AutismKB 2.0

Annotation Detail for ITGA3


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Basic Information Top
Gene Symbol:ITGA3 ( CD49C,FLJ34631,FLJ34704,GAP-B3,GAPB3,MSK18,VCA-2,VL3A,VLA3a )
Gene Full Name: integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Band: 17q21.33
Quick LinksEntrez ID:3675; OMIM: 605025; Uniprot ID:ITA3_HUMAN; ENSEMBL ID: ENSG00000005884; HGNC ID: 6139
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05222Small cell lung cancer
hsa04810Regulation of actin cytoskeleton
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Hemostasis
Integrin cell surface interactions
Pathway IDPathway Name
200131IL23-mediated signaling events
200051Reelin signaling pathway
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500004Integrin cell surface interactions
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ITGA3 proteinaffects expression 20106945
D000537 Aluminum Oxide Aluminum Oxide results in increased expression of ITGA3 mRNAincreases expression 19464052
C061133 Am 80 Am 80 results in increased expression of ITGA3 mRNAincreases expression 17229644
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ITGA3 mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ITGA3 mRNAincreases expression 15003993
14729362
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ITGA3 mRNAaffects expression 17484886
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ITGA3 mRNAincreases expression 15056808
D002330 Carmustine Carmustine results in decreased expression of ITGA3 mRNAdecreases expression 15980968
D016572 Cyclosporine Cyclosporine results in increased expression of ITGA3 mRNAincreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of ITGA3 proteinincreases expression 16912569
D005492 Folic Acid Folic Acid affects the expression of ITGA3 mRNAaffects expression 16361273
D019833 Genistein Genistein results in decreased expression of ITGA3 mRNAdecreases expression 16169203
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ITGA3 mRNAdecreases expression 12419474
D008345 Manganese Manganese results in increased expression of ITGA3 mRNAincreases expression 17175027
C025340 manganese chloride manganese chloride results in increased expression of ITGA3 mRNAincreases expression 17175027
C008493 methylselenic acid methylselenic acid results in increased expression of ITGA3 mRNAincreases expression 18548127
D010100 Oxygen Oxygen deficiency results in increased expression of ITGA3 mRNAincreases expression 17175027
D010634 Phenobarbital Phenobarbital affects the expression of ITGA3 mRNAaffects expression 19136022
C006253 pirinixic acid NCF1 protein inhibits the reaction [pirinixic acid results in decreased expression of ITGA3 mRNA]decreases expression|decreases reaction 17950772
C006253 pirinixic acid pirinixic acid affects the expression of ITGA3 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of ITGA3 mRNAdecreases expression 17950772
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ITGA3 mRNA]decreases expression|increases reaction 17950772
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of ITGA3 mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium results in increased expression of ITGA3 mRNAincreases expression 19244175
D013481 Superoxides [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGA3 proteindecreases expression|increases abundance 16400006
D014212 Tretinoin Tretinoin results in increased expression of ITGA3 mRNAincreases expression 16604517
D014801 Vitamin A Vitamin A results in increased expression of ITGA3 proteinincreases expression 17241391
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of ITGA3 mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of ITGA3 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.296195326
MESH:D000015 Abnormalities, Multiple Vitamin A 4.7210992263
MESH:D058186 Acute Kidney Injury Folic Acid 9.0217003819 16316344 16595132
MESH:D058186 Acute Kidney Injury Superoxides 9.0218460982
MESH:D055371 Acute Lung Injury Oxygen 8.7516759491
MESH:D055371 Acute Lung Injury pirinixic acid 8.7518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.8620127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 6.8611473722
MESH:D000230 Adenocarcinoma Genistein 6.8611473722
MESH:D000236 Adenoma Benzo(a)pyrene 6.696695378
MESH:D000236 Adenoma Folic Acid 6.6916963246
MESH:D018248 Adenoma, Liver Cell Phenobarbital 9.6117620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.6116434500
MESH:D000505 Alopecia Tretinoin 3.4915955085
MESH:D000544 Alzheimer Disease Folic Acid 3.0117116317
MESH:D000740 Anemia Vitamin A 4.3916960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.6616960172
MESH:D000756 Anemia, Sideroblastic Manganese 17.2116910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 17.2116910769
MESH:D000756 Anemia, Sideroblastic Superoxides 17.2116910769
MESH:D000860 Anoxia Oxygen 4.9020872349
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9219183758
MESH:D001169 Arthritis, Experimental Tretinoin 2.9816412693
MESH:D001172 Arthritis, Rheumatoid Am 80 4.9916819260
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.9916292516
MESH:D001249 Asthma Tretinoin 5.0616456186
MESH:D001249 Asthma Vitamin A 5.0616732791
MESH:D050197 Atherosclerosis Am 80 7.1916484594
MESH:D050197 Atherosclerosis Oxygen 7.1916391483
MESH:D001321 Autistic Disorder Folic Acid 2.8421388746
MESH:D001471 Barrett Esophagus Tretinoin 4.2516935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.5119483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.5116197459 16206674
MESH:D001932 Brain Neoplasms Carmustine 4.2616187019
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9020146248 17474063
MESH:D001943 Breast Neoplasms Estradiol 2.9012948864 16675129 17289903 17261762 18497071 14630087 17018787 19861407
MESH:D001943 Breast Neoplasms Folic Acid 2.9016777985
MESH:D001943 Breast Neoplasms Genistein 2.9017200150 16541309 16873071
MESH:D001943 Breast Neoplasms Oxygen 2.9017263869
MESH:D001943 Breast Neoplasms Tretinoin 2.9016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 12.5116813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 12.5117426644 17377406
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 9.4318705752 15700767 16050911 15721981 16011737 16227642 16097048 15673190 16192424 16124888 10355542 3786805
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 9.4316050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0116168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.0712619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.0718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.0716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 11.0716924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.0717173139 20935162 20007298 6705139 1701930
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.071917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.4220419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.4216051514 16096774
MESH:D002318 Cardiovascular Diseases Folic Acid 11.7216755160
MESH:D002318 Cardiovascular Diseases Genistein 11.7216332659
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 11.7216936243
MESH:D002386 Cataract Tretinoin 3.0117460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.2312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.2318566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.104080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4416129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.3216153327
MESH:D002779 Cholestasis Cyclosporine 12.8919486331
MESH:D002779 Cholestasis pirinixic acid 12.8919176532
MESH:D002779 Cholestasis Vitamin A 12.8916175620
MESH:D002822 Choriocarcinoma Tretinoin 5.0116461808
MESH:D002971 Cleft Lip Folic Acid 3.9021254359
MESH:D002972 Cleft Palate Folic Acid 9.758946559 21254359
MESH:D002972 Cleft Palate Tretinoin 9.759407595
MESH:D002972 Cleft Palate Vitamin A 9.7516054864
MESH:D003092 Colitis Selenium 9.0017936198
MESH:D003092 Colitis Tretinoin 9.0017035595
MESH:D003110 Colonic Neoplasms Genistein 4.0517182828
MESH:D003110 Colonic Neoplasms Vitamin A 4.0517219422 16267017
MESH:D015179 Colorectal Neoplasms Folic Acid 2.7017245555 16963246 17087956 17116713 16985020
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8810589399 9211117 17551590 9142499 16925845 9664655 8800419 9224671 9125849 14991402
MESH:D019465 Craniofacial Abnormalities Vitamin A 3.8810992263
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.8819769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3618249437
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.4616506275
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.7416886840
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.7416647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.2819279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.816884620 15968718 7120509 16177239 6623471 16227642 15998439 4309450 3786805 10915739 11566570 19085960 7179309 21278145 19336974 7440962 3732212 17522070 10092053 2869522 15027814 9327722
MESH:D056486 Drug-Induced Liver Injury Selenium 3.8115131321
MESH:D015352 Dry Eye Syndromes Vitamin A 5.6516146918
MESH:D004417 Dyspnea Oxygen 4.6820016425
MESH:D004421 Dystonia Phenobarbital 3.861851702
MESH:C538011 Eales disease Vitamin A 12.629068938
MESH:C538011 Eales disease Vitamin E 12.629068938
MESH:D004480 Ectromelia Vitamin A 5.6716054864
MESH:D004487 Edema pirinixic acid 2.3512083418
