AutismKB 2.0

Annotation Detail for ITGA4


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Basic Information Top
Gene Symbol:ITGA4 ( CD49D,IA4,MGC90518 )
Gene Full Name: integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Band: 2q31.3
Quick LinksEntrez ID:3676; OMIM: 192975; Uniprot ID:ITA4_HUMAN; ENSEMBL ID: ENSG00000115232; HGNC ID: 6140
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04672Intestinal immune network for IgA production
hsa04670Leukocyte transendothelial migration
hsa04640Hematopoietic cell lineage
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05140Leishmaniasis
hsa04810Regulation of actin cytoskeleton
hsa04514Cell adhesion molecules (CAMs)
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Hemostasis
Signaling in Immune system
Integrin cell surface interactions
Pathway IDPathway Name
200178Paxillin-independent events mediated by a4b1 and a4b7
200092a4b1 and a4b7 Integrin signaling
200117Paxillin-dependent events mediated by a4b1
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500305Cell surface interactions at the vascular wall
500004Integrin cell surface interactions
500477Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1781Rheumatoid arthritis
1830Demyelinating disease
1842Sickle cell disease
1951Overnutrition
1970Virus disease
1993Esophagus cancer
1999Thalassemia
1764Purpura, Thrombocytopenic, Idiopathic
2051Leukemia
2074Asthma
2111Systemic infection
2192Lung disease
2251Osteosarcoma
Desease Name
CHEMDEPENDENCY
Celiac Disease
IMMUNE
smoking cessation
Desease Name
Celiac disease
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C001079 2-(2,6-dioxopiperidin-3-yl)phthalimidine 2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGA4 proteindecreases expression 8538367
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of ITGA4 mRNAincreases expression 15982314
C103303 alitretinoin alitretinoin results in increased expression of ITGA4 mRNAincreases expression 15982314
D000499 Allylamine Allylamine results in decreased expression of ITGA4 mRNAdecreases expression 15698866
D000499 Allylamine Allylamine results in decreased expression of ITGA4 proteindecreases expression 15698866
D001194 Asbestos Asbestos affects the expression of ITGA4 mRNAaffects expression 17297452
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of ITGA4 mRNAincreases expression 15336504
D002927 Cimetidine Cimetidine results in decreased expression of ITGA4 proteindecreases expression 11556524
D003907 Dexamethasone Dexamethasone results in decreased expression of ITGA4 mRNAdecreases expression 12782123
D004041 Dietary Fats Dietary Fats results in decreased expression of ITGA4 mRNAdecreases expression 18042831
D017308 Etodolac Etodolac results in decreased expression of [ITGA4 protein binds to ITGB1 protein]affects binding|decreases expression 16046235
D005492 Folic Acid Folic Acid affects the expression of ITGA4 mRNAaffects expression 17320366
C043062 N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine results in decreased expression of ITGA4 proteindecreases expression 11556524
C041786 palm oil palm oil results in decreased expression of ITGA4 mRNAdecreases expression 18042831
D015474 Isotretinoin Isotretinoin results in increased expression of ITGA4 mRNAincreases expression 15982314
C017947 sodium arsenite sodium arsenite results in increased expression of ITGA4 mRNAincreases expression 12760830
D014212 Tretinoin Tretinoin metabolite results in increased expression of ITGA4 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of ITGA4 mRNAincreases expression 15982314
D014311 Triprolidine Triprolidine results in decreased expression of ITGA4 proteindecreases expression 11556524
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-(2,6-dioxopiperidin-3-yl)phthalimidine 9.70473085 6734493 3355362 3196154
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 9.7018769834
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.9618769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.2816232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.4818769834 16185265
MESH:D058186 Acute Kidney Injury Folic Acid 4.3117003819 16316344 16595132
MESH:D000230 Adenocarcinoma 2-(2,6-dioxopiperidin-3-yl)phthalimidine 4.451933837
MESH:D000236 Adenoma Folic Acid 3.7816963246
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9016712894 17306315
OMIM:607154 ALLERGIC RHINITIS Etodolac 5.8016979129
MESH:D000505 Alopecia Tretinoin 3.6015955085
MESH:D000544 Alzheimer Disease Folic Acid 3.0417116317
MESH:D001161 Arteriosclerosis Dietary Fats 3.8715238619
MESH:D001169 Arthritis, Experimental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 12.569598899
MESH:D001169 Arthritis, Experimental Dexamethasone 12.5617659584
MESH:D001169 Arthritis, Experimental Tretinoin 12.5616412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D050197 Atherosclerosis Asbestos 4.2118795166
MESH:D001321 Autistic Disorder marker/mechanism 18348195
MESH:D001321 Autistic Disorder Folic Acid 2.8321388746
MESH:D001471 Barrett Esophagus Tretinoin 4.3916935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.5916206674 16197459
MESH:D001848 Bone Diseases, Developmental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 5.543355362
MESH:D001943 Breast Neoplasms alitretinoin 2.4016344269
MESH:D001943 Breast Neoplasms Dietary Fats 2.4020435547
MESH:D001943 Breast Neoplasms Folic Acid 2.4016777985
MESH:D001943 Breast Neoplasms N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 2.4018986763
MESH:D001943 Breast Neoplasms Tretinoin 2.4016166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5816813970
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1616168501
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 3.0817306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.081917145
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 10.9211237771
MESH:D002294 Carcinoma, Squamous Cell N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 10.9218986763
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 10.9218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.9216096774 16051514
MESH:D002318 Cardiovascular Diseases Folic Acid 3.9316755160
MESH:D002386 Cataract Tretinoin 3.0817460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.9720056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5816129372
MESH:D002822 Choriocarcinoma Tretinoin 5.1616461808
MESH:D002971 Cleft Lip Folic Acid 3.9721254359
MESH:D002972 Cleft Palate Folic Acid 6.288946559 21254359
MESH:D002972 Cleft Palate Tretinoin 6.289407595
MESH:D003092 Colitis Tretinoin 3.6917035595
MESH:D003110 Colonic Neoplasms 2-(2,6-dioxopiperidin-3-yl)phthalimidine 6.391933837
MESH:D003110 Colonic Neoplasms Dexamethasone 6.3915824018
MESH:D003110 Colonic Neoplasms Etodolac 6.3916004971
MESH:D015179 Colorectal Neoplasms Etodolac 3.4911076880
MESH:D015179 Colorectal Neoplasms Folic Acid 3.4917245555 16985020 17087956 16963246 17116713
MESH:D019465 Craniofacial Abnormalities Dexamethasone 4.0317728286
MESH:D019465 Craniofacial Abnormalities Isotretinoin 4.039879862 18769834
MESH:D019465 Craniofacial Abnormalities Tretinoin 4.039142499 16925845 9224671 17551590 8800419 10589399 9125849 9664655 9211117 14991402
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.3912438553
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.1316886840
MESH:D003967 Diarrhea Dexamethasone 3.687237001
MESH:D050171 Dyslipidemias Dietary Fats 3.4418367378
MESH:D004480 Ectromelia 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.047940403
MESH:D004485 Eczema Dexamethasone 4.4412438553
MESH:D004487 Edema Cimetidine 7.7319703484
MESH:D004487 Edema Dexamethasone 7.7319703484
MESH:D004489 Edema, Cardiac Tretinoin 4.4718230668
MESH:D016889 Endometrial Neoplasms Folic Acid 7.7417301261
MESH:D016889 Endometrial Neoplasms Tretinoin 7.7416569247
MESH:D017889 Exfoliation Syndrome Folic Acid 5.4816504073
MESH:D005124 Eye Abnormalities Tretinoin 3.5616938888 9664655
MESH:D005234 Fatty Liver Dietary Fats 3.2217967931 19004024 18296743 19551842
MESH:D005355 Fibrosis Dietary Fats 8.7918296743
MESH:D005355 Fibrosis Tretinoin 8.7917994277
MESH:D005756 Gastritis Folic Acid 5.0917171786
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6716452187
MESH:D005901 Glaucoma Folic Acid 5.0616504073
MESH:D005909 Glioblastoma Tretinoin 2.9917312396
MESH:D006258 Head and Neck Neoplasms N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 8.5118986763
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.5116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1616084493
MESH:D006330 Heart Defects, Congenital Folic Acid 7.0417286298 16524890
MESH:D006330 Heart Defects, Congenital Tretinoin 7.049664655 14991402
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.067520565
MESH:D006679 HIV Seropositivity Folic Acid 5.4817209195
MESH:D006689 Hodgkin Disease sodium arsenite 3.1312676792
MESH:D006930 Hyperalgesia Tretinoin 3.1916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.5721332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5516778211
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.4816395265 16397167 16865747 16755160 16433478
MESH:D006949 Hyperlipidemias Dietary Fats 3.6021332399
MESH:D006973 Hypertension Dexamethasone 2.9217042910
MESH:D007248 Infertility, Male sodium arsenite 2.9715346721 12646999
MESH:D007249 Inflammation Dexamethasone 5.268960868 11099482
MESH:D007249 Inflammation Dietary Fats 5.2620412841
MESH:D007333 Insulin Resistance Dietary Fats 3.0911836018 18457598
MESH:D007410 Intestinal Diseases Tretinoin 3.7517994277
MESH:D007569 Jaw Abnormalities Tretinoin 3.8817551590 15992940
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.6316144296
MESH:D007674 Kidney Diseases sodium arsenite 2.7920008137
MESH:D007938 Leukemia Tretinoin 2.7617143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6816482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0719850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1419029980 16788101 16331271 16823087 15748426 17294898 17506722 19075265 16766008 17339181 16140955 17649720 16935935 17712046 17301526 17361223 19225113 19035177 17217047 17107899 17368321 16891316 12679006 19642359 9834237
MESH:D017880 Limb Deformities, Congenital 2-(2,6-dioxopiperidin-3-yl)phthalimidine 8.903355362 6734493
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.909224671
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8618296743
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 2.6816718785
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.6818397230 16248980
MESH:D008107 Liver Diseases Folic Acid 3.0416877991
MESH:D008113 Liver Neoplasms sodium arsenite 2.3616712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 3.1619095001
MESH:D008175 Lung Neoplasms alitretinoin 6.6416413115
MESH:D008175 Lung Neoplasms Asbestos 6.6412111688
MESH:D008175 Lung Neoplasms Dexamethasone 6.6411195469 15824018
MESH:D008175 Lung Neoplasms Isotretinoin 6.6415899809
MESH:D008175 Lung Neoplasms sodium arsenite 6.6415276417 16712894 19931552 17306315 17077188
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.3317718048
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.6916832597
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Isotretinoin 5.2417237267
MESH:D008545 Melanoma sodium arsenite 5.2419082730 16487513
MESH:D008545 Melanoma Tretinoin 5.2416752155
MESH:D008591 Meningomyelocele Tretinoin 4.4116940565
MESH:D008654 Mesothelioma Asbestos 4.0818709470 16319530 16919927 16564556 18310086
MESH:D009101 Multiple Myeloma Dexamethasone 3.4915867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.509809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5017596541
MESH:D009369 Neoplasms alitretinoin 8.3516946489
MESH:D009369 Neoplasms sodium arsenite 8.3511559025
MESH:D009369 Neoplasms Tretinoin 8.3516946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6520056578
MESH:D009421 Nervous System Malformations Tretinoin 3.769125849
MESH:D009436 Neural Tube Defects Folic Acid 12.1917438019
MESH:D009436 Neural Tube Defects sodium arsenite 12.1912854658
MESH:D009436 Neural Tube Defects Tretinoin 12.199142499
MESH:D009447 Neuroblastoma Isotretinoin 4.0317368321
MESH:D009503 Neutropenia Folic Acid 4.4916322990
MESH:D009765 Obesity Dietary Fats 2.2811836018 19632207 20518802 18674790 21332399 20132043 17217161 18457598 16723640
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.8615276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8616936753
MESH:D010146 Pain Tretinoin 2.8816870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4515976015
MESH:D010195 Pancreatitis Cimetidine 5.2610484002
MESH:D017499 Porokeratosis alitretinoin 6.0016144296
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.5321297632
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 4.8718769834
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.3116039940
MESH:D011507 Proteinuria Tretinoin 3.5916636307
MESH:D011596 Psychomotor Disorders Isotretinoin 5.9118769834
MESH:D011625 Pterygium Tretinoin 4.7816723453
MESH:D051437 Renal Insufficiency Folic Acid 4.7615728788
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.0011700416 18379247
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0816116481 16283617
MESH:D012559 Schizophrenia Folic Acid 2.8916641680
MESH:D012772 Shock, Septic Triprolidine 6.2118063050
MESH:D012852 Sinusitis Triprolidine 6.327327846
MESH:D012871 Skin Diseases Folic Acid 3.2418709164
MESH:D012878 Skin Neoplasms sodium arsenite 9.4618572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 9.468532709
MESH:D012878 Skin Neoplasms Tretinoin 9.4616467112
MESH:D013118 Spinal Cord Diseases Folic Acid 5.4816361298
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7812854658
MESH:D013272 Stomach Diseases Dexamethasone 4.3115472012
MESH:D013274 Stomach Neoplasms Folic Acid 2.7617171786
MESH:D013274 Stomach Neoplasms Tretinoin 2.7617261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.4715138204
MESH:D020521 Stroke Folic Acid 4.3116517955
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7716051514
MESH:D014376 Tuberculosis Tretinoin 3.2116040207
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.5017306315 11723127 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.3511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.3516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6116752155
MESH:D014605 Uveitis Dexamethasone 4.821336536
MESH:D014652 Vascular Diseases sodium arsenite 4.4217056641
MESH:D014820 Vitiligo Tretinoin 4.0416761959
MESH:D015430 Weight Gain Dietary Fats 3.7216723640
MESH:D009396 Wilms Tumor Tretinoin 3.9516287080
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04640 Hematopoietic cell lineage
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:04672 Intestinal immune network for IgA production
KEGG:05140 Leishmaniasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04810 Regulation of actin cytoskeleton
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29940
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450952phospholipids
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00108 antibody Natalizumab Immunomodulatory Agents
    DB06822 inhibitor Tinzaparin Anticoagulants;Antithrombotics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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