AutismKB 2.0

Annotation Detail for IRS1


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Basic Information Top
Gene Symbol:IRS1 ( HIRS-1 )
Gene Full Name: insulin receptor substrate 1
Band: 2q36.3
Quick LinksEntrez ID:3667; OMIM: 147545; Uniprot ID:IRS1_HUMAN; ENSEMBL ID: ENSG00000169047; HGNC ID: 6125
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04920Adipocytokine signaling pathway
hsa04910Insulin signaling pathway
hsa04722Neurotrophin signaling pathway
hsa04960Aldosterone-regulated sodium reabsorption
hsa04930Type II diabetes mellitus
Pathway IDPathway Name
Signalling by NGF
Signaling by Insulin receptor
Signaling by FGFR
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200181S1P2 pathway
200012Insulin Pathway
200080mTOR signaling pathway
200082IL2-mediated signaling events
200084IGF1 pathway
200018IL4-mediated signaling events
200109Integrins in angiogenesis
200058Signaling events regulated by Ret tyrosine kinase
Pathway IDPathway Name
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00048PI3 kinase pathway
P00032Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P00036Interleukin signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1856Obesity
1889Hyperinsulinism
1904Diabetes mellitus
1934Cancer
2097Hyperlipidemia
2102Polycystic ovary syndrome
2176Tuberous sclerosis
Desease Name
cardiovascular disease
polycystic ovary syndrome
atherogenic profile
atherosclerosis, coronary
colorectal cancer
CARDIOVASCULAR
diabetes, type 1
adiponectin
C-peptide insulin-like growth factor sex hormones
Birth Weight
CANCER
anthropometric measuments
type 2 diabetes and other traits
polycystic ovarian syndrome
glucose tolerance
precocious puberty
IMMUNE
METABOLIC
diabetes, type 2 sleep apnea
diabetes, gestational
obesity
insulin
androgen levels
DEVELOPMENTAL
body fat
REPRODUCTION
diabetes, type 2
adrenal androgen
Insulin Resistance
Desease Name
Type 2 diabetes
Desease Name
Diabetes mellitus, noninsulin-dependent
Coronary artery disease, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of IRS1 mRNAaffects expression 21346803
D000643 Ammonium Chloride Ammonium Chloride affects the expression of IRS1 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in decreased expression of IRS1 mRNAdecreases expression 20458559
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of IRS1 mRNAaffects expression 20382639
C511635 bis(allixinato)oxovanadium(IV) bis(allixinato)oxovanadium(IV) results in increased phosphorylation of IRS1 proteinincreases phosphorylation 17805585
C512927 bis(alpha-furancarboxylato)oxovanadium(IV) bis(alpha-furancarboxylato)oxovanadium(IV) inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA]decreases expression|decreases reaction 18812026
C006780 bisphenol A bisphenol A results in increased expression of IRS1 mRNAincreases expression 16029874
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of IRS1 mRNAaffects expression 17484886
D002330 Carmustine Carmustine results in decreased expression of IRS1 mRNAdecreases expression 15980968
D002791 Cholesterol, Dietary [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS1 proteinaffects cotreatment|decreases expression|decreases phosphorylation 19509184
C503589 cis-9, trans-11-conjugated linoleic acid cis-9, trans-11-conjugated linoleic acid inhibits the reaction [TNF protein results in decreased expression of IRS1 mRNA]decreases expression|decreases reaction 17327424
D003513 Cycloheximide [Cycloheximide co-treated with Estradiol] results in increased expression of IRS1 mRNAaffects cotreatment|increases expression 15072547
D003513 Cycloheximide Cycloheximide results in decreased expression of IRS1 mRNAdecreases expression 15072547
D003520 Cyclophosphamide [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNAaffects cotreatment|affects expression 16322899
D016572 Cyclosporine Cyclosporine results in decreased expression of IRS1 mRNAdecreases expression 20106945
D003907 Dexamethasone bis(alpha-furancarboxylato)oxovanadium(IV) inhibits the reaction [Dexamethasone results in decreased expression of IRS1 mRNA]decreases expression|decreases reaction 18812026
D003907 Dexamethasone Dexamethasone results in decreased expression of IRS1 mRNAdecreases expression 18812026
D004041 Dietary Fats [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS1 proteinaffects cotreatment|decreases expression|decreases phosphorylation 19509184
D004052 Diethylnitrosamine Diethylnitrosamine affects the expression of IRS1 mRNAaffects expression 20387270
D002117 Calcitriol Calcitriol results in increased expression of IRS1 mRNAincreases expression 16002434
D004317 Doxorubicin [Doxorubicin co-treated with Cyclophosphamide] affects the expression of IRS1 mRNAaffects cotreatment|affects expression 16322899
D004958 Estradiol [Cycloheximide co-treated with Estradiol] results in increased expression of IRS1 mRNAaffects cotreatment|increases expression 15072547
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRS1 mRNAaffects cotreatment|decreases expression 15688983
D004958 Estradiol Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]affects binding|increases reaction 19435893
D004958 Estradiol Estradiol results in decreased phosphorylation of IRS1 proteindecreases phosphorylation 15949379
D004958 Estradiol Estradiol results in increased expression of IRS1 mRNAincreases expression 15072547
16029874
15688983
D004958 Estradiol NVP-AEW541 inhibits the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]]affects binding|decreases reaction|increases reaction 19435893
D004958 Estradiol PTEN protein affects the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]]affects binding|affects reaction|increases reaction 19435893
D004958 Estradiol Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of IRS1 mRNA]decreases reaction|increases expression 15688983
D004958 Estradiol Estradiol results in increased phosphorylation of IRS1 proteinincreases phosphorylation 15604210
D000431 Ethanol Ethanol affects the phosphorylation of IRS1 proteinaffects phosphorylation 18377926
D005227 Fatty Acids Fatty Acids affects the expression of IRS1 mRNAaffects expression 17940560
D005576 Forskolin Forskolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA]decreases reaction|increases expression 17407152
D005632 Fructose [Fructose co-treated with Dietary Fats co-treated with Cholesterol, Dietary] results in decreased expression of and results in decreased phosphorylation of IRS1 proteinaffects cotreatment|decreases expression|decreases phosphorylation 19509184
D005632 Fructose Fructose results in decreased expression of IRS1 mRNAdecreases expression 19165636
D005632 Fructose Fructose results in decreased expression of IRS1 proteindecreases expression 19008412
D005632 Fructose NOS3 protein inhibits the reaction [Fructose results in decreased expression of IRS1 protein]decreases expression|decreases reaction 19008412
C070081 fulvestrant fulvestrant results in decreased expression of IRS1 mRNAdecreases expression 15072547
D006581 Hexachlorobenzene Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein]decreases reaction|increases phosphorylation 16237195
D006581 Hexachlorobenzene Hexachlorobenzene results in increased expression of IRS1 proteinincreases expression 16237195
D006581 Hexachlorobenzene Hexachlorobenzene results in increased phosphorylation of IRS1 proteinincreases phosphorylation 16237195
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of IRS1 mRNAincreases expression 15072547
C533894 LG 100815 LG 100815 results in decreased expression of IRS1 mRNAdecreases expression 16951191
D008770 Methylnitrosourea Hexachlorobenzene inhibits the reaction [Methylnitrosourea results in increased phosphorylation of IRS1 protein]decreases reaction|increases phosphorylation 16237195
D008770 Methylnitrosourea Methylnitrosourea results in increased phosphorylation of IRS1 proteinincreases phosphorylation 16237195
C063509 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA]decreases reaction|increases expression 17407152
C002741 N-nitrosomorpholine N-nitrosomorpholine results in increased expression of IRS1 proteinincreases expression 9466558
C501177 NVP-AEW541 NVP-AEW541 inhibits the reaction [Estradiol promotes the reaction [AKT1 protein modified form binds to IRS1 protein]]affects binding|decreases reaction|increases reaction 19435893
C062198 octa-2,4,6-trienoic acid octa-2,4,6-trienoic acid results in decreased expression of IRS1 mRNAdecreases expression 16951191
C006253 pirinixic acid pirinixic acid results in decreased expression of IRS1 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of IRS1 mRNAincreases expression 18301758
D011374 Progesterone Progesterone results in decreased phosphorylation of IRS1 proteindecreases phosphorylation 15949379
D011374 Progesterone Progesterone results in increased phosphorylation of IRS1 proteinincreases phosphorylation 15604210
C059514 resveratrol resveratrol results in decreased activity of [IRS1 protein binds to PIK3R1 protein]affects binding|decreases activity 17550345
C059514 resveratrol resveratrol inhibits the reaction [INS1 protein promotes the reaction [IRS1 protein binds to PIK3R1 protein]]affects binding|decreases reaction|increases reaction 16626303
D017673 Sodium Chloride, Dietary Sodium Chloride, Dietary results in increased phosphorylation of IRS1 proteinincreases phosphorylation 14670806
D013629 Tamoxifen Tamoxifen affects the expression of IRS1 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRS1 mRNAaffects cotreatment|decreases expression 15688983
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of IRS1 mRNA]decreases reaction|increases expression 15688983
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNA]affects reaction|decreases expression 20181658
D013749 Tetrachlorodibenzodioxin Forskolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA]decreases reaction|increases expression 17407152
D013749 Tetrachlorodibenzodioxin MAPK8 protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]affects reaction|decreases expression 20181658
D013749 Tetrachlorodibenzodioxin N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA]decreases reaction|increases expression 17407152
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IRS1 mRNAdecreases expression 18691609
20181658
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IRS1 proteindecreases expression 20181658
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNAincreases expression 17407152
D013749 Tetrachlorodibenzodioxin TNF protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]affects reaction|decreases expression 20181658
D013749 Tetrachlorodibenzodioxin TNFRSF1A protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]affects reaction|decreases expression 20181658
D013749 Tetrachlorodibenzodioxin U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]decreases expression|decreases reaction 20181658
C113580 U 0126 U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IRS1 protein]decreases expression|decreases reaction 20181658
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1214745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.0918926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.0911752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 9.0818287403
MESH:D000138 Acidosis Ethanol 9.0811192467
MESH:D000168 Acrocephalosyndactylia U 0126 5.0717694057
MESH:D058186 Acute Kidney Injury resveratrol 3.4816538975
MESH:D055371 Acute Lung Injury pirinixic acid 2.7318653653
MESH:D000230 Adenocarcinoma arsenic trioxide 9.2211798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 9.2217418594
MESH:D000230 Adenocarcinoma Estradiol 9.2211473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 9.2215113128 15688392
MESH:D000236 Adenoma Diethylnitrosamine 6.046695378 10737359
MESH:D000236 Adenoma resveratrol 6.0415688382
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.8517620307 17162532 19052882 16434500 19061943 18056438
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.8516434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.8516835633
MESH:D000419 Albuminuria Doxorubicin 4.1521441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8915451039 15451040
MESH:D000544 Alzheimer Disease Cholesterol, Dietary 4.5320157255
MESH:D000544 Alzheimer Disease resveratrol 4.5316183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5911748828
MESH:D000853 Anophthalmos Ethanol 4.4115513904
MESH:D001008 Anxiety Disorders Ethanol 3.6711141031
MESH:D001161 Arteriosclerosis Cholesterol, Dietary 14.9915552841
MESH:D001161 Arteriosclerosis Cyclophosphamide 14.9915014928
MESH:D001161 Arteriosclerosis Dietary Fats 14.9915238619
MESH:D001169 Arthritis, Experimental Dexamethasone 6.8017659584
MESH:D001169 Arthritis, Experimental resveratrol 6.8017115116
MESH:D050197 Atherosclerosis resveratrol 3.0216873680 17967414
MESH:D001284 Atrophy fulvestrant 4.4511514358
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.1116206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 13.1119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.1112125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4915746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.2714601052
MESH:D001862 Bone Resorption bisphenol A 3.4911985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9117868700
MESH:D001930 Brain Injuries Progesterone 3.8515665606 15380490 15845082
MESH:D002545 Brain Ischemia resveratrol 3.8717600658
MESH:D001932 Brain Neoplasms Carmustine 7.9316187019
MESH:D001932 Brain Neoplasms Doxorubicin 7.9317150277
MESH:D001943 Breast Neoplasms bisphenol A 11.9017123778
MESH:D001943 Breast Neoplasms Calcitriol 11.9011237771
MESH:D001943 Breast Neoplasms Cyclophosphamide 11.9016978400 11325840 17020986 18234424 15093573 17388661 12006526 18323546 15136595
MESH:D001943 Breast Neoplasms Dietary Fats 11.9020435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 11.9017474063
MESH:D001943 Breast Neoplasms Doxorubicin 11.9015136595 15994142 15939500 16322301 15634643 16595493 18695136 16935488 16264153 15692762 18628466 17369602 16096432 15567936 19526202 16826403 18234424 17983394 11325840 15993339 15668708 17426702 18382427 16115903
MESH:D001943 Breast Neoplasms Estradiol 11.9017289903 19861407 12948864 18497071 14630087 16675129 17018787 17261762
MESH:D001943 Breast Neoplasms fulvestrant 11.9018984771
MESH:D001943 Breast Neoplasms Hexachlorobenzene 11.9015061365 12709520
MESH:D001943 Breast Neoplasms Methylnitrosourea 11.9011306469 16253758 14633655
MESH:D001943 Breast Neoplasms Progesterone 11.9017614352 15562024 16175315
MESH:D001943 Breast Neoplasms resveratrol 11.9016393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tamoxifen 11.9016818667 19155303 19059307 18629630 16873071 18815881 19410462 20544844 18425577 18351453 18821012 15565566 17242785 15668708 19289846 19189210 17261762 19084267 19244106 19189212 17440819 11161223 21152245 19011961 20859285 20135344 19487384 17893378 19142967 19221464 16273361 19115204 20065188 16202921 19103187 18855134 20005174 18984771 19200415 19288272 20390343 18997820 19066611 17049068 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 11.9020435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9411589617
MESH:D002056 Burns Ethanol 4.2416374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0416111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.3716050911 16227642 3786805 15673190 10355542 15721981 16011737 15700767 16097048 16192424 18705752 16124888
MESH:D002276 Carcinoid Tumor Doxorubicin 4.3816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4716835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1019066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 24.2116705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 24.2115073043 16217749 15553829 11135700 14691202
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 24.2118788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 24.2119701751
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 24.2119701751 19519916 18785209 20524982 19052882 19394651 3084413 20084675 16878318 20935162 16807293 17428255 16569478 19383236 19171122 19107877 16935385 18665156 16328049 10737359 10672840 3581430 19919837 19418558 18506893 19335982 20514400 20512989 17173139 18971187 17055752 21159647 16288022 16779866 18210153 11831363 17978847 16698587 20214788 16540662 17761372 20432363 19539802 18494052 18393292 20007298 19208518 18056438 16502159 16681979 18788625 18691550 20727157 16830150 17138121 17162532 20101231 18978308 19822196
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 24.2118059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 24.2116924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 24.2115289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular N-nitrosomorpholine 24.2116935385 1701930 15543204 11509945 15010824 2885971 9029167 19383236 1917145 19335982 1967229 10629087 8364915 9311599 9466558
MESH:D006528 Carcinoma, Hepatocellular resveratrol 24.2116227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 24.2116924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.5717123778
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 10.0916152834
MESH:D018827 Carcinoma, Lewis Lung resveratrol 10.0916675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4519014326
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 9.9216201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 9.9216201981 1485588
MESH:D002292 Carcinoma, Renal Cell N-nitrosomorpholine 9.921429202 7921415
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7512490120
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 6.8711237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 6.876189445
MESH:D002294 Carcinoma, Squamous Cell resveratrol 6.8716227395
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2517572228
