Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
---|
D000082 |
Acetaminophen |
Acetaminophen affects the expression of ITGA2B mRNA | affects expression | 17562736
|
D000244 |
Adenosine Diphosphate |
cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]] | affects binding|decreases reaction|increases expression | 18404433
|
D000244 |
Adenosine Diphosphate |
N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]] | affects binding|decreases reaction|increases expression | 18404433
|
D000244 |
Adenosine Diphosphate |
N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] | affects binding|decreases reaction|increases expression|increases reaction | 18404433
|
C006632 |
arsenic trioxide |
arsenic trioxide results in increased expression of ITGA2B mRNA | increases expression | 15761015
|
C117446 |
cangrelor |
cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]] | affects binding|decreases reaction|increases expression | 18404433
|
C117446 |
cangrelor |
N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] | affects binding|decreases reaction|increases expression|increases reaction | 18404433
|
D003474 |
Curcumin |
Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein] | decreases reaction|increases expression | 18565277
|
D004391 |
Dust |
Dust results in decreased expression of ITGA2B mRNA | decreases expression | 17805423
|
D005419 |
Flavonoids |
Flavonoids results in increased expression of ITGA2B mRNA | increases expression | 15465739
|
D009240 |
N-Formylmethionine Leucyl-Phenylalanine |
ITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] | increases expression|increases reaction | 11116075
|
C013038 |
hydroxyhydroquinone |
hydroxyhydroquinone results in increased expression of ITGA2B mRNA | increases expression | 17572062
|
C111914 |
N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate |
N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]] | affects binding|decreases reaction|increases expression | 18404433
|
C111914 |
N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate |
N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] | affects binding|decreases reaction|increases expression|increases reaction | 18404433
|
D010936 |
Plant Extracts |
Plant Extracts results in increased expression of ITGA2B mRNA | increases expression | 15465739
|
C025299 |
polyphenols |
polyphenols results in increased expression of ITGA2B mRNA | increases expression | 15465739
|
C106774 |
SR 121566 |
SR 121566 binds to and results in decreased activity of ITGA2B protein | affects binding|decreases activity | 11116075
|
D013755 |
Tetradecanoylphorbol Acetate |
Tetradecanoylphorbol Acetate results in increased expression of ITGA2B protein | increases expression | 10428506
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
---|
MESH:D000230 |
Adenocarcinoma |
|
arsenic trioxide |
2.30 | 19825857 11798837 |
MESH:D019973 |
Alcohol-Related Disorders |
|
Curcumin |
5.18 | 17887948 |
MESH:D000544 |
Alzheimer Disease |
|
Curcumin |
4.65 | 15590663 |
MESH:D000544 |
Alzheimer Disease |
|
Plant Extracts |
4.65 | 16962711 |
MESH:D000799 |
Angioedema |
|
Acetaminophen |
3.94 | 10982225 |
