AutismKB 2.0

Annotation Detail for ITGAX


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ITGAX ( CD11C,SLEB6 )
Gene Full Name: integrin, alpha X (complement component 3 receptor 4 subunit)
Band: 16p11.2
Quick LinksEntrez ID:3687; OMIM: 151510; Uniprot ID:ITAX_HUMAN; ENSEMBL ID: ENSG00000140678; HGNC ID: 6152
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04810Regulation of actin cytoskeleton
Pathway IDPathway Name
Hemostasis
Integrin cell surface interactions
No data
Pathway IDPathway Name
P00034Integrin signalling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
2051Leukemia
Desease Name
systemic lupus erythematosus
IMMUNE
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C111855 6-formylindolo(3,2-b)carbazole 6-formylindolo(3,2-b)carbazole results in decreased expression of ITGAX proteindecreases expression 20350561
D000082 Acetaminophen Acetaminophen affects the expression of ITGAX mRNAaffects expression 17562736
C103303 alitretinoin Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGAX protein]increases expression|increases reaction 15964820
C103303 alitretinoin Vitamin D promotes the reaction [alitretinoin results in increased expression of ITGAX protein]increases expression|increases reaction 15964820
C015001 arsenite arsenite results in decreased expression of ITGAX mRNAdecreases expression 18191166
D002927 Cimetidine Cimetidine results in decreased expression of ITGAX proteindecreases expression 11556524
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGAX protein]increases expression|increases reaction 15964820
C051890 irinotecan irinotecan metabolite results in increased expression of ITGAX mRNAincreases expression 15956246
C051890 irinotecan irinotecan results in increased expression of ITGAX mRNAincreases expression 15956246
C043062 N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine results in decreased expression of ITGAX proteindecreases expression 11556524
11306145
D010126 Ozone Ozone results in increased expression of ITGAX proteinincreases expression 15036748
D017632 Asbestos, Serpentine Asbestos, Serpentine results in increased expression of ITGAX mRNAincreases expression 16251409
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ITGAX protein]affects reaction|decreases expression 20350561
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ITGAX proteindecreases expression 20350561
D013755 Tetradecanoylphorbol Acetate [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ITGAX mRNAaffects cotreatment|affects expression 16979875
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of ITGAX mRNAdecreases expression 18087596
D014212 Tretinoin Tretinoin results in increased expression of ITGAX mRNAincreases expression 15770638
15988048
D014212 Tretinoin Tretinoin results in increased expression of ITGAX proteinincreases expression 16764927
17361223
15770638
D014311 Triprolidine Triprolidine results in decreased expression of ITGAX proteindecreases expression 11556524
D014807 Vitamin D Vitamin D promotes the reaction [alitretinoin results in increased expression of ITGAX protein]increases expression|increases reaction 15964820
D002762 Cholecalciferol [Cholecalciferol co-treated with TGFB1 protein] results in increased expression of ITGAX mRNAaffects cotreatment|increases expression 15988048
D015032 Zinc [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of ITGAX mRNAaffects cotreatment|affects expression 16979875
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8115322242 11752688 14514962
MESH:D000169 Acrodermatitis Zinc 5.3716889938 17190629 17202136
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.5015814487
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000544 Alzheimer Disease Ozone 4.4215513908
MESH:D000544 Alzheimer Disease Zinc 4.4216580781 16325427 16410023 17119284
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000755 Anemia, Sickle Cell Zinc 4.8616916123
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.0516412693
MESH:D001172 Arthritis, Rheumatoid Ozone 7.4715570426
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 7.4719898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 7.4716292516
MESH:D001195 Asbestosis Asbestos, Serpentine 5.6310751356
MESH:D001249 Asthma Ozone 7.9116373670 17854713
MESH:D001249 Asthma Tretinoin 7.9116456186
MESH:D001249 Asthma Zinc 7.9117085522
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.9916142846
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.8012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.8016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001930 Brain Injuries Zinc 4.6517109824
MESH:D001943 Breast Neoplasms alitretinoin 2.0816344269
MESH:D001943 Breast Neoplasms N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 2.0818986763
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0820435547