MESH:D006332 Cardiomegaly Ethanol 6.0519332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.0518850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.2517308081 16364871 16952015 16109756 16278810 15505089 17924179 16651473 16242529 17329180 17007740 17131338 15811867 18627295 16455267 16731534 17382496 17351982 16612575 17519947 17974986 16269455 15792986 15476868 17928571
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.7916243910 17334414
MESH:D002318 Cardiovascular Diseases resveratrol 3.1815458977
MESH:D002386 Cataract Methylnitrosourea 3.7412484553
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 18.0120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.0112371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 18.0117174075 21159647 2727394 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.0118566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 18.017505956 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.1519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.1516835633
MESH:D002779 Cholestasis Cyclosporine 6.7219486331
MESH:D002779 Cholestasis pirinixic acid 6.7219176532
MESH:D002971 Cleft Lip Ethanol 3.3615513904
MESH:D002972 Cleft Palate Ethanol 5.3215513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3215668235 8697196 16354765 15340226 12621046
MESH:D003092 Colitis resveratrol 3.7216474422
MESH:D003110 Colonic Neoplasms Dexamethasone 3.7115824018
MESH:D003110 Colonic Neoplasms resveratrol 3.7116338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.2520501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.2518802399 18259882
MESH:D015179 Colorectal Neoplasms resveratrol 3.2516550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7117141729 14669216
MESH:D003324 Coronary Artery Disease marker/mechanism
MESH:D003327 Coronary Disease Fructose 7.8718504504
MESH:D003327 Coronary Disease resveratrol 7.8716507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7912609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.9810525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.9817728286
MESH:D019465 Craniofacial Abnormalities Ethanol 4.9811873399 19302082 15513904 15451039 10194807 11198716 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.9815322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 3.6118551238
MESH:D003556 Cystitis Cyclophosphamide 4.5618710439 12388444 18483878 16413132 12161096 18093676 17979934 10498854 17010015 16614059 18295254 15276878 16651033 18372110 10700343 18433785 16989017 15643279 11948286 12913760
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7115213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9519031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.0212438553
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2218249437
MESH:D003921 Diabetes Mellitus, Experimental bis(alpha-furancarboxylato)oxovanadium(IV) 17.2317651728
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 17.2315331540 11751995 10990075
MESH:D003921 Diabetes Mellitus, Experimental Fructose 17.2318603373
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 17.2316873680
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0818772604
MESH:D003924 Diabetes Mellitus, Type 2 marker/mechanism 19734900 15688983
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.5220387270
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 6.5218603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.5217107852
MESH:D003928 Diabetic Nephropathies Estradiol 12.9919279558
MESH:D003928 Diabetic Nephropathies resveratrol 12.9916286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.9919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0817187935
MESH:D003967 Diarrhea Dexamethasone 3.317237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 13.4221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 13.426623471 16227642 7120509 7440962 19336974 10915739 15027814 21278145 3786805 9327722 7179309 4309450 2869522 17522070 11566570 16177239 10092053 15968718 3732212 19085960 15998439 6884620
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 13.4219107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 13.4217416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 13.4211566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.4220420201
MESH:D004362 Drug Toxicity Doxorubicin 7.0818602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.0811462148
MESH:D050171 Dyslipidemias Dietary Fats 3.1518367378
MESH:D004485 Eczema Dexamethasone 4.0612438553
MESH:D004487 Edema Dexamethasone 13.4119703484
MESH:D004487 Edema pirinixic acid 13.4112083418
MESH:D004487 Edema resveratrol 13.418985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4715322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 18.7015138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.7017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 18.7017872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 18.7019031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 10.8617359293
MESH:D016889 Endometrial Neoplasms Estradiol 10.8611473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.8617893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Progesterone 7.7316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.739294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.7318037988
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4417923197
MESH:D004802 Eosinophilia Cyclophosphamide 3.8111006010
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6916302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.5820426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.5812903497
MESH:D004938 Esophageal Neoplasms Ethanol 6.5816704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7011564622
MESH:D005234 Fatty Liver arsenic trioxide 42.4915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 42.4912631006 17595544 12795759 16239168 15959796 61145 16045604 19224547
MESH:D005234 Fatty Liver Cyclosporine 42.4919224547
MESH:D005234 Fatty Liver Dietary Fats 42.4917967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 42.4920387270 21071580
MESH:D005234 Fatty Liver Ethanol 42.4916409862 19236843 18620774