MESH:D001169 |
Arthritis, Experimental |
|
Plant Extracts |
3.98 | 14686799 |
MESH:D001172 |
Arthritis, Rheumatoid |
|
Curcumin |
2.75 | 16807698 |
MESH:D050197 |
Atherosclerosis |
|
Curcumin |
3.35 | 18704882 |
MESH:D001321 |
Autistic Disorder |
|
Acetaminophen |
1.41 | 18445737 |
MESH:D001327 |
Autoimmune Diseases |
|
Curcumin |
4.56 | 19761891 |
MESH:D001778 |
Blood Coagulation Disorders |
|
arsenic trioxide |
3.72 | 16206674 |
MESH:D002545 |
Brain Ischemia |
|
Curcumin |
10.77 | 16770732 |
MESH:D002545 |
Brain Ischemia |
|
Plant Extracts |
10.77 | 16041641 |
MESH:D001932 |
Brain Neoplasms |
|
Curcumin |
3.99 | 17596214 |
MESH:D001943 |
Breast Neoplasms |
|
Curcumin |
2.74 | 16243823 19250217 18462866 18593918 |
MESH:D002051 |
Burkitt Lymphoma |
|
arsenic trioxide |
4.39 | 11589617 |
MESH:D002057 |
Burns, Chemical |
|
Plant Extracts |
5.43 | 9625245 |
MESH:D002277 |
Carcinoma |
|
Curcumin |
3.88 | 18593918 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Acetaminophen |
4.71 | 3084413 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
arsenic trioxide |
4.71 | 11135700 16217749 15553829 14691202 15073043 |
MESH:D006528 |
Carcinoma, Hepatocellular |
|
Plant Extracts |
4.71 | 18834353 |
MESH:D002289 |
Carcinoma, Non-Small-Cell Lung |
|
Curcumin |
2.99 | 18414057 |
MESH:D002291 |
Carcinoma, Papillary |
|
arsenic trioxide |
4.97 | 19014326 |
MESH:D018288 |
Carcinoma, Small Cell |
|
arsenic trioxide |
4.17 | 12490120 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Curcumin |
5.12 | 18462866 |
MESH:D002294 |
Carcinoma, Squamous Cell |
|
Tetradecanoylphorbol Acetate |
5.12 | 18922899 |
MESH:D006332 |
Cardiomegaly |
|
Plant Extracts |
3.83 | 17645561 |
MESH:D002386 |
Cataract |
|
Acetaminophen |
2.61 | 10977129 |
MESH:D003092 |
Colitis |
|
Curcumin |
4.25 | 18200517 16782535 16804969 |
MESH:D003103 |
Coloboma |
|
Curcumin |
4.60 | 18809619 |
MESH:D003110 |
Colonic Neoplasms |
|
Curcumin |
4.12 | 16340194 19359593 |
MESH:D003110 |
Colonic Neoplasms |
|
polyphenols |
4.12 | 16293270 |
MESH:D015179 |
Colorectal Neoplasms |
|
arsenic trioxide |
1.86 | 20501625 |
MESH:D016510 |
Corneal Neovascularization |
|
Curcumin |
4.97 | 18497527 |
MESH:D023903 |
Coronary Restenosis |
|
arsenic trioxide |
4.25 | 12609071 |
MESH:D019465 |
Craniofacial Abnormalities |
|
arsenic trioxide |
1.88 | 10525206 |
MESH:D016757 |
Death, Sudden, Cardiac |
|
arsenic trioxide |
4.15 | 15213294 |
MESH:D003924 |
Diabetes Mellitus, Type 2 |
|
Curcumin |
2.71 | 18403477 |
MESH:D003928 |
Diabetic Nephropathies |
|
Curcumin |
9.56 | 18204486 |
MESH:D003928 |
Diabetic Nephropathies |
|
Plant Extracts |
9.56 | 19706694 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Acetaminophen |
4.05 | 16177239 19164858 19416960 14550746 12705907 10774834 16781746 12594235 11421492 19923254 15968718 12153990 19739265 18713872 11287661 12540782 11461765 16393943 15619225 11529661 16109766 17562736 11834606 19370779 16081117 11743745 14986274 16485898 17522070 2444490 17906064 10663392 10915739 11739529 14725611 12392966 12958197 19420014 16227642 18071297 19085960 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
polyphenols |
4.05 | 19370779 |
MESH:D056487 |
Drug-Induced Liver Injury, Chronic |
|
Acetaminophen |
4.19 | 19426721 |
MESH:D004381 |
Duodenal Ulcer |
|
Curcumin |
4.11 | 17351913 |
MESH:D004487 |
Edema |
|
Plant Extracts |
7.66 | 12787963 |
MESH:D004487 |
Edema |
|
Tetradecanoylphorbol Acetate |
7.66 | 8113982 16716910 7812673 15177302 8273558 11698051 9599246 |
MESH:D004719 |
Endomyocardial Fibrosis |
|
Plant Extracts |
5.78 | 15268973 |
MESH:D004827 |
Epilepsy |
|
Plant Extracts |
3.75 | 19439326 19700373 |
MESH:D004938 |
Esophageal Neoplasms |
|
arsenic trioxide |
2.32 | 12903497 |
MESH:D005234 |
Fatty Liver |
|
arsenic trioxide |
13.68 | 15073043 |
MESH:D005234 |
Fatty Liver |
|
Curcumin |
13.68 | 19297423 |
MESH:D005234 |
Fatty Liver |
|
Plant Extracts |
13.68 | 15975614 |
MESH:D005355 |
Fibrosis |
|
Curcumin |
4.06 | 18705752 |
MESH:D005706 |
Gallbladder Neoplasms |
|
arsenic trioxide |
4.33 | 16904648 |
MESH:D005756 |
Gastritis |
|
Acetaminophen |
3.77 | 16983495 |
MESH:D005770 |
Gastrointestinal Neoplasms |
|
Curcumin |
4.77 | 18462866 |
MESH:D005909 |
Glioblastoma |
|
Curcumin |
3.51 | 17596214 |
MESH:D006258 |
Head and Neck Neoplasms |
|
Curcumin |
3.69 | 18829502 18462866 |
MESH:D006333 |
Heart Failure |
|
Plant Extracts |
3.90 | 18097624 |
MESH:D015417 |
Hereditary Sensory and Motor Neuropathy |
|
Curcumin |
5.11 | 17701891 |
MESH:D006561 |
Herpes Simplex |
|
Plant Extracts |
4.71 | 10715843 |
MESH:D015658 |
HIV Infections |
|
Plant Extracts |
3.71 | 12878215 |
MESH:D019584 |
Hot Flashes |
|
Plant Extracts |
4.84 | 17454163 16566672 14716179 |
MESH:D006930 |
Hyperalgesia |
|
Acetaminophen |
2.74 | 16870215 |
MESH:D006937 |
Hypercholesterolemia |
|
Curcumin |
4.11 | 18704882 |
MESH:D020138 |
Hyperhomocysteinemia |
|
Plant Extracts |
4.51 | 16484555 |
MESH:D006949 |
Hyperlipidemias |
|
Plant Extracts |
4.53 | 15975614 15268973 |
MESH:D007249 |
Inflammation |
|
Curcumin |
16.23 | 17151092 18403477 16956363 |
MESH:D007249 |
Inflammation |
|
Flavonoids |
16.23 | 17296493 |
MESH:D007249 |
Inflammation |
|
Plant Extracts |
16.23 | 15997105 12787963 19332304 16366677 |
MESH:D007249 |
Inflammation |
|
polyphenols |
16.23 | 16366677 |
MESH:D007249 |
Inflammation |
|
Tetradecanoylphorbol Acetate |
16.23 | 15177302 8273558 7562506 7812673 11698051 |
MESH:D015212 |
Inflammatory Bowel Diseases |
|
Curcumin |
3.23 | 18596194 18200517 |
MESH:D007414 |
Intestinal Neoplasms |
|
Curcumin |
10.28 | 10783313 |
MESH:D007414 |
Intestinal Neoplasms |
|
Plant Extracts |
10.28 | 12628509 12584176 12351151 |
MESH:D007674 |
Kidney Diseases |
|
Acetaminophen |
2.23 | 15629191 12587719 |
MESH:D007889 |
Leiomyoma |
|
Curcumin |
4.63 | 18555241 |
MESH:D007938 |
Leukemia |
|
arsenic trioxide |
6.60 | 15070760 |
MESH:D007938 |
Leukemia |
|
Curcumin |
6.60 | 18462866 |
MESH:D015459 |
Leukemia-Lymphoma, Adult T-Cell |
|
arsenic trioxide |
9.95 | 17077332 12560223 |
MESH:D015459 |
Leukemia-Lymphoma, Adult T-Cell |
|
Curcumin |
9.95 | 16106398 |
MESH:D007948 |
Leukemia, Monocytic, Acute |
|
arsenic trioxide |
4.39 | 16972261 |
MESH:D015464 |
Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
|
