16443354 16873071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8515286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6617687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2816813970
MESH:D002105 Cadmium Poisoning Quercetin 5.2316962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8416168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.233581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.233084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.2316807293 17138121 3581430 20514400 18971187 18978308 21159647 3084413 19335982 16288022 17428255 19208518 16779866 18788625 11831363 19052882 18210153 16328049 19822196 19539802 18665156 16569478 18785209 16935385 10737359 16878318 19418558 17761372 20512989 17173139 20935162 18506893 20007298 18393292 20432363 17978847 19519916 20727157 19394651 19171122 20524982 19919837 18056438 10672840 18691550 16502159 16681979 19701751 20084675 17055752 20101231 20214788 19107877 18494052 16698587 17162532 16830150 16540662 19383236
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.2316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.2312508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.2316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.231917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.6517234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.537296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.2520419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.2516096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.3517572228
MESH:D006332 Cardiomegaly Quercetin 6.2319794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.2318670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Folic Acid 3.7416755160
MESH:D002386 Cataract Acetaminophen 6.6210977129
MESH:D002386 Cataract Tretinoin 6.6217460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 9.957505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.9520889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.9517174075 21159647 2727394 7505956
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2816129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.4619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.4616835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.059022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.0515861022 17681005 16919318 16105132 17333356 17110522 11677210
MESH:D002779 Cholestasis pirinixic acid 12.0519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8416461808
MESH:D002971 Cleft Lip Folic Acid 3.8221254359
MESH:D002972 Cleft Palate Folic Acid 9.128946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.1216354765 8697196 12621046 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 9.129407595
MESH:D003092 Colitis Tretinoin 3.4017035595
MESH:D003110 Colonic Neoplasms arsenite 3.8215037631
MESH:D003110 Colonic Neoplasms Quercetin 3.8211134977 15741050 19056647 19440933 17191121 16640504 17148506
MESH:D015179 Colorectal Neoplasms Folic Acid 2.8417116713 17087956 16963246 17245555 16985020
MESH:D015179 Colorectal Neoplasms Quercetin 2.8418095365 18852136
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8017141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3515322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.359664655 16925845 9224671 17551590 9142499 10589399 14991402 9125849 8800419 9211117
MESH:D003456 Cryptorchidism Diethylstilbestrol 10.3912952375 16002989
MESH:D003456 Cryptorchidism vinclozolin 10.3914966744
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0619031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.5118759878 2524372 8156756 14531868 12868966 8970840 11298694 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.212952479 3621924
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.4819496084
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7020387270
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 6.7016886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7017107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2219279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.1218692083 9328219 18289764 1440618 6482804 6679447 8291058 18648102 16192314 7440962 11289319 9653073 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.1217906064 19085960 12705907 12958197 15619225 16227642 11529661 15968718 11287661 14986274 18713872 16081117 12594235 16781746 14550746 10774834 10663392 11834606 16393943 19739265 10915739 19416960 11739529 11461765 17562736 18071297 19370779 11421492 12540782 16177239 19923254 17522070 2444490 14725611 12153990 16109766 19420014 19164858 12392966 11743745 16485898
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.1219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7819426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5311462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2318367378
MESH:D004487 Edema Arachidonic Acid 14.229599246 15177302 16716910 11698051 7990266 9831321
MESH:D004487 Edema Mustard Gas 14.229260866 11428647 11428631 11402378
MESH:D004487 Edema pirinixic acid 14.2212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.2211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.8918230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.8918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.9712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.9719031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.3816402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.1715700306 16804899
MESH:D016889 Endometrial Neoplasms Folic Acid 16.1717301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.1719155303 17893378 20544844 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 16.1716569247
MESH:D004715 Endometriosis Mifepristone 8.2616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.269294722 10568697
OMIM:226730 EPIDERMOLYSIS BULLOSA JUNCTIONALIS WITH PYLORIC ATRESIA marker/mechanism
MESH:D004890 Erythema Mustard Gas 4.859357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8016302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.683581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.6820426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.6816530937
MESH:D017889 Exfoliation Syndrome Folic Acid 5.1816504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0811564622
MESH:D005124 Eye Abnormalities Tretinoin 8.0816938888 9664655
MESH:D005234 Fatty Liver arsenite 27.1118296743
MESH:D005234 Fatty Liver Dietary Fats 27.1119004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 27.1121071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 27.1115345470
MESH:D005234 Fatty Liver pirinixic acid 27.1120131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 27.1119224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.5815751030 16513791 16534752 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.5816709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1511858732
MESH:D005334 Fever Arachidonic Acid 4.3911852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.706705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.2214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8719069698
MESH:D005355 Fibrosis arsenite 24.5118296743
MESH:D005355 Fibrosis Dietary Fats 24.5118296743
MESH:D005355 Fibrosis Quercetin 24.5119474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 24.5120067830
MESH:D005355 Fibrosis Tretinoin 24.5117994277
MESH:D005756 Gastritis Acetaminophen 10.2216983495