MESH:D005234 Fatty Liver Fructose 42.4919196556 18641190 18395287
MESH:D005234 Fatty Liver pirinixic acid 42.4920131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 42.4914986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.2417920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9816709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8816946407 10194807 15513904 15451040
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1114745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.0519069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.0519069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 4.8111555667
MESH:D005355 Fibrosis Carbon Tetrachloride 23.4118705752
MESH:D005355 Fibrosis Cyclosporine 23.4112639820 12168785
MESH:D005355 Fibrosis Dietary Fats 23.4118296743
MESH:D005355 Fibrosis Fructose 23.4118504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 23.4120067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8616904648
MESH:D005756 Gastritis Ethanol 4.2715046732
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.808708960
MESH:D005909 Glioblastoma Carmustine 6.6616187019
MESH:D005909 Glioblastoma Doxorubicin 6.6617150277
MESH:D005910 Glioma Methylnitrosourea 3.399825942
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0911389073
MESH:D018149 Glucose Intolerance Fructose 4.9419165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1710696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.6316376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.2415692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1010048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.1916330681 16495754 18674790 16244372 16144979 17875725 12587719 14766674 16244371 16879835 17888722 18006777 16707910
MESH:D006333 Heart Failure Doxorubicin 6.1717481944
MESH:D006333 Heart Failure pirinixic acid 6.1720558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.5315692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.0015720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.8811918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9611000095
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.1114986274
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2019110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 6.9119772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.9115340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 2.917520565
MESH:D006558 Herpes Genitalis Estradiol 4.6015709030
MESH:D006561 Herpes Simplex resveratrol 3.7616876885
MESH:D006689 Hodgkin Disease Cyclophosphamide 6.5617606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 6.5618501091 15147373 17606976
MESH:D019584 Hot Flashes Estradiol 3.3317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6215340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Ethanol 3.3918783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1116899240
MESH:D006937 Hypercholesterolemia Cholesterol, Dietary 13.3710876104
MESH:D006937 Hypercholesterolemia Dietary Fats 13.3721332399
MESH:D006937 Hypercholesterolemia resveratrol 13.3717188708
MESH:D006943 Hyperglycemia pirinixic acid 2.8220558911
MESH:D006946 Hyperinsulinism marker/mechanism 19734900
MESH:D006946 Hyperinsulinism Fructose 4.5518563319 14757778 15752949 19008412 18360027
MESH:D006949 Hyperlipidemias Dietary Fats 13.3621332399
MESH:D006949 Hyperlipidemias Fructose 13.3615752949
MESH:D006949 Hyperlipidemias resveratrol 13.3616873680
MESH:D006973 Hypertension Cyclosporine 14.5910903974
MESH:D006973 Hypertension Dexamethasone 14.5917042910
MESH:D006973 Hypertension Fructose 14.5914568997 14573337 14633139 16843071 19008412
MESH:D006973 Hypertension Sodium Chloride, Dietary 14.5918524855
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 14.5918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6815338365
MESH:D015228 Hypertriglyceridemia Fructose 4.7119799862 19342510
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9417488730
MESH:D007154 Immune System Diseases Cyclophosphamide 4.9016076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.1215869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.1217600658
MESH:D007248 Infertility, Male Cyclophosphamide 9.9216517039 7193160
MESH:D007248 Infertility, Male fulvestrant 9.9211514358
MESH:D007248 Infertility, Male Methylnitrosourea 9.927193160
MESH:D007249 Inflammation Dexamethasone 20.7411099482 8960868
MESH:D007249 Inflammation Dietary Fats 20.7420412841
MESH:D007249 Inflammation Diethylnitrosamine 20.7418785209
MESH:D007249 Inflammation Progesterone 20.7415869954
MESH:D007249 Inflammation resveratrol 20.7416366677
MESH:D007249 Inflammation Tamoxifen 20.7419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.7412200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.1216624496
MESH:D007333 Insulin Resistance marker/mechanism 19734900
MESH:D007333 Insulin Resistance bisphenol A 20.2516393666
MESH:D007333 Insulin Resistance Dietary Fats 20.2511836018 18457598
MESH:D007333 Insulin Resistance Estradiol 20.2516393666 16627594
MESH:D007333 Insulin Resistance Fructose 20.2514633139 19008412 18563319 17133782 14573337 19799862 18981581 19342510 18057795 14757778 19586609
MESH:D007333 Insulin Resistance pirinixic acid 20.2516306350
MESH:D007569 Jaw Abnormalities Ethanol 8.8715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.0115604871
MESH:D007674 Kidney Diseases Cyclosporine 8.6418776723 10903974 8314463
MESH:D007674 Kidney Diseases Doxorubicin 8.6415369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 8.6415618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.7816707910
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.9616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 14.9612371664
MESH:D007680 Kidney Neoplasms Estradiol 14.9615610895
MESH:D007680 Kidney Neoplasms Tamoxifen 14.9618625569
MESH:D007859 Learning Disorders Ethanol 3.8015451040
MESH:D007938 Leukemia arsenic trioxide 5.8815070760