arsenic trioxide |
3.47 | 14633726 |
MESH:D007951 |
Leukemia, Myeloid |
|
arsenic trioxide |
3.81 | 19077051 |
MESH:D015470 |
Leukemia, Myeloid, Acute |
|
arsenic trioxide |
2.15 | 16467208 16968895 17050201 19850784 20471514 |
MESH:D015473 |
Leukemia, Promyelocytic, Acute |
|
arsenic trioxide |
3.25 | 16330433 15748426 17649720 12679006 17107899 12018890 16823087 19225113 16112521 15622746 9834237 16966277 17712046 17869043 12712474 15336539 11468182 17217047 15213294 11161223 16891316 16331271 19035177 19642359 19075265 |
MESH:D015458 |
Leukemia, T-Cell |
|
arsenic trioxide |
11.93 | 16882451 |
MESH:D015458 |
Leukemia, T-Cell |
|
Curcumin |
11.93 | 16106398 |
MESH:D008103 |
Liver Cirrhosis |
|
Plant Extracts |
3.76 | 17157831 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Curcumin |
3.02 | 18006644 18705752 17355460 |
MESH:D008106 |
Liver Cirrhosis, Experimental |
|
Plant Extracts |
3.02 | 15479170 |
MESH:D008107 |
Liver Diseases |
|
Acetaminophen |
9.59 | 12587719 19784758 16610002 12969438 19014921 19460945 11587558 16611625 |
MESH:D008107 |
Liver Diseases |
|
Curcumin |
9.59 | 16956363 |
MESH:D008107 |
Liver Diseases |
|
Plant Extracts |
9.59 | 17034775 |
MESH:D008107 |
Liver Diseases |
|
polyphenols |
9.59 | 16698588 |
MESH:D017114 |
Liver Failure, Acute |
|
Acetaminophen |
3.29 | 17185352 16871587 |
MESH:D008113 |
Liver Neoplasms |
|
arsenic trioxide |
5.03 | 14682389 |
MESH:D008113 |
Liver Neoplasms |
|
Plant Extracts |
5.03 | 19168119 |
MESH:D008114 |
Liver Neoplasms, Experimental |
|
arsenic trioxide |
2.76 | 20377131 |
MESH:D008133 |
Long QT Syndrome |
|
arsenic trioxide |
3.39 | 15213294 |
MESH:D008175 |
Lung Neoplasms |
|
arsenic trioxide |
5.01 | 11798837 19825857 |
MESH:D008175 |
Lung Neoplasms |
|
Curcumin |
5.01 | 19359593 16243823 18462866 |
MESH:D008175 |
Lung Neoplasms |
|
Plant Extracts |
5.01 | 20869020 |
MESH:D008175 |
Lung Neoplasms |
|
Tetradecanoylphorbol Acetate |
5.01 | 11807781 |
MESH:D008223 |
Lymphoma |
|
Curcumin |
3.62 | 18462866 |
MESH:D016399 |
Lymphoma, T-Cell |
|
Curcumin |
4.77 | 16173963 |
MESH:D008325 |
Mammary Neoplasms, Experimental |
|
Tetradecanoylphorbol Acetate |
3.39 | 8985016 |
MESH:D008545 |
Melanoma |
|
Curcumin |
2.42 | 17885582 18462866 |
MESH:D008546 |
Melanoma, Experimental |
|
Acetaminophen |
3.64 | 19513568 |
MESH:D008569 |
Memory Disorders |
|
Curcumin |
4.22 | 17263510 |
MESH:D009101 |
Multiple Myeloma |
|
arsenic trioxide |
7.57 | 11468182 15949261 19549372 14977855 19417148 |
MESH:D009101 |
Multiple Myeloma |
|
Curcumin |
7.57 | 19372569 |
MESH:D009134 |
Muscular Atrophy, Spinal |
|
Curcumin |
5.00 | 17962980 |
MESH:D009182 |
Mycosis Fungoides |
|
arsenic trioxide |
4.77 | 18349030 |
MESH:D009190 |
Myelodysplastic Syndromes |
|
arsenic trioxide |
3.17 | 16882451 16105982 |
MESH:D009361 |
Neoplasm Invasiveness |
|
arsenic trioxide |
10.54 | 16624393 |
MESH:D009361 |
Neoplasm Invasiveness |
|
Curcumin |
10.54 | 18495463 |
MESH:D009376 |
Neoplasms, Hormone-Dependent |
|
Curcumin |
4.63 | 12497104 |
MESH:D009423 |
Nervous System Neoplasms |
|
Curcumin |
5.73 | 18462866 |
MESH:D009436 |
Neural Tube Defects |
|
arsenic trioxide |
