AutismKB 2.0

Annotation Detail for ITGAM


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Basic Information Top
Gene Symbol:ITGAM ( CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6 )
Gene Full Name: integrin, alpha M (complement component 3 receptor 3 subunit)
Band: 16p11.2
Quick LinksEntrez ID:3684; OMIM: 120980; Uniprot ID:ITAM_HUMAN; ENSEMBL ID: ENSG00000169896; HGNC ID: 6149
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04640Hematopoietic cell lineage
hsa04145Phagosome
hsa05140Leishmaniasis
hsa05146Amoebiasis
hsa05150Staphylococcus aureus infection
hsa04810Regulation of actin cytoskeleton
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Hemostasis
Integrin cell surface interactions
Pathway IDPathway Name
200108amb2 Integrin signaling
Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1706Thrombophilia
1712Yersinia infection
1740Alzheimer's disease
1770Melanoma
1804Chronic obstructive airway disease
1902Kidney failure
1904Diabetes mellitus
1929Pertussis
2051Leukemia
2111Systemic infection
2146Lupus erythematosus
Desease Name
Lupus Erythematosus, Systemic
systemic lupus erythematosus
nephritis
IMMUNE
Desease Name
Systemic lupus erythematosus
Desease Name
Systemic lupus erythematous, association with susceptibility to, 6
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C120227 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Tretinoin results in increased expression of ITGAM protein]decreases reaction|increases expression 17077328
C490707 2-(4-isobutylphenyl)propionylmethanesulfonamide 2-(4-isobutylphenyl)propionylmethanesulfonamide inhibits the reaction [IL8 protein results in increased expression of ITGAM protein]decreases reaction|increases expression 15652230
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]decreases reaction|increases expression 11980903
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased expression of ITGAM protein]decreases reaction|increases expression 16617325
C002010 4-(2-aminoethyl)benzenesulfonylfluoride 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein]decreases reaction|increases localization 10739673
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]decreases reaction|increases expression 11980903
C090942 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Indomethacin results in increased expression of ITGAM protein]decreases reaction|increases expression 11980903
D000082 Acetaminophen Acetaminophen affects the expression of ITGAM mRNAaffects expression 17562736
C056165 acetovanillone acetovanillone inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]decreases reaction|increases expression 16357311
C103303 alitretinoin Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 15964820
C103303 alitretinoin Vitamin D promotes the reaction [alitretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 15964820
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ITGAM mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of ITGAM mRNAdecreases expression 19654921
C058317 arsenic disulfide arsenic disulfide results in increased expression of ITGAM proteinincreases expression 19996592
C058317 arsenic disulfide Hydrogen Peroxide promotes the reaction [arsenic disulfide results in increased expression of ITGAM protein]increases expression|increases reaction 19996592
C006632 arsenic trioxide arsenic trioxide results in increased expression of ITGAM mRNAincreases expression 16468075
C006632 arsenic trioxide arsenic trioxide results in increased expression of ITGAM proteinincreases expression 16430862
C006632 arsenic trioxide [Tretinoin co-treated with arsenic trioxide] results in increased expression of ITGAM mRNAaffects cotreatment|increases expression 16468075
C055494 caffeic acid phenethyl ester caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 16766008
C055494 caffeic acid phenethyl ester caffeic acid phenethyl ester results in increased expression of ITGAM proteinincreases expression 16766008
C014347 decitabine decitabine affects the expression of ITGAM mRNAaffects expression 18460780
D004041 Dietary Fats Dietary Fats results in decreased expression of ITGAM mRNAdecreases expression 18042831
D002117 Calcitriol Calcitriol results in increased expression of ITGAM proteinincreases expression 14729647
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 15964820
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide results in increased expression of ITGAM proteinincreases expression 16617325
C007517 diphenyleneiodonium diphenyleneiodonium inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]decreases reaction|increases expression 16357311
D005230 Fatty Acids, Nonesterified acetovanillone inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]decreases reaction|increases expression 16357311
D005230 Fatty Acids, Nonesterified diphenyleneiodonium inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]decreases reaction|increases expression 16357311
D005230 Fatty Acids, Nonesterified Fatty Acids, Nonesterified results in increased expression of ITGAM mRNAincreases expression 16357311
D005230 Fatty Acids, Nonesterified Glutathione inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]decreases reaction|increases expression 16357311
D005419 Flavonoids Flavonoids results in decreased expression of ITGAM mRNAdecreases expression 18035473
D009240 N-Formylmethionine Leucyl-Phenylalanine N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM proteinincreases expression 10215738
15774851
11116075
D009240 N-Formylmethionine Leucyl-Phenylalanine plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]decreases reaction|increases expression 10215738
D009240 N-Formylmethionine Leucyl-Phenylalanine SR 27417 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]decreases reaction|increases expression 11116075
D005978 Glutathione Glutathione inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA]decreases reaction|increases expression 16357311
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of ITGAM mRNAaffects cotreatment|decreases expression 17183730
D006861 Hydrogen Peroxide Hydrogen Peroxide promotes the reaction [arsenic disulfide results in increased expression of ITGAM protein]increases expression|increases reaction 19996592
D019796 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of ITGAM proteinincreases expression 11116075
