AutismKB 2.0

Annotation Detail for ITGA2


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Basic Information Top
Gene Symbol:ITGA2 ( BR,CD49B,GPIa,VLA-2,VLAA2 )
Gene Full Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Band: 5q11.2
Quick LinksEntrez ID:3673; OMIM: 192974; Uniprot ID:ITA2_HUMAN; ENSEMBL ID: ENSG00000164171; HGNC ID: 6137
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04145Phagosome
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05222Small cell lung cancer
hsa04810Regulation of actin cytoskeleton
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Axon guidance
Hemostasis
Integrin cell surface interactions
Pathway IDPathway Name
200188VEGFR3 signaling in lymphatic endothelium
200164Syndecan-2-mediated signaling events
Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1739Oral cancer
1770Melanoma
1794Thromboangiitis obliterans
1831Prostate cancer
1869Behcet syndrome
1870Drug abuse
1884Mesothelioma
1904Diabetes mellitus
1907Depression
1918Atherosclerosis
1944Breast cancer
1954Stroke
1841Stomach cancer
2053Colon cancer
2066Lung cancer
2106Pancreas cancer
Desease Name
HEMATOLOGICAL
oral cancer
hematology indices
atherosclerosis, coronary
variation in platelet integrin alpha 2 beta 1 density
CARDIOVASCULAR
myocardial infarct
premature myocardial infarction in men.
thrombocytopenic purpura, iimmune
double homozygosity for receptor polymorphisms of platelet GPIa and GPIIIa
CANCER
stroke, ischemic
carotid plaque
angina
RENAL
vascular disease
hypertension
cardiovascular mortality
bleeding complications
IMMUNE
Behcet's Disease
METABOLIC
Myocardial Infarction
Glomerulonephritis, IGA
DEVELOPMENTAL
platelet alpha2 beta1 density
thrombosis, deep vein
diabetes, type 2
limb deficiency anomalies
Diabetic Retinopathy
intima-media thickness
No data
Desease Name
Neonatal alloimmune thrombocytopenia
Glycoprotein Ia deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000244 Adenosine Diphosphate ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]affects cotreatment|affects response to substance 16214444
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ITGA2 proteinaffects expression 20106945
D020875 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of ITGA2 mRNA]decreases reaction|increases expression 17299060
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ITGA2 mRNAaffects expression 16483693
D001241 Aspirin ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel]affects cotreatment|affects response to substance 16214444
15205592
D001241 Aspirin ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]affects cotreatment|affects response to substance 16214444
D001241 Aspirin ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]affects cotreatment|affects response to substance 16214444
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ITGA2 mRNAincreases expression 12766906
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ITGA2 mRNAincreases expression 17299060
D002251 Carbon Tetrachloride Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Carbon Tetrachloride results in increased expression of ITGA2 mRNA]decreases reaction|increases expression 17299060
C055162 clopidogrel ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel]affects cotreatment|affects response to substance 16214444
15205592
C055162 clopidogrel ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]affects cotreatment|affects response to substance 16214444
C055162 clopidogrel ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]affects cotreatment|affects response to substance 16214444
C018021 cobaltous chloride cobaltous chloride results in increased expression of ITGA2 proteinincreases expression 16798617
D016572 Cyclosporine Cyclosporine results in increased expression of ITGA2 mRNAincreases expression 20106945
D004837 Epinephrine ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]affects cotreatment|affects response to substance 16214444
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ITGA2 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of ITGA2 mRNAincreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of ITGA2 proteinincreases expression 16912569
D019833 Genistein Genistein results in decreased expression of ITGA2 mRNAdecreases expression 16169203
D006812 Humic Substances Humic Substances results in increased expression of ITGA2 proteinincreases expression 19686714
C051890 irinotecan irinotecan analog results in increased expression of ITGA2 mRNAincreases expression 18927307
D015741 Metribolone Metribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein]affects binding|decreases expression 17541959
D009151 Mustard Gas Mustard Gas results in increased expression of ITGA2 mRNAincreases expression 15674843
D010672 Phenytoin Phenytoin results in decreased expression of ITGA2 proteindecreases expression 15948689
D013467 Sulindac Sulindac results in increased expression of ITGA2 mRNAincreases expression 11906190
C436947 T 113242 T 113242 results in increased expression of ITGA2 mRNAincreases expression 11545736
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of ITGA2 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ITGA2 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITGA2 mRNAincreases expression 16704738
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of ITGA2 mRNAincreases expression 17669516
D014635 Valproic Acid Valproic Acid results in increased expression of ITGA2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 5.3514745880
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 13.466195326 3425630 9118846 9677735 8986270 10563481
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 13.4615322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 13.468875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7919490988
MESH:D000138 Acidosis Ammonium Chloride 3.4118287403
MESH:D054058 Acute Coronary Syndrome clopidogrel 5.8519106084