MESH:D004489 Edema, Cardiac Tretinoin 4.3218230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 4.9416819260
MESH:D004714 Endometrial Hyperplasia Genistein 4.4416402032
MESH:D016889 Endometrial Neoplasms Estradiol 17.0211473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Folic Acid 17.0217301261
MESH:D016889 Endometrial Neoplasms Genistein 17.0211473722
MESH:D016889 Endometrial Neoplasms Tretinoin 17.0216569247
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.963659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.723922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.416401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.107750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.873659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9716530937
MESH:D017889 Exfoliation Syndrome Folic Acid 5.3416504073
MESH:D005124 Eye Abnormalities Tretinoin 3.4616938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 12.2417595544 19224547 16239168 12795759 16045604 15959796 61145 12631006
MESH:D005234 Fatty Liver Cyclosporine 12.2419224547
MESH:D005234 Fatty Liver pirinixic acid 12.2419236843 20131406
MESH:D005327 Fetal Resorption Vitamin A 5.2116054864
MESH:D005355 Fibrosis Carbon Tetrachloride 13.9118705752
MESH:D005355 Fibrosis Cyclosporine 13.9112639820 12168785
MESH:D005355 Fibrosis Tretinoin 13.9117994277
MESH:D005739 Gas Poisoning Oxygen 5.0720016425
MESH:D005756 Gastritis Folic Acid 4.9417171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.078708960
MESH:D005901 Glaucoma Folic Acid 4.9316504073
MESH:D005909 Glioblastoma Carmustine 16.2216187019
MESH:D005909 Glioblastoma Genistein 16.2216598420
MESH:D005909 Glioblastoma Manganese 16.2217043766
MESH:D005909 Glioblastoma Tretinoin 16.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0116084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 20.2420471113
MESH:D006330 Heart Defects, Congenital Folic Acid 20.2417286298 16524890
MESH:D006330 Heart Defects, Congenital Tretinoin 20.2414991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 20.2410992263 16080930
MESH:D006330 Heart Defects, Congenital Vitamin E 20.2416080930
MESH:D006333 Heart Failure pirinixic acid 6.6420558911
MESH:D006333 Heart Failure Selenium 6.6417162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2715720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4519110552 19900420
MESH:D006529 Hepatomegaly Phenobarbital 7.9816109766
MESH:D006529 Hepatomegaly pirinixic acid 7.9819176532 16221962 19772884 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin A 6.0016863852 15707848 16877224 16292552 16490937 17436238
MESH:D006548 Hernia, Diaphragmatic Vitamin E 6.0016863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.8815709030
MESH:D015658 HIV Infections Vitamin A 3.7416960176
MESH:D006679 HIV Seropositivity Folic Acid 12.8417209195
MESH:D006679 HIV Seropositivity Vitamin A 12.8417209195
MESH:D019584 Hot Flashes Estradiol 9.5517088409
MESH:D019584 Hot Flashes Vitamin E 9.5514716179
MESH:D006930 Hyperalgesia Tretinoin 3.0916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3816899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4216778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0520558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 9.6116395265 16433478 16755160 16865747 16397167
MESH:D020138 Hyperhomocysteinemia Superoxides 9.6112615666
MESH:D006973 Hypertension Cyclosporine 2.0410903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9415338365
MESH:D006986 Hypervitaminosis A Vitamin A 6.0216054864
MESH:D007251 Influenza, Human Selenium 10.4516624496
MESH:D007251 Influenza, Human Vitamin E 10.4516624496
MESH:D007333 Insulin Resistance Estradiol 6.8716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.8716306350
MESH:D007410 Intestinal Diseases Superoxides 9.7910210152
MESH:D007410 Intestinal Diseases Tretinoin 9.7917994277
MESH:D019586 Intracranial Hypertension Vitamin A 5.6715955940
MESH:D007569 Jaw Abnormalities Tretinoin 3.7617551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2915604871
MESH:D007674 Kidney Diseases Cyclosporine 9.558314463 18776723 10903974
MESH:D007674 Kidney Diseases Estradiol 9.5515618244
MESH:D007674 Kidney Diseases Vitamin E 9.5512488133
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 9.5716518626
MESH:D007676 Kidney Failure, Chronic Selenium 9.5716518626
MESH:D007680 Kidney Neoplasms Cyclosporine 6.8612371664
MESH:D007680 Kidney Neoplasms Estradiol 6.8615610895
MESH:D007938 Leukemia Genistein 6.1617468513 18980019
MESH:D007938 Leukemia Tretinoin 6.1617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5616482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0516294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 7.8316819260 16531727
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.8319029980 9834237 17294898 19035177 17368321 16823087 12679006 16788101 17506722 19642359 16140955 17339181 17301526 17361223 16935935 17107899 16766008 19075265 19225113 16891316 15748426 17649720 16331271 17712046 17217047
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.149224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 8.1416054864
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6811903743 16943688 17157831 11408273 17174718 21278145 16221502 16239168 17334410
MESH:D008103 Liver Cirrhosis Phenobarbital 10.6821047994
MESH:D008103 Liver Cirrhosis Vitamin A 10.6816256175
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 10.6417761835 17944888 17805973 16638106 16248980 12445421 18472332 17721639 18156304 18263696 12546737 17976157 15673190 15959796 18395914 15876570 18412020 11481614 17714472 12958196 18429990 18187930 12666154 10355542 18251166 12741479 18376398 18317297 17557913 18166357 12445418 16011737 16015684 18418968 14716496 17565644 18210741 17631135 17708605 17922224 12898905 18339082 18277467 15057751 12632514 14716833 17823541 15996030 15730626 15650968 14748882 14724832 15818738 18279442 15338365 16192424 18006644 20821823 12649538 17900296 14620537 15893842 14512876 15362042 17698563 18395095 17869086 16033810 15370692 15052691 15925388 12586293 16136751 13678700 12389079 12667390 17481882 12609069 15931870 16116963 18472094 17525996 18054572 18420326 17640975 18205269 16097048 18705752 16027843 15123356 17766677 18481824 12632512
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.6414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 10.6417823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.6415474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 10.6416248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 10.6416248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 10.6416169303
MESH:D008107 Liver Diseases Carbon Tetrachloride 9.1616964402 17285989 15720792 15830285 16246199
MESH:D008107 Liver Diseases Folic Acid 9.1616877991
MESH:D008107 Liver Diseases Phenobarbital 9.1619363144
MESH:D008107 Liver Diseases Vitamin A 9.1616175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 5.0016762690
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0115123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5616899240 14706259
MESH:D008113 Liver Neoplasms Aflatoxin B1 13.639163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 13.6320195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.6319294768
MESH:D008113 Liver Neoplasms Phenobarbital 13.638742319 19812893 19482888 15975961 19073162 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 13.6320007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.428603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.4215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.4218308698 17172636 6150874 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 13.4217113696
MESH:D008171 Lung Diseases Vitamin A 7.4416863852
MESH:D008171 Lung Diseases Vitamin E 7.4416863852
MESH:D055370 Lung Injury Oxygen 4.3618339021
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.3520464547 20064080 20869020 18816296 18520028 20135361 6695378 17053015 18569708
MESH:D008175 Lung Neoplasms Vitamin E 3.3511062179
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3017718048
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.4411807958 11408345 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 9.4414578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Selenium 9.4415318939
MESH:D020149 Manganese Poisoning Estradiol 12.5019453300
MESH:D020149 Manganese Poisoning Manganese 12.5019453300 16568477 16551646
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.5416832597
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma Carmustine 3.5612393984
MESH:D008545 Melanoma Tretinoin 3.5616752155
MESH:D008591 Meningomyelocele Tretinoin 4.2716940565
MESH:D008654 Mesothelioma Selenium 2.7315107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6416801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0716381670
MESH:D009069 Movement Disorders Manganese 4.8716551646
MESH:D009101 Multiple Myeloma Am 80 7.8017229644
MESH:D009101 Multiple Myeloma Vitamin A 7.8016374440
MESH:D009135 Muscular Diseases pirinixic acid 3.3616239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9917596541
MESH:D009203 Myocardial Infarction Genistein 5.4717141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.4719151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.5016810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.5017141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.5016411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.3217484760
MESH:D009369 Neoplasms Benzo(a)pyrene 7.7611141357
MESH:D009369 Neoplasms pirinixic acid 7.7617405874
MESH:D009369 Neoplasms Tretinoin 7.7616594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5817289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1518481113 19348381
MESH:D009410 Nerve Degeneration Manganese 4.1616551646
MESH:D009421 Nervous System Malformations Estradiol 15.5911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 15.5916427766
MESH:D009421 Nervous System Malformations Tretinoin 15.599125849
MESH:D009436 Neural Tube Defects Folic Acid 11.8217438019
MESH:D009436 Neural Tube Defects Tretinoin 11.829142499
MESH:D009436 Neural Tube Defects Vitamin A 11.8217400914
MESH:D009503 Neutropenia Folic Acid 4.3616322990
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D010018 Osteomalacia Phenobarbital 4.2117016548
MESH:D010024 Osteoporosis Genistein 3.1619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.9416169203
MESH:D010051 Ovarian Neoplasms Estradiol 7.6219401270
MESH:D010051 Ovarian Neoplasms Genistein 7.6219005980
MESH:D010051 Ovarian Neoplasms Tretinoin 7.6216936753
MESH:D010146 Pain Tretinoin 2.7816870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.1016965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1015976015
MESH:D010212 Papilloma Hydrogen Peroxide 3.9412065085
MESH:D010300 Parkinson Disease Manganese 3.3211181820
MESH:D020734 Parkinsonian Disorders Manganese 4.3416140633
MESH:D010954 Plasmacytoma Selenium 4.7415087411
MESH:D011230 Precancerous Conditions Cyclosporine 8.5412371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.542563599
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7520887781
MESH:D011471 Prostatic Neoplasms Am 80 1.8916289102
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8916925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.8916205645
MESH:D011471 Prostatic Neoplasms Vitamin E 1.8915084515
MESH:D011507 Proteinuria Tretinoin 3.4616636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.3412752131
MESH:D011565 Psoriasis Am 80 5.9716819260
MESH:D011565 Psoriasis Cyclosporine 5.9716882103
MESH:D011625 Pterygium Tretinoin 4.6416723453
MESH:D051437 Renal Insufficiency Folic Acid 4.6315728788
MESH:D015427 Reperfusion Injury pirinixic acid 6.7919058328
MESH:D015427 Reperfusion Injury Superoxides 6.7918460982
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 4.3718339021 17627322
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.6516877224
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9616116481 16283617
MESH:D012559 Schizophrenia Folic Acid 2.8816641680
MESH:D012640 Seizures Phenobarbital 2.594039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.676407741
MESH:D012871 Skin Diseases Folic Acid 7.9318709164
MESH:D012871 Skin Diseases Vitamin A 7.9318709164
MESH:D012871 Skin Diseases Vitamin E 7.9318709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.0119755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 13.0112065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.018532709
MESH:D012878 Skin Neoplasms Tretinoin 13.0116467112
MESH:D013118 Spinal Cord Diseases Folic Acid 5.3416361298
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.372093021 20155912
MESH:D013274 Stomach Neoplasms Folic Acid 3.3717171786
MESH:D013274 Stomach Neoplasms Tretinoin 3.3717261132
MESH:D020521 Stroke Folic Acid 8.5016517955
MESH:D020521 Stroke Vitamin E 8.5016517955
MESH:D013398 Sudden Infant Death Oxygen 5.3912563064
MESH:D013964 Thyroid Neoplasms Phenobarbital 6.811399818
MESH:D013964 Thyroid Neoplasms Tretinoin 6.8116026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.5319048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6516051514
MESH:D014376 Tuberculosis Tretinoin 3.1316040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1217053015
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.4616752155
MESH:D014605 Uveitis Cyclosporine 3.831336536
MESH:D014802 Vitamin A Deficiency Vitamin A 5.1316175781 16960172 16146918
MESH:D014820 Vitiligo Tretinoin 3.9116761959
MESH:D009396 Wilms Tumor Tretinoin 3.8416287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2917120751
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04640 Hematopoietic cell lineage
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:05200 Pathways in cancer
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05222 Small cell lung cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29939
    • No data
    No data
    Releated drug ID Related drug Name
    PA152241909PP2
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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