D019796 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid ICI 192605 inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of ITGAM protein]decreases reaction|increases expression 11116075
C057498 ICI 192605 ICI 192605 inhibits the reaction [15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid results in increased expression of ITGAM protein]decreases reaction|increases expression 11116075
D007213 Indomethacin 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Indomethacin results in increased expression of ITGAM protein]decreases reaction|increases expression 11980903
D007213 Indomethacin Indomethacin results in increased expression of ITGAM proteinincreases expression 11980903
D007213 Indomethacin Indomethacin results in increased expression of [ITGAM protein binds to ITGB2 protein]affects binding|increases expression 10761979
D007501 Iron Iron deficiency results in increased expression of ITGAM mRNAincreases expression 20368581
D007501 Iron Iron deficiency results in increased expression of ITGAM proteinincreases expression 20368581
D007501 Iron Vitamin D promotes the reaction [Iron deficiency results in increased expression of ITGAM protein]increases expression|increases reaction 20368581
C063302 KN 62 KN 62 results in increased expression of ITGAM proteinincreases expression 17431504
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ITGAM proteinincreases expression 12734376
D008070 Lipopolysaccharides ITGAM protein affects the reaction [Lipopolysaccharides affects the localization of and results in increased activity of [NFKB1 protein binds to RELA protein]]affects binding|affects localization|affects reaction|increases activity 11123339
D008070 Lipopolysaccharides ITGAM protein affects the reaction [Lipopolysaccharides results in increased expression of IL12A mRNA]affects reaction|increases expression 11123339
D008070 Lipopolysaccharides ITGAM protein affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]affects reaction|increases expression 11123339
D008070 Lipopolysaccharides ITGAM protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 11123339
D008070 Lipopolysaccharides ITGAM protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 11123339
D008070 Lipopolysaccharides ITGAM protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]affects reaction|increases phosphorylation 11123339
D008070 Lipopolysaccharides ITGAM protein affects the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]affects binding|affects reaction|increases secretion 11123339
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ITGAM proteinincreases expression 8566054
15328337
D008070 Lipopolysaccharides tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]decreases reaction|increases expression 8566054
D008070 Lipopolysaccharides zileuton inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]decreases reaction|increases expression 15328337
D015058 1-Naphthylisothiocyanate 1-Naphthylisothiocyanate results in increased expression of ITGAM mRNAincreases expression 12832660
C056709 N,N-diacetylcystine N,N-diacetylcystine results in decreased expression of ITGAM proteindecreases expression 17157857
D010126 Ozone Ozone results in increased expression of ITGAM proteinincreases expression 15036748
D017239 Paclitaxel ITGAM protein affects the reaction [Paclitaxel affects the localization of and results in increased activity of [NFKB1 protein binds to RELA protein]]affects binding|affects localization|affects reaction|increases activity 11123339
D017239 Paclitaxel ITGAM protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]affects reaction|increases expression 11123339
D017239 Paclitaxel ITGAM protein affects the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]affects reaction|increases expression 11123339
D017239 Paclitaxel ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 11123339
D017239 Paclitaxel ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 11123339
D017239 Paclitaxel ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK8 protein]affects reaction|increases phosphorylation 11123339
D017239 Paclitaxel ITGAM protein affects the reaction [Paclitaxel results in increased secretion of [IL12A protein binds to IL12B protein]]affects binding|affects reaction|increases secretion 11123339
C041786 palm oil palm oil results in decreased expression of ITGAM mRNAdecreases expression 18042831
C093973 PD 98059 PD 98059 inhibits the reaction [Tretinoin results in increased expression of ITGAM protein]decreases reaction|increases expression 16617325
D010634 Phenobarbital Phenobarbital results in increased expression of ITGAM mRNAincreases expression 12832660
D010972 Platelet Activating Factor Platelet Activating Factor results in increased expression of ITGAM proteinincreases expression 11116075
D010972 Platelet Activating Factor SR 27417 inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]decreases reaction|increases expression 11116075
C047686 plaunotol plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]decreases reaction|increases expression 10215738
C071317 SR 27417 SR 27417 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]decreases reaction|increases expression 11116075
C071317 SR 27417 SR 27417 inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]decreases reaction|increases expression 11116075
D013619 Tacrine Tacrine results in increased expression of ITGAM mRNAincreases expression 12832660
C021751 tanshinone tanshinone results in increased expression of ITGAM proteinincreases expression 16009009
C073135 tepoxalin tepoxalin inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]decreases reaction|increases expression 8566054
D013755 Tetradecanoylphorbol Acetate 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein]decreases reaction|increases localization 10739673
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of ITGAM proteinincreases expression 16430862
16617325
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased localization of ITGAM proteinincreases localization 10739673
D013755 Tetradecanoylphorbol Acetate Tosyllysine Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein]decreases reaction|increases localization 10739673
D013755 Tetradecanoylphorbol Acetate Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein]decreases reaction|increases localization 10739673
