AutismKB 2.0

Annotation Detail for IRF5


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Basic Information Top
Gene Symbol:IRF5 ( SLEB10 )
Gene Full Name: interferon regulatory factor 5
Band: 7q32.1
Quick LinksEntrez ID:3663; OMIM: 607218; Uniprot ID:IRF5_HUMAN; ENSEMBL ID: ENSG00000128604; HGNC ID: 6120
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04620Toll-like receptor signaling pathway
No data
Pathway IDPathway Name
200101Direct p53 effectors
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1807Autoimmune disease
2146Lupus erythematosus
Desease Name
rheumatoid arthritis
Wegener's granulomatosis- reduced risk
systemic lupus erythematosus
IMMUNE
Arthritis, Rheumatoid
lupus erythematosus
Desease Name
Rheumatoid arthritis
Primary biliary cirrhosis
Systemic lupus erythematosus
Desease Name
Systemic lupus erythematosus, susceptibility to, 10
Inflammatory bowel disease 14, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of IRF5 mRNAincreases expression 18648102
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of IRF5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of IRF5 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of IRF5 mRNAincreases expression 20064835
D002101 Cacodylic Acid Cacodylic Acid results in decreased expression of IRF5 mRNAdecreases expression 17720352
D004041 Dietary Fats Dietary Fats results in decreased expression of IRF5 mRNAdecreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF5 mRNAaffects cotreatment|increases expression 17942748
C029938 nickel sulfate nickel sulfate results in increased expression of IRF5 mRNAincreases expression 16780908
C041786 palm oil palm oil results in decreased expression of IRF5 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IRF5 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of IRF5 mRNAdecreases expression 20059764
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of IRF5 mRNA]decreases expression|increases reaction 20059764
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF5 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IRF5 mRNAincreases expression 15328365
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 9.147525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.1411752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.1617505938
MESH:D055371 Acute Lung Injury nickel sulfate 9.6512718980 11954676 16100012 19131640
MESH:D055371 Acute Lung Injury pirinixic acid 9.6518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.853712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.856695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.5616835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0811748828
MESH:D000799 Angioedema Acetaminophen 4.0610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.5015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.5011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7415885639
MESH:D001172 Arthritis, Rheumatoid marker/mechanism 20453842
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.2419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8515746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0120146248 17474063
MESH:D001943 Breast Neoplasms Cacodylic Acid 2.0117474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.0120435547
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9116835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.877296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.873084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4416120746 18670907 18850075
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.6814694615
MESH:D002386 Cataract Acetaminophen 7.6810977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.857505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.989022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.9817110522 17681005 15861022 16105132 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 13.9819176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1515668235 15340226 12621046 8697196 16354765
MESH:D003093 Colitis, Ulcerative marker/mechanism 21297633
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 9.6115095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 9.6114669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 7.7318759878 14531868 12868966 11298694 8156756 8970840 2524372 11906362
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 7.7316823706 16780908 11298694
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.299328219 18692083 1440618 18289764 6679447 8291058 7440962 9022650 9653073 16192314 11289319 6482804 18648102
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 9.2921346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.2912392966 16177239 12540782 14986274 18713872 19085960 10663392 18071297 11743745 11834606 10915739 16227642 12594235 19416960 19420014 14725611 16485898 16081117 19923254 16781746 15619225 17522070 17562736 11421492 16393943 19739265 2444490 16109766 12153990 15968718 11287661 12958197 11739529 11461765 14550746 12705907 11529661 17906064 19370779 10774834 19164858
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema pirinixic acid 7.0012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.159294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.473581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4716530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1211564622
MESH:D005234 Fatty Liver Dietary Fats 13.8819551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8815345470
MESH:D005234 Fatty Liver pirinixic acid 13.8820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6311858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Dietary Fats 9.2218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.2220067830
MESH:D005756 Gastritis Acetaminophen 3.8916983495
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8110696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.6720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly pirinixic acid 8.8516221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.8515340226 16120746 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.268697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8116870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9518850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9816945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5717937319
MESH:D007249 Inflammation Dietary Fats 5.1420412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1412200463 12878042
MESH:D015212 Inflammatory Bowel Diseases marker/mechanism
MESH:D007333 Insulin Resistance Dietary Fats 7.5411836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.248074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4816580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2712587719 15629191
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D008103 Liver Cirrhosis Dietary Fats 2.9518296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1715474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1712878042
MESH:D008107 Liver Diseases Acetaminophen 1.6619014921 16610002 12969438 16611625 19460945 11587558 19784758 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3717185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.5921137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 7.5915890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5916984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.01598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0112151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.226695378 18569708 20135361 18816296 18520028 20464547 17053015 20064080 20869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2219555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism 18204446 19838193
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7419513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1312213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.3714600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9918514411
MESH:D009765 Obesity Dietary Fats 4.5418457598 20518802 16723640 17217161 19632207 21332399 18674790 20132043 11836018
MESH:D009765 Obesity pirinixic acid 4.5420558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.576482804 4026338
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.5714694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010146 Pain Acetaminophen 2.5016870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8411578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7218163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3811118676 11399792 11896295 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.9517292933
MESH:D011537 Pruritus Ethinyl Estradiol 3.5116919318 15861022
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0018990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012595 Scleroderma, Systemic marker/mechanism 20383147
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.6719755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6716192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.1616709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.996582329 1399818 3712494 6587162 7505956
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.758074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.7517053015
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 8.7515537745
MESH:D014581 Urticaria Acetaminophen 3.1210982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.4614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4715886252
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
KEGG:04620 Toll-like receptor signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29919
    • No data
    Releated disease ID Related disease Name
    PA444987Multiple Sclerosis
    PA444822Lupus Erythematosus, Systemic
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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