AutismKB 2.0

Annotation Detail for ISG20


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ISG20 ( CD25,HEM45 )
Gene Full Name: interferon stimulated exonuclease gene 20kDa
Band: 15q26.1
Quick LinksEntrez ID:3669; OMIM: 604533; Uniprot ID:ISG20_HUMAN; ENSEMBL ID: ENSG00000172183; HGNC ID: 6130
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ISG20 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of ISG20 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of ISG20 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of ISG20 mRNAdecreases expression 17942131
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ISG20 proteinaffects expression 20106945
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ISG20 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ISG20 mRNAdecreases expression 17942131
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of ISG20 mRNAdecreases expression 17942131
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ISG20 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of ISG20 mRNAincreases expression 20106945
D016572 Cyclosporine Cyclosporine results in decreased expression of ISG20 mRNAdecreases expression 17942131
D004041 Dietary Fats Dietary Fats results in decreased expression of ISG20 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ISG20 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ISG20 mRNAincreases expression 19638242
D004958 Estradiol Estradiol affects the expression of ISG20 mRNAaffects expression 14699072
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ISG20 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of ISG20 mRNAincreases expression 20106945
19619570
15913882
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ISG20 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ISG20 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ISG20 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ISG20 mRNAincreases expression 17557909
D005047 Etoposide ISG20 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D008942 Mitoxantrone ISG20 protein affects the susceptibility to Mitoxantroneaffects response to substance 16217747
D009151 Mustard Gas Mustard Gas affects the expression of ISG20 mRNAaffects expression 15651846
C041786 palm oil palm oil results in decreased expression of ISG20 mRNAdecreases expression 18042831
D011374 Progesterone Progesterone affects the expression of ISG20 mRNAaffects expression 17251523
D011374 Progesterone Progesterone results in decreased expression of ISG20decreases expression 17510236
D020849 Raloxifene Raloxifene affects the expression of ISG20 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in increased expression of ISG20 mRNAaffects cotreatment|increases expression 19059307
C025462 sulindac sulfide sulindac sulfide results in increased expression of ISG20 mRNAincreases expression 16184548
D013629 Tamoxifen Tamoxifen affects the expression of ISG20 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in increased expression of ISG20 mRNAaffects cotreatment|increases expression 19059307
C021751 tanshinone tanshinone results in increased expression of ISG20 mRNAincreases expression 15849732
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ISG20 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ISG20 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ISG20 mRNAaffects cotreatment|increases expression 17942748
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of ISG20 mRNAincreases expression 17951470
D014303 Trinitrotoluene Trinitrotoluene affects the expression of ISG20 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3514745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9315322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 7.937525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.7120127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.7111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.7114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 15.083712494
MESH:D000236 Adenoma Benzo(a)pyrene 15.086695378
MESH:D000236 Adenoma beta-Naphthoflavone 15.0819389873
MESH:D000236 Adenoma Diethylnitrosamine 15.086695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 9.4118056438 17620307 17162532 19061943 16434500 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.4116835633
MESH:D000419 Albuminuria Raloxifene 4.4117308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 4.4615800139
MESH:D000544 Alzheimer Disease sulindac sulfide 4.4618759972
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D000799 Angioedema Acetaminophen 3.6510982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8819183758
MESH:D001161 Arteriosclerosis Dietary Fats 9.2815238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001249 Asthma Mustard Gas 2.6510378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.831440618 11289319
MESH:D001768 Blister Mustard Gas 4.9719167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.9714601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1417868700
MESH:D001930 Brain Injuries Progesterone 10.3415665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 10.3416580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.8217474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 6.8220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.8217474063
MESH:D001943 Breast Neoplasms Estradiol 6.8212948864 19861407 17289903 16675129 17261762 17018787 14630087 18497071
MESH:D001943 Breast Neoplasms Etoposide 6.8216322251
MESH:D001943 Breast Neoplasms Progesterone 6.8217614352 15562024 16175315
MESH:D001943 Breast Neoplasms Raloxifene 6.8216837676 16912660 17595753 15572757 17952589 17893378 17242785 15758505 15775269 17049068 17440819 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 6.8218855134 17893378 19189212 18815881 18629630 19221464 19142967 19115204 19189210 19244106 20135344 17049068 16202921 18821012 11161223 19059307 19084267 17261762 19011961 16873071 15668708 20544844 18351453 20859285 19155303 15565566 21152245 19289846 19066611 19288272 21138602 19487384 17242785 17440819 19410462 20390343 16818667 18425577 18997820 19103187 16273361 19200415 18984771 20065188 20005174
MESH:D001943 Breast Neoplasms tanshinone 6.8215849732 19885617
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.8220435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9715286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7817687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3219066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 13.6016705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.607296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.603084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.6021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.6010737359 18506893 19394651 19919837 16807293 17978847 11831363 18788625 20007298 18393292 18785209 19208518 20084675 16878318 18665156 20214788 19335982 17055752 3581430 16569478 19418558 19539802 19519916 16502159 18691550 16328049 18978308 17761372 19822196 18210153 21159647 20512989 18056438 3084413 16779866 10672840 20524982 19052882 20432363 16288022 20935162 20727157 16681979 19701751 18971187 19171122 17428255 20514400 19383236 17173139 20101231 16935385 16540662 17138121 16830150 18494052 19107877 16698587 17162532
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.6016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.6016924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.3812391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.597296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0020419170
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.9417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.9417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2616120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.3115775269