MESH:D058186 Acute Kidney Injury Sulindac 4.187897758
MESH:D000230 Adenocarcinoma Estradiol 7.0211473722
MESH:D000230 Adenocarcinoma Genistein 7.0211473722
MESH:D000230 Adenocarcinoma Sulindac 7.0211910360
MESH:D000236 Adenoma Sulindac 3.6910223192
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2316835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.4612394442 11874996 16460482 11535846 19003578 15623613 17611924
MESH:D000550 Amblyopia Valproic Acid 5.0817688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8111748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.4517497229
MESH:D001249 Asthma Mustard Gas 2.6710378619
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.5712372130 20485159
MESH:D050197 Atherosclerosis Phenytoin 3.8415136057
MESH:D001321 Autistic Disorder Valproic Acid 2.0218775368 18316065 18396377 17507914 16609825 20603192 17157402 18985861 19460635 15238991 18177632 18558336 17688650 19232924 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.0020046352 17594078
MESH:D001768 Blister Mustard Gas 5.0119167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.9112125929
MESH:D001791 Blood Platelet Disorders marker/mechanism
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.7015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.708888407
MESH:D001913 Bowen's Disease Sulindac 5.2011207687
MESH:D001932 Brain Neoplasms Aspirin 4.2815481559
MESH:D001943 Breast Neoplasms Aspirin 2.3115161893
MESH:D001943 Breast Neoplasms Estradiol 2.3116675129 12948864 17261762 17289903 14630087 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Genistein 2.3117200150 16541309 16873071
MESH:D001943 Breast Neoplasms Sulindac 2.3116642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3120435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8317687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.633786805 15673190 16050911 16227642 18705752 15721981 16192424 15700767 16097048 16124888 16011737 10355542
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6816835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.3912619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.3918788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.3916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.3916924424
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 2.9218922899
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2818850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases clopidogrel 7.5820180610
MESH:D002318 Cardiovascular Diseases Genistein 7.5816332659
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.2312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.2318566989
MESH:D002493 Central Nervous System Diseases Phenytoin 5.154080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6520734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0316835633
MESH:D002779 Cholestasis Cyclosporine 2.8019486331
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.7211748493
MESH:D002971 Cleft Lip Phenytoin 4.082227380
MESH:D002972 Cleft Palate Phenytoin 5.952227380 6862529 10789828 3877104 6856622 1687470
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.9515340226 12621046 8697196 16354765 15668235
MESH:D003103 Coloboma Phenytoin 5.019212184
MESH:D003110 Colonic Neoplasms Aspirin 8.1812411196
MESH:D003110 Colonic Neoplasms Genistein 8.1817182828
MESH:D003110 Colonic Neoplasms irinotecan 8.1817287894 17725105
MESH:D003110 Colonic Neoplasms Sulindac 8.1812458338 12902858
MESH:D015179 Colorectal Neoplasms Aspirin 3.6417047198
MESH:D015179 Colorectal Neoplasms irinotecan 3.6417159606 18509181 18259882 15273666 16391804 17454858 16303861
MESH:D015179 Colorectal Neoplasms Sulindac 3.6418059344 11076880 11197048 10666051
MESH:D000013 Congenital Abnormalities Phenytoin 8.9510627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.9514669216 17141729
MESH:D019465 Craniofacial Abnormalities Phenytoin 3.818986270 19952982 9212184
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.818888407 17688650 16575769
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 3.8915059100 11298694 16823706
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.2016647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D003930 Diabetic Retinopathy Sulindac 5.0317621415 12861449
OMIM:607208 DRAVET SYNDROME Phenytoin 5.2411748493
MESH:D003875 Drug Eruptions Phenytoin 5.3515024534
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.943732212 7440962 6884620 10915739 15998439 2869522 7120509 21278145 7179309 19085960 3786805 16177239 6623471 16227642 15027814 17522070 11566570 4309450 10092053 15968718 19336974 9327722
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9420420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.941733752 19641884
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6511462148
MESH:D004421 Dystonia Valproic Acid 3.911851702
MESH:D004487 Edema Aspirin 15.3917259670
MESH:D004487 Edema Mustard Gas 15.3911402378 9260866 11428647 11428631
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.3912711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 15.3911698051 8273558 16716910 8113982 15177302 7812673 9599246
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7518230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 4.5317654737
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.1811473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.1811473722
MESH:D004715 Endometriosis Sulindac 8.7415652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.749294722 10568697
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 5.0520235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 6.081399206 6251365
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.0017275665 3659116
MESH:D004828 Epilepsies, Partial Phenytoin 9.8517116037 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 9.853922381 16628512
MESH:D004827 Epilepsy Epinephrine 10.94821787