MESH:D005756 Gastritis Folic Acid 10.2217171786
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.6216973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9816417039
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.6416452187
MESH:D005901 Glaucoma Folic Acid 4.7916504073
MESH:D005909 Glioblastoma Quercetin 6.5919804834
MESH:D005909 Glioblastoma Tretinoin 6.5917312396
MESH:D005910 Glioma Quercetin 6.1917643826
MESH:D005910 Glioma tanshinone 6.1916955220
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.757505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2810696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8416084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 14.6420471113
MESH:D006330 Heart Defects, Congenital Folic Acid 14.6417286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 14.6411294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 14.649664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.3520558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.226705139
MESH:D006529 Hepatomegaly pirinixic acid 7.2516221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.2515340226 12621046 16120746
MESH:D006679 HIV Seropositivity Folic Acid 5.1817209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.738697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.8216870215
MESH:D006930 Hyperalgesia Tretinoin 6.8216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3221332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2616778211
MESH:D006943 Hyperglycemia pirinixic acid 8.3520558911
MESH:D006943 Hyperglycemia Quercetin 8.3511834736 18262572
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.2416395265 16865747 16397167 16433478 16755160
MESH:D006949 Hyperlipidemias Dietary Fats 3.3321332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.8215034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.8212960047 14722030
MESH:D006973 Hypertension Quercetin 4.8218356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8218850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 4.9719662366
MESH:D007021 Hypospadias Diethylstilbestrol 10.2316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.2316945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.0615036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.9817937319
MESH:D007248 Infertility, Male vinclozolin 5.9816467254
MESH:D007249 Inflammation Arachidonic Acid 17.8417371808 15177302 9831321
MESH:D007249 Inflammation Dietary Fats 17.8420412841
MESH:D007249 Inflammation Diethylnitrosamine 17.8418785209
MESH:D007249 Inflammation Mustard Gas 17.8417524151 16001271 11428620 11428647 8975870 11402378 9260866 9357497 11428631
MESH:D007249 Inflammation Tamoxifen 17.8419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 17.8412878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.1916624496
MESH:D007333 Insulin Resistance Dietary Fats 6.5718457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 6.5716306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4617994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.709022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0116580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.0115992940 17551590
MESH:D007627 Keloid Quercetin 4.6517086741
MESH:D007674 Kidney Diseases Acetaminophen 5.4812587719 15629191
MESH:D007674 Kidney Diseases Quercetin 5.4816962696
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 11.036582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 11.0314681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Tamoxifen 11.0318625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7617184923
MESH:D007938 Leukemia Quercetin 5.9417468513
MESH:D007938 Leukemia Tretinoin 5.9417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4216482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0219850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Thiophenes 7.5516140954 16140955
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5519035177 17506722 19075265 19225113 16823087 16140955 17294898 12679006 17107899 16331271 16891316 17217047 17361223 15748426 17339181 19029980 9834237 17301526 19642359 16935935 17712046 16766008 17649720 16788101 17368321
MESH:D007984 Leydig Cell Tumor vinclozolin 4.4216417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.099224671
MESH:D008064 Lipidoses Tamoxifen 2.9417567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 10.1018296743
MESH:D008103 Liver Cirrhosis Dietary Fats 10.1018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.1018522880 20032147 18665156 19638242 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.0015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.2715474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 6.2712741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.2718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.2712878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.2718397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 6.0919014921 16610002 12969438 16611625 19460945 11587558 19784758 12587719
MESH:D008107 Liver Diseases Diethylnitrosamine 6.0917034775
MESH:D008107 Liver Diseases Folic Acid 6.0916877991
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9716871587 17185352
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.0120195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 20.0119255062 2422723 19996281 19090486 20583210 21047994 15885732 20405173 19499222 19073162 20137499 19833225 20452335 20434301 19812893 9163691 21167192 19850985 18648771 20492335 18644402 20501860 21278145 10737359 19254457 18978307 20101389 20118626 19426721 19551842 12771043 16942905 19294768 21071580 19690152 19642983 12112319 2862719 18977376 19427195 15175105 19256749 18754104 19638242
MESH:D008113 Liver Neoplasms Diethylstilbestrol 20.0116712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 20.0115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 20.0118980244
MESH:D008113 Liver Neoplasms Tamoxifen 20.0116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.0116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 12.53598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 12.539362446 18544905 17854601 16267830 18093689 18775883 2563599 18079962 19519916 19009564 17174075 19539802 19126423 16842330 19004024 18282651 3124819 21159647 17942915 18308698 18253720 18164116
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.5319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.5312151625
MESH:D008171 Lung Diseases Mustard Gas 3.2418702808 18161513
MESH:D008175 Lung Neoplasms arsenite 10.0516809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.0518816296 6695378 18569708 20869020 20464547 20135361 17053015 18520028 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.0520970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Mustard Gas 10.053148597 8781369
MESH:D008175 Lung Neoplasms Quercetin 10.0516280456
MESH:D008175 Lung Neoplasms Tamoxifen 10.0518625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0511884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2517718048
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.8415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.2515700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2016002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4519428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.4311731420 19196722 16827153 19196723 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.2319453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.3816832597