MESH:D001943 Breast Neoplasms Tretinoin 2.0816166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.6414754758 15516495 17626835 18417511 19059883 18315731 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002100 Cachexia Ozone 4.7016183385
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.843084413
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 2.841917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4111212258
MESH:D002294 Carcinoma, Squamous Cell N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 14.2818986763
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 14.2818922899
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 14.2811212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.2816051514 16096774
MESH:D002294 Carcinoma, Squamous Cell Zinc 14.2816543248
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3416120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Zinc 3.6316936243
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Tretinoin 7.1417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7012621046 16354765 15668235 15340226 8697196
MESH:D002972 Cleft Palate Tretinoin 5.709407595
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D003110 Colonic Neoplasms arsenite 4.0715037631
MESH:D003110 Colonic Neoplasms irinotecan 4.0717725105 17287894
MESH:D015179 Colorectal Neoplasms irinotecan 2.3617454858 18259882 16303861 17159606 15273666 16391804 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.8115322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.8114991402 16925845 9125849 10589399 9142499 17551590 8800419 9664655 9211117 9224671
MESH:D019465 Craniofacial Abnormalities Zinc 3.8119302082
MESH:D003920 Diabetes Mellitus Zinc 4.1616479319
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5119739265 19923254 17522070 16485898 11461765 19420014 15968718 10774834 14725611 12594235 11287661 14986274 16227642 12153990 16781746 11529661 19085960 12540782 19416960 2444490 11421492 11743745 12958197 11739529 16177239 12392966 18071297 19164858 16109766 15619225 17906064 16393943 16081117 19370779 10915739 14550746 12705907 17562736 11834606 10663392 18713872
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004487 Edema Cimetidine 11.5519703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.5512711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 11.5515177302 8113982 16716910 9599246 8273558 7812673 11698051
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8515322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.5320641076
MESH:D016889 Endometrial Neoplasms Tretinoin 3.0816569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D004938 Esophageal Neoplasms Zinc 2.8516543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.7216938888 9664655
MESH:D005234 Fatty Liver arsenite 3.7418296743
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis arsenite 14.6218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.6220067830
MESH:D005355 Fibrosis Tretinoin 14.6217994277
MESH:D005756 Gastritis Acetaminophen 11.0716983495
MESH:D005756 Gastritis Zinc 11.0717241300
MESH:D005909 Glioblastoma Tretinoin 2.9817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006130 Growth Disorders Zinc 3.9317217573
MESH:D006258 Head and Neck Neoplasms N,N-diethyl-2-((4-phenylmethyl)phenoxy)ethanamine 8.4518986763
MESH:D006258 Head and Neck Neoplasms Tretinoin 8.4516096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 5.1320641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.469664655 14991402
MESH:D006333 Heart Failure Zinc 3.5817162251
MESH:D006335 Heart Injuries Zinc 5.7417074742
MESH:D016481 Helicobacter Infections Zinc 4.4917241300
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006527 Hepatolenticular Degeneration Zinc 4.6517276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8516120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0215340226 16354765 8697196 16959395 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.5016870215
MESH:D006930 Hyperalgesia Tretinoin 7.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3612878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.3615177302 8273558 7562506 7812673 11698051
MESH:D007249 Inflammation Tobacco Smoke Pollution 8.3618590791
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007511 Ischemia Zinc 4.5916584753
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8015992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.6016144296
MESH:D007674 Kidney Diseases Acetaminophen 6.0715629191 12587719
MESH:D007674 Kidney Diseases Zinc 6.0716960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.3816518626
MESH:D007938 Leukemia Tretinoin 2.7517143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6616482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.4616294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Vitamin D 4.4620368581
MESH:D015473 Leukemia, Promyelocytic, Acute marker/mechanism 16764927
