AutismKB 2.0

Annotation Detail for IREB2


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Basic Information Top
Gene Symbol:IREB2 ( ACO3,FLJ23381,IRP2,IRP2AD )
Gene Full Name: iron-responsive element binding protein 2
Band: 15q25.1
Quick LinksEntrez ID:3658; OMIM: 147582; Uniprot ID:IREB2_HUMAN; ENSEMBL ID: ENSG00000136381; HGNC ID: 6115
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200045Validated targets of C-MYC transcriptional activation
Pathway IDPathway Name
P02754Methylcitrate cycle
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1709Parkinson disease
1740Alzheimer's disease
Desease Name
CARDIOVASCULAR
Alzheimer's disease
NEUROLOGICAL
chronic obstructive pulmonary disease
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of IREB2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of IREB2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of IREB2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IREB2 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IREB2 mRNAdecreases expression 19150397
D003676 Deferoxamine Deferoxamine results in increased activity of IREB2 proteinincreases activity 11054110
D003676 Deferoxamine Deferoxamine results in increased expression of and results in increased activity of IREB2 proteinincreases activity|increases expression 16568477
D003676 Deferoxamine Deferoxamine results in increased expression of IREB2 proteinincreases expression 17469137
D004317 Doxorubicin Doxorubicin results in decreased activity of IREB2 proteindecreases activity 16770644
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of IREB2 mRNAincreases expression 17942748
C013531 ferric ammonium citrate ferric ammonium citrate results in decreased activity of IREB2 proteindecreases activity 11054110
C013531 ferric ammonium citrate ferric ammonium citrate results in decreased expression of IREB2 proteindecreases expression 17469137
D005419 Flavonoids Flavonoids results in decreased expression of IREB2 mRNAdecreases expression 18035473
D005472 Fluorouracil Fluorouracil results in increased expression of IREB2 mRNAincreases expression 16584549
D006427 Hemin Hemin results in decreased expression of and results in decreased activity of IREB2 proteindecreases activity|decreases expression 16568477
D007501 Iron IREB2 protein affects the metabolism of Ironaffects metabolic processing 17194590
D008070 Lipopolysaccharides [Lipopolysaccharides co-treated with IFNG protein] results in decreased activity of IREB2 proteinaffects cotreatment|decreases activity 11054110
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased activity of IREB2 proteindecreases activity 11054110
D008345 Manganese Manganese results in decreased activity of IREB2 proteindecreases activity 16568477
D008345 Manganese Manganese results in increased expression of IREB2 proteinincreases expression 17469137
C025340 manganese chloride manganese chloride results in decreased activity of IREB2 proteindecreases activity 16568477
C006253 pirinixic acid pirinixic acid results in increased expression of IREB2 mRNAincreases expression 17426115
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IREB2 mRNAdecreases expression 18163543
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8111752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.9018653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.9018653653
MESH:D000230 Adenocarcinoma Doxorubicin 7.0617418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.0614692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.0617638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D000419 Albuminuria Doxorubicin 4.5021441931
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.6216640825
MESH:D000544 Alzheimer Disease Iron 2.9916640825 16563566
MESH:D000740 Anemia Fluorouracil 14.6716511603 17963324 15504547
MESH:D000740 Anemia Iron 14.6716434484 16566752
MESH:D000740 Anemia Tetrachlorodibenzodioxin 14.6711748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.6117162259 17163184 16569441 17147795 17375513
MESH:D000756 Anemia, Sideroblastic Iron 17.6716910769
MESH:D000756 Anemia, Sideroblastic Manganese 17.6716910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 17.6716910769
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001145 Arrhythmias, Cardiac Iron 4.3316604332
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001260 Ataxia Telangiectasia Iron 5.4115336622
MESH:D050197 Atherosclerosis Iron 3.6816640825 16632123
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001424 Bacterial Infections Iron 5.1616640825
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6714601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.7717150277
MESH:D001943 Breast Neoplasms Deferoxamine 2.0315993339
MESH:D001943 Breast Neoplasms Doxorubicin 2.0317983394 15136595 15692762 15939500 16115903 16595493 16826403 16096432 16322301 18695136 16935488 18628466 15634643 16264153 18382427 19526202 15668708 11325840 17426702 15993339 17369602 18234424 15994142 15567936
MESH:D001943 Breast Neoplasms Fluorouracil 2.0315136595 16110121 19217205 18608205 16557594 16595493 18357371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0320435547
MESH:D002276 Carcinoid Tumor Doxorubicin 12.2616051944
MESH:D002276 Carcinoid Tumor Fluorouracil 12.2616051944
MESH:D002277 Carcinoma Fluorouracil 8.0617121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.0616835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.8016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.8016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.803084413
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.8016234567 18059187 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.8016799960 17045692 17088986 16332177 17971768 18930000
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6116201981 1485588
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 6.6118695887
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.816189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.8116757204 17066447 18986760 16280240
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 8.0717974986 16364871 16612575 15811867 16952015 17519947 16242529 16269455 16455267 16109756 17924179 18627295 16278810 17329180 17382496 15476868 17928571 17131338 17007740 15505089 15792986 17308081 16731534 16651473 17351982
MESH:D009202 Cardiomyopathies Iron 8.0716640825
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 6.1416243910 17334414
MESH:D002311 Cardiomyopathy, Dilated Iron 6.1416604332
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.546135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5420889678
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6317110522 16919318 15861022 16105132 17333356 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 7.6319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0816354765 8697196 15668235 15340226 12621046
MESH:D003110 Colonic Neoplasms Fluorouracil 4.0517725105 17169374 16510598 17016597 15001691 16340194 17287894 18772588 17172411 17018589
MESH:D003110 Colonic Neoplasms Iron 4.0516640825
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.6418259882 18802399
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6418802399 18288408 14970324 16303861 18448328 15148649 15289873 16282729 17255274 18509181 18949393 17401013 17594712 17695437 17016601 18383874 16391804 17454858 17094418 16331619 20501625 16524972
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.7618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.7618551238
MESH:D007644 Darier Disease Fluorouracil 4.7616733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003920 Diabetes Mellitus Iron 4.4116640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.3416506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.5216506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5217107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.8721346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.8721346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.8712540782 14725611 11743745 17906064 11529661 16781746 11739529 16227642 12594235 16109766 10663392 12705907 15619225 14986274 10774834 17522070 17562736 19739265 19923254 11834606 16485898 18071297 16393943 16081117 18713872 11461765 12392966 19416960 19420014 15968718 19370779 11421492 12153990 12958197 19164858 10915739 2444490 19085960 14550746 16177239 11287661
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.8717416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.8720420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Doxorubicin 8.0018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0011462148
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.4217359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1318037988
MESH:D019446 Endotoxemia Lipopolysaccharides 4.3615328337 15821434 17637181
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4720426865
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.4717638652 15173087 16481741 16337965 16785472
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.9315345470
MESH:D005234 Fatty Liver Iron 12.9316640825
MESH:D005234 Fatty Liver pirinixic acid 12.9320131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005334 Fever Lipopolysaccharides 3.979205823 11852909
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5519069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9120067830
MESH:D005621 Friedreich Ataxia Iron 5.3916604332 16640825
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005909 Glioblastoma Doxorubicin 7.4817150277
MESH:D005909 Glioblastoma Manganese 7.4817043766
MESH:D005910 Glioma Fluorouracil 2.8516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 7.8215692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.8215162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3111294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4512587719 14766674 17888722 16244372 16707910 16879835 18674790 18006777 16330681 16495754 16244371 17875725 16144979
MESH:D006333 Heart Failure Doxorubicin 6.9617481944
MESH:D006333 Heart Failure pirinixic acid 6.9620558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8615692506
MESH:D006432 Hemochromatosis Iron 4.4616604332 16640825 17053826 16574947 17236123 17255318
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.3416366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006486 Hemosiderosis Iron 5.1916604332
MESH:D006525 Hepatitis, Viral, Human Iron 5.4416640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.9017182432
MESH:D006529 Hepatomegaly Iron 14.2716890145
MESH:D006529 Hepatomegaly pirinixic acid 14.2718467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.2712621046 16120746 15340226
MESH:D015658 HIV Infections Iron 3.6516597321
MESH:D006689 Hodgkin Disease Doxorubicin 3.3717606976 18501091 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.6616870215
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918670907 18850075
MESH:D007006 Hypogonadism Iron 4.3716640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007037 Hypothyroidism Iron 5.0416640825
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Flavonoids 8.2417296493
MESH:D007249 Inflammation Lipopolysaccharides 8.249205823 17237260 17255318 12878042 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2412878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6016306350
MESH:D019189 Iron Metabolism Disorders Iron 11.4617163184
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 11.4617255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007674 Kidney Diseases Acetaminophen 5.9712587719 15629191
MESH:D007674 Kidney Diseases Doxorubicin 5.9716775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1116707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.2316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.2316705839
MESH:D007680 Kidney Neoplasms Fluorouracil 12.2316985049
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1316085563
MESH:D015470 Leukemia, Myeloid, Acute Deferoxamine 3.5120368581
MESH:D007970 Leukopenia Lipopolysaccharides 4.6615821434
MESH:D020961 Lewy Body Disease Iron 5.3916563566
MESH:D008103 Liver Cirrhosis Iron 3.7016640825
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.9216439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 4.9212878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9212878042
MESH:D008107 Liver Diseases Acetaminophen 4.5312969438 11587558 19460945 16611625 19014921 12587719 19784758 16610002
MESH:D008107 Liver Diseases Hemin 4.5317173083
MESH:D008108 Liver Diseases, Alcoholic Iron 4.9717207112 16737972
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 14.087678174
MESH:D008113 Liver Neoplasms Fluorouracil 14.0815113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms Iron 14.0816640825 20302851
MESH:D008113 Liver Neoplasms pirinixic acid 14.0820007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.0816984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 9.682876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.6816842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.6812151625
MESH:D055370 Lung Injury Lipopolysaccharides 3.9721114838
MESH:D008175 Lung Neoplasms Doxorubicin 4.8617418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 4.8615246190
MESH:D008175 Lung Neoplasms Iron 4.8616640825
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8611884234 19555203
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.7615086387
MESH:D008223 Lymphoma Doxorubicin 3.4316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.5315621674
MESH:D008268 Macular Degeneration Iron 3.9616640825
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.0015458769
MESH:D020149 Manganese Poisoning Manganese 5.4916568477 16551646 19453300
MESH:D008545 Melanoma Doxorubicin 2.2816827129
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008654 Mesothelioma Doxorubicin 3.0417638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4615792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6016757204 18986760
MESH:D009069 Movement Disorders Manganese 4.9716551646
MESH:D052016 Mucositis Doxorubicin 4.7517415656
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.6417086897
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009181 Mycoses Iron 5.4416640825
MESH:D009203 Myocardial Infarction Doxorubicin 5.6519429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 5.6519151258
MESH:D017202 Myocardial Ischemia Iron 9.0516604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.0512213967
MESH:D015428 Myocardial Reperfusion Injury Iron 8.5016604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5016411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.2318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.237678174 18551238
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9318259882
MESH:D009369 Neoplasms Fluorouracil 4.9116928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 4.9117405874
MESH:D009401 Nephrosis Doxorubicin 4.7316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.6215640375 16889571
MESH:D009404 Nephrotic Syndrome Iron 9.6217178036
MESH:D009410 Nerve Degeneration Manganese 4.2416551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009447 Neuroblastoma Doxorubicin 3.2415555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.3918514411
MESH:D019636 Neurodegenerative Diseases Iron 8.3916604332 17296847
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4116436463
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.7512819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.7516049721
MESH:D010003 Osteoarthritis Iron 3.9416640825
MESH:D010024 Osteoporosis Iron 3.8316640825 16648989
MESH:D012516 Osteosarcoma Doxorubicin 4.0815930896
MESH:D010146 Pain Acetaminophen 2.3516870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.6516500647 19003803 15113037 16929163
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010212 Papilloma Iron 4.4412065085
MESH:D020447 Parasomnias Iron 5.9917352947
MESH:D010300 Parkinson Disease Iron 5.8616563566 16640825
MESH:D010300 Parkinson Disease Manganese 5.8611181820
MESH:D020734 Parkinsonian Disorders Manganese 4.4316140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1317983394
MESH:D010900 Pituitary Diseases Iron 5.6416604332
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1317638057
MESH:D011014 Pneumonia Lipopolysaccharides 4.5212224865 11605937
MESH:D011041 Poisoning Iron 4.2516604332
MESH:D017119 Porphyria Cutanea Tarda Iron 10.8916640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 10.8918163543
MESH:D011225 Pre-Eclampsia Iron 4.3916640825
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4616888761 16729912 15749863 18437689 16868541 15897917
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.4618626508 19082440
MESH:D011528 Protozoan Infections Iron 5.9916640825
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9715538739 18722050 16160472 18286688
MESH:D051437 Renal Insufficiency Doxorubicin 4.1817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.7010835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012148 Restless Legs Syndrome Iron 4.5116930377
MESH:D012509 Sarcoma Doxorubicin 3.9515625365 17203757 16767912 15675481 18313854 17710206
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7517846226
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.7718551238
MESH:D012878 Skin Neoplasms Doxorubicin 9.4615692506
MESH:D012878 Skin Neoplasms Iron 9.4612065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4616192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5315625365 17203757 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 16951190 18396642 19084572 16424979 17498489 18567086 19015929 15786421 17172411
MESH:D013398 Sudden Infant Death Iron 5.4116640825
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.1215821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.3316010429 17909728
MESH:D014062 Tongue Neoplasms Fluorouracil 3.9516280240
MESH:D014376 Tuberculosis Iron 4.0616597321
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.2516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.2516049721
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.2517653716
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.8710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.8710091137
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.8416803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1817334414 16364871 17678736 17638931
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
Pathway ID Pathway Name
KEGG:00020 Citrate cycle (TCA cycle)
KEGG:00630 Glyoxylate and dicarboxylate metabolism
KEGG:01100 Metabolic pathways
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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