AutismKB 2.0

Annotation Detail for ITGA2B


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Basic Information Top
Gene Symbol:ITGA2B ( CD41,CD41B,GP2B,GPIIb,GTA,HPA3 )
Gene Full Name: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Band: 17q21.31
Quick LinksEntrez ID:3674; OMIM: 607759; Uniprot ID:ITA2B_HUMAN; ENSEMBL ID: ENSG00000005961; HGNC ID: 6138
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05222Small cell lung cancer
hsa04810Regulation of actin cytoskeleton
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Axon guidance
Hemostasis
Integrin cell surface interactions
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200060Arf6 signaling events
200173Ephrin B reverse signaling
Pathway IDPathway Name
P00034Integrin signalling pathway
P00011Blood coagulation
Pathway IDPathway Name
500004Integrin cell surface interactions
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00226Glanzmann thrombasthenia
Desease IDDesease Name
1807Autoimmune disease
1858Hemorrhagic disorder
1863Aplastic anemia
1904Diabetes mellitus
1918Atherosclerosis
1954Stroke
1764Purpura, Thrombocytopenic, Idiopathic
2069Schizophrenia
2114Thrombocytopenia
2199Takayasu's arteritis
Desease Name
myocardial injury
deletion-insertion and alternative splicing
CARDIOVASCULAR
pregnancy loss, recurrent
METABOLIC
Myocardial Infarction
retinopathy, diabetic
REPRODUCTION
fetal loss
No data
Desease Name
Glanzmann thrombasthenia, type A
Thrombocytopenia, neonatal alloimmune
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ITGA2B mRNAaffects expression 17562736
D000244 Adenosine Diphosphate cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]affects binding|decreases reaction|increases expression 18404433
D000244 Adenosine Diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]affects binding|decreases reaction|increases expression 18404433
D000244 Adenosine Diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]affects binding|decreases reaction|increases expression|increases reaction 18404433
C006632 arsenic trioxide arsenic trioxide results in increased expression of ITGA2B mRNAincreases expression 15761015
C117446 cangrelor cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]affects binding|decreases reaction|increases expression 18404433
C117446 cangrelor N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]affects binding|decreases reaction|increases expression|increases reaction 18404433
D003474 Curcumin Curcumin inhibits the reaction [F2 protein results in increased expression of ITGA2B protein]decreases reaction|increases expression 18565277
D004391 Dust Dust results in decreased expression of ITGA2B mRNAdecreases expression 17805423
D005419 Flavonoids Flavonoids results in increased expression of ITGA2B mRNAincreases expression 15465739
D009240 N-Formylmethionine Leucyl-Phenylalanine ITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]increases expression|increases reaction 11116075
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of ITGA2B mRNAincreases expression 17572062
C111914 N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]affects binding|decreases reaction|increases expression 18404433
C111914 N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]affects binding|decreases reaction|increases expression|increases reaction 18404433
D010936 Plant Extracts Plant Extracts results in increased expression of ITGA2B mRNAincreases expression 15465739
C025299 polyphenols polyphenols results in increased expression of ITGA2B mRNAincreases expression 15465739
C106774 SR 121566 SR 121566 binds to and results in decreased activity of ITGA2B proteinaffects binding|decreases activity 11116075
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of ITGA2B proteinincreases expression 10428506
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3019825857 11798837
MESH:D019973 Alcohol-Related Disorders Curcumin 5.1817887948
MESH:D000544 Alzheimer Disease Curcumin 4.6515590663
MESH:D000544 Alzheimer Disease Plant Extracts 4.6516962711
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D001169 Arthritis, Experimental Plant Extracts 3.9814686799
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7516807698
MESH:D050197 Atherosclerosis Curcumin 3.3518704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001327 Autoimmune Diseases Curcumin 4.5619761891
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 3.7216206674
MESH:D002545 Brain Ischemia Curcumin 10.7716770732
MESH:D002545 Brain Ischemia Plant Extracts 10.7716041641
MESH:D001932 Brain Neoplasms Curcumin 3.9917596214
MESH:D001943 Breast Neoplasms Curcumin 2.7416243823 19250217 18462866 18593918
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3911589617
MESH:D002057 Burns, Chemical Plant Extracts 5.439625245
