AutismKB 2.0

Annotation Detail for IRF2


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Basic Information Top
Gene Symbol:IRF2 ( DKFZp686F0244,IRF-2 )
Gene Full Name: interferon regulatory factor 2
Band: 4q35.1
Quick LinksEntrez ID:3660; OMIM: 147576; Uniprot ID:IRF2_HUMAN; ENSEMBL ID: ENSG00000168310; HGNC ID: 6117
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
IMMUNE
psoriasis
atopic dermatitis
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of IRF2 mRNAdecreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of IRF2 mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IRF2 mRNAdecreases expression 19150397
20382639
D016572 Cyclosporine Cyclosporine results in decreased expression of IRF2 mRNAdecreases expression 20106945
D005419 Flavonoids Flavonoids results in increased expression of IRF2 mRNAincreases expression 15465739
D008070 Lipopolysaccharides IRF2 protein affects the reaction [IFNG protein promotes the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]]affects reaction|increases expression|increases reaction 10415056
D008070 Lipopolysaccharides IRF2 protein affects the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]affects reaction|increases expression 10415056
D008070 Lipopolysaccharides IRF2 protein affects the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]affects binding|affects reaction|increases secretion 10415056
D008070 Lipopolysaccharides IRF2 protein affects the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]affects reaction|increases secretion 10415056
D010634 Phenobarbital Phenobarbital affects the expression of IRF2 mRNAaffects expression 19136022
C006253 pirinixic acid NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of IRF2 mRNA]decreases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid affects the expression of IRF2 mRNAaffects expression 19136022
17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of IRF2 mRNAdecreases expression 17950772
D010936 Plant Extracts Plant Extracts results in increased expression of IRF2 mRNAincreases expression 15465739
C025299 polyphenols polyphenols results in increased expression of IRF2 mRNAincreases expression 15465739
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of IRF2 mRNAaffects cotreatment|increases expression 20370541
D015054 Zymosan IRF2 protein affects the reaction [Zymosan affects the expression of [IL12A protein binds to IL12B protein]]affects binding|affects expression|affects reaction 10415056
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.227525203
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.226195326
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.969612607
MESH:D055371 Acute Lung Injury Lipopolysaccharides 9.4418653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 9.4418653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.813712494
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.6417620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.6416434500
MESH:D000544 Alzheimer Disease Plant Extracts 3.0316962711
MESH:D000740 Anemia Zymosan 4.6618664788
MESH:D001169 Arthritis, Experimental Plant Extracts 8.2814686799
MESH:D001169 Arthritis, Experimental Zymosan 8.2816872482 15142272 17659584 15188379 15944321
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.191440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D002545 Brain Ischemia Plant Extracts 4.8816041641
MESH:D002057 Burns, Chemical Plant Extracts 5.519625245
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.807296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.8017173139 1701930 20007298 20935162 6705139
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 4.8018834353
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.727296757
MESH:D006332 Cardiomegaly Plant Extracts 3.8617645561
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 3.6914694615
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.577505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.5720889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.5712371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.394080065
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.8619486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.8619486331
MESH:D002779 Cholestasis pirinixic acid 13.8619176532
MESH:D003110 Colonic Neoplasms polyphenols 2.6916293270
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.2615095906
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9418759878 14531868 8156756 8970840 12868966 2524372 11298694 11906362
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.612952479 3621924
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.5019706694
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.5918648102 18692083 9022650 18289764 9328219 11289319 16192314 6482804 7440962 8291058 1440618 9653073 6679447
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.5921346803
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.5919370779
MESH:D004362 Drug Toxicity Zidovudine 4.0815040536
MESH:D004421 Dystonia Phenobarbital 4.121851702
MESH:D004487 Edema pirinixic acid 12.3612083418
MESH:D004487 Edema Plant Extracts 12.3612787963
MESH:D004487 Edema Zymosan 12.367907874
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.8615268973
MESH:D019446 Endotoxemia Lipopolysaccharides 4.5515821434 15328337 17637181
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.253659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.043922381 11558140
MESH:D004827 Epilepsy Phenobarbital 7.1320417680
MESH:D004827 Epilepsy Plant Extracts 7.1319700373 19439326
MESH:D004832 Epilepsy, Absence Phenobarbital 3.646401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.397750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.173659116
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.4720426865
MESH:D005234 Fatty Liver Cyclosporine 19.7819224547
MESH:D005234 Fatty Liver pirinixic acid 19.7819236843 20131406
MESH:D005234 Fatty Liver Plant Extracts 19.7815975614
MESH:D005234 Fatty Liver Zidovudine 19.7818299183
MESH:D005334 Fever Lipopolysaccharides 4.129205823 11852909