MESH:D007938 Leukemia Cyclophosphamide 5.8810602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.7316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.3117658394 17802794 17296974 17008537 18587576 18172266
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4217077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 10.3616972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 10.3616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.5814633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 7.5810373061
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.3919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0616467208 17050201 20471514 19850784 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.8617712046 11161223 17107899 17217047 9834237 15336539 19035177 16330433 19642359 12018890 16891316 19225113 16823087 12679006 16966277 17869043 15213294 15622746 16112521 15748426 17649720 16331271 11468182 12712474 19075265
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.8616087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9516882451
MESH:D007970 Leukopenia Cyclophosphamide 4.5511830472 10052129
MESH:D017880 Limb Deformities, Congenital Ethanol 7.6417676605
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 7.6415526292
MESH:D008064 Lipidoses Tamoxifen 2.8615342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 13.8017157831 16221502 17174718 16943688 11903743 11408273 21278145 16239168 17334410
MESH:D008103 Liver Cirrhosis Dietary Fats 13.8018296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 13.8020032147 19638242 18522880 18407596 18665156
MESH:D008103 Liver Cirrhosis Ethanol 13.8015289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6818295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.4315818738 12632512 15730626 17976157 12898905 12609069 17761835 18395095 17698563 18418968 17922224 20821823 18251166 12667390 15931870 17525996 18472094 15123356 17557913 17640975 14748882 12445421 16015684 18420326 17481882 15876570 12389079 11481614 12445418 16027843 17805973 12958196 18210741 12741479 18006644 18376398 15673190 15362042 12666154 18429990 15370692 18166357 17714472 15996030 18472332 12586293 15338365 17766677 16248980 18481824 18054572 15959796 18277467 18263696 17823541 14716833 16638106 17900296 12649538 18156304 18412020 16097048 12546737 15057751 17869086 18705752 12632514 17721639 14716496 16033810 17708605 10355542 14620537 18279442 18395914 18187930 15925388 16192424 14512876 18339082 16136751 13678700 17565644 17631135 15893842 14724832 15650968 18205269 15052691 16011737 16116963 17944888 18317297
MESH:D008106 Liver Cirrhosis, Experimental cis-9, trans-11-conjugated linoleic acid 14.4317869086
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 14.4316718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 14.4316439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.4314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 14.4318166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.4315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.4318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.4312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 3.6716964402 17285989 15830285 16246199 15720792
MESH:D008107 Liver Diseases Diethylnitrosamine 3.6717034775
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.2417207112 17347304
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3316899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 19.2314682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 19.2319294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 19.2321071580 19294768 20434301 18977376 19850985 18648771 19551842 19426721 19255062 20101389 19090486 19690152 2862719 19254457 19427195 10737359 21047994 12771043 19642983 19638242 19073162 18754104 21167192 18644402 16942905 15175105 15885732 20452335 2422723 21278145 19996281 19812893 20501860 19499222 20583210 12112319 19833225 20137499 18978307 20405173 20118626 20492335 9163691 19256749
MESH:D008113 Liver Neoplasms pirinixic acid 19.2316377806 20007298 15890375
MESH:D008113 Liver Neoplasms resveratrol 19.2319812893 19321006 20405173 19073162
MESH:D008113 Liver Neoplasms Tamoxifen 19.2316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.2316984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 19.9020377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.9012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.9021159647 18775883 17174075 16267830 9362446 19539802 17854601 19009564 2563599 18079962 3124819 18544905 18282651 18164116 18308698 17942915 16842330 18253720 19004024 18093689 19126423 19519916
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 19.9017085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 19.901423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.9012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0315213294
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.0516080182
MESH:D008175 Lung Neoplasms arsenic trioxide 9.7411798837 19825857
MESH:D008175 Lung Neoplasms Dexamethasone 9.7415824018 11195469
MESH:D008175 Lung Neoplasms Diethylnitrosamine 9.746695378 20970405 21163286 20512841
MESH:D008175 Lung Neoplasms Doxorubicin 9.7417418594 6189445
MESH:D008175 Lung Neoplasms Methylnitrosourea 9.7418062963
MESH:D008175 Lung Neoplasms Tamoxifen 9.7418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.7411884234 19555203
MESH:D008223 Lymphoma Cyclophosphamide 11.0212854902
MESH:D008223 Lymphoma Doxorubicin 11.0216098063
MESH:D008223 Lymphoma Methylnitrosourea 11.0211418001 16257854
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 15.0716675587
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 15.0714633661
MESH:D016393 Lymphoma, B-Cell resveratrol 15.0717088997
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 12.6711911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 12.6717654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 12.6714749477
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.1615621674
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.6115688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.6119428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 20.0215458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 20.0211807958 17203775 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 20.0217020996 14999141 14633655 12931682 10838139 16944150 17131329 15688392 16051031 11807958 16827153 10767621 19196723 15313902 16619500 11751437 15113128
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 20.0211408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 20.028985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 20.0214580682 16827153 11731420 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 11.2219453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.2219453300
MESH:D008545 Melanoma Carmustine 6.6312393984
MESH:D008545 Melanoma Doxorubicin 6.6316827129
MESH:D008545 Melanoma resveratrol 6.6317992120
MESH:D008545 Melanoma Tamoxifen 6.6312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7615990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.3916388313
MESH:D008569 Memory Disorders Ethanol 3.7915451040 18411066
MESH:D008654 Mesothelioma Doxorubicin 2.8817638057
MESH:D008659 Metabolic Diseases resveratrol 4.0017112576
MESH:D024821 Metabolic Syndrome X Fructose 4.4719165636 18497449 17261469 17098227 16815490
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3616801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.1215792986
MESH:D052016 Mucositis Doxorubicin 4.3717415656
MESH:D009101 Multiple Myeloma arsenic trioxide 10.4619549372 19417148 14977855 11468182 15949261
MESH:D009101 Multiple Myeloma Dexamethasone 10.4615744524 15867202 16118317
MESH:D009101 Multiple Myeloma resveratrol 10.4614749477 17049120 17164350 16490592 16267019 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.4517962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1016239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.7416105982 16882451
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 6.749809623
MESH:D009203 Myocardial Infarction Doxorubicin 8.4219429709 15857846
MESH:D009203 Myocardial Infarction pirinixic acid 8.4219151258
MESH:D009203 Myocardial Infarction resveratrol 8.4216525036 16317513 17188708 16456233 17125593 17015251
MESH:D017202 Myocardial Ischemia resveratrol 7.9117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.9112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.1816810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.1816411023
MESH:D009205 Myocarditis resveratrol 4.3417322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.4418551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5616624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.473581430 9029167
MESH:D009362 Neoplasm Metastasis Doxorubicin 8.4718259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.4719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3719410462
MESH:D009369 Neoplasms Cyclophosphamide 7.1818854779
MESH:D009369 Neoplasms Methylnitrosourea 7.1815533788
MESH:D009369 Neoplasms pirinixic acid 7.1817405874
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 8.1712696579
MESH:D009374 Neoplasms, Experimental resveratrol 8.178985016
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.5719189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3217289903
MESH:D009401 Nephrosis Doxorubicin 4.3616899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.0117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.1319348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.1316889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 14.0611399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 14.0616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.0614600291
MESH:D009436 Neural Tube Defects arsenic trioxide 2.8410525206
MESH:D009442 Neurilemmoma Methylnitrosourea 5.0711555667
MESH:D009447 Neuroblastoma Cyclophosphamide 6.468761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 6.4615555623
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.4020387270
MESH:D019636 Neurodegenerative Diseases resveratrol 7.4017652729
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.478761367 12837982
MESH:D020078 Neurogenic Inflammation resveratrol 4.0117929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6920387270
MESH:D009503 Neutropenia Cyclophosphamide 3.948291058
MESH:D009765 Obesity Dietary Fats 6.8221332399 18674790 17217161 11836018 19632207 16723640 18457598 20518802 20132043
MESH:D009765 Obesity Fructose 6.8218585860 17707055
MESH:D009765 Obesity pirinixic acid 6.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.0712819281 16049721
MESH:D009845 Oligospermia Cyclophosphamide 4.2916517039
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.8717513867
MESH:D012516 Osteosarcoma Doxorubicin 3.7815930896
MESH:D010049 Ovarian Diseases bisphenol A 4.5711985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.1219769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 10.1219401270
MESH:D010051 Ovarian Neoplasms Progesterone 10.1216525653 17393432
MESH:D010051 Ovarian Neoplasms U 0126 10.1216211241
MESH:D010146 Pain Cyclophosphamide 3.3012161096 18093676
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 14.5815580305
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 14.5811332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 14.5816540662
MESH:D010190 Pancreatic Neoplasms Ethanol 14.5812384795
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 14.5816965848
MESH:D010235 Paraganglioma arsenic trioxide 3.7819927285
MESH:D010300 Parkinson Disease Cholesterol, Dietary 4.0119014385
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.7317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 4.7317638057
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 9.789918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.7818163543
MESH:D011230 Precancerous Conditions marker/mechanism 9466558
MESH:D011230 Precancerous Conditions Cyclosporine 7.7812371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.782563599