MESH:D008527 Medulloblastoma Tretinoin 2.6617453147
MESH:D008545 Melanoma Tamoxifen 3.1019393235 12393984
MESH:D008545 Melanoma Tretinoin 3.1016752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2619513568
MESH:D008591 Meningomyelocele Tretinoin 4.1216940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9616381670
MESH:D009135 Muscular Diseases pirinixic acid 3.2016239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9017596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.2819151258
MESH:D009203 Myocardial Infarction Quercetin 5.2819595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.6616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.6619207477
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.713581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.713581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.7119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 14.0611141357
MESH:D009369 Neoplasms Diethylstilbestrol 14.0615313581
MESH:D009369 Neoplasms pirinixic acid 14.0617405874
MESH:D009369 Neoplasms Quercetin 14.0615185748
MESH:D009369 Neoplasms Tretinoin 14.0616946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6819200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 4.1015738583
MESH:D009421 Nervous System Malformations Diethylstilbestrol 14.6811399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.6814600291
MESH:D009421 Nervous System Malformations Tretinoin 14.689125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 11.076679447
MESH:D009436 Neural Tube Defects Folic Acid 11.0717438019
MESH:D009436 Neural Tube Defects Tretinoin 11.079142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3518514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3520387270
MESH:D020078 Neurogenic Inflammation Quercetin 4.0817929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8020387270
MESH:D009503 Neutropenia Folic Acid 8.6516322990
MESH:D009503 Neutropenia Mustard Gas 8.657688884 16761898
MESH:D009765 Obesity Dietary Fats 4.1621332399 18674790 17217161 11836018 20518802 19632207 20132043 16723640 18457598
MESH:D009765 Obesity pirinixic acid 4.1620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.156482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.703988306
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.9319495926
MESH:D010051 Ovarian Neoplasms Mifepristone 7.4316525653
MESH:D010051 Ovarian Neoplasms Quercetin 7.4319005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.4316936753
MESH:D010146 Pain Acetaminophen 5.7716870215
MESH:D010146 Pain Tretinoin 5.7716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 7.9816540662
MESH:D010190 Pancreatic Neoplasms Quercetin 7.9816965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.9815976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4011578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.187296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9312520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 11.946228378
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 11.9411550810
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3715687265 16977796
MESH:D011041 Poisoning Mustard Gas 3.5115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2618163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.362563599
MESH:D011230 Precancerous Conditions Quercetin 8.3619056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 14.4717184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.4711896295 11399792 11118676 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.4719015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.6218220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9117292933
MESH:D011471 Prostatic Neoplasms Cholecalciferol 1.9117024972
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9117136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Quercetin 1.9117292933 14715546
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9115067354
MESH:D011472 Prostatitis vinclozolin 4.6218629315
MESH:D011507 Proteinuria Tretinoin 3.3216636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.4915861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.4918058305
MESH:D011625 Pterygium Tretinoin 4.4816723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8117620002 17266442 10334151 17894541 17720292
MESH:D051437 Renal Insufficiency Folic Acid 4.4815728788
MESH:D015427 Reperfusion Injury pirinixic acid 2.2319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.153692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8116116481 16283617
MESH:D012554 Schistosomiasis japonica Quercetin 5.2316862918
MESH:D012559 Schizophrenia Folic Acid 2.8516641680
MESH:D012871 Skin Diseases Folic Acid 5.0418709164
MESH:D012871 Skin Diseases Mustard Gas 5.0416961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.3110029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.318532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.3116192470
MESH:D012878 Skin Neoplasms Tretinoin 12.3116467112
MESH:D013088 Spermatocele Diethylstilbestrol 18.3016002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 18.3016709447
MESH:D013088 Spermatocele Tamoxifen 18.3016709447
MESH:D013118 Spinal Cord Diseases Folic Acid 5.1816361298
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7319457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.4720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.4718456281
MESH:D013274 Stomach Neoplasms Folic Acid 4.4717171786
MESH:D013274 Stomach Neoplasms Tretinoin 4.4717261132
MESH:D020521 Stroke Folic Acid 4.0916517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3311994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 10.606587162 6582329 7505956 1399818 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.607505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.6016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.5216051514
MESH:D014376 Tuberculosis Tretinoin 3.0416040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 14.468074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 14.4617053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 14.4616452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Quercetin 14.4616720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 14.468653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 2.6910982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.6216175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.6216129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.4915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.4914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.2916752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.1316002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2614671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7616761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9315886252
MESH:D015430 Weight Gain Dietary Fats 3.4816723640
MESH:D009396 Wilms Tumor Tretinoin 3.7116287080
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04640 Hematopoietic cell lineage
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:05200 Pathways in cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05222 Small cell lung cancer
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29942
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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