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D005355 Fibrosis Cyclosporine 3.2812639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006333 Heart Failure pirinixic acid 7.4620558911
MESH:D006333 Heart Failure Plant Extracts 7.4618097624
MESH:D006402 Hematologic Diseases Zidovudine 4.8312579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.4916366002
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.066705139
MESH:D006505 Hepatitis Zymosan 10.0619110552
MESH:D006529 Hepatomegaly Phenobarbital 8.9516109766
MESH:D006529 Hepatomegaly pirinixic acid 8.9519772884 16221962 19176532 18467677
MESH:D006561 Herpes Simplex Plant Extracts 4.7810715843
MESH:D015658 HIV Infections Plant Extracts 7.2112878215
MESH:D015658 HIV Infections Zidovudine 7.2120032539 17358032 11698656 11363243 11141242
MESH:D019584 Hot Flashes Plant Extracts 4.9217454163 16566672 14716179
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.5616484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.5915268973 15975614
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007249 Inflammation Flavonoids 16.5317296493
MESH:D007249 Inflammation Lipopolysaccharides 16.5317963957 17237260 9205823 12878042 17255318
MESH:D007249 Inflammation Plant Extracts 16.5312787963 16366677 15997105 19332304
MESH:D007249 Inflammation polyphenols 16.5316366677
MESH:D007249 Inflammation Zymosan 16.538014878 11289658
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.7212584176 12351151 12628509
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.7517255318
MESH:D043183 Irritable Bowel Syndrome Zymosan 5.9917553498
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.199022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Cyclosporine 2.4018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 13.026582329
MESH:D007680 Kidney Neoplasms Cyclosporine 13.0212371664
MESH:D007680 Kidney Neoplasms Zidovudine 13.0212579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.5220370541
MESH:D007970 Leukopenia Lipopolysaccharides 4.8515821434
MESH:D008103 Liver Cirrhosis Phenobarbital 7.1721047994
MESH:D008103 Liver Cirrhosis Plant Extracts 7.1717157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.269327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 3.7112878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.7115474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 3.7115479170
MESH:D008107 Liver Diseases Phenobarbital 6.9219363144
MESH:D008107 Liver Diseases Plant Extracts 6.9217034775
MESH:D008107 Liver Diseases polyphenols 6.9216698588
MESH:D008113 Liver Neoplasms Phenobarbital 7.7615975961 19812893 8742319 19073162 19482888 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 7.7615890375 16377806 20007298
MESH:D008113 Liver Neoplasms Plant Extracts 7.7619168119
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.173712494 598648 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.171399818 18308698 17172636 2563599 6150874
MESH:D055370 Lung Injury Lipopolysaccharides 4.1521114838
MESH:D008175 Lung Neoplasms Plant Extracts 3.0820869020
MESH:D008175 Lung Neoplasms Zidovudine 3.0818800350
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 6.0117358032
MESH:D009102 Multiple Organ Failure Zymosan 5.3112879239 10479408 15834315 12130978 15259001 15241586 10890648 18160304 15213630 17724436
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.6317484760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.513581430
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3818481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.3217168769
MESH:D009765 Obesity pirinixic acid 4.8320558911
MESH:D009765 Obesity Plant Extracts 4.8319056576 20132043
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.474026338 6482804
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.4714694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D010018 Osteomalacia Phenobarbital 4.5217016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5316965848
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 9.937296757
MESH:D010212 Papilloma Plant Extracts 9.9315173996 16517061
MESH:D010538 Peritonitis Zymosan 5.0214761945 19088179 17371808 17826846 18977430 18557954 18760300 19641140 11985352 15259001 15979727
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D011014 Pneumonia Lipopolysaccharides 4.7111605937 12224865
MESH:D011230 Precancerous Conditions Cyclosporine 9.3012371664
MESH:D011230 Precancerous Conditions Phenobarbital 9.302563599
MESH:D011471 Prostatic Neoplasms Plant Extracts 4.0614666653 17804756
MESH:D019310 Pseudolymphoma Phenobarbital 4.6712752131
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8010835634
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012640 Seizures Phenobarbital 2.7611442880 3137016 16876388 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.986407741
MESH:D018805 Sepsis Zymosan 4.7411441115
MESH:D012878 Skin Neoplasms Plant Extracts 3.5216517061 15173996
MESH:D013274 Stomach Neoplasms Zidovudine 2.4817696246
MESH:D013276 Stomach Ulcer Plant Extracts 4.0017135157 15255614 18193104 18237397 12787963
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 13.8617997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 13.8617997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.2715821434
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.431399818 7505956 6587162 6582329 3712494
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.431399818
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.318074119
MESH:D014605 Uveitis Cyclosporine 12.571336536
MESH:D014605 Uveitis Zymosan 12.5711006244
MESH:D014625 Vaginal Neoplasms Zidovudine 4.9012579204
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.8818097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.4718097624
MESH:D014947 Wounds and Injuries Plant Extracts 4.3419894650 20213670
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:604 Hemostasis
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29916
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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