MESH:D002277 Carcinoma Curcumin 3.8818593918
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.7111135700 16217749 15553829 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 4.7118834353
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.9918414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1712490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 5.1218462866
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 5.1218922899
MESH:D006332 Cardiomegaly Plant Extracts 3.8317645561
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D003092 Colitis Curcumin 4.2518200517 16782535 16804969
MESH:D003103 Coloboma Curcumin 4.6018809619
MESH:D003110 Colonic Neoplasms Curcumin 4.1216340194 19359593
MESH:D003110 Colonic Neoplasms polyphenols 4.1216293270
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D016510 Corneal Neovascularization Curcumin 4.9718497527
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1515213294
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7118403477
MESH:D003928 Diabetic Nephropathies Curcumin 9.5618204486
MESH:D003928 Diabetic Nephropathies Plant Extracts 9.5619706694
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0516177239 19164858 19416960 14550746 12705907 10774834 16781746 12594235 11421492 19923254 15968718 12153990 19739265 18713872 11287661 12540782 11461765 16393943 15619225 11529661 16109766 17562736 11834606 19370779 16081117 11743745 14986274 16485898 17522070 2444490 17906064 10663392 10915739 11739529 14725611 12392966 12958197 19420014 16227642 18071297 19085960
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.0519370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004381 Duodenal Ulcer Curcumin 4.1117351913
MESH:D004487 Edema Plant Extracts 7.6612787963
MESH:D004487 Edema Tetradecanoylphorbol Acetate 7.668113982 16716910 7812673 15177302 8273558 11698051 9599246
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.7815268973
MESH:D004827 Epilepsy Plant Extracts 3.7519439326 19700373
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3212903497
MESH:D005234 Fatty Liver arsenic trioxide 13.6815073043
MESH:D005234 Fatty Liver Curcumin 13.6819297423
MESH:D005234 Fatty Liver Plant Extracts 13.6815975614
MESH:D005355 Fibrosis Curcumin 4.0618705752
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3316904648
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.7718462866
MESH:D005909 Glioblastoma Curcumin 3.5117596214
MESH:D006258 Head and Neck Neoplasms Curcumin 3.6918829502 18462866
MESH:D006333 Heart Failure Plant Extracts 3.9018097624
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.1117701891
MESH:D006561 Herpes Simplex Plant Extracts 4.7110715843
MESH:D015658 HIV Infections Plant Extracts 3.7112878215
MESH:D019584 Hot Flashes Plant Extracts 4.8417454163 16566672 14716179
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006937 Hypercholesterolemia Curcumin 4.1118704882
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.5116484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.5315975614 15268973
MESH:D007249 Inflammation Curcumin 16.2317151092 18403477 16956363
MESH:D007249 Inflammation Flavonoids 16.2317296493
MESH:D007249 Inflammation Plant Extracts 16.2315997105 12787963 19332304 16366677
MESH:D007249 Inflammation polyphenols 16.2316366677
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 16.2315177302 8273558 7562506 7812673 11698051
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2318596194 18200517
MESH:D007414 Intestinal Neoplasms Curcumin 10.2810783313
MESH:D007414 Intestinal Neoplasms Plant Extracts 10.2812628509 12584176 12351151
MESH:D007674 Kidney Diseases Acetaminophen 2.2315629191 12587719
MESH:D007889 Leiomyoma Curcumin 4.6318555241
MESH:D007938 Leukemia arsenic trioxide 6.6015070760
MESH:D007938 Leukemia Curcumin 6.6018462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 9.9517077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 9.9516106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8119077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1516467208 16968895 17050201 19850784 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2516330433 15748426 17649720 12679006 17107899 12018890 16823087 19225113 16112521 15622746 9834237 16966277 17712046 17869043 12712474 15336539 11468182 17217047 15213294 11161223 16891316 16331271 19035177 19642359 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 11.9316882451
MESH:D015458 Leukemia, T-Cell Curcumin 11.9316106398
MESH:D008103 Liver Cirrhosis Plant Extracts 3.7617157831
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 3.0218006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 3.0215479170
MESH:D008107 Liver Diseases Acetaminophen 9.5912587719 19784758 16610002 12969438 19014921 19460945 11587558 16611625
MESH:D008107 Liver Diseases Curcumin 9.5916956363
MESH:D008107 Liver Diseases Plant Extracts 9.5917034775
MESH:D008107 Liver Diseases polyphenols 9.5916698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 5.0314682389
MESH:D008113 Liver Neoplasms Plant Extracts 5.0319168119
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 2.7620377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 5.0111798837 19825857
MESH:D008175 Lung Neoplasms Curcumin 5.0119359593 16243823 18462866
MESH:D008175 Lung Neoplasms Plant Extracts 5.0120869020
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 5.0111807781
MESH:D008223 Lymphoma Curcumin 3.6218462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.7716173963
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.398985016
MESH:D008545 Melanoma Curcumin 2.4217885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008569 Memory Disorders Curcumin 4.2217263510
MESH:D009101 Multiple Myeloma arsenic trioxide 7.5711468182 15949261 19549372 14977855 19417148
MESH:D009101 Multiple Myeloma Curcumin 7.5719372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.0017962980
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1716882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 10.5416624393
MESH:D009361 Neoplasm Invasiveness Curcumin 10.5418495463
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.6312497104
MESH:D009423 Nervous System Neoplasms Curcumin 5.7318462866
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1510525206
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.2517168769
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D009765 Obesity Curcumin 5.1319297423
MESH:D009765 Obesity Plant Extracts 5.1319056576 20132043
MESH:D010024 Osteoporosis Curcumin 3.5018719352
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1012452020 19769630 16624393
MESH:D010051 Ovarian Neoplasms Curcumin 5.1019020741 18462866
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.8815580305
MESH:D010190 Pancreatic Neoplasms Curcumin 8.8817440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 8.8815976015
MESH:D010212 Papilloma Plant Extracts 10.0116517061 15173996
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 10.0112065085 8330346 18922899 18404319
MESH:D010235 Paraganglioma arsenic trioxide 4.2219927285
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.7419131511
MESH:D011471 Prostatic Neoplasms Curcumin 2.7418226269 11398177 18156803 10851300 15129424 12497104 18769126
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.7414666653 17804756
MESH:D011656 Pulmonary Emphysema Curcumin 4.5819168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.0810666014 18379247
MESH:D012509 Sarcoma Curcumin 4.1718462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0216646077
MESH:D018805 Sepsis Curcumin 4.1218389075
MESH:D012878 Skin Neoplasms Plant Extracts 6.4115173996 16517061
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 6.4111807781 8330346 12065085 18404319 8985016
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer Curcumin 7.8719188055 16631530
MESH:D013276 Stomach Ulcer Plant Extracts 7.8718237397 15255614 17135157 18193104 12787963
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 13.6017997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 13.6017997062
OMIM:273800 THROMBASTHENIA OF GLANZMANN AND NAEGELI marker/mechanism
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1319014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0415213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.3712973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.3718593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.3518462866
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.8218097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.4018097624
MESH:D014947 Wounds and Injuries Plant Extracts 4.3019894650 20213670
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REACT:18266 Axon guidance
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04640 Hematopoietic cell lineage
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:05200 Pathways in cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05222 Small cell lung cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29938
    • No data
    Releated disease ID Related disease Name
    PA445843Thrombasthenia
    Releated drug ID Related drug Name
    PA448006abciximab
    PA448497aspirin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00054 antagonist Abciximab Anticoagulants;Antiplatelet Agents
    DB00775 antagonist Tirofiban Platelet Aggregation Inhibitors;Fibrinolytic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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