AutismKB 2.0

Annotation Detail for IRAK2


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Basic Information Top
Gene Symbol:IRAK2 ( IRAK-2,MGC150550 )
Gene Full Name: interleukin-1 receptor-associated kinase 2
Band: 3p25.3
Quick LinksEntrez ID:3656; OMIM: 603304; Uniprot ID:IRAK2_HUMAN; ENSEMBL ID: ENSG00000134070; HGNC ID: 6113
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04722Neurotrophin signaling pathway
hsa04210Apoptosis
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200177Endogenous TLR signaling
No data
Pathway IDPathway Name
500490Interleukin-1 signaling
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of IRAK2 mRNAincreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of IRAK2 mRNAaffects expression 17562736
C061133 Am 80 Am 80 results in increased expression of IRAK2 mRNAincreases expression 17229644
D000638 Amiodarone Amiodarone results in increased expression of IRAK2 mRNAincreases expression 19774075
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of IRAK2 mRNAincreases expression 18687144
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IRAK2 mRNAdecreases expression 19150397
D016572 Cyclosporine Cyclosporine results in increased expression of IRAK2 mRNAincreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of IRAK2 mRNAdecreases expression 18691550
D004052 Diethylnitrosamine MAPK14 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of IRAK2 mRNA]decreases expression|decreases reaction 18691550
D002117 Calcitriol Calcitriol results in increased expression of IRAK2 mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in increased expression of IRAK2 mRNAincreases expression 20106945
C056507 gemcitabine gemcitabine results in increased expression of IRAK2 mRNAincreases expression 17039268
D015735 Mifepristone Mifepristone results in decreased expression of IRAK2 proteindecreases expression 17701593
C006253 pirinixic acid pirinixic acid results in increased expression of IRAK2 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in increased expression of IRAK2 proteinincreases expression 17701593
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IRAK2 mRNAincreases expression 19933214
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 11752688 14514962
MESH:D055371 Acute Lung Injury pirinixic acid 3.1518653653
MESH:D000230 Adenocarcinoma Estradiol 2.1011473722
MESH:D000236 Adenoma Diethylnitrosamine 2.8710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.5918056438 19052882 17162532 19061943 16434500 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.5916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.8318057881 18218290 20041841
MESH:D001172 Arthritis, Rheumatoid Am 80 3.7616819260
MESH:D050197 Atherosclerosis Am 80 4.3516484594
MESH:D001281 Atrial Fibrillation Amiodarone 3.9219698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 15.4919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.4919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.4912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4017868700
MESH:D001930 Brain Injuries Progesterone 4.3015665606 15845082 15380490
MESH:D001943 Breast Neoplasms Calcitriol 2.9811237771
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9817474063
MESH:D001943 Breast Neoplasms Estradiol 2.9817289903 19861407 12948864 16675129 14630087 17018787 17261762 18497071
MESH:D001943 Breast Neoplasms gemcitabine 2.9817039268 18382427
MESH:D001943 Breast Neoplasms Progesterone 2.9816175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5116111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.543084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.5411831363 18210153 16807293 17173139 18785209 19539802 20084675 19171122 18665156 17138121 19394651 16935385 19335982 19052882 3581430 16288022 19519916 19701751 21159647 16878318 16779866 18788625 18691550 3084413 16681979 18393292 18056438 20512989 20524982 20514400 19418558 16502159 20007298 20214788 20432363 16328049 18971187 19919837 19822196 17761372 20935162 16569478 10737359 17055752 18978308 20727157 17428255 19208518 17162532 17978847 20101231 10672840 19383236 18506893 19107877 16698587 18494052 16830150 16540662
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.5416924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6311237771
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3816120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9015710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.1318974383
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.1720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.1712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 16.1717174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.1718566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4116835633
MESH:D002779 Cholestasis Cyclosporine 7.8319486331
MESH:D002779 Cholestasis pirinixic acid 7.8319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1116354765 8697196 15668235 15340226 12621046
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4418249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2420387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.5317187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0317906064 17562736 12705907 12594235 19416960 16393943 16227642 18713872 16109766 19420014 11834606 12540782 12958197 16485898 14725611 14550746 16781746 19164858 10915739 19923254 11421492 12153990 11287661 15619225 17522070 11529661 14986274 11739529 11461765 10663392 16081117 12392966 19085960 11743745 15968718 10774834 16177239 19370779 19739265 18071297 2444490
MESH:D056486 Drug-Induced Liver Injury Amiodarone 9.0318218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 9.0319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema pirinixic acid 6.6312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.6311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 15.8616819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 15.8615138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 15.8617692515
MESH:D016889 Endometrial Neoplasms Estradiol 3.0011473722 19148513 18566989
MESH:D004715 Endometriosis Mifepristone 15.5016134523
MESH:D004715 Endometriosis Progesterone 15.5016134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 15.5010568697 9294722
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0820426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Amiodarone 19.0214986274