3.15 | 10525206 |
MESH:D019954 |
Neurobehavioral Manifestations |
|
Plant Extracts |
5.25 | 17168769 |
MESH:D019636 |
Neurodegenerative Diseases |
|
Acetaminophen |
2.91 | 18514411 |
MESH:D009765 |
Obesity |
|
Curcumin |
5.13 | 19297423 |
MESH:D009765 |
Obesity |
|
Plant Extracts |
5.13 | 19056576 20132043 |
MESH:D010024 |
Osteoporosis |
|
Curcumin |
3.50 | 18719352 |
MESH:D010051 |
Ovarian Neoplasms |
|
arsenic trioxide |
5.10 | 12452020 19769630 16624393 |
MESH:D010051 |
Ovarian Neoplasms |
|
Curcumin |
5.10 | 19020741 18462866 |
MESH:D010146 |
Pain |
|
Acetaminophen |
2.43 | 16870215 |
MESH:D010190 |
Pancreatic Neoplasms |
|
arsenic trioxide |
8.88 | 15580305 |
MESH:D010190 |
Pancreatic Neoplasms |
|
Curcumin |
8.88 | 17440100 19401701 19196508 |
MESH:D010190 |
Pancreatic Neoplasms |
|
Tetradecanoylphorbol Acetate |
8.88 | 15976015 |
MESH:D010212 |
Papilloma |
|
Plant Extracts |
10.01 | 16517061 15173996 |
MESH:D010212 |
Papilloma |
|
Tetradecanoylphorbol Acetate |
10.01 | 12065085 8330346 18922899 18404319 |
MESH:D010235 |
Paraganglioma |
|
arsenic trioxide |
4.22 | 19927285 |
MESH:D011471 |
Prostatic Neoplasms |
|
arsenic trioxide |
2.74 | 19131511 |
MESH:D011471 |
Prostatic Neoplasms |
|
Curcumin |
2.74 | 18226269 11398177 18156803 10851300 15129424 12497104 18769126 |
MESH:D011471 |
Prostatic Neoplasms |
|
Plant Extracts |
2.74 | 14666653 17804756 |
MESH:D011656 |
Pulmonary Emphysema |
|
Curcumin |
4.58 | 19168576 |
MESH:D012128 |
Respiratory Distress Syndrome, Adult |
|
Curcumin |
4.08 | 10666014 18379247 |
MESH:D012509 |
Sarcoma |
|
Curcumin |
4.17 | 18462866 |
MESH:D012512 |
Sarcoma, Ewing's |
|
arsenic trioxide |
4.02 | 16646077 |
MESH:D018805 |
Sepsis |
|
Curcumin |
4.12 | 18389075 |
MESH:D012878 |
Skin Neoplasms |
|
Plant Extracts |
6.41 | 15173996 16517061 |
MESH:D012878 |
Skin Neoplasms |
|
Tetradecanoylphorbol Acetate |
6.41 | 11807781 8330346 12065085 18404319 8985016 |
MESH:D013274 |
Stomach Neoplasms |
|
arsenic trioxide |
1.86 | 17007042 |
MESH:D013276 |
Stomach Ulcer |
|
Curcumin |
7.87 | 19188055 16631530 |
MESH:D013276 |
Stomach Ulcer |
|
Plant Extracts |
7.87 | 18237397 15255614 17135157 18193104 12787963 |
MESH:D013705 |
Temporomandibular Joint Disorders |
|
Plant Extracts |
13.60 | 17997062 |
MESH:D013705 |
Temporomandibular Joint Disorders |
|
polyphenols |
13.60 | 17997062 |
OMIM:273800 |
THROMBASTHENIA OF GLANZMANN AND NAEGELI |
marker/mechanism |
|
| |
MESH:D013964 |
Thyroid Neoplasms |
|
arsenic trioxide |
3.13 | 19014326 |
MESH:D016171 |
Torsades de Pointes |
|
arsenic trioxide |
4.04 | 15213294 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
arsenic trioxide |
5.37 | 12973940 20435036 11780464 12845720 |
MESH:D001749 |
Urinary Bladder Neoplasms |
|
Curcumin |
5.37 | 18593936 |
MESH:D014565 |
Urogenital Neoplasms |
|
Curcumin |
5.35 | 18462866 |
MESH:D014581 |
Urticaria |
|
Acetaminophen |
3.03 | 10982225 |
MESH:D018487 |
Ventricular Dysfunction, Left |
|
Plant Extracts |
4.82 | 18097624 |
MESH:D020257 |
Ventricular Remodeling |
|
Plant Extracts |
5.40 | 18097624 |
MESH:D014947 |
Wounds and Injuries |
|
Plant Extracts |
4.30 | 19894650 20213670 |