AutismKB 2.0

Annotation Detail for ITGA5


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Basic Information Top
Gene Symbol:ITGA5 ( CD49e,FNRA,VLA5A )
Gene Full Name: integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Band: 12q13.13
Quick LinksEntrez ID:3678; OMIM: 135620; Uniprot ID:ITA5_HUMAN; ENSEMBL ID: ENSG00000161638; HGNC ID: 6141
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04145Phagosome
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05131Shigellosis
hsa05100Bacterial invasion of epithelial cells
hsa04810Regulation of actin cytoskeleton
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Axon guidance
Hemostasis
Integrin cell surface interactions
Pathway IDPathway Name
200188VEGFR3 signaling in lymphatic endothelium
200066Angiopoietin receptor Tie2-mediated signaling
200164Syndecan-2-mediated signaling events
200115Syndecan-4-mediated signaling events
200192Signaling events mediated by focal adhesion kinase
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500305Cell surface interactions at the vascular wall
500004Integrin cell surface interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1779Cervical cancer
1827Bone metastases
1831Prostate cancer
1859Ovarian cancer
1929Pertussis
2025Polyarthritis
1976Squamous cell cancer
2053Colon cancer
2066Lung cancer
2214Malignant glioma
2256Aortic aneurysm
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ITGA5 mRNAaffects expression 21346803
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]affects binding|affects localization|decreases reaction|increases expression 16465378
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ITGA5 mRNAaffects expression 21346803
C426703 3-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid 3-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]affects binding|decreases activity 16384862
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of ITGA5 mRNAdecreases expression 12419474
D000096 Acetone Acetone results in increased expression of ITGA5 mRNAincreases expression 12720008
D000537 Aluminum Oxide [Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGA5 proteinaffects cotreatment|increases expression 12209937
C047981 arginyl-glycyl-aspartic acid arginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]affects binding|decreases reaction 16790523
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ITGA5 mRNAdecreases expression 12419474
C422910 Cilengitide Cilengitide results in decreased activity of [ITGA5 protein binds to ITGB3 protein]affects binding|decreases activity 16729916
C422910 Cilengitide Cilengitide results in decreased activity of [ITGA5 protein binds to ITGB5 protein]affects binding|decreases activity 16729916
C018021 cobaltous chloride cobaltous chloride results in increased expression of ITGA5 proteinincreases expression 16798617
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of ITGA5 mRNAincreases expression 15829613
C529593 EMD 527040 EMD 527040 binds to and results in decreased activity of [ITGA5 protein binds to ITGB6 protein]affects binding|decreases activity 18221819
D000431 Ethanol Ethanol results in increased expression of ITGA5 mRNAincreases expression 12720008
D005492 Folic Acid Folic Acid affects the expression of ITGA5 mRNAaffects expression 16361273
D005665 Furosemide Furosemide results in decreased expression of ITGA5 mRNAdecreases expression 16526316
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ITGA5 mRNAdecreases expression 12419474
D016729 Leuprolide Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]affects binding|affects localization|decreases reaction|increases expression 17143537
D008274 Magnesium [Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGA5 proteinaffects cotreatment|increases expression 12209937
D009151 Mustard Gas Mustard Gas results in increased expression of ITGA5 mRNAincreases expression 15674843
C007350 nitrofen nitrofen results in increased expression of ITGA5 proteinincreases expression 15119844
D011374 Progesterone Progesterone affects the expression of ITGA5 mRNAaffects expression 17962213
D011374 Progesterone Progesterone affects the expression of ITGA5 proteinaffects expression 17962213
C037219 quinoline quinoline analog binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]affects binding|decreases activity 16984141
C059514 resveratrol arginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]affects binding|decreases reaction 16790523
C059514 resveratrol [ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK1 protein]affects binding|increases phosphorylation|increases reaction 16790523
C059514 resveratrol [ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK3 protein]affects binding|increases phosphorylation|increases reaction 16790523
C059514 resveratrol [ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of TP53 protein]affects binding|increases phosphorylation|increases reaction 16790523
C059514 resveratrol resveratrol binds to [ITGA5 protein binds to ITGB3 protein]affects binding 16790523
D018038 Sodium Selenite Sodium Selenite results in increased expression of ITGA5 mRNAincreases expression 18175754
D014284 Triiodothyronine Triiodothyronine binds to [ITGA5 protein binds to ITGB3 protein]affects binding 16384862
D013974 Thyroxine Thyroxine binds to [ITGA5 protein binds to ITGB3 protein]affects binding 16384862
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITGA5 mRNAincreases expression 16051281
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ITGA5 mRNAaffects binding|decreases expression 16214954
C011126 tetraiodothyroacetic acid tetraiodothyroacetic acid binds to [ITGA5 protein binds to ITGB3 protein]affects binding 16384862
D019772 Topotecan ITGA5 protein affects the susceptibility to Topotecanaffects response to substance 16217747
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 7.5418926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5411752688 15322242 14514962
MESH:D000138 Acidosis Ethanol 4.2211192467
MESH:D058186 Acute Kidney Injury Folic Acid 8.1916316344 16595132 17003819
MESH:D058186 Acute Kidney Injury resveratrol 8.1916538975
MESH:D000236 Adenoma Folic Acid 10.6516963246
MESH:D000236 Adenoma Magnesium 10.6517823441
MESH:D000236 Adenoma resveratrol 10.6515688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1016835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.0315451039 15451040
MESH:D000544 Alzheimer Disease Folic Acid 4.3817116317
MESH:D000544 Alzheimer Disease resveratrol 4.3816183991 16162502
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.9310965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7111748828
MESH:D000853 Anophthalmos Ethanol 4.5515513904
MESH:D001008 Anxiety Disorders Ethanol 3.7911141031
MESH:D001169 Arthritis, Experimental resveratrol 3.3317115116
MESH:D001249 Asthma Mustard Gas 2.6310378619
MESH:D050197 Atherosclerosis resveratrol 3.1117967414 16873680
MESH:D001321 Autistic Disorder Folic Acid 2.7321388746
MESH:D001321 Autistic Disorder Leuprolide 2.7317187010
MESH:D001321 Autistic Disorder Magnesium 2.7316846101
MESH:D001768 Blister Mustard Gas 4.8819167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.8012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5915746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0517868700
MESH:D001930 Brain Injuries Progesterone 3.9815665606 15845082 15380490
MESH:D002545 Brain Ischemia resveratrol 4.0017600658
MESH:D001943 Breast Neoplasms Folic Acid 1.9716777985
MESH:D001943 Breast Neoplasms Progesterone 1.9716175315 15562024 17614352
MESH:D001943 Breast Neoplasms resveratrol 1.9717534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9720435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.8815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6917687719 10378619
MESH:D002056 Burns Ethanol 4.3816374292
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5816835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.3916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 8.3916705839
MESH:D006528 Carcinoma, Hepatocellular Ethanol 8.3915289165 15763234 18788625
MESH:D006528 Carcinoma, Hepatocellular quinoline 8.39598648
MESH:D006528 Carcinoma, Hepatocellular resveratrol 8.3916227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.3116675471
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.6416227395
MESH:D006332 Cardiomegaly Ethanol 10.6719332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 10.6718850075 18670907 16120746
MESH:D006332 Cardiomegaly Thyroxine 10.6718093424
MESH:D002318 Cardiovascular Diseases Folic Acid 11.2416755160
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 11.2416936243
MESH:D002318 Cardiovascular Diseases resveratrol 11.2415458977
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.586135515
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4815894690
MESH:D002971 Cleft Lip Ethanol 7.4015513904
MESH:D002971 Cleft Lip Folic Acid 7.4021254359
MESH:D002972 Cleft Palate Ethanol 9.2715513904
MESH:D002972 Cleft Palate Folic Acid 9.278946559 21254359
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 9.2716354765 15340226 12621046 8697196 15668235
MESH:D003092 Colitis resveratrol 3.8616474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4116338953
MESH:D003111 Colonic Polyps Magnesium 5.7917823441
MESH:D015179 Colorectal Neoplasms Folic Acid 3.6517245555 16985020 17087956 17116713 16963246
MESH:D015179 Colorectal Neoplasms Magnesium 3.6517823441
MESH:D015179 Colorectal Neoplasms resveratrol 3.6516550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8317141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.5716507316
MESH:D019465 Craniofacial Abnormalities Ethanol 3.8119302082 15513904 15451039 10194807 15451040 11198716 11873399
MESH:D019465 Craniofacial Abnormalities nitrofen 3.8111405365
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8110048152 15322242 20055451
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.1816037377
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.9818551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.9818551238
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 3.7715059100 11298694 16823706
MESH:D002658 Developmental Disabilities Magnesium 4.7216846101
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.5416285004
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5516873680
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 4.3216886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3217107852
MESH:D003928 Diabetic Nephropathies resveratrol 3.7316286809
MESH:D003929 Diabetic Neuropathies Progesterone 4.2217187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.0821346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 11.0818551238 21346803
MESH:D056486 Drug-Induced Liver Injury Ethanol 11.0811566570
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 11.0815131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.0820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5611462148
MESH:D004417 Dyspnea Furosemide 4.6616935035
MESH:D004487 Edema Furosemide 14.4811834646
MESH:D004487 Edema Mustard Gas 14.489260866 11428631 11402378 11428647
MESH:D004487 Edema resveratrol 14.488985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 14.4811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.4617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.4617872969
MESH:D016889 Endometrial Neoplasms Folic Acid 3.8317301261
MESH:D004715 Endometriosis Progesterone 8.1316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.139294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5717923197
MESH:D004890 Erythema Mustard Gas 4.889357497
MESH:D004938 Esophageal Neoplasms Ethanol 2.6816704527
MESH:D017889 Exfoliation Syndrome Folic Acid 5.2116504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8111564622
MESH:D005234 Fatty Liver Ethanol 3.4916409862 19236843 18620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.3817920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.0216946407 10194807 15451040 15513904
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1811858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.6820067830
MESH:D005756 Gastritis Ethanol 10.7015046732
MESH:D005756 Gastritis Folic Acid 10.7017171786
MESH:D005901 Glaucoma Folic Acid 4.8216504073
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3110696789
MESH:D034381 Hearing Loss Furosemide 4.5917868369
MESH:D006330 Heart Defects, Congenital Folic Acid 10.5717286298 16524890
MESH:D006330 Heart Defects, Congenital nitrofen 10.5716080930
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.5710048152 11294989
MESH:D006333 Heart Failure Furosemide 3.8912660669 16845234 16011733
MESH:D006390 Hemangioendothelioma quinoline 5.62598648
MESH:D006394 Hemangiosarcoma quinoline 4.75598648
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0911000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6212621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic nitrofen 3.8416292651 15578192 7576705 12759764 9473106 11584395 18958481 11076806 10541330 17245593 16473863 15088113 10359170 12904592 16863852 15793718 18280291 9859898 11588001 15756563 17270546 16720372 9575882 12021965 11685700 18280292 12746050 12407540 12547725 10898224 9476886 8863223 10370017 16490937 10646786 7520565 15707848 12194112 16080930 10370016 10898222 12505043 11051153 11057544 15764645 15136996 17618886 7760232 10693666 11409163 9698600 15185205 11329586
MESH:D006561 Herpes Simplex resveratrol 3.9016876885
MESH:D006679 HIV Seropositivity Folic Acid 5.2117209195
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7615340226 16959395 8697196 16354765 18606429
MESH:D006930 Hyperalgesia Ethanol 3.5018783367
MESH:D006934 Hypercalcemia Furosemide 4.8217652376
MESH:D053565 Hypercalciuria Furosemide 5.3717652376
MESH:D006937 Hypercholesterolemia resveratrol 3.7617188708
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.2616395265 16865747 16397167 16433478 16755160
MESH:D006949 Hyperlipidemias resveratrol 3.7716873680
MESH:D006962 Hyperparathyroidism, Secondary Furosemide 5.5915086907
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8018850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Furosemide 5.0116612254
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0617488730
MESH:C537153 Hypomagnesemia primary Furosemide 5.3711041285
MESH:D007019 Hypoproteinemia Furosemide 5.5916096441
MESH:D007022 Hypotension Furosemide 4.3611041285
MESH:D007024 Hypotension, Orthostatic Furosemide 5.1315811171
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.5715869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.5717600658
MESH:D007249 Inflammation Mustard Gas 10.7911402378 8975870 11428647 17524151 9357497 11428620 11428631 9260866 16001271
MESH:D007249 Inflammation Progesterone 10.7915869954
MESH:D007249 Inflammation resveratrol 10.7916366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.7912878042 12200463
MESH:D007251 Influenza, Human resveratrol 4.2616624496
MESH:D007333 Insulin Resistance Sodium Selenite 3.1014714311
MESH:D007569 Jaw Abnormalities Ethanol 9.2915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.2916580747
MESH:D007674 Kidney Diseases Furosemide 3.6211041285
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.0216518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 6.6216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.6216705839
MESH:D007859 Learning Disorders Ethanol 3.9415451040
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 3.6612970779
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.4016087638
MESH:D017880 Limb Deformities, Congenital Ethanol 3.6217676605
MESH:D008103 Liver Cirrhosis EMD 527040 7.2918221819
MESH:D008103 Liver Cirrhosis Ethanol 7.2915289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.8218295389
MESH:D008106 Liver Cirrhosis, Experimental arginyl-glycyl-aspartic acid 3.6615547672
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.6618166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6612878042
MESH:D008107 Liver Diseases Folic Acid 2.9816877991
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.3817347304 17207112
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 6.817678174
MESH:D008113 Liver Neoplasms resveratrol 6.8119073162 19812893 19321006 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.8116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.162876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.1612151625
MESH:D008171 Lung Diseases Mustard Gas 7.3818161513 18702808
MESH:D008171 Lung Diseases nitrofen 7.3817245593 16863852 9614859 9859898
MESH:D008175 Lung Neoplasms Mustard Gas 2.323148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3219555203 11884234
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.2617718048
MESH:D016393 Lymphoma, B-Cell resveratrol 9.4217088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 9.4214737004
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6514749477
MESH:D008275 Magnesium Deficiency Magnesium 6.1717823441
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.9715688416
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.6717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 5.6711606380 8985016
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.4116832597
MESH:D008545 Melanoma resveratrol 2.3317992120
MESH:D008569 Memory Disorders Ethanol 3.9218411066 15451040
MESH:D008659 Metabolic Diseases resveratrol 4.1317112576
MESH:D008881 Migraine Disorders Magnesium 4.5718803445
MESH:D009101 Multiple Myeloma resveratrol 3.2716267019 17049120 17935668 16490592 14749477 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5917962980
MESH:D009203 Myocardial Infarction resveratrol 2.9117188708 17125593 16525036 17015251 16456233 16317513
MESH:D017202 Myocardial Ischemia resveratrol 8.2817125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.2812213967
MESH:D009205 Myocarditis resveratrol 4.4817322642
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.4118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.417678174 18551238
MESH:D009361 Neoplasm Invasiveness Leuprolide 5.7617143537
MESH:D009362 Neoplasm Metastasis quinoline 3.93598648
MESH:D009374 Neoplasms, Experimental resveratrol 3.738985016
MESH:D009397 Nephrocalcinosis Furosemide 5.5915086907
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.9514600291
MESH:D009436 Neural Tube Defects Folic Acid 3.7817438019
MESH:D009447 Neuroblastoma Topotecan 3.7115176712
MESH:D019636 Neurodegenerative Diseases resveratrol 3.5817652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.1417929310
MESH:D009503 Neutropenia Folic Acid 8.7416322990
MESH:D009503 Neutropenia Mustard Gas 8.747688884 16761898
MESH:D053206 Nocturnal Enuresis Furosemide 5.5917945291
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.0816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.0816049721
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.0017513867
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 4.9916211241
MESH:D010051 Ovarian Neoplasms Progesterone 4.9916525653 17393432
MESH:D010190 Pancreatic Neoplasms Ethanol 2.8712384795
MESH:D010212 Papilloma Hydrogen Peroxide 3.8212065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9612520081
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 5.2211550810
MESH:D011041 Poisoning Mustard Gas 3.5415727166
MESH:D011141 Polyuria Furosemide 5.3717945291
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2918163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 8.6616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.6611118676 11222880 11896295 11399792
MESH:D011471 Prostatic Neoplasms Cilengitide 2.3916729916
MESH:D011471 Prostatic Neoplasms Leuprolide 2.3917143537
MESH:D011471 Prostatic Neoplasms resveratrol 2.3917675339 15767336 17804756 17718901 17636462 16731767
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.3918760546
MESH:D011537 Pruritus Mustard Gas 3.8118058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8217720292 17894541 10334151 17266442 17620002
MESH:D051437 Renal Insufficiency Folic Acid 4.5115728788
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.3016325855
MESH:D015427 Reperfusion Injury marker/mechanism 16526316
MESH:D015427 Reperfusion Injury Furosemide 6.6716526316
MESH:D015427 Reperfusion Injury resveratrol 6.6716314181 16317513 17058453 15827377 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Furosemide 4.3612394941 15912074 16096441
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5718990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7618045962
MESH:D012559 Schizophrenia Folic Acid 2.8616641680
MESH:D012640 Seizures 2,4-dinitrotoluene 8.7818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.7818551238
MESH:D012640 Seizures Ethanol 8.789754883
MESH:D012871 Skin Diseases Folic Acid 5.0718709164
MESH:D012871 Skin Diseases Mustard Gas 5.0716961503 12880345 15451306
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 12.5112065085
MESH:D012878 Skin Neoplasms resveratrol 12.5115837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 12.518532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.5116192470
MESH:D013118 Spinal Cord Diseases Folic Acid 5.2116361298
MESH:D013119 Spinal Cord Injuries Progesterone 4.0016503802 15862959
MESH:D013274 Stomach Neoplasms marker/mechanism 17786296
MESH:D013274 Stomach Neoplasms Ethanol 3.5418456281
MESH:D013274 Stomach Neoplasms Folic Acid 3.5417171786
MESH:D013274 Stomach Neoplasms Furosemide 3.5417052386
MESH:D013276 Stomach Ulcer Ethanol 3.2911906479 9562338 16755016 17189318 17918041 9211565
MESH:D020521 Stroke Folic Acid 4.1116517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.2416321402
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.019754883
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.4312697716
MESH:D013959 Thyroid Diseases Thyroxine 11.4319910387
MESH:D014062 Tongue Neoplasms resveratrol 3.9716227395
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 4.6416049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.6416049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.0510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.0510091137
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.8617473185
MESH:D014594 Uterine Neoplasms resveratrol 3.8717044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3112125929
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.0317488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9615886252
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REACT:18266 Axon guidance
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04640 Hematopoietic cell lineage
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:04145 Phagosome
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05131 Shigellosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29941
    • No data
    No data
    Releated drug ID Related drug Name
    PA450952phospholipids
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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