MESH:D005234 Fatty Liver Cyclosporine 19.0219224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.0221071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 19.0220131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005355 Fibrosis Cyclosporine 8.6212168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.5520558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly Amiodarone 14.6715265979
MESH:D006529 Hepatomegaly pirinixic acid 14.6719772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.6715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0915709030
MESH:D019584 Hot Flashes Estradiol 3.8117088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.118697196 16354765 15340226 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006937 Hypercholesterolemia Amiodarone 3.908137927 9751232
MESH:D006943 Hyperglycemia pirinixic acid 3.2120558911
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 4.5618020914 17991464
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.4415869954
MESH:D007249 Inflammation Diethylnitrosamine 8.3818785209
MESH:D007249 Inflammation Progesterone 8.3815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.2616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.2616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 10.0712587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.078314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 10.0715618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.3512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.3515610895
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 4.6616819260 16531727
MESH:D008064 Lipidoses Amiodarone 3.5315342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8420032147 19638242 18522880 18407596 18665156
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3914716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3912878042
MESH:D008107 Liver Diseases Acetaminophen 3.9312969438 16611625 19460945 16610002 19014921 12587719 19784758 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.9317034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms Diethylnitrosamine 7.3920137499 19833225 19690152 20118626 20452335 2422723 18754104 18978307 19638242 19642983 21278145 21047994 12771043 21071580 12112319 21167192 15175105 20501860 18644402 19073162 19426721 20405173 18648771 19427195 20101389 10737359 19254457 20492335 19294768 2862719 19850985 16942905 19499222 19090486 20434301 19256749 19812893 19551842 18977376 9163691 15885732 20583210 19996281 19255062
MESH:D008113 Liver Neoplasms pirinixic acid 7.3916377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3916984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 5.8218308698 18544905 3124819 17854601 18253720 19539802 19126423 18079962 16842330 19009564 17942915 16267830 9362446 18775883 18164116 21159647 19004024 18282651 18093689 2563599 19519916 17174075
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.8212151625
MESH:D008133 Long QT Syndrome Amiodarone 3.6017391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.3912587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.5418516814
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0617365036
MESH:D008175 Lung Neoplasms Diethylnitrosamine 2.2620970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2619555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.1211807958 16891317 17203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.1217203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.5519453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.1916166281 16966607 18303189
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009101 Multiple Myeloma Am 80 4.5517229644
MESH:D009135 Muscular Diseases pirinixic acid 3.5516239165
MESH:D009181 Mycoses Amiodarone 4.9617974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1519151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.3216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.3216411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.589029167 3581430
MESH:D009369 Neoplasms pirinixic acid 1.9617405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.5911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.5914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.2618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.2620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D010051 Ovarian Neoplasms Estradiol 8.0419401270
MESH:D010051 Ovarian Neoplasms Mifepristone 8.0416525653
MESH:D010051 Ovarian Neoplasms Progesterone 8.0417393432 16525653
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.6816540662
MESH:D010190 Pancreatic Neoplasms gemcitabine 5.6818992248 11504793 17440100 18383843 16929163
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9310923243
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.0312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.032563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411222880 11118676 11399792 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.8315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9120887781
MESH:D011471 Prostatic Neoplasms Am 80 2.7916289102
MESH:D011471 Prostatic Neoplasms Calcitriol 2.7916289102 18247401 16644109 15754350 12479363
MESH:D011471 Prostatic Neoplasms Estradiol 2.7916740699
MESH:D011565 Psoriasis Am 80 6.1816819260
MESH:D011565 Psoriasis Cyclosporine 6.1816882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 5.9212832656 12490602 11597910
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.9217975199 17365031 15814490 17322281
MESH:D015427 Reperfusion Injury pirinixic acid 2.4019058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8618045962
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.1318724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.3316503802 15862959
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D013276 Stomach Ulcer Amiodarone 3.3418087811
MESH:D013610 Tachycardia Amiodarone 4.3211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.2219225199
MESH:D013959 Thyroid Diseases Amiodarone 12.2619731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 12.2612697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.007505956
MESH:D013971 Thyrotoxicosis Amiodarone 4.9019584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.7519048282
MESH:D016171 Torsades de Pointes Amiodarone 4.2417467628 11989578
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
KEGG:04210 Apoptosis
REACT:25035 Innate immune response mediated by toll like receptors
KEGG:04722 Neurotrophin signaling pathway
REACT:6900 Signaling in Immune system
KEGG:05152 Tuberculosis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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