D014107 Tosyllysine Chloromethyl Ketone Tosyllysine Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein]decreases reaction|increases localization 10739673
D014108 Tosylphenylalanyl Chloromethyl Ketone Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of ITGAM protein]decreases reaction|increases localization 10739673
D014212 Tretinoin 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Tretinoin results in increased expression of ITGAM protein]decreases reaction|increases expression 17077328
D014212 Tretinoin 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased expression of ITGAM protein]decreases reaction|increases expression 16617325
D014212 Tretinoin AKT1 protein promotes the reaction [Tretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 16617325
D014212 Tretinoin caffeic acid phenethyl ester promotes the reaction [Tretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 16766008
D014212 Tretinoin CSF3 protein promotes the reaction [Tretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 18055984
D014212 Tretinoin ICAM1 protein promotes the reaction [Tretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 18055984
D014212 Tretinoin PD 98059 inhibits the reaction [Tretinoin results in increased expression of ITGAM protein]decreases reaction|increases expression 16617325
D014212 Tretinoin PTK2 protein inhibits the reaction [Tretinoin results in increased expression of ITGAM protein]decreases reaction|increases expression 16226872
D014212 Tretinoin TGFB1 protein promotes the reaction [Tretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 16242776
D014212 Tretinoin [Tretinoin co-treated with arsenic trioxide] results in increased expression of ITGAM mRNAaffects cotreatment|increases expression 16468075
D014212 Tretinoin Tretinoin results in increased expression of ITGAM mRNAincreases expression 16322068
15988048
15770638
16468075
D014212 Tretinoin Tretinoin results in increased expression of ITGAM proteinincreases expression 18055984
16226872
16764927
17431504
16766008
16430862
17077328
16510162
15770638
16617325
15194426
D014415 Tunicamycin Tunicamycin results in increased expression of ITGAM mRNAincreases expression 17127020
C113580 U 0126 U 0126 inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]decreases reaction|increases expression 11980903
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of ITGAM mRNAaffects cotreatment|decreases expression 17183730
C025643 vinclozolin vinclozolin results in increased expression of ITGAM mRNAincreases expression 18629315
D014807 Vitamin D Vitamin D promotes the reaction [alitretinoin results in increased expression of ITGAM protein]increases expression|increases reaction 15964820
D014807 Vitamin D Vitamin D promotes the reaction [Iron deficiency results in increased expression of ITGAM protein]increases expression|increases reaction 20368581
D014807 Vitamin D Vitamin D results in increased expression of ITGAM mRNAincreases expression 20368581
D002762 Cholecalciferol [Cholecalciferol co-treated with TGFB1 protein] results in increased expression of ITGAM mRNAaffects cotreatment|increases expression 15988048
C063449 zileuton zileuton inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]decreases reaction|increases expression 15328337
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 6.676195326
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 6.678875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.4219490988
MESH:D000138 Acidosis Ammonium Chloride 3.0018287403
MESH:D000152 Acne Vulgaris zileuton 5.1920436887
MESH:D000168 Acrocephalosyndactylia U 0126 4.9317694057
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.0011850527 18653653
MESH:D055371 Acute Lung Injury zileuton 8.0017118201
MESH:D000230 Adenocarcinoma arsenic trioxide 4.0611798837 19825857
MESH:D000230 Adenocarcinoma Indomethacin 4.0616537180
MESH:D000236 Adenoma Indomethacin 3.1111497255
MESH:D018248 Adenoma, Liver Cell Phenobarbital 3.4117620307
MESH:D018246 Adrenocortical Adenoma Arsenic 4.6417306315
MESH:D000505 Alopecia Tretinoin 3.1615955085
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.0816640825
MESH:D016301 Alveolar Bone Loss Indomethacin 4.7917225004
MESH:D000544 Alzheimer Disease Indomethacin 8.1917627676 15579461
MESH:D000544 Alzheimer Disease Iron 8.1916563566 16640825
MESH:D000544 Alzheimer Disease Ozone 8.1915513908
MESH:D000544 Alzheimer Disease Tacrine 8.1912725862
MESH:D000550 Amblyopia Valproic Acid 4.6617688650
MESH:D000740 Anemia Iron 3.8816434484 16566752
MESH:D018798 Anemia, Iron-Deficiency Iron 4.1517375513 16569441 17163184 17162259 17147795
MESH:D000756 Anemia, Sideroblastic Iron 4.3016910769
MESH:D000799 Angioedema Acetaminophen 3.2710982225
MESH:D001008 Anxiety Disorders Valproic Acid 7.3517497229
MESH:D001008 Anxiety Disorders vinclozolin 7.3519015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.3110231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.3210388637
MESH:D001145 Arrhythmias, Cardiac Iron 3.8816604332
MESH:D020261 Arsenic Poisoning Arsenic 2.6816835338 12569548 16251483 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 3.3415238619
MESH:D018771 Arthralgia Indomethacin 4.592160914
MESH:D001169 Arthritis, Experimental Tosylphenylalanyl Chloromethyl Ketone 6.7618706406
MESH:D001169 Arthritis, Experimental Tretinoin 6.7616412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 6.4711248219
MESH:D001172 Arthritis, Rheumatoid Ozone 6.4715570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.4716292516
MESH:D001249 Asthma Ozone 6.8617854713 16373670
MESH:D001249 Asthma Tretinoin 6.8616456186
MESH:D001249 Asthma zileuton 6.8617944539 8598621 19214143 10764316 10181070 20332717 9620945
MESH:D001250 Asthma, Exercise-Induced zileuton 5.0310984370
MESH:D001260 Ataxia Telangiectasia Iron 4.8815336622
MESH:D050197 Atherosclerosis Arsenic 5.8619371607 12928151
MESH:D050197 Atherosclerosis Iron 5.8616632123 16640825
MESH:D001321 Autistic Disorder Acetaminophen 2.4818445737
MESH:D001321 Autistic Disorder Glutathione 2.4819056591 16917939 18929414 19267885
MESH:D001321 Autistic Disorder Iron 2.4817352947
MESH:D001321 Autistic Disorder Valproic Acid 2.4818558336 17688650 17507914 18775368 18985861 18940202 15238991 16609825 18316065 18396377 20603192 17157402 19460635 18177632 19232924
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.4816142846
MESH:D001424 Bacterial Infections Iron 4.6316640825
MESH:D001471 Barrett Esophagus Tretinoin 3.8616935849
MESH:D001477 Bartter Syndrome Indomethacin 4.4310684365
MESH:D001714 Bipolar Disorder Valproic Acid 2.7620046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 7.4816206674
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.4816197459 16206674
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.028888407
MESH:D001859 Bone Neoplasms Paclitaxel 4.0415867366
MESH:D001929 Brain Edema Indomethacin 10.9611481608
MESH:D001929 Brain Edema zileuton 10.9619309543
MESH:D002545 Brain Ischemia Indomethacin 3.8612524144
MESH:D001943 Breast Neoplasms alitretinoin 4.1116344269
MESH:D001943 Breast Neoplasms Calcitriol 4.1111237771
MESH:D001943 Breast Neoplasms decitabine 4.1119208741 18320071
MESH:D001943 Breast Neoplasms Dietary Fats 4.1120435547
MESH:D001943 Breast Neoplasms Indomethacin 4.1117401462
MESH:D001943 Breast Neoplasms Paclitaxel 4.1116273361 11325840 15136595 18223236 16244791 16115903 18323546 18234424
MESH:D001943 Breast Neoplasms tanshinone 4.1115849732 19885617
MESH:D001943 Breast Neoplasms Tretinoin 4.1116443354 16873071 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 7.5118315731 16777450 18417511 14754758 15516495 19059883 17626835
MESH:D016535 Bronchial Hyperreactivity zileuton 7.5112654629 12794006 12388339
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.0216813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8111589617
MESH:D002056 Burns Indomethacin 4.1510459503
MESH:D002100 Cachexia Indomethacin 10.5215141370 16537180 11239499 15625704
MESH:D002100 Cachexia Ozone 10.5216183385
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.2517687452 15504454
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.5816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.193084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 12.1917306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 12.1915553829 14691202 11135700 15073043 16217749
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 12.1916391822
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 12.1916313753
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 12.196705139 17173139 20007298 20935162 1701930
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 12.191917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.1611053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.7814736730 11352223 18791128
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3019014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.0817341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6212490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 18.8818922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 18.8811237771
MESH:D002294 Carcinoma, Squamous Cell decitabine 18.8819215824
MESH:D002294 Carcinoma, Squamous Cell Glutathione 18.8817015178
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 18.8812636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 18.8818922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 18.8816096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.5818640142
MESH:D009202 Cardiomyopathies Iron 3.6616640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.2416604332
MESH:D002318 Cardiovascular Diseases Arsenic 6.2315738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 6.2316936243
MESH:D002340 Carotid Artery Diseases Arsenic 3.8318022660 16973168
MESH:D002386 Cataract Acetaminophen 6.0410977129
MESH:D002386 Cataract Tretinoin 6.0417460283
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.704080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0216129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.4820734317
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.6212912871
MESH:D002764 Cholecystitis Indomethacin 4.5911181007
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 3.9019486331 18590720 15913567 7624871 15500046 16629650 18164287 12927374
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.2819407337 10220858
MESH:D002822 Choriocarcinoma Tretinoin 4.5816461808
MESH:D002972 Cleft Palate Tretinoin 2.419407595
MESH:D003092 Colitis Tretinoin 3.1617035595
MESH:D003110 Colonic Neoplasms decitabine 7.2617616700
MESH:D003110 Colonic Neoplasms Indomethacin 7.2615963497 15936596 15637740 11260862 15625704 15786552
MESH:D003110 Colonic Neoplasms Iron 7.2616640825
MESH:D003110 Colonic Neoplasms zileuton 7.2618927292
MESH:D015179 Colorectal Neoplasms arsenic trioxide 4.2420501625
MESH:D015179 Colorectal Neoplasms decitabine 4.2418981723
MESH:D015179 Colorectal Neoplasms Indomethacin 4.2411197048 12606626 17054584 18059344
MESH:D015179 Colorectal Neoplasms Paclitaxel 4.2418802399
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6512609071
MESH:D018352 Coronavirus Infections Indomethacin 5.1417302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.3910525206
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.399142499 17551590 14991402 10589399 9224671 16925845 9664655 9211117 9125849 8800419
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.398888407 17688650 16575769
MESH:D003456 Cryptorchidism vinclozolin 3.8014966744
MESH:D003550 Cystic Fibrosis Glutathione 4.0019747007
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5715213294
MESH:D003665 Decompression Sickness zileuton 5.6518309904
MESH:D003920 Diabetes Mellitus Iron 3.9716640825 16604332
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.1616506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 2.9416506275
MESH:D003967 Diarrhea Indomethacin 3.277907874 7237001
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 7.4117522070 20133375 7624871 18289764
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 7.4112958197 11529661 17906064 11743745 10915739 11739529 14725611 14550746 11834606 2444490 17522070 19923254 16109766 19370779 12540782 16393943 11461765 10774834 19739265 15619225 16177239 18713872 16781746 16485898 16227642 12594235 14986274 10663392 11287661 17562736 19416960 12392966 19085960 12153990 15968718 19164858 16081117 19420014 18071297 11421492 12705907
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 7.4119641884 1733752
MESH:D056486 Drug-Induced Liver Injury zileuton 7.4117944539
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5219426721
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.5818446180 17190690 18043480 16133044 16326151 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 3.6011535926 16699067 17045617 11595415 17151854 11991626 17329845 17351913 10671773 17202747 11595431
MESH:D050171 Dyslipidemias Dietary Fats 3.0318367378
MESH:D004421 Dystonia Phenobarbital 8.701851702
MESH:D004421 Dystonia Valproic Acid 8.701851702
MESH:D004487 Edema Indomethacin 8.9810653021 16100529 8985016 7907874 19703484 7990266 8273558
MESH:D004487 Edema Tetradecanoylphorbol Acetate 8.987812673 15177302 8113982 11698051 9599246 16716910 8273558
MESH:D004487 Edema zileuton 8.989831321 8273558 11698051 19703484 17118201 7990266 7812673
MESH:D004489 Edema, Cardiac Tretinoin 3.8918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 3.4015138306
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.5419294695
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 5.9820641076
MESH:D016889 Endometrial Neoplasms Tretinoin 2.7216569247
MESH:D004715 Endometriosis Indomethacin 3.6515652904
MESH:D019446 Endotoxemia Indomethacin 14.4818509659
MESH:D019446 Endotoxemia Lipopolysaccharides 14.4817637181 15821434 15328337
MESH:D019446 Endotoxemia zileuton 14.4815328337
MESH:D004751 Enteritis Indomethacin 4.1717763956 10567023 16328016
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4317980183
MESH:D004802 Eosinophilia Indomethacin 7.6711298111
MESH:D004802 Eosinophilia zileuton 7.678621850 10764316
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 8.963659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 8.9617275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.063922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 8.063922381 16628512
MESH:D004827 Epilepsy Phenobarbital 5.6020417680
MESH:D004827 Epilepsy Valproic Acid 5.6018234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 7.276401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.277562514 6426943 6254150
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.477750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.603659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.603659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.3612903497
MESH:D004938 Esophageal Neoplasms Indomethacin 6.3611005569
MESH:D004938 Esophageal Neoplasms Paclitaxel 6.3616481741
MESH:D005124 Eye Abnormalities Tretinoin 3.159664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 14.7115073043
MESH:D005234 Fatty Liver Dietary Fats 14.7119551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Iron 14.7116640825
MESH:D005234 Fatty Liver Valproic Acid 14.7114986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.3116575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.598888407 18558336
MESH:D005334 Fever Indomethacin 7.7211852909 17627676 10431976
MESH:D005334 Fever Lipopolysaccharides 7.729205823 11852909
MESH:D005354 Fibrosarcoma Indomethacin 4.3310962813
MESH:D005355 Fibrosis Dietary Fats 11.7418296743
MESH:D005355 Fibrosis Indomethacin 11.7417994277
MESH:D005355 Fibrosis Tretinoin 11.7417994277
MESH:D005499 Folliculitis Indomethacin 4.5911298111
MESH:D005534 Foot Diseases Arsenic 4.986392382
MESH:D005596 Fractures, Closed zileuton 5.2919544365
MESH:D005621 Friedreich Ataxia Iron 4.8716604332 16640825
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7216904648
MESH:D005756 Gastritis Acetaminophen 9.2316983495
MESH:D005756 Gastritis Indomethacin 9.2315046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.3716973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7216417039
MESH:D005909 Glioblastoma Indomethacin 6.0412870263
MESH:D005909 Glioblastoma Tretinoin 6.0417312396
MESH:D005910 Glioma Indomethacin 5.8216487511 18371953
MESH:D005910 Glioma tanshinone 5.8216955220
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8311849393
MESH:D006073 Gout Indomethacin 4.7811248219
MESH:D006258 Head and Neck Neoplasms decitabine 10.7219215824
MESH:D006258 Head and Neck Neoplasms Indomethacin 10.7215482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 10.7216096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 4.6920641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.5816084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.5814991402 9664655
MESH:D006432 Hemochromatosis Iron 4.0717053826 16640825 17236123 16574947 16604332 17255318
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 3.8916366002
MESH:D006486 Hemosiderosis Iron 4.6416604332
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.0615633222
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 4.1618590720
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.1415135802
MESH:D006525 Hepatitis, Viral, Human Iron 4.8916640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.3917182432
MESH:D006529 Hepatomegaly Iron 11.6516890145
MESH:D006529 Hepatomegaly Phenobarbital 11.6516109766
MESH:D006529 Hepatomegaly zileuton 11.658661344
MESH:D015658 HIV Infections Iron 3.3516597321
MESH:D006849 Hydrocephalus Valproic Acid 4.3017688650
MESH:D006930 Hyperalgesia Acetaminophen 10.4616870215
MESH:D006930 Hyperalgesia Indomethacin 10.4612727271
MESH:D006930 Hyperalgesia Tretinoin 10.4616870215
MESH:D034321 Hyperamylasemia Indomethacin 5.1417883296
MESH:D006937 Hypercholesterolemia Dietary Fats 3.0921332399
MESH:D006940 Hyperemia Indomethacin 4.4412524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0116778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.9617050553
MESH:D006949 Hyperlipidemias Dietary Fats 7.6121332399
MESH:D006949 Hyperlipidemias Indomethacin 7.6117546600
MESH:D006973 Hypertension Arsenic 2.6416076760 11953799 9931084
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.0716612254
MESH:D006976 Hypertension, Pulmonary zileuton 4.2514726295
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 4.7419662366
MESH:D006987 Hypesthesia Arsenic 4.9816093927
MESH:D007006 Hypogonadism Iron 3.9916640825
MESH:D007037 Hypothyroidism Iron 4.5316640825
MESH:D007077 Ileal Diseases Indomethacin 4.4510574470 18306037
MESH:D007079 Ileitis marker/mechanism 10647630
MESH:D007079 Ileitis Indomethacin 4.7810651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.7916133044
MESH:D020244 Infarction, Middle Cerebral Artery zileuton 5.0819309543
MESH:D007248 Infertility, Male decitabine 5.6217581917
MESH:D007248 Infertility, Male vinclozolin 5.6216467254
MESH:D007249 Inflammation Dietary Fats 15.7920412841
MESH:D007249 Inflammation Flavonoids 15.7917296493
MESH:D007249 Inflammation Indomethacin 15.7912568917 3291741 7812673
MESH:D007249 Inflammation Lipopolysaccharides 15.7917237260 9205823 12878042 17963957 17255318
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 15.7915177302 8273558 7562506 7812673 11698051
MESH:D007249 Inflammation zileuton 15.799831321 17118201 18309904 7812673 18059327 18295198 8960868 8621850
MESH:D015212 Inflammatory Bowel Diseases zileuton 3.9015339030
MESH:D007333 Insulin Resistance Dietary Fats 2.7218457598 11836018
MESH:D007410 Intestinal Diseases Indomethacin 8.0617329856 17994277 11713966 15610444 18236018 11855677 15831440 11686837 10210152
MESH:D007410 Intestinal Diseases Tretinoin 8.0617994277
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 4.0910783313
MESH:D019586 Intracranial Hypertension Indomethacin 4.7915241188
MESH:D019189 Iron Metabolism Disorders Iron 9.8517163184
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 9.8517255318
MESH:D007569 Jaw Abnormalities Tretinoin 3.3917551590 15992940
MESH:D007579 Jejunal Diseases Indomethacin 4.4518306037 10574470 16133968
MESH:D007642 Keratosis Arsenic 4.4216930632 12749816
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.0716144296
MESH:D007674 Kidney Diseases Acetaminophen 8.2015629191 12587719
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 8.2015369732
MESH:D007674 Kidney Diseases Indomethacin 8.2017190690
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.7716518626
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.4411703811 12228301 10320625
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 12.4412970779
MESH:D007938 Leukemia arsenic trioxide 12.4415070760
MESH:D007938 Leukemia decitabine 12.4418980019 19235587
MESH:D007938 Leukemia Tretinoin 12.4417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.2917077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 16.4016972261
MESH:D007948 Leukemia, Monocytic, Acute PD 98059 16.4016972261
MESH:D007948 Leukemia, Monocytic, Acute U 0126 16.4016972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 16.6012421474
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 16.6014633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 16.6010785260 15631656 16572323
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive zileuton 16.6019503090 19823023
MESH:D007951 Leukemia, Myeloid arsenic trioxide 13.0719077051
MESH:D007951 Leukemia, Myeloid decitabine 13.0718454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 13.0716932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 16.0216467208 17077328
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 16.0216467208 16968895 20471514 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute decitabine 16.0218460780 19387464 17679729 18206229 19010910 18704418
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 16.0218360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 16.0216294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 16.0216294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Vitamin D 16.0220368581
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 4.8818055864
MESH:D015473 Leukemia, Promyelocytic, Acute marker/mechanism 16764927
MESH:D015473 Leukemia, Promyelocytic, Acute 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 19.7817077328
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 19.7817339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 19.7819642359 12018890 11468182 17869043 17712046 15336539 12712474 15622746 19035177 16331271 16823087 15748426 19075265 16330433 15213294 17217047 16112521 12679006 9834237 11161223 16966277 19225113 17649720 16891316 17107899
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 19.7816766008
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 19.789834237 16766008 17712046 17368321 17361223 17217047 17649720 16140955 19075265 16935935 16788101 17301526 12679006 15748426 17506722 16331271 16891316 19225113 16823087 19029980 17339181 19642359 17294898 19035177 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.8116882451
MESH:D007964 Leukocytosis Indomethacin 4.7916537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.1417980183
MESH:D007970 Leukopenia Lipopolysaccharides 4.1315821434
MESH:D020961 Lewy Body Disease Iron 4.8716563566
MESH:D007984 Leydig Cell Tumor vinclozolin 4.1716417039
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.899224671
MESH:D008080 Liposarcoma Paclitaxel 4.3017353645
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.1411479899
MESH:D008103 Liver Cirrhosis Dietary Fats 9.1918296743
MESH:D008103 Liver Cirrhosis Iron 9.1916640825
MESH:D008103 Liver Cirrhosis Phenobarbital 9.1921047994
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 4.3511682029
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 4.3518194892
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 4.3512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.3516248980 18397230
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 7.9117184895
MESH:D008107 Liver Diseases Acetaminophen 7.9112587719 19460945 11587558 19014921 16610002 12969438 16611625 19784758
MESH:D008107 Liver Diseases Arsenic 7.9111134558
MESH:D008107 Liver Diseases Phenobarbital 7.9119363144
MESH:D008108 Liver Diseases, Alcoholic Iron 4.4517207112 16737972
MESH:D017114 Liver Failure, Acute Acetaminophen 2.7416871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 8.7316368122
MESH:D008113 Liver Neoplasms arsenic trioxide 8.7314682389
MESH:D008113 Liver Neoplasms Iron 8.7316640825 20302851
MESH:D008113 Liver Neoplasms Phenobarbital 8.7319812893 15975961 19073162 21047994 8742319 19482888
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 4.8020377131
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 4.801399818 6150874 17172636 2563599 18308698
MESH:D008133 Long QT Syndrome arsenic trioxide 2.9115213294
MESH:D008171 Lung Diseases Ozone 2.9919066396 8266340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.6917228818
MESH:D055370 Lung Injury Lipopolysaccharides 7.4221114838
MESH:D055370 Lung Injury Ozone 7.4220417186
MESH:D008175 Lung Neoplasms alitretinoin 9.2416413115
MESH:D008175 Lung Neoplasms Arsenic 9.2419168569 17306315 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 9.2411798837 19825857
MESH:D008175 Lung Neoplasms Indomethacin 9.2411497255 16537180 11053908
MESH:D008175 Lung Neoplasms Iron 9.2416640825
MESH:D008175 Lung Neoplasms Ozone 9.247614698 8597069
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 9.2411807781
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism 18204446 18204448
MESH:D008223 Lymphoma decitabine 3.0119470736
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.6314749477
MESH:D008268 Macular Degeneration Iron 3.6516640825
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.008985016
MESH:D008527 Medulloblastoma Tretinoin 2.5317453147
MESH:D008545 Melanoma decitabine 4.4616505122 17785578
MESH:D008545 Melanoma Paclitaxel 4.4612025231 12040289 16342250
MESH:D008545 Melanoma Tretinoin 4.4616752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0219513568
MESH:D008591 Meningomyelocele Tretinoin 3.8716940565
MESH:D008679 Metaplasia Ozone 4.5310496685
MESH:D008881 Migraine Disorders Indomethacin 6.3411903285
MESH:D008881 Migraine Disorders Valproic Acid 6.3418803445 18765137
MESH:D009062 Mouth Neoplasms Indomethacin 3.5512636206
MESH:D009101 Multiple Myeloma arsenic trioxide 9.8019417148 14977855 19549372 15949261 11468182
MESH:D009101 Multiple Myeloma decitabine 9.8018172295
MESH:D009101 Multiple Myeloma Paclitaxel 9.8014749477
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.0917086897
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.528888407
MESH:D009181 Mycoses Iron 4.8916640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.0918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 14.7116882451 16105982
MESH:D009190 Myelodysplastic Syndromes decitabine 14.7119010910 18608210 19157545 16882708
MESH:D009190 Myelodysplastic Syndromes Tretinoin 14.7117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 14.7117596541
MESH:D017202 Myocardial Ischemia Arsenic 8.0115371236
MESH:D017202 Myocardial Ischemia Iron 8.0116604332
MESH:D015428 Myocardial Reperfusion Injury Iron 3.8316604332
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9117484760
MESH:D009298 Nasal Polyps zileuton 5.6510665187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.4216624393
MESH:D009362 Neoplasm Metastasis Indomethacin 5.3416537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis Paclitaxel 5.3415867366
MESH:D009369 Neoplasms alitretinoin 6.6516946489
MESH:D009369 Neoplasms decitabine 6.6519116145 17925555 19470736
MESH:D009369 Neoplasms Tretinoin 6.6516594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 3.5910663608 15625704
MESH:D009404 Nephrotic Syndrome Iron 4.0417178036
MESH:D009421 Nervous System Malformations Tretinoin 3.249125849
MESH:D009436 Neural Tube Defects Arsenic 14.1716620997
MESH:D009436 Neural Tube Defects arsenic trioxide 14.1710525206
MESH:D009436 Neural Tube Defects Tretinoin 14.179142499
MESH:D009436 Neural Tube Defects Valproic Acid 14.1716359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.5018514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 11.5012349958
MESH:D019636 Neurodegenerative Diseases Iron 11.5017296847 16604332
MESH:D020078 Neurogenic Inflammation Arsenic 3.8517056641
MESH:D009765 Obesity Dietary Fats 2.1320132043 17217161 18674790 21332399 16723640 11836018 19632207 18457598 20518802
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.596374098
MESH:D010003 Osteoarthritis Indomethacin 6.777009135
MESH:D010003 Osteoarthritis Iron 6.7716640825
MESH:D010014 Osteolysis Paclitaxel 4.4115867366
MESH:D010018 Osteomalacia Phenobarbital 3.8017016548
MESH:D010024 Osteoporosis Iron 6.8116640825 16648989
MESH:D010024 Osteoporosis Vitamin D 6.8117882678
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19.6316211241
MESH:D010051 Ovarian Neoplasms Arsenic 19.6317306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 19.6316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms decitabine 19.6319331143 19259094
MESH:D010051 Ovarian Neoplasms Paclitaxel 19.6311161223
MESH:D010051 Ovarian Neoplasms Tretinoin 19.6316936753
MESH:D010051 Ovarian Neoplasms U 0126 19.6316211241
MESH:D010146 Pain Acetaminophen 12.4016870215
MESH:D010146 Pain Indomethacin 12.4017440234 17627676 13679232 3291741
MESH:D010146 Pain Tretinoin 12.4016870215
MESH:D010146 Pain zileuton 12.4015935457
MESH:D010149 Pain, Postoperative Indomethacin 4.1012538197 18702446
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 13.7715580305
MESH:D010190 Pancreatic Neoplasms decitabine 13.7719294695
MESH:D010190 Pancreatic Neoplasms Phenobarbital 13.7716965848
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 13.7715976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 13.7715976015
MESH:D010195 Pancreatitis Fatty Acids, Nonesterified 7.5918983441
MESH:D010195 Pancreatitis Indomethacin 7.5915028970 17883296
MESH:D010212 Papilloma Hydrogen Peroxide 12.5812065085
MESH:D010212 Papilloma Iron 12.5812065085
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 12.588330346 12065085 18404319 18922899
MESH:D010235 Paraganglioma arsenic trioxide 3.6419927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.1416537180
MESH:D020447 Parasomnias Iron 5.4417352947
MESH:D010300 Parkinson Disease Iron 3.0916563566 16640825
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6312349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.1411903285
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 5.2820133375
MESH:D010437 Peptic Ulcer Indomethacin 4.5811148446
MESH:D010518 Periodontitis Indomethacin 4.3417225004
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.6416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.4216905509 6392382 15371236
MESH:D010538 Peritonitis Ozone 8.7216369182
MESH:D010538 Peritonitis zileuton 8.7217371808
MESH:D010900 Pituitary Diseases Iron 5.0916604332
MESH:D011014 Pneumonia Lipopolysaccharides 9.2311605937 12224865
MESH:D011014 Pneumonia Ozone 9.2318929643 18381685 18007984
MESH:D011041 Poisoning Iron 3.7816604332
MESH:D017499 Porokeratosis alitretinoin 5.4316144296
MESH:D017119 Porphyria Cutanea Tarda Iron 4.4416640825
MESH:D011230 Precancerous Conditions Phenobarbital 3.142563599
MESH:D011225 Pre-Eclampsia Iron 3.9816640825
MESH:D047928 Premature Birth Indomethacin 4.5717000239
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 7.8520603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 7.8518220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 4.1717616702
MESH:D011469 Prostatic Diseases vinclozolin 4.3718220299
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.2115572423
MESH:D011471 Prostatic Neoplasms Arsenic 1.9716140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9719131511
MESH:D011471 Prostatic Neoplasms Calcitriol 1.9715754350 16289102 12479363 18247401 16644109
MESH:D011471 Prostatic Neoplasms Cholecalciferol 1.9717024972
MESH:D011471 Prostatic Neoplasms Paclitaxel 1.9716729912 17172428 16356831 17136230
MESH:D011472 Prostatitis vinclozolin 4.3718629315
MESH:D011507 Proteinuria Arsenic 12.5021343184
MESH:D011507 Proteinuria Indomethacin 12.5011849393
MESH:D011507 Proteinuria Tretinoin 12.5016636307
MESH:D011528 Protozoan Infections Iron 5.4416640825
MESH:D011537 Pruritus zileuton 4.5817827870 19657356
MESH:D019310 Pseudolymphoma Phenobarbital 10.2712752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.2712752131 11422049
MESH:D011625 Pterygium Tretinoin 4.2316723453
MESH:D011654 Pulmonary Edema zileuton 4.8518309904
MESH:D015427 Reperfusion Injury zileuton 3.9615266012 9865762
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.3410835634
MESH:D012148 Restless Legs Syndrome Iron 4.1116930377
MESH:D012208 Rhabdomyosarcoma decitabine 15.5019155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 15.5016283617 16116481
MESH:D012208 Rhabdomyosarcoma Valproic Acid 15.5019155313
MESH:D012220 Rhinitis zileuton 4.3520332717
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.4216646077
MESH:D012559 Schizophrenia Valproic Acid 1.9819110320 15737665
MESH:D012640 Seizures Phenobarbital 4.703137016 11442880 16876388 4039156
MESH:D012640 Seizures Valproic Acid 4.701511512 15475178 3137016 17978042 14763951 16876388 11044598 11738929
MESH:D003294 Seizures, Febrile Phenobarbital 4.256407741
MESH:D012852 Sinusitis zileuton 4.9510665187
MESH:D012871 Skin Diseases Arsenic 2.5819834688 17453740 16702368 16759981 17938729 15952646 17050553 17548696 6392382 16353154 18709164
MESH:D012878 Skin Neoplasms Arsenic 14.8017976673 19538983 17029826 16251483 17050553 15504454
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 14.8012065085
MESH:D012878 Skin Neoplasms Iron 14.8012065085
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 14.8018404319 8985016 8330346 11807781 12065085
MESH:D012878 Skin Neoplasms Tretinoin 14.8016467112
MESH:D020181 Sleep Apnea, Obstructive zileuton 5.2919118273
MESH:D013119 Spinal Cord Injuries zileuton 4.9518059327
MESH:D016135 Spinal Dysraphism Valproic Acid 3.3419490988
MESH:D013226 Status Epilepticus Valproic Acid 3.9612833885
MESH:D013272 Stomach Diseases Indomethacin 9.3417638125 15472012 16280098 10486359 16113693 17160473 18545984 17207306 16184426 10215738 18209964 15038085 10192188
MESH:D013272 Stomach Diseases plaunotol 9.3410215738
MESH:D013274 Stomach Neoplasms arsenic trioxide 5.5817007042
MESH:D013274 Stomach Neoplasms decitabine 5.5819037991
MESH:D013274 Stomach Neoplasms Indomethacin 5.5815609394
MESH:D013274 Stomach Neoplasms Paclitaxel 5.5818506536 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 5.5817261132
MESH:D013276 Stomach Ulcer Indomethacin 3.1016755016 16252198 16397915 12500499 17918041 18726076 11906479 11595431 17135157 12498302 18431645 18181030 18543354 11595415 15138204 12467913 10878458 15255614 12077510 16169175 18237397 16934674 10750652 11729361 16150113 14567935 17627676 18209962 15104355 11523592 1323529 17654042 10423059 18087811 16631530 17657623 17895592 11145282 17977527 18193104 18299717 12787963
MESH:D013398 Sudden Infant Death Iron 4.8816640825
MESH:D024801 Tauopathies Paclitaxel 4.2516930453
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 8.4020133375
MESH:D013921 Thrombocytopenia Lipopolysaccharides 8.4015821434
MESH:D013964 Thyroid Neoplasms 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide 22.3916940797
MESH:D013964 Thyroid Neoplasms arsenic trioxide 22.3919014326
MESH:D013964 Thyroid Neoplasms decitabine 22.3917967635
MESH:D013964 Thyroid Neoplasms Indomethacin 22.3918791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Phenobarbital 22.391399818
MESH:D013964 Thyroid Neoplasms Tretinoin 22.3917045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.2916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.4015213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.6617262798
MESH:D014376 Tuberculosis Iron 6.9416597321
MESH:D014376 Tuberculosis Tretinoin 6.9416040207
MESH:D014456 Ulcer Indomethacin 4.3317380554 10574470
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.963119515
MESH:D001749 Urinary Bladder Neoplasms Arsenic 6.9417976673 17306315 11144890 15987713 19322015 19429237 18640142
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 6.9411780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms decitabine 6.9417616700 19087683
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.098888407
MESH:D014581 Urticaria Acetaminophen 2.4610982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.1816129372
MESH:D014604 Uveal Neoplasms decitabine 10.9117785578
MESH:D014604 Uveal Neoplasms Tretinoin 10.9116752155
MESH:D014652 Vascular Diseases Arsenic 4.1717056641
MESH:D014820 Vitiligo Tretinoin 3.5216761959
MESH:D014839 Vomiting Indomethacin 4.1711897121
MESH:D015430 Weight Gain Dietary Fats 3.2616723640
MESH:D009396 Wilms Tumor Tretinoin 3.4916287080
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:04640 Hematopoietic cell lineage
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
KEGG:05140 Leishmaniasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:04145 Phagosome
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05150 Staphylococcus aureus infection
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29949
    • No data
    Releated disease ID Related disease Name
    PA444819Lupus erythematosus
    PA444822Lupus Erythematosus, Systemic
    PA444822Lupus Erythematosus, Systemic
    Releated drug ID Related drug Name
    PA450952phospholipids
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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