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Trinitrotoluene 7.1414694615 15817613
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.947505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.9412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.9417174075 2727394 21159647 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.9418566989
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.7919052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.7916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 12.5719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 12.5719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.5717681005 17110522 16919318 15861022 16105132 17333356 11677210
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0315340226 12621046 8697196 16354765 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.4315800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.7414669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 8.7415095906
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 15322242 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.6018551238
MESH:D003490 Cyanosis Trinitrotoluene 10.6018551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1719031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.0017474826
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6218759878 11906362 12868966 8970840 8156756 2524372 14531868 11298694
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.313621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.0620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0617107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.0919279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.0917451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.0919279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3017187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 14.5118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 14.511440618 16192314 18289764 9328219 18692083 6679447 6482804 11289319 18648102 8291058 7440962 9653073 9022650
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 14.5119420014 16227642 15619225 11421492 11529661 14986274 14550746 12958197 12540782 16109766 19164858 16781746 17562736 14725611 10663392 10915739 10774834 17522070 2444490 19416960 16485898 19739265 18071297 11287661 18713872 19085960 12392966 15968718 11743745 11834606 19923254 16177239 11739529 11461765 19370779 16081117 16393943 12705907 12594235 17906064 12153990
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 14.5119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 14.5120420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 14.5118551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.9119426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6211462148
MESH:D050171 Dyslipidemias Dietary Fats 3.3218367378
MESH:D004487 Edema Mustard Gas 10.5411428647 9260866 11428631 11402378
MESH:D004487 Edema Raloxifene 10.5415860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.5412711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7115322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 20.4112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 20.4117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 20.4115845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 20.4119031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.9818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.9819155303 17893378 16202921 20544844
MESH:D004715 Endometriosis Progesterone 8.3716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.3710568697 9294722
MESH:D004890 Erythema Mustard Gas 4.979357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.9216302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.193581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005234 Fatty Liver Cyclosporine 28.4719224547
MESH:D005234 Fatty Liver Dietary Fats 28.4717967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 28.4721071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 28.4715345470
MESH:D005234 Fatty Liver Raloxifene 28.4717473493
MESH:D005234 Fatty Liver Tamoxifen 28.4719224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.836705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9919069698
MESH:D005355 Fibrosis Cyclosporine 13.6212168785 12639820
MESH:D005355 Fibrosis Dietary Fats 13.6218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.6220067830
MESH:D005756 Gastritis Acetaminophen 3.4816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D005910 Glioma tanshinone 3.9516955220
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.867505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.1220471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1210048152 11294989
MESH:D006331 Heart Diseases Mitoxantrone 7.6516019553
MESH:D006331 Heart Diseases Raloxifene 7.6511110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.336705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0915340226 16120746 12621046
MESH:D006529 Hepatomegaly Trinitrotoluene 8.0915817613
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D006561 Herpes Simplex Etoposide 4.3710809021
MESH:D006689 Hodgkin Disease Etoposide 3.7116135485 18180244 16200630 17606976 15147373
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.858697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5516870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4221332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.4421332399
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.7515034207
MESH:D006973 Hypertension Cyclosporine 8.1610903974
MESH:D006973 Hypertension Raloxifene 8.1615787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1618850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 5.0719662366
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4817937319
MESH:D007248 Infertility, Male Trinitrotoluene 6.4812150543
MESH:D007249 Inflammation Dietary Fats 18.6920412841
MESH:D007249 Inflammation Diethylnitrosamine 18.6918785209
MESH:D007249 Inflammation Mustard Gas 18.699260866 9357497 8975870 11428647 17524151 11428631 11428620 16001271 11402378
MESH:D007249 Inflammation Progesterone 18.6915869954
MESH:D007249 Inflammation Tamoxifen 18.6919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 18.6912878042 12200463
MESH:D007333 Insulin Resistance Dietary Fats 6.9611836018 18457598
MESH:D007333 Insulin Resistance Estradiol 6.9616393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.839022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Acetaminophen 9.3412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.348314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.3415618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 21.6716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 21.676582329
MESH:D007680 Kidney Neoplasms Cyclosporine 21.6712371664
MESH:D007680 Kidney Neoplasms Estradiol 21.6715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 21.6718625569
MESH:D007889 Leiomyoma Raloxifene 4.3216973256
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.7118172266
MESH:D008064 Lipidoses Tamoxifen 3.0217567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 6.2918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.2920032147 19638242 18665156 18407596 18522880
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.089327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.3014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.3018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.3012878042
MESH:D008107 Liver Diseases Acetaminophen 3.7412969438 11587558 19460945 12587719 19014921 16610002 19784758 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 3.7417034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0716871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.0418177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.0420195826 21137059
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 17.0419389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.0418977376 19833225 19294768 18978307 19499222 10737359 12112319 20118626 20137499 19642983 19812893 16942905 20101389 21167192 20434301 2422723 19426721 21047994 19850985 21071580 18754104 19638242 19690152 19427195 18644402 20501860 19254457 20405173 18648771 2862719 20452335 20492335 15175105 19551842 12771043 19090486 21278145 19073162 19996281 19256749 19255062 9163691 20583210 15885732
MESH:D008113 Liver Neoplasms Tamoxifen 17.0416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.0416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.39598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.398603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 17.3918164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 17.3918282651 18544905 21159647 17854601 18308698 19009564 3124819 18775883 16842330 19539802 17942915 16267830 9362446 18079962 18164116 18093689 19126423 18253720 19519916 19004024 2563599 17174075
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.3912151625
MESH:D008171 Lung Diseases Mustard Gas 3.3218702808 18161513
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.2414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2420464547 18520028 18816296 20135361 18569708 20064080 6695378 20869020 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 8.2420970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Mustard Gas 8.248781369 3148597
MESH:D008175 Lung Neoplasms Tamoxifen 8.2418625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2419555203 11884234
MESH:D008223 Lymphoma Etoposide 3.7912854902 12556972
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5719428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.2711408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.2717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.2716827153 14580682 19196723 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 12.0019453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.0019453300
MESH:D008545 Melanoma Tamoxifen 1.8619393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3819513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.3615863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0416381670
MESH:D009101 Multiple Myeloma Raloxifene 3.3016497877
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1316810080
MESH:D009232 Myxoma Raloxifene 5.3616343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.0418551238
MESH:D009336 Necrosis Trinitrotoluene 10.0418551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.023581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.023581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.0219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0511141357
MESH:D009369 Neoplasms Mitoxantrone 5.0516640825
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8119196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1219348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 8.8511399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.8514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.796679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.6618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.6620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.9220387270
MESH:D009503 Neutropenia Mustard Gas 3.7916761898 7688884
MESH:D009765 Obesity Dietary Fats 2.2416723640 11836018 18457598 17217161 20518802 21332399 19632207 20132043 18674790
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.2212819281 16049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 14.224026338 6482804
MESH:D009784 Occupational Diseases Trinitrotoluene 14.2212819281 17852074 14694615
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.833988306
MESH:D010024 Osteoporosis Raloxifene 3.2817882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.0517893378 17823083 15579764 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 4.6719401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.6717393432 16525653
MESH:D010146 Pain Acetaminophen 2.2416870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.3216540662
MESH:D010190 Pancreatic Neoplasms Etoposide 5.3219003803
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.307296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.286228378
MESH:D011041 Poisoning Mustard Gas 3.6215727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.4112371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.412563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0011399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Etoposide 1.8817172428
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8816220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8815067354
MESH:D011537 Pruritus Ethinyl Estradiol 8.8815861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.8818058305
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8617894541 17720292 17266442 17620002 10334151
MESH:D011693 Purpura Raloxifene 5.3615770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.233692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7918045962
MESH:D012512 Sarcoma, Ewing's Etoposide 4.5214601052
MESH:D012640 Seizures 2,4-dinitrotoluene 5.7718551238
MESH:D012640 Seizures Trinitrotoluene 5.7718551238
MESH:D012871 Skin Diseases Mustard Gas 2.6715451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.8810029692 19755658
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.888532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.9216709447
MESH:D013088 Spermatocele Tamoxifen 10.9216709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.2315862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.2319457130
MESH:D013163 Splenomegaly Trinitrotoluene 5.0115817613
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.282093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.2818456281
MESH:D020521 Stroke Raloxifene 3.6716837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7112697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 6.646587162 6582329 3712494 7505956 1399818
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 6.647505956
MESH:D013978 Tibial Fractures Estradiol 13.0719048282
MESH:D013978 Tibial Fractures Raloxifene 13.0719048282
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.0016049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 15.008074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.0017053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.0017572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.0016712894 8653321 17572228
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1210091137
MESH:D014581 Urticaria Acetaminophen 2.8010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.0814692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 9.0818645019
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.0216837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.3616343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D015430 Weight Gain Dietary Fats 3.5816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
Pathway ID Pathway Name
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29930
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA451096prednisolone
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03685 - Uridine-5'-Monophosphate
    DB04184 - Acetate Ion Indicators and Reagents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved