AutismKB 2.0

Annotation Detail for ITGA9


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Basic Information Top
Gene Symbol:ITGA9 ( ALPHA-RLC,ITGA4L,RLC )
Gene Full Name: integrin, alpha 9
Band: 3p22.2
Quick LinksEntrez ID:3680; OMIM: 603963; Uniprot ID:ITA9_HUMAN; ENSEMBL ID: ENSG00000144668; HGNC ID: 6145
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa04810Regulation of actin cytoskeleton
hsa04514Cell adhesion molecules (CAMs)
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Axon guidance
Integrin cell surface interactions
No data
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500004Integrin cell surface interactions
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
nasopharyngeal carcinoma
Desease Name
Nasopharyngeal carcinoma
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ITGA9 mRNAaffects expression 17562736
D002945 Cisplatin Cisplatin results in increased expression of ITGA9 mRNAincreases expression 12066199
D010656 Phenylephrine Phenylephrine results in increased expression of ITGA9 mRNAincreases expression 18158353
D013629 Tamoxifen Tamoxifen results in decreased expression of ITGA9 mRNAdecreases expression 17555576
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.2714745880
MESH:D058186 Acute Kidney Injury Cisplatin 4.3815814532 17670903 12690470
MESH:D000230 Adenocarcinoma Cisplatin 2.8311798837 17638652
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.5117460149
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.6114601052
MESH:D001919 Bradycardia Phenylephrine 5.1715306635
MESH:D001943 Breast Neoplasms Cisplatin 2.3319526202 18382427
MESH:D001943 Breast Neoplasms Tamoxifen 2.3318425577 19011961 19289846 15668708 19288272 20544844 19059307 19115204 20859285 19155303 19410462 16202921 19487384 19221464 17049068 20135344 16873071 19142967 21138602 19189212 20390343 11161223 19244106 18351453 16273361 17893378 17440819 15565566 19103187 19189210 19200415 18855134 21152245 18815881 17261762 19084267 18984771 18629630 18997820 19066611 16818667 20005174 18821012 17242785 20065188
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 5.0719066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.883084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.8817982673
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.8816924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1416685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.9118337622 17066447 6189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 4.0117572228
MESH:D006332 Cardiomegaly Phenylephrine 3.7211179087 15728586 16170337 17124262 11754973 17287366
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D003711 Demyelinating Diseases Tamoxifen 4.9219031437
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.8419279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6719164858 11421492 10774834 11287661 11743745 15968718 14550746 19085960 11739529 17906064 2444490 16227642 12153990 17522070 12540782 11461765 18713872 19416960 16393943 12958197 11529661 11834606 17562736 14986274 19370779 16177239 12594235 18071297 16485898 16081117 19923254 12705907 10663392 16109766 12392966 14725611 19420014 10915739 16781746 19739265 15619225
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004362 Drug Toxicity Cisplatin 4.1512231392 12649298 15033597 19839026
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 4.0419031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.2916202921 17893378 19155303 20544844
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8517638652 15464296 16481741 15173087 16785472
MESH:D005234 Fatty Liver Tamoxifen 3.5919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4516709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.8119069698
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.9715102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.6719898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.7715464296
MESH:D006689 Hodgkin Disease Cisplatin 3.9616200630 16170182
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D006973 Hypertension Phenylephrine 3.1912717712 8949925
MESH:D006984 Hypertrophy Phenylephrine 4.9812791704 18502941
MESH:D007249 Inflammation Tamoxifen 2.5319457130
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.8615464296
MESH:D007674 Kidney Diseases Acetaminophen 6.8115629191 12587719
MESH:D007674 Kidney Diseases Cisplatin 6.8112231392 12649298 19839026 15190930 18289764
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3818625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.5211231351
MESH:D008064 Lipidoses Tamoxifen 3.4317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 1.7518564211
MESH:D008107 Liver Diseases Acetaminophen 1.7016611625 12969438 11587558 19460945 19014921 19784758 12587719 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms Tamoxifen 2.3316684651
MESH:D008175 Lung Neoplasms Cisplatin 2.7411798837 17225452 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 2.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.8616827153 19196722 19196723 11731420 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 5.2719453300
MESH:D008545 Melanoma Cisplatin 3.6512883367 17023156 18176117 15577323 18332650 16432458 12393984 17761969 11135225 16809738 12374674 18505091 16248763
MESH:D008545 Melanoma Tamoxifen 3.6519393235 12393984
MESH:D018328 Melanoma, Amelanotic Cisplatin 13.7115990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 13.7115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D008654 Mesothelioma Cisplatin 3.3717638057
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6719393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6119410462
MESH:D009369 Neoplasms Cisplatin 3.1016773208
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.7219196722 19200415 19189210
MESH:D009395 Nephritis, Interstitial Cisplatin 5.2115464296
MESH:D009447 Neuroblastoma Cisplatin 3.628761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.338761367
MESH:D010051 Ovarian Neoplasms Cisplatin 2.9719769630 6897625 17225452 15464296
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.1019003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.8115464296
MESH:D010997 Pleural Neoplasms Cisplatin 6.0717638057
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.0915067354
MESH:D051437 Renal Insufficiency Cisplatin 4.9715464296
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.9314601052
MESH:D012852 Sinusitis Phenylephrine 5.337327846
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 6.0715464296
MESH:D013088 Spermatocele Tamoxifen 5.0216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.6719457130
MESH:D013274 Stomach Neoplasms Cisplatin 2.3317522103 15958060 18396642
MESH:D013736 Testicular Neoplasms Cisplatin 5.0917225452 15464296
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.7015464296 17225452 12973940
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.7016712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.6016803524
MESH:D014625 Vaginal Neoplasms Cisplatin 5.1715577323
MESH:D014839 Vomiting Cisplatin 5.4411897121
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REACT:18266 Axon guidance
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29945
    • No data
    Releated disease ID Related disease Name
    PA443560Breast Neoplasms
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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