AutismKB 2.0

Annotation Detail for ITGAL


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Basic Information Top
Gene Symbol:ITGAL ( CD11A,LFA-1,LFA1A )
Gene Full Name: integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Band: 16p11.2
Quick LinksEntrez ID:3683; OMIM: 153370; Uniprot ID:ITAL_HUMAN; ENSEMBL ID: ENSG00000005844; HGNC ID: 6148
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04650Natural killer cell mediated cytotoxicity
hsa05416Viral myocarditis
hsa05144Malaria
hsa05150Staphylococcus aureus infection
hsa04810Regulation of actin cytoskeleton
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Hemostasis
Signaling in Immune system
Integrin cell surface interactions
Pathway IDPathway Name
200150CXCR3-mediated signaling events
200117Paxillin-dependent events mediated by a4b1
Pathway IDPathway Name
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1767Immunologic deficiency syndrome
1804Chronic obstructive airway disease
1850Herpes
1894Abortion
1909Migraine
1918Atherosclerosis
1964Primary biliary cirrhosis
1986Eating disorder
1998Enteritis
2029Tuberculosis
2051Leukemia
2094Ulcerative colitis
2125Bladder cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C001079 2-(2,6-dioxopiperidin-3-yl)phthalimidine 2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGAL proteindecreases expression 8538367
D000584 Amiloride Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]decreases reaction|increases expression 10198263
D000584 Amiloride Amiloride inhibits the reaction [TNF protein results in increased expression of ITGAL protein]decreases reaction|increases expression 10198263
D015081 2-Naphthylamine 2-Naphthylamine results in decreased expression of ITGAL mRNAdecreases expression 18247414
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ITGAL mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of ITGAL mRNAdecreases expression 18191166
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ITGAL mRNAdecreases expression 18247414
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of ITGAL mRNAdecreases expression 12419474
D002392 Catechin Catechin results in increased expression of ITGAL mRNAincreases expression 15465739
D017308 Etodolac Etodolac results in decreased expression of ITGAL proteindecreases expression 16046235
D005419 Flavonoids Flavonoids results in increased expression of ITGAL mRNAincreases expression 15465739
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ITGAL mRNAdecreases expression 12419474
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ITGAL mRNAincreases expression 10198263
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ITGAL proteinincreases expression 10198263
D008070 Lipopolysaccharides Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL mRNA]decreases reaction|increases expression 10198263
D008070 Lipopolysaccharides Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL protein]decreases reaction|increases expression 10198263
D009538 Nicotine Nicotine results in decreased expression of ITGAL mRNAdecreases expression 18247414
D010654 Phenylbutyrates Phenylbutyrates promotes the reaction [Tretinoin results in increased expression of ITGAL protein]increases expression|increases reaction 18055984
D010936 Plant Extracts Plant Extracts results in increased expression of ITGAL mRNAincreases expression 15465739
C025299 polyphenols polyphenols results in increased expression of ITGAL mRNAincreases expression 15465739
C059514 resveratrol resveratrol inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in decreased expression of ITGAL mRNA]affects cotreatment|decreases expression|decreases reaction 16267019
D019311 Staurosporine Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL mRNA]decreases reaction|increases expression 10198263
D019311 Staurosporine Staurosporine inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAL protein]decreases reaction|increases expression 10198263
D019311 Staurosporine Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL mRNA]decreases reaction|increases expression 10198263
D019311 Staurosporine Staurosporine inhibits the reaction [TNF protein results in increased expression of ITGAL protein]decreases reaction|increases expression 10198263
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITGAL mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased activity of ITGALdecreases activity 17201180
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ITGALdecreases expression 17201180
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ITGAL proteindecreases expression 15310856
D014212 Tretinoin CSF3 protein promotes the reaction [Tretinoin results in increased expression of ITGAL protein]increases expression|increases reaction 18055984
D014212 Tretinoin Phenylbutyrates promotes the reaction [Tretinoin results in increased expression of ITGAL protein]increases expression|increases reaction 18055984
D014212 Tretinoin Tretinoin results in increased expression of ITGAL proteinincreases expression 18055984
C025643 vinclozolin vinclozolin affects the expression of ITGAL mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-(2,6-dioxopiperidin-3-yl)phthalimidine 8.74473085 3196154 6734493 3355362
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.7414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.4518287403
MESH:D058186 Acute Kidney Injury resveratrol 3.7516538975
MESH:D055371 Acute Lung Injury Lipopolysaccharides 3.9311850527 18653653
MESH:D000230 Adenocarcinoma 2-(2,6-dioxopiperidin-3-yl)phthalimidine 5.061933837
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 5.0620127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 6.596695378
MESH:D000236 Adenoma resveratrol 6.5915688382
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2716835633
OMIM:607154 ALLERGIC RHINITIS Etodolac 5.7116979129
MESH:D000505 Alopecia Tretinoin 3.5315955085
MESH:D000544 Alzheimer Disease Nicotine 6.7516627626
MESH:D000544 Alzheimer Disease Plant Extracts 6.7516962711
MESH:D000544 Alzheimer Disease resveratrol 6.7516183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.5519015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9619183758
MESH:D001169 Arthritis, Experimental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 17.149598899
MESH:D001169 Arthritis, Experimental Plant Extracts 17.1414686799
MESH:D001169 Arthritis, Experimental resveratrol 17.1417115116
MESH:D001169 Arthritis, Experimental Tretinoin 17.1416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Tretinoin 2.3116456186
MESH:D050197 Atherosclerosis resveratrol 3.2117967414 16873680
MESH:D001471 Barrett Esophagus Tretinoin 4.2916935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6915340226
MESH:D001848 Bone Diseases, Developmental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 8.583355362
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 8.5815746008
MESH:D002545 Brain Ischemia Plant Extracts 10.1116041641
MESH:D002545 Brain Ischemia resveratrol 10.1117600658
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9320146248 17474063
MESH:D001943 Breast Neoplasms resveratrol 1.9317651959 16393696 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9316873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4816813970
MESH:D002057 Burns, Chemical Plant Extracts 5.239625245
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7116835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0516168501
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 4.6918834353
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.6919321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 4.691917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.4816675471
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.3720419170
MESH:D002294 Carcinoma, Squamous Cell resveratrol 7.3716227395
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.3716096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Amiloride 4.9814644129
MESH:D006332 Cardiomegaly Plant Extracts 6.7817645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.7818850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 7.3416936243
MESH:D002318 Cardiovascular Diseases resveratrol 7.3415458977
MESH:D002386 Cataract Tretinoin 3.0317460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0716835633
MESH:D002822 Choriocarcinoma Tretinoin 5.0516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6116354765 8697196 12621046 15340226 15668235
MESH:D002972 Cleft Palate Tretinoin 5.619407595
MESH:D003092 Colitis Amiloride 15.5912065299
MESH:D003092 Colitis resveratrol 15.5916474422
MESH:D003092 Colitis Tretinoin 15.5917035595
MESH:D003110 Colonic Neoplasms 2-(2,6-dioxopiperidin-3-yl)phthalimidine 10.981933837
MESH:D003110 Colonic Neoplasms arsenite 10.9815037631
MESH:D003110 Colonic Neoplasms Etodolac 10.9816004971
MESH:D003110 Colonic Neoplasms polyphenols 10.9816293270
MESH:D003110 Colonic Neoplasms resveratrol 10.9816338953
MESH:D015179 Colorectal Neoplasms Etodolac 3.2911076880
MESH:D015179 Colorectal Neoplasms resveratrol 3.2916550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9617141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.6816507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4115322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.419211117 16925845 9664655 17551590 9224671 10589399 9142499 8800419 9125849 14991402
MESH:D003456 Cryptorchidism vinclozolin 4.2314966744
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.6816873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 9.0719706694
MESH:D003928 Diabetic Nephropathies resveratrol 9.0716286809
MESH:D056486 Drug-Induced Liver Injury polyphenols 3.8819370779
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8820420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6811462148
MESH:D020821 Dystonic Disorders Nicotine 5.8217881519
MESH:D004480 Ectromelia 2-(2,6-dioxopiperidin-3-yl)phthalimidine 6.947940403
MESH:D004487 Edema Plant Extracts 15.7312787963
MESH:D004487 Edema resveratrol 15.738985016
MESH:D004487 Edema Staurosporine 15.738273558
MESH:D004487 Edema Tetrachlorodibenzodioxin 15.7312711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5915322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.5918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 3.9217872969
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0416569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.929294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.5815268973
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2915328337 17637181 15821434
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.7417923197
MESH:D004827 Epilepsy Plant Extracts 3.6719700373 19439326
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5611564622
MESH:D005124 Eye Abnormalities Tretinoin 8.5616938888 9664655
MESH:D005234 Fatty Liver arsenite 8.0518296743
MESH:D005234 Fatty Liver Plant Extracts 8.0515975614
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3511858732
MESH:D005334 Fever Lipopolysaccharides 3.9111852909 9205823
MESH:D005355 Fibrosis arsenite 14.2118296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.2120067830
MESH:D005355 Fibrosis Tretinoin 14.2117994277
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8316973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1916417039
MESH:D005909 Glioblastoma Tretinoin 2.9317312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4910696789
MESH:D006130 Growth Disorders Amiloride 4.6819703807
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.7620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.7610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.7614991402 9664655
MESH:D006333 Heart Failure Plant Extracts 3.8018097624
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2816366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2311000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.7812621046 16120746 15340226
MESH:D006561 Herpes Simplex Plant Extracts 9.7610715843
MESH:D006561 Herpes Simplex resveratrol 9.7616876885
MESH:D015658 HIV Infections Plant Extracts 3.6212878215
MESH:D019584 Hot Flashes Plant Extracts 4.6414716179 16566672 17454163
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9416959395 8697196 18606429 15340226 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.1216870215
MESH:D006937 Hypercholesterolemia resveratrol 3.9017188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4616778211
MESH:D020138 Hyperhomocysteinemia Catechin 9.6117292331
MESH:D020138 Hyperhomocysteinemia Plant Extracts 9.6116484555
MESH:D006949 Hyperlipidemias Plant Extracts 9.2615268973 15975614
MESH:D006949 Hyperlipidemias resveratrol 9.2616873680
MESH:D006973 Hypertension Amiloride 5.4618524855 19344079 15174897
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4618670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.2017488730
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 5.7419822448
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.5417600658
MESH:D007248 Infertility, Male vinclozolin 2.9716467254
MESH:D007249 Inflammation Amiloride 23.4117237260
MESH:D007249 Inflammation Flavonoids 23.4117296493
MESH:D007249 Inflammation Lipopolysaccharides 23.4117963957 12878042 9205823 17237260 17255318
MESH:D007249 Inflammation Plant Extracts 23.4112787963 19332304 15997105 16366677
MESH:D007249 Inflammation polyphenols 23.4116366677
MESH:D007249 Inflammation resveratrol 23.4116366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 23.4112200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.4416624496
MESH:D007410 Intestinal Diseases Tretinoin 3.6617994277
MESH:D007414 Intestinal Neoplasms Plant Extracts 4.5212351151 12584176 12628509
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.5317255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5916580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5915992940 17551590
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.1716518626
MESH:D007938 Leukemia Tretinoin 2.7217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6016482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0619850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute marker/mechanism 16764927
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 7.5316087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.5317339181 16766008 9834237 17368321 17294898 16140955 17361223 17217047 16891316 17506722 17649720 12679006 17712046 19029980 19642359 15748426 16788101 19225113 16823087 16331271 19075265 16935935 19035177 17301526 17107899
MESH:D007970 Leukopenia Lipopolysaccharides 4.5915821434
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6216417039
MESH:D056929 Liddle Syndrome Amiloride 5.8619344079
MESH:D017880 Limb Deformities, Congenital 2-(2,6-dioxopiperidin-3-yl)phthalimidine 8.693355362 6734493
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.699224671
MESH:D008103 Liver Cirrhosis arsenite 6.9718296743
MESH:D008103 Liver Cirrhosis Plant Extracts 6.9717157831
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 4.9012878042
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 4.9015479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.9018397230 16248980
MESH:D008107 Liver Diseases Plant Extracts 4.5717034775
MESH:D008107 Liver Diseases polyphenols 4.5716698588
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 10.4120195826 21137059
MESH:D008113 Liver Neoplasms Plant Extracts 10.4119168119
MESH:D008113 Liver Neoplasms resveratrol 10.4119812893 19321006 20405173 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.4116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0412151625
MESH:D055370 Lung Injury Lipopolysaccharides 3.9021114838
MESH:D008175 Lung Neoplasms arsenite 4.7916809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7920869020 17053015 18569708 18520028 20464547 20135361 18816296 20064080 6695378
MESH:D008175 Lung Neoplasms Plant Extracts 4.7920869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7919555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 4.1917088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.7814749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.1415688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.048985016 11606380
MESH:D008527 Medulloblastoma Tretinoin 2.7417453147
MESH:D008545 Melanoma resveratrol 3.4017992120
MESH:D008545 Melanoma Tretinoin 3.4016752155
MESH:D008591 Meningomyelocele Tretinoin 4.3216940565
MESH:D008659 Metabolic Diseases resveratrol 4.2717112576
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1016381670
MESH:D009101 Multiple Myeloma resveratrol 3.3916490592 17935668 17049120 16267019 14749477 17164350
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.7617962980
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0217596541
MESH:D009203 Myocardial Infarction resveratrol 2.9817188708 17125593 16525036 16456233 16317513 17015251
MESH:D017202 Myocardial Ischemia resveratrol 8.7217015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.7212213967
MESH:D009205 Myocarditis resveratrol 4.6517322642
MESH:D009361 Neoplasm Invasiveness Amiloride 5.1914644129
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0911141357
MESH:D009369 Neoplasms Nicotine 8.0916365874
MESH:D009369 Neoplasms Tretinoin 8.0916594593 16946489
MESH:D009374 Neoplasms, Experimental resveratrol 3.898985016
MESH:D009389 Neovascularization, Pathologic arsenite 10.2515738583
MESH:D009389 Neovascularization, Pathologic Nicotine 10.2516365874
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.1514600291
MESH:D009421 Nervous System Malformations Tretinoin 9.159125849
MESH:D009436 Neural Tube Defects Tretinoin 2.989142499
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.0717168769
MESH:D019636 Neurodegenerative Diseases resveratrol 3.7217652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.2917929310
MESH:D009765 Obesity Plant Extracts 3.1220132043 19056576
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.1517513867
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3116936753
MESH:D010146 Pain Tretinoin 2.8116870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4215976015
MESH:D010212 Papilloma Hydrogen Peroxide 9.3212065085
MESH:D010212 Papilloma Plant Extracts 9.3216517061 15173996
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1412520081
MESH:D011014 Pneumonia Lipopolysaccharides 4.4511605937 12224865
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4518163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 15.6616679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.6611222880 11896295 11399792 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 15.6618042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.8318220299
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7417292933
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.7417804756 14666653
MESH:D011471 Prostatic Neoplasms resveratrol 2.7417804756 16731767 17636462 17718901 17675339 15767336
MESH:D011472 Prostatitis vinclozolin 4.8318629315
MESH:D011507 Proteinuria Tretinoin 3.5016636307
MESH:D011625 Pterygium Tretinoin 4.6816723453
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.4816325855
MESH:D015427 Reperfusion Injury resveratrol 3.2216314181 17520802 17058453 16317513 15827377
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6610835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9916283617 16116481
MESH:D012640 Seizures Nicotine 3.7217873105
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 26.4419755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 26.4412065085
MESH:D012878 Skin Neoplasms Plant Extracts 26.4415173996 16517061
MESH:D012878 Skin Neoplasms resveratrol 26.4415837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 26.448532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 26.4416192470
MESH:D012878 Skin Neoplasms Tretinoin 26.4416467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.3220155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 2.3217261132
MESH:D013276 Stomach Ulcer Plant Extracts 3.8017135157 12787963 18193104 15255614 18237397
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.3816321402
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 12.9217997062
MESH:D013705 Temporomandibular Joint Disorders polyphenols 12.9217997062
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0715821434
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8012697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9416026305 17045167
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.6516720336 11259349 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 5.3415735609 18305452 17979512 18041664
MESH:D014062 Tongue Neoplasms resveratrol 9.5816227395
MESH:D014062 Tongue Neoplasms Tretinoin 9.5816051514
MESH:D014376 Tuberculosis Tretinoin 3.1616040207
MESH:D001749 Urinary Bladder Neoplasms 2-Naphthylamine 5.3611144890
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.3617053015
MESH:D002583 Uterine Cervical Neoplasms resveratrol 9.2117473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.2116129372
MESH:D014594 Uterine Neoplasms resveratrol 4.0317044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.5016752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4912125929
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 10.1718097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 10.1717488730
MESH:D020257 Ventricular Remodeling Plant Extracts 5.2118097624
MESH:D014820 Vitiligo Tretinoin 3.9516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1415886252
MESH:D009396 Wilms Tumor Tretinoin 3.8716287080
MESH:D014947 Wounds and Injuries Plant Extracts 4.1620213670 19894650
Pathway ID Pathway Name
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
KEGG:04670 Leukocyte transendothelial migration
KEGG:05144 Malaria
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05323 Rheumatoid arthritis
REACT:6900 Signaling in Immune system
KEGG:05150 Staphylococcus aureus infection
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29948
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450952phospholipids
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00095 antibody Efalizumab Immunomodulatory Agents;Immunosuppressive Agents
    DB00098 - Antithymocyte globulin Immunomodulatory Agents
    DB00227 other/unknown Lovastatin Antineoplastic Agents;Anticholesteremic Agents;HMG-CoA Reductase Inhibitors;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    DB02177 - 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine
    DB03932 - LFA703
    DB04724 - (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE
    DB06972 - 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile
    DB07486 - 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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