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 7.0121297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 7.0121297632
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.8710548101
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 13.8716679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.8711399792 11896295 11118676 11222880
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.3615572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.3120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.3120887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 15678496
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7819131511
MESH:D011471 Prostatic Neoplasms bisphenol A 2.7816740699
MESH:D011471 Prostatic Neoplasms Calcitriol 2.7816289102 12479363 15754350 16644109 18247401
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.7817136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.7815897917 16868541 18437689 16888761 15749863 16729912
MESH:D011471 Prostatic Neoplasms Estradiol 2.7816740699
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.7812376480 15682402
MESH:D011471 Prostatic Neoplasms resveratrol 2.7816731767 17636462 17718901 17804756 15767336 17675339
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7815067354
MESH:D011565 Psoriasis Cyclosporine 2.0716882103
MESH:D011629 Puberty, Precocious bisphenol A 4.3710548101
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.1116636934
MESH:D051437 Renal Insufficiency Doxorubicin 3.8117922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1616325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.8519058328
MESH:D015427 Reperfusion Injury resveratrol 5.8517058453 16314181 17520802 15827377 16317513
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.6311700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4418990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.1018172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.0711555667
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7018045962
MESH:D012509 Sarcoma Doxorubicin 3.6315625365 18313854 16767912 15675481 17203757 17710206
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 8.9616646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 8.9616326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.3717846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.4416636934
MESH:D012640 Seizures 2,4-dinitrotoluene 5.1518551238
MESH:D012640 Seizures Ethanol 5.159754883
MESH:D012878 Skin Neoplasms Doxorubicin 8.3015692506
MESH:D012878 Skin Neoplasms resveratrol 8.3015837718 8985016
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.3016192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.1615625365 17203757 16767912
MESH:D013088 Spermatocele Tamoxifen 3.8716709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0916517039
MESH:D013119 Spinal Cord Injuries Progesterone 9.4815862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.4819457130
MESH:D013272 Stomach Diseases Dexamethasone 3.9015472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.3817007042
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.3818456281
MESH:D013274 Stomach Neoplasms Ethanol 4.3818456281
MESH:D013274 Stomach Neoplasms Methylnitrosourea 4.3816257854 15930296 18593901
MESH:D013276 Stomach Ulcer Dexamethasone 6.3315138204
MESH:D013276 Stomach Ulcer Ethanol 6.339211565 11906479 9562338 16755016 17189318 17918041
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1216321402
MESH:D019966 Substance-Related Disorders bisphenol A 3.5716684133 16045194
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.899754883
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.6412837982
MESH:D013953 Thymus Neoplasms Methylnitrosourea 4.8111418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.5519014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.557505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 14.5517909728 16010429
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 14.557505956 3078959
MESH:D013978 Tibial Fractures Estradiol 4.2619048282
MESH:D014062 Tongue Neoplasms resveratrol 3.8516227395
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5415213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.9216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 13.9211780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 13.9214692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 13.9217653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 13.9216712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 3.9010091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.7417473185
MESH:D014591 Uterine Diseases bisphenol A 4.5814652134
MESH:D014594 Uterine Neoplasms resveratrol 3.7417044934
MESH:D014605 Uveitis Cyclosporine 10.351336536
MESH:D014605 Uveitis Dexamethasone 10.351336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 8.9817334414 16364871 17678736 17638931
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.9817488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8215886252
MESH:D015430 Weight Gain Dietary Fats 3.3916723640
MESH:D014985 Xerophthalmia Cyclosporine 4.0117120751
Pathway ID Pathway Name
KEGG:04920 Adipocytokine signaling pathway
KEGG:04960 Aldosterone-regulated sodium reabsorption
KEGG:04910 Insulin signaling pathway
KEGG:04722 Neurotrophin signaling pathway
REACT:9470 Signaling by FGFR
REACT:498 Signaling by Insulin receptor
REACT:11061 Signalling by NGF
KEGG:04930 Type II diabetes mellitus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA203
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    PA444283Glioblastoma
    PA443890Diabetes Mellitus, Type 2
    Releated drug ID Related drug Name
    PA450196letrozole
    PA451365sirolimus
    PA10390sulfonamides, urea derivatives
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB08513 - [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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