MESH:D004827 Epilepsy Phenytoin 10.9420417680 11434505 821787
MESH:D004827 Epilepsy Valproic Acid 10.9420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.466254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Phenytoin 11.187750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.187750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 10.363659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.363659116
MESH:D004890 Erythema Mustard Gas 5.019357497
MESH:D004938 Esophageal Neoplasms Sulindac 3.1012235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.3212795759 16045604 12631006 61145 15959796 17595544 16239168 19224547
MESH:D005234 Fatty Liver Cyclosporine 12.3219224547
MESH:D005234 Fatty Liver Valproic Acid 12.3219224547 14986274
MESH:D005313 Fetal Death Phenytoin 10.2410627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 10.2411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.7416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.9818558336 8888407
MESH:D018221 Fibromatosis, Abdominal Sulindac 5.3214745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 4.9819069698
MESH:D005355 Fibrosis Carbon Tetrachloride 13.8418705752
MESH:D005355 Fibrosis Cyclosporine 13.8412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.8420067830
MESH:D005764 Gastroesophageal Reflux Sulindac 4.8611910360
MESH:D005885 Gingival Hyperplasia Cyclosporine 12.408708960
MESH:D005885 Gingival Hyperplasia Phenytoin 12.409029455
MESH:D019214 Gingival Overgrowth Phenytoin 6.0816390469 14659971
MESH:D005909 Glioblastoma Aspirin 7.2312870263
MESH:D005909 Glioblastoma Genistein 7.2316598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4410696789
MESH:D006261 Headache Aspirin 4.8115240983
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2511294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2011000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519900420 19110552
MESH:D006526 Hepatitis C Enkephalin, Ala(2)-MePhe(4)-Gly(5)- 5.9917299060
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7415340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D019584 Hot Flashes Estradiol 3.6017088409
MESH:D006849 Hydrocephalus Valproic Acid 4.7117688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.898697196 16959395 15340226 18606429 16354765
MESH:D012001 Hyperacusis Aspirin 5.6115240983
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D020138 Hyperhomocysteinemia Phenytoin 4.5410459572
MESH:D006973 Hypertension Cyclosporine 4.7510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7518670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D007022 Hypotension Epinephrine 5.186740701
MESH:D007249 Inflammation Mustard Gas 11.408975870 11402378 11428620 11428647 9260866 16001271 17524151 11428631 9357497
MESH:D007249 Inflammation Sulindac 11.403291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.4012200463 12878042
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 11.407562506 8273558 15177302 7812673 11698051
MESH:D007333 Insulin Resistance Estradiol 2.8716393666 16627594
MESH:D007414 Intestinal Neoplasms Sulindac 4.5012663524 12584176 12628509 10223192 12351151 10213222
MESH:D007417 Intestinal Polyps Sulindac 4.8412394442 11245490
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2016580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Cyclosporine 5.658314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.6515618244
MESH:D007680 Kidney Neoplasms Cyclosporine 6.8612371664
MESH:D007680 Kidney Neoplasms Estradiol 6.8615610895
MESH:D007938 Leukemia Genistein 2.9518980019 17468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1316294345 17596541
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7317334410 11408273 16239168 16943688 17174718 17157831 16221502 11903743 21278145
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 4.1312468960
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8017481882 18705752 17869086 17900296 15730626 12667390 16136751 18420326 15818738 12741479 15931870 10355542 15338365 12586293 17922224 18395095 15925388 12609069 18277467 17525996 12898905 17976157 12632514 18418968 14512876 18481824 17708605 16011737 18054572 14716833 17766677 18263696 12649538 17565644 12445418 15959796 16015684 14724832 18210741 18156304 12546737 18279442 17761835 18339082 17714472 17721639 14748882 18166357 16248980 18429990 18472094 15057751 17557913 16027843 15673190 15362042 18395914 11481614 18472332 16116963 18187930 15052691 18376398 15996030 17805973 17944888 18412020 15893842 12389079 20821823 18006644 18205269 18251166 15123356 17698563 15650968 14620537 16033810 14716496 15876570 15370692 18317297 17823541 16097048 16638106 12445421 12666154 17640975 12958196 16192424 17631135 12632512 13678700
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 4.8017823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8012878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.5815720792 15830285 16964402 17285989 16246199
MESH:D008107 Liver Diseases Phenytoin 6.5814986274
MESH:D008107 Liver Diseases Sulindac 6.5814986274 16867024
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5614706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.079163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.0719294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.0716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 9.268603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.2615583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.2612151625
MESH:D008171 Lung Diseases Mustard Gas 3.3518161513 18702808
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.1117228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.3414755239
MESH:D008175 Lung Neoplasms Humic Substances 8.3419686714
MESH:D008175 Lung Neoplasms Mustard Gas 8.343148597 8781369
MESH:D008175 Lung Neoplasms Sulindac 8.3419359593 15713900
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3419555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 8.3411807781
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.5217203775 16891317 11807958 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.5212929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 9.528985016
MESH:D020149 Manganese Poisoning Estradiol 4.3319453300
MESH:D008545 Melanoma Sulindac 2.8116642371
MESH:D008607 Mental Retardation Phenytoin 3.629212184
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D008881 Migraine Disorders Aspirin 7.5115240983
MESH:D008881 Migraine Disorders Valproic Acid 7.5118765137 18803445
MESH:D052016 Mucositis irinotecan 4.8617159606
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.898888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0717596541
MESH:D009203 Myocardial Infarction Aspirin 5.9912692751
MESH:D009203 Myocardial Infarction Genistein 5.9917141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9012213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.1316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 8.1317141266
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 5.3717484760
MESH:D009224 Myotonia Congenita Phenytoin 5.261896199
MESH:D009325 Nausea Aspirin 5.0615240983
MESH:D009362 Neoplasm Metastasis clopidogrel 6.3511875746
MESH:D009362 Neoplasm Metastasis irinotecan 6.3518259882
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1519348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 15.5116427766 11399458
MESH:D009421 Nervous System Malformations Genistein 15.5116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5114600291
MESH:D009436 Neural Tube Defects Phenytoin 7.379118846
MESH:D009436 Neural Tube Defects Valproic Acid 7.3716359493 8888407
MESH:D009447 Neuroblastoma irinotecan 3.408761367
MESH:D019636 Neurodegenerative Diseases Sulindac 4.1516850258 17266991
MESH:D017599 Neuroectodermal Tumors irinotecan 4.588761367
MESH:D009503 Neutropenia Mustard Gas 3.8316761898 7688884
MESH:D010003 Osteoarthritis Aspirin 3.977009135
MESH:D010018 Osteomalacia Phenytoin 5.2617016548
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9416169203
MESH:D010051 Ovarian Neoplasms Estradiol 4.7419401270
MESH:D010051 Ovarian Neoplasms Genistein 4.7419005980
MESH:D010146 Pain Aspirin 10.946363464 6995502
MESH:D010146 Pain Phenytoin 10.9415215642
MESH:D010146 Pain Sulindac 10.943291741
MESH:D010190 Pancreatic Neoplasms Sulindac 5.6611504793 16820089
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.6615976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.1412065085 18922899 8330346 18404319
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1012520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.3911156591
MESH:D020795 Photophobia Aspirin 5.6115240983
MESH:D011041 Poisoning Mustard Gas 3.6615727166
MESH:D017689 Polydactyly Phenytoin 4.919212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4118163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0912371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9611896295 11118676 11222880 11399792
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 8.9620603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.3416740699
MESH:D011471 Prostatic Neoplasms Genistein 3.3416925846 15256057 15378649
MESH:D011537 Pruritus Mustard Gas 3.9418058305
MESH:D019310 Pseudolymphoma Phenytoin 12.0712752131 1419762 8603615
MESH:D019310 Pseudolymphoma Valproic Acid 12.0711422049 12752131
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8717894541 10334151 17266442 17720292 17620002
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6918990726
MESH:D012170 Retinal Vein Occlusion marker/mechanism 12928694
MESH:D012170 Retinal Vein Occlusion clopidogrel 5.9719371211
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.0319155313
MESH:D012220 Rhinitis Aspirin 4.2412372130
MESH:D012559 Schizophrenia Valproic Acid 2.0519110320 15737665
MESH:D012640 Seizures Phenytoin 6.0519919933 15946322 3691417 3137016 16876388 11044598 9844417 10029267
MESH:D012640 Seizures Valproic Acid 6.0514763951 17978042 1511512 11738929 3137016 15475178 11044598 16876388
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.1112269725
MESH:D012871 Skin Diseases Mustard Gas 2.6812880345 15451306 16961503
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.118532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.1116192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 9.1118404319 11807781 8330346 8985016 12065085
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.3912833885
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 5.0020235791
MESH:D013274 Stomach Neoplasms irinotecan 2.3615723263
MESH:D020521 Stroke Aspirin 4.2616403987
MESH:D013927 Thrombosis Aspirin 4.3917672075
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7512697716
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.0817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.373119515
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.498888407
MESH:D014581 Urticaria Aspirin 4.3020485159 10982225
MESH:D014594 Uterine Neoplasms Sulindac 4.4518645019
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4412125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1015886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REACT:18266 Axon guidance
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04640 Hematopoietic cell lineage
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:05200 Pathways in cancer
KEGG:04145 Phagosome
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05222 Small cell lung cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA204
    • Releated gene ID Related gene Name
    PA204ITGA2
    Releated disease ID Related disease Name
    PA445019Myocardial Infarction
    Releated drug ID Related drug Name
    PA448497aspirin
    PA449053clopidogrel
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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