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1219035177 17217047 17649720 19225113 19075265 16140955 16891316 17368321 17361223 17506722 17107899 19029980 16788101 12679006 16823087 16331271 17339181 15748426 17294898 16766008 19642359 16935935 17712046 17301526 9834237
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008103 Liver Cirrhosis arsenite 3.3918296743
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 3.6211682029
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6218397230 16248980
MESH:D008107 Liver Diseases Acetaminophen 1.6219784758 16611625 11587558 16610002 19460945 12587719 19014921 12969438
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2016871587 17185352
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7016984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0812151625
MESH:D008171 Lung Diseases Asbestos, Serpentine 7.8517200189
MESH:D008171 Lung Diseases Ozone 7.858266340 19066396
MESH:D055370 Lung Injury Ozone 3.8120417186
MESH:D008175 Lung Neoplasms alitretinoin 10.6516413115
MESH:D008175 Lung Neoplasms arsenite 10.6516809336
MESH:D008175 Lung Neoplasms Asbestos, Serpentine 10.6511198217
MESH:D008175 Lung Neoplasms Ozone 10.658597069 7614698
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.6519555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 10.6511807781
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 10.6511091918 3440675 16288123 12111688
MESH:D008180 Lupus Erythematosus, Systemic marker/mechanism
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 6.418985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 6.4112773700
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D008679 Metaplasia Ozone 5.0810496685
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.3115006635
MESH:D052016 Mucositis irinotecan 4.9717159606
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0517596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D009362 Neoplasm Metastasis irinotecan 3.1518259882
MESH:D009369 Neoplasms alitretinoin 5.3216946489
MESH:D009369 Neoplasms Tretinoin 5.3216946489 16594593
MESH:D009374 Neoplasms, Experimental Asbestos, Serpentine 4.8111704859
MESH:D009389 Neovascularization, Pathologic arsenite 4.3815738583
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3814600291
MESH:D009421 Nervous System Malformations Tretinoin 9.389125849
MESH:D009436 Neural Tube Defects Tretinoin 3.029142499
MESH:D009447 Neuroblastoma irinotecan 3.468761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D017599 Neuroectodermal Tumors irinotecan 4.698761367
MESH:D010024 Osteoporosis Vitamin D 4.6917882678
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3316936753
MESH:D010146 Pain Acetaminophen 6.4616870215
MESH:D010146 Pain Tretinoin 6.4616870215
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 5.4615976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.4615976015
MESH:D010195 Pancreatitis Cimetidine 5.2410484002
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.2512065085 18922899 18404319 8330346
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010538 Peritonitis Ozone 4.0916369182
MESH:D010995 Pleural Diseases Asbestos, Serpentine 5.6510923243
MESH:D011014 Pneumonia Ozone 4.3618381685 18929643 18007984
MESH:D017499 Porokeratosis alitretinoin 5.9816144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011225 Pre-Eclampsia Zinc 4.1417114810
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Cholecalciferol 3.8517024972
MESH:D011471 Prostatic Neoplasms Zinc 3.8516606632 16517595 16700911 12429649
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Serpentine 3.8118569384 15511213
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.5818410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012162 Retinal Degeneration Zinc 4.0916584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616116481 16283617
MESH:D012772 Shock, Septic Triprolidine 6.1818063050
MESH:D012852 Sinusitis Triprolidine 6.307327846
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.4716192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 13.478330346 8985016 18404319 12065085 11807781
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 13.4718590791
MESH:D012878 Skin Neoplasms Tretinoin 13.4716467112
MESH:D013274 Stomach Neoplasms irinotecan 2.6315723263
MESH:D013274 Stomach Neoplasms Tretinoin 2.6317261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 9.8516051514
MESH:D014062 Tongue Neoplasms Zinc 9.8516543248
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 3.3212846360
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
Pathway ID Pathway Name
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29952
    • No data
    Releated disease ID Related disease Name
    PA443434Arthritis, Rheumatoid
    PA444819Lupus erythematosus
    PA444822Lupus Erythematosus, Systemic
    PA444822Lupus Erythematosus, Systemic
    Releated drug ID Related drug Name
    PA450952phospholipids
    PA10004adalimumab
    PA450428methotrexate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved