AutismKB 2.0

Annotation Detail for ITGB1


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Basic Information Top
Gene Symbol:ITGB1 ( CD29,FNRB,GPIIA,MDF2,MSK12,VLA-BETA,VLAB )
Gene Full Name: integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Band: 10p11.22
Quick LinksEntrez ID:3688; OMIM: 135630; Uniprot ID:ITB1_HUMAN; ENSEMBL ID: ENSG00000150093; HGNC ID: 6153
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04360Axon guidance
hsa04145Phagosome
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05131Shigellosis
hsa05130Pathogenic Escherichia coli infection
hsa05100Bacterial invasion of epithelial cells
hsa05222Small cell lung cancer
hsa04810Regulation of actin cytoskeleton
hsa04514Cell adhesion molecules (CAMs)
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Axon guidance
Hemostasis
Cell junction organization
Signaling in Immune system
Integrin cell surface interactions
Pathway IDPathway Name
200171Validated targets of C-MYC transcriptional repression
200188VEGFR3 signaling in lymphatic endothelium
200178Paxillin-independent events mediated by a4b1 and a4b7
200006Signaling events mediated by PRL
200066Angiopoietin receptor Tie2-mediated signaling
200065Signaling events mediated by TCPTP
200092a4b1 and a4b7 Integrin signaling
200164Syndecan-2-mediated signaling events
200162a6b1 and a6b4 Integrin signaling
200117Paxillin-dependent events mediated by a4b1
200115Syndecan-4-mediated signaling events
200192Signaling events mediated by focal adhesion kinase
200051Reelin signaling pathway
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500305Cell surface interactions at the vascular wall
500078Other semaphorin interactions
500004Integrin cell surface interactions
500124Localization of the PINCH-ILK-PARVIN complex to focal adhesions
500477Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
501010Collagen adhesion via alpha 2 beta 1 glycoprotein
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1781Rheumatoid arthritis
1842Sickle cell disease
1870Drug abuse
1904Diabetes mellitus
1907Depression
1934Cancer
1999Thalassemia
1764Purpura, Thrombocytopenic, Idiopathic
1925Pemphigoid, Bullous
2065Shigella infection
2105Primary hyperparathyroidism
2111Systemic infection
2146Lupus erythematosus
2230Alopecia
1846Pleural effusion, Malignant
2256Aortic aneurysm
No data
Desease Name
Depression--quantitative trait
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C001079 2-(2,6-dioxopiperidin-3-yl)phthalimidine 2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGB1 proteindecreases expression 8538367
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of ITGB1 mRNAaffects expression 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ITGB1 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of ITGB1 mRNA]affects expression|affects reaction 19414516
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ITGB1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ITGB1 mRNAaffects expression 21346803
C029955 2-nitrotoluene 2-nitrotoluene results in decreased expression of ITGB1 mRNAdecreases expression 16460773
D000082 Acetaminophen Acetaminophen affects the expression of ITGB1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen affects the expression of ITGB1 mRNAaffects expression 16701773
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of ITGB1 mRNA]affects expression|affects reaction 19414516
D013196 Dihydrotestosterone Dihydrotestosterone results in decreased expression of ITGB1 mRNAdecreases expression 17023530
D000537 Aluminum Oxide [Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGB1 proteinaffects cotreatment|increases expression 12209937
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ITGB1 mRNAaffects expression 16483693
C058317 arsenic disulfide arsenic disulfide affects the expression of ITGB1 mRNAaffects expression 12776498
C058317 arsenic disulfide arsenic disulfide results in decreased expression of ITGB1 mRNAdecreases expression 12890387
C006632 arsenic trioxide arsenic trioxide results in decreased expression of ITGB1 mRNAdecreases expression 12852829
D001280 Atrazine Atrazine results in increased expression of ITGB1 mRNAincreases expression 18585445
D019207 beta Carotene beta Carotene results in decreased expression of ITGB1 mRNAdecreases expression 17034753
C099813 bromochloroacetic acid bromochloroacetic acid results in decreased expression of ITGB1 mRNAdecreases expression 16460773
D002087 Butyrates Butyrates results in decreased expression of ITGB1 mRNAdecreases expression 14674679
D002101 Cacodylic Acid Cacodylic Acid results in decreased expression of ITGB1 mRNAdecreases expression 17720352
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of ITGB1 mRNAaffects expression 17484886
D002712 Chlorides ITGB1 protein results in increased transport of Chloridesincreases transport 20164377
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of ITGB1 mRNAaffects cotreatment|decreases expression 18636392
D003474 Curcumin Curcumin inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]decreases expression|decreases reaction 17291458
D003474 Curcumin Curcumin results in increased expression of ITGB1 proteinincreases expression 17291458
D004280 Dobutamine ITGB1 protein affects the susceptibility to Dobutamineaffects response to substance 11884376
D004958 Estradiol Estradiol results in increased expression of ITGB1 proteinincreases expression 16912569
D017308 Etodolac Etodolac results in decreased expression of [ITGA4 protein binds to ITGB1 protein]affects binding|decreases expression 16046235
D005492 Folic Acid Folic Acid affects the expression of ITGB1 mRNAaffects expression 16361273
C039281 furan furan results in increased expression of ITGB1 mRNAincreases expression 15120968
D006861 Hydrogen Peroxide Hydrogen Peroxide results in decreased expression of ITGB1 mRNAdecreases expression 12419474
C031927 hydroquinone hydroquinone results in decreased activity of ITGB1 proteindecreases activity 17464197
C031927 hydroquinone hydroquinone results in decreased expression of ITGB1 proteindecreases expression 17464197
C027185 indirubin indirubin results in decreased expression of ITGB1 mRNAdecreases expression 15056799
D007545 Isoproterenol DMD gene mutant form promotes the reaction [ITGB1 gene affects the susceptibility to Isoproterenol]affects response to substance|increases reaction 18340010
D008274 Magnesium [Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGB1 proteinaffects cotreatment|increases expression 12209937
D008345 Manganese Manganese results in increased activity of ITGB1 proteinincreases activity 16606368
C008493 methylselenic acid methylselenic acid results in decreased expression of ITGB1 mRNAdecreases expression 11172735
D015741 Metribolone Metribolone results in decreased expression of [ITGA2 protein binds to ITGB1 protein]affects binding|decreases expression 17541959
D009151 Mustard Gas Mustard Gas results in increased expression of ITGB1 mRNAincreases expression 15674843
18955075
D009538 Nicotine Nicotine results in decreased expression of ITGB1 proteindecreases expression 11338295
D010100 Oxygen ITGB1 affects the reaction [Oxygen deficiency affects the expression of BIRC5 mRNA]affects expression|affects reaction 16628086
D010100 Oxygen ITGB1 affects the reaction [Oxygen deficiency affects the expression of BIRC5 protein]affects expression|affects reaction 16628086
D010126 Ozone Ozone affects the localization of ITGB1 proteinaffects localization 9730863
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of ITGB1 mRNAaffects cotreatment|decreases expression 18636392
D010672 Phenytoin Phenytoin results in decreased expression of ITGB1 proteindecreases expression 15948689
C006253 pirinixic acid pirinixic acid results in increased expression of ITGB1 mRNAincreases expression 16221962
D011374 Progesterone Progesterone affects the expression of ITGB1 mRNAaffects expression 17962213
D011374 Progesterone Progesterone affects the expression of ITGB1 proteinaffects expression 17962213
D020849 Raloxifene Raloxifene results in increased expression of ITGB1 mRNAincreases expression 19429434
C059514 resveratrol resveratrol inhibits the reaction [IL1B protein results in decreased expression of ITGB1 protein]decreases expression|decreases reaction 17404069
C410733 scriptaid scriptaid affects the expression of ITGB1 mRNAaffects expression 18813790
D013481 Superoxides [DDIT3 protein results in increased abundance of Superoxides] which results in decreased expression of ITGB1 proteindecreases expression|increases abundance 16400006
D013629 Tamoxifen Tamoxifen results in increased expression of ITGB1 mRNAincreases expression 19429434
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ITGB1 mRNAdecreases expression 15056799
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITGB1 mRNAincreases expression 19684285
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITGB1 mRNAincreases expression 16611356
15328365
19684285
16960034
D014415 Tunicamycin Tunicamycin results in decreased expression of ITGB1 mRNAdecreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of ITGB1 mRNAaffects expression 19015723
D014801 Vitamin A Vitamin A affects the localization of ITGB1 proteinaffects localization 17241391
D014801 Vitamin A Vitamin A results in increased expression of ITGB1 proteinincreases expression 17241391
D002762 Cholecalciferol Cholecalciferol results in increased expression of ITGB1 mRNAincreases expression 17170073
C028541 zirconium oxide zirconium oxide results in increased expression of ITGB1 mRNAincreases expression 17197017
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.9914745880
MESH:D000014 Abnormalities, Drug-Induced 2-(2,6-dioxopiperidin-3-yl)phthalimidine 11.49473085 3355362 6734493 3196154
MESH:D000014 Abnormalities, Drug-Induced Phenytoin 11.498986270 10563481 6195326 9677735 9118846 3425630
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.4915322242 14514962 11752688
MESH:D000015 Abnormalities, Multiple Vitamin A 4.3710992263
MESH:D000138 Acidosis Ammonium Chloride 3.0118287403
MESH:D058186 Acute Kidney Injury Folic Acid 11.9116595132 16316344 17003819
MESH:D058186 Acute Kidney Injury resveratrol 11.9116538975
MESH:D058186 Acute Kidney Injury Superoxides 11.9118460982
MESH:D055371 Acute Lung Injury Chlorine 12.4820601635
MESH:D055371 Acute Lung Injury Oxygen 12.4816759491
MESH:D055371 Acute Lung Injury pirinixic acid 12.4818653653
MESH:D000230 Adenocarcinoma 2-(2,6-dioxopiperidin-3-yl)phthalimidine 6.391933837
MESH:D000230 Adenocarcinoma arsenic trioxide 6.3911798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 6.3911473722
MESH:D000236 Adenoma Folic Acid 9.6216963246
MESH:D000236 Adenoma Magnesium 9.6217823441
MESH:D000236 Adenoma resveratrol 9.6215688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.0916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.0916835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 3.6911874814
MESH:D000419 Albuminuria Raloxifene 4.0717308373 17451421
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5217887948
OMIM:607154 ALLERGIC RHINITIS Etodolac 5.3116979129
MESH:D000544 Alzheimer Disease Curcumin 13.8215590663
MESH:D000544 Alzheimer Disease Folic Acid 13.8217116317
MESH:D000544 Alzheimer Disease Nicotine 13.8216627626
MESH:D000544 Alzheimer Disease Ozone 13.8215513908
MESH:D000544 Alzheimer Disease Raloxifene 13.8215800139
MESH:D000544 Alzheimer Disease resveratrol 13.8216162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.4011748828
MESH:D000740 Anemia Vitamin A 7.4016960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.3216960172
MESH:D000756 Anemia, Sideroblastic Manganese 9.6416910769
MESH:D000756 Anemia, Sideroblastic Superoxides 9.6416910769
MESH:D000799 Angioedema Acetaminophen 3.2910982225
MESH:D000860 Anoxia Oxygen 4.5120872349
MESH:D001008 Anxiety Disorders vinclozolin 3.2019015723
MESH:D001169 Arthritis, Experimental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.159598899
MESH:D001169 Arthritis, Experimental resveratrol 7.1517115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.3016807698
MESH:D001172 Arthritis, Rheumatoid Ozone 4.3015570426
MESH:D001249 Asthma Mustard Gas 6.9110378619
MESH:D001249 Asthma Ozone 6.9117854713 16373670
MESH:D001249 Asthma Vitamin A 6.9116732791
MESH:D050197 Atherosclerosis Curcumin 12.9218704882
MESH:D050197 Atherosclerosis Oxygen 12.9216391483
MESH:D050197 Atherosclerosis Phenytoin 12.9215136057
MESH:D050197 Atherosclerosis resveratrol 12.9217967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 2.3118445737
MESH:D001321 Autistic Disorder Folic Acid 2.3121388746
MESH:D001321 Autistic Disorder Magnesium 2.3116846101
MESH:D001327 Autoimmune Diseases Cholecalciferol 9.3216142846
MESH:D001327 Autoimmune Diseases Curcumin 9.3219761891
MESH:D001768 Blister Mustard Gas 4.6119167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 12.4416206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.4419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.4412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2315340226
MESH:D001848 Bone Diseases, Developmental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.593355362
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5915746008
MESH:D001919 Bradycardia Isoproterenol 4.646740701
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.7817868700
MESH:D001930 Brain Injuries Progesterone 9.1915665606 15380490 15845082
MESH:D001930 Brain Injuries Raloxifene 9.1916580743
MESH:D002545 Brain Ischemia beta Carotene 14.0416157235
MESH:D002545 Brain Ischemia Curcumin 14.0416770732
MESH:D002545 Brain Ischemia resveratrol 14.0417600658
MESH:D001932 Brain Neoplasms Curcumin 3.4717596214
MESH:D001943 Breast Neoplasms Cacodylic Acid 6.1917474063
MESH:D001943 Breast Neoplasms Curcumin 6.1918462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Estradiol 6.1917289903 19861407 12948864 18497071 17018787 16675129 17261762 14630087
MESH:D001943 Breast Neoplasms Folic Acid 6.1916777985
MESH:D001943 Breast Neoplasms Oxygen 6.1917263869
MESH:D001943 Breast Neoplasms Progesterone 6.1916175315 15562024 17614352
MESH:D001943 Breast Neoplasms Raloxifene 6.1917440819 17893378 17595753 15758505 15775269 15572757 17049068 16912660 17952589 17242785 17261762 16837676
MESH:D001943 Breast Neoplasms resveratrol 6.1917651959 17534123 16393696
MESH:D001943 Breast Neoplasms Tamoxifen 6.1919410462 19189210 16818667 18815881 17049068 18351453 20065188 16202921 20859285 18629630 20390343 18984771 18997820 20544844 18821012 19011961 19103187 19221464 17440819 20135344 19244106 17893378 19487384 20005174 19288272 19084267 19200415 19142967 19066611 15565566 21152245 18855134 19059307 19189212 16873071 19115204 17261762 15668708 16273361 11161223 21138602 19155303 17242785 19289846 18425577
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.1920435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2415516495 17626835 18417511 14754758 18315731 16777450 19059883
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.4217687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 5.0517377406 17426644
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.8211589617
MESH:D002100 Cachexia Ozone 4.1916183385
MESH:D002114 Calcinosis marker/mechanism 18340010
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9216111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.253786805 15673190 16097048 16227642 16050911 15721981 10355542 15700767 18705752 16011737 16192424 16124888
MESH:D002277 Carcinoma Curcumin 6.8318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 6.8316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.9719066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 14.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 14.8416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.843084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 14.8415553829 16217749 15073043 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 14.8418788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.8416924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 14.8419321006 16227395
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.8416924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.0516675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.7718414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.3219014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.6412490120
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.3518462866
MESH:D002294 Carcinoma, Squamous Cell resveratrol 4.3516227395
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 7.9217572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 7.9217572228
MESH:D006332 Cardiomegaly Isoproterenol 6.037544033 11179087
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.0318670907 18850075 16120746
MESH:D009202 Cardiomyopathies marker/mechanism 18340010
MESH:D002311 Cardiomyopathy, Dilated marker/mechanism 11884376
MESH:D002318 Cardiovascular Diseases Folic Acid 14.1916755160
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 14.1916936243
MESH:D002318 Cardiovascular Diseases Raloxifene 14.1915775269
MESH:D002318 Cardiovascular Diseases resveratrol 14.1915458977
MESH:D002386 Cataract Acetaminophen 2.2410977129
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.1914688030
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 5.386135515
MESH:D002471 Cell Transformation, Neoplastic Estradiol 5.3818566989
MESH:D002493 Central Nervous System Diseases Phenytoin 4.764080065
MESH:D015362 Child Nutrition Disorders Vitamin A 4.9216153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7016835633
MESH:D002779 Cholestasis pirinixic acid 6.8919176532
MESH:D002779 Cholestasis Vitamin A 6.8916175620
OMIM:601042 CHOREOATHETOSIS/SPASTICITY, EPISODIC Phenytoin 5.3211748493
MESH:D002971 Cleft Lip Folic Acid 7.0621254359
MESH:D002971 Cleft Lip Phenytoin 7.062227380
MESH:D002972 Cleft Palate Folic Acid 12.0621254359 8946559
MESH:D002972 Cleft Palate Phenytoin 12.066862529 10789828 3877104 2227380 6856622 1687470
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 12.0615668235 15340226 16354765 8697196 12621046
MESH:D002972 Cleft Palate Vitamin A 12.0616054864
MESH:D003072 Cognition Disorders Raloxifene 4.0815800139
MESH:D003092 Colitis Curcumin 8.0316782535 18200517 16804969
MESH:D003092 Colitis resveratrol 8.0316474422
MESH:D003103 Coloboma Curcumin 9.6918809619
MESH:D003103 Coloboma Phenytoin 9.699212184
MESH:D003110 Colonic Neoplasms 2-(2,6-dioxopiperidin-3-yl)phthalimidine 12.361933837
MESH:D003110 Colonic Neoplasms Butyrates 12.3615936596
MESH:D003110 Colonic Neoplasms Curcumin 12.3619359593 16340194
MESH:D003110 Colonic Neoplasms Etodolac 12.3616004971
MESH:D003110 Colonic Neoplasms resveratrol 12.3616338953
MESH:D003110 Colonic Neoplasms Vitamin A 12.3617219422 16267017
MESH:D003111 Colonic Polyps Magnesium 5.5317823441
MESH:D015179 Colorectal Neoplasms arsenic trioxide 5.7820501625
MESH:D015179 Colorectal Neoplasms Etodolac 5.7811076880
MESH:D015179 Colorectal Neoplasms Folic Acid 5.7817245555 16985020 17087956 16963246 17116713
MESH:D015179 Colorectal Neoplasms Magnesium 5.7817823441
MESH:D015179 Colorectal Neoplasms resveratrol 5.7816550006
MESH:D000013 Congenital Abnormalities Phenytoin 7.8510627286
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.8514669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.3618497527
MESH:D003327 Coronary Disease resveratrol 3.3816507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.6612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 4.8410525206
MESH:D019465 Craniofacial Abnormalities Phenytoin 4.848986270 9212184 19952982
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 4.8410048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin A 4.8410992263
MESH:D003456 Cryptorchidism vinclozolin 3.8214966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.1218551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.5915213294
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8319031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.7017474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1518249437
MESH:D002658 Developmental Disabilities Magnesium 4.5316846101
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.3216873680
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.3216506275
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 6.2718403477
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 6.2716886840
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2717107852
MESH:D003928 Diabetic Nephropathies Curcumin 23.1718204486
MESH:D003928 Diabetic Nephropathies Estradiol 23.1719279558
MESH:D003928 Diabetic Nephropathies Raloxifene 23.1715920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies resveratrol 23.1716286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 23.1719279558
MESH:D003929 Diabetic Neuropathies Progesterone 3.9617187935
OMIM:607208 DRAVET SYNDROME Phenytoin 4.8511748493
MESH:D003875 Drug Eruptions Phenytoin 4.9615024534
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.8921346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.8921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.8912540782 16177239 19370779 10915739 16485898 16781746 10663392 15968718 12594235 12705907 11739529 16109766 14550746 14725611 11743745 19739265 18713872 16081117 12153990 11461765 19420014 12392966 19923254 19416960 2444490 17906064 11529661 17522070 16393943 19085960 17562736 18071297 19164858 11287661 15619225 14986274 10774834 12958197 11421492 11834606 16227642
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.8910092053 7440962 3732212 21278145 19336974 15968718 3786805 9327722 11566570 16227642 15027814 10915739 6623471 4309450 7179309 19085960 6884620 2869522 15998439 17522070 7120509 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.8920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3511462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.2516146918
MESH:D004381 Duodenal Ulcer Curcumin 3.5317351913
MESH:D004417 Dyspnea Chlorine 8.8420016425
MESH:D004417 Dyspnea Oxygen 8.8420016425
MESH:D020821 Dystonic Disorders Nicotine 5.3817881519
MESH:C538011 Eales disease Vitamin A 5.069068938
MESH:D004480 Ectromelia 2-(2,6-dioxopiperidin-3-yl)phthalimidine 12.957940403
MESH:D004480 Ectromelia Vitamin A 12.9516054864
MESH:D004487 Edema Mustard Gas 16.5211428631 9260866 11428647 11402378
MESH:D004487 Edema pirinixic acid 16.5212083418
MESH:D004487 Edema Raloxifene 16.5215860553
MESH:D004487 Edema resveratrol 16.528985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 16.5211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3416714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Phenytoin 23.2717654737
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 23.2717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 23.2715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 23.2717872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 23.2719031437
MESH:D016889 Endometrial Neoplasms Estradiol 10.3818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Folic Acid 10.3817301261
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.3817893378 19155303 20544844 16202921
MESH:D004715 Endometriosis Progesterone 7.3516134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.3510568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.3117923197
MESH:D004816 Epidermal Necrolysis, Toxic Phenytoin 4.6820235791
MESH:D004820 Epidermolysis Bullosa Phenytoin 5.671399206 6251365
MESH:D004828 Epilepsies, Partial Phenytoin 4.3611558140 17116037
MESH:D004827 Epilepsy Phenytoin 3.63821787 11434505 20417680
MESH:D017029 Epilepsy, Complex Partial Phenytoin 4.767750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenytoin 4.523659116
MESH:D004890 Erythema Mustard Gas 4.619357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.1612903497
MESH:D017889 Exfoliation Syndrome Folic Acid 4.9416504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6011564622
MESH:D005234 Fatty Liver arsenic trioxide 24.3915073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 24.3912631006 16045604 15959796 17595544 12795759 16239168 19224547 61145
MESH:D005234 Fatty Liver Curcumin 24.3919297423
MESH:D005234 Fatty Liver pirinixic acid 24.3919236843 20131406
MESH:D005234 Fatty Liver Raloxifene 24.3917473493
MESH:D005234 Fatty Liver Tamoxifen 24.3919224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.8816709447
MESH:D005313 Fetal Death Phenytoin 8.9610627286
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 8.9611858732
MESH:D005327 Fetal Resorption Vitamin A 4.8116054864
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.9814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 11.7518705752
MESH:D005355 Fibrosis Curcumin 11.7518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 11.7520067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.7416904648
MESH:D005739 Gas Poisoning Chlorine 10.1820016425
MESH:D005739 Gas Poisoning Oxygen 10.1820016425
MESH:D005756 Gastritis Acetaminophen 9.4216983495
MESH:D005756 Gastritis Folic Acid 9.4217171786
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.1618462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.3916973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.7416417039
MESH:D005885 Gingival Hyperplasia Phenytoin 5.129029455
MESH:D019214 Gingival Overgrowth Phenytoin 5.6714659971 16390469
MESH:D005901 Glaucoma Folic Acid 4.5716504073
MESH:D005909 Glioblastoma Curcumin 6.3917596214
MESH:D005909 Glioblastoma Manganese 6.3917043766
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0410696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.2818829502 18462866
MESH:D006330 Heart Defects, Congenital Folic Acid 9.5617286298 16524890
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.5611294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin A 9.5616080930 10992263
MESH:D006331 Heart Diseases Raloxifene 3.1511110106
MESH:D006333 Heart Failure marker/mechanism 11884376
MESH:D006333 Heart Failure Dobutamine 10.0517440445
MESH:D006333 Heart Failure Isoproterenol 10.0518097624
MESH:D006333 Heart Failure pirinixic acid 10.0520558911
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 4.5913678655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8411000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.0819900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 6.5019772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.5015340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5017701891
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.4016863852 16292552 16877224 16490937 15707848 17436238
MESH:D006558 Herpes Genitalis Estradiol 4.4715709030
MESH:D006561 Herpes Simplex resveratrol 3.6416876885
MESH:D015658 HIV Infections beta Carotene 6.2516960176
MESH:D015658 HIV Infections Vitamin A 6.2516960176
MESH:D006679 HIV Seropositivity Folic Acid 11.5317209195
MESH:D006679 HIV Seropositivity Vitamin A 11.5317209195
MESH:D019584 Hot Flashes Estradiol 3.2017088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.498697196 16959395 16354765 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.2716870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 3.9816899240
MESH:D006937 Hypercholesterolemia Curcumin 7.7618704882
MESH:D006937 Hypercholesterolemia resveratrol 7.7617188708
MESH:D006943 Hyperglycemia pirinixic acid 2.7120558911
MESH:D020138 Hyperhomocysteinemia Folic Acid 13.1416395265 16397167 16433478 16755160 16865747
MESH:D020138 Hyperhomocysteinemia Phenytoin 13.1410459572
MESH:D020138 Hyperhomocysteinemia Superoxides 13.1412615666
MESH:D006949 Hyperlipidemias resveratrol 3.5316873680
MESH:D006968 Hypersensitivity, Delayed indirubin 5.3811275354
MESH:D006973 Hypertension Raloxifene 4.4415787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.4418850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5515338365
MESH:D006984 Hypertrophy Isoproterenol 4.7012791704
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.8217488730
MESH:D006986 Hypervitaminosis A Vitamin A 5.6116054864
MESH:D007022 Hypotension Isoproterenol 4.296740701
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 9.7115869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 9.7117600658
MESH:D007248 Infertility, Male Atrazine 5.8612948887
MESH:D007248 Infertility, Male vinclozolin 5.8616467254
MESH:D007249 Inflammation Curcumin 15.9316956363 17151092 18403477
MESH:D007249 Inflammation Mustard Gas 15.9317524151 9357497 8975870 11428647 9260866 16001271 11428620 11428631 11402378
MESH:D007249 Inflammation Progesterone 15.9315869954
MESH:D007249 Inflammation resveratrol 15.9316366677
MESH:D007249 Inflammation Tamoxifen 15.9319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.9312200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.9618596194 18200517
MESH:D007251 Influenza, Human resveratrol 3.9916624496
MESH:D007333 Insulin Resistance Estradiol 5.9516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 5.9516306350
MESH:D007410 Intestinal Diseases Superoxides 4.9110210152
MESH:D007414 Intestinal Neoplasms Curcumin 3.7410783313
MESH:D019586 Intracranial Hypertension Vitamin A 5.2615955940
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8416580747
MESH:D007674 Kidney Diseases Acetaminophen 4.7715629191 12587719
MESH:D007674 Kidney Diseases Estradiol 4.7715618244
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 3.7816518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.0916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.0916705839
MESH:D007680 Kidney Neoplasms Estradiol 14.0915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 14.0918625569
MESH:D007889 Leiomyoma Curcumin 9.4718555241
MESH:D007889 Leiomyoma Raloxifene 9.4716973256
MESH:D007938 Leukemia arsenic trioxide 5.5215070760
MESH:D007938 Leukemia Curcumin 5.5218462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.1317077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.1316106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.7616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic disulfide 7.5412421474
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 7.5414633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.2719077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0317050201 16467208 16968895 20471514 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.559834237 16331271 16823087 15748426 17649720 12679006 17107899 19225113 15213294 12018890 11468182 16966277 19075265 17217047 16112521 15622746 19035177 17869043 12712474 11161223 17712046 15336539 16891316 16330433 19642359
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 6.5516087638
MESH:D015458 Leukemia, T-Cell arsenic trioxide 9.9816882451
MESH:D015458 Leukemia, T-Cell Curcumin 9.9816106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.1816417039
MESH:D017880 Limb Deformities, Congenital 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.983355362 6734493
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.9816054864
MESH:D008064 Lipidoses Tamoxifen 2.7615342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 5.9111903743 11408273 21278145 16943688 16239168 17157831 16221502 17334410 17174718
MESH:D008103 Liver Cirrhosis Vitamin A 5.9116256175
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.5016136751 15052691 18412020 11481614 15338365 17944888 18472332 14620537 17869086 18705752 12898905 12445421 12632514 15893842 17557913 15362042 17708605 17721639 17481882 12667390 14716496 18279442 15673190 20821823 17761835 17640975 12649538 18317297 18376398 17565644 17714472 18481824 15730626 18263696 12546737 15996030 18277467 15123356 18472094 15925388 18251166 17766677 17823541 17698563 12666154 18395095 15818738 18166357 18395914 12586293 16248980 13678700 18210741 17525996 16015684 18418968 14748882 18339082 17805973 15370692 16638106 15876570 17922224 18187930 18054572 15057751 15931870 12609069 12445418 18420326 14512876 18156304 18429990 16192424 14716833 14724832 18205269 12741479 15650968 16011737 17976157 18006644 12632512 17900296 15959796 12958196 16027843 10355542 16116963 17631135 16033810 16097048 12389079
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 9.5018006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 9.5014659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.5015474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 9.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 9.5016248980
MESH:D008107 Liver Diseases Acetaminophen 13.5719784758 11587558 19014921 16610002 12969438 12587719 19460945 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 13.5716964402 16246199 15720792 15830285 17285989
MESH:D008107 Liver Diseases Curcumin 13.5716956363
MESH:D008107 Liver Diseases Folic Acid 13.5716877991
MESH:D008107 Liver Diseases Phenytoin 13.5714986274
MESH:D008107 Liver Diseases Vitamin A 13.5716175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.6216762690
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6315123358
MESH:D017114 Liver Failure, Acute Acetaminophen 7.8216871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 7.8214706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 18.207678174
MESH:D008113 Liver Neoplasms arsenic trioxide 18.2014682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.2019294768
MESH:D008113 Liver Neoplasms pirinixic acid 18.2016377806 20007298 15890375
MESH:D008113 Liver Neoplasms resveratrol 18.2019812893 19073162 20405173 19321006
MESH:D008113 Liver Neoplasms Tamoxifen 18.2016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.2016984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 18.722876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 18.7220377131
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 18.7217113696
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 18.7215583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.7212151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 18.7217113696
MESH:D008133 Long QT Syndrome arsenic trioxide 7.2115213294
MESH:D008133 Long QT Syndrome Dobutamine 7.2119353679
MESH:D008171 Lung Diseases Dobutamine 14.5816638327
MESH:D008171 Lung Diseases Mustard Gas 14.5818161513 18702808
MESH:D008171 Lung Diseases Ozone 14.5819066396 8266340
MESH:D008171 Lung Diseases Vitamin A 14.5816863852
MESH:D055370 Lung Injury Oxygen 7.6618339021
MESH:D055370 Lung Injury Ozone 7.6620417186
MESH:D008175 Lung Neoplasms arsenic trioxide 9.3019825857 11798837
MESH:D008175 Lung Neoplasms beta Carotene 9.3016401635
MESH:D008175 Lung Neoplasms Curcumin 9.3019359593 16243823 18462866
MESH:D008175 Lung Neoplasms Mustard Gas 9.303148597 8781369
MESH:D008175 Lung Neoplasms Ozone 9.308597069 7614698
MESH:D008175 Lung Neoplasms Tamoxifen 9.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.3011884234 19555203
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.1617718048
MESH:D008223 Lymphoma Curcumin 3.1918462866
MESH:D016393 Lymphoma, B-Cell resveratrol 3.8017088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.4214749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.1616173963
MESH:D008275 Magnesium Deficiency Magnesium 5.9017823441
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.1915688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.1919428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.2711408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.2717203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 11.2711606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.2716827153 14580682 19196722 11731420 19196723
MESH:D020149 Manganese Poisoning Estradiol 19.1619453300
MESH:D020149 Manganese Poisoning Manganese 19.1619453300 16551646 16568477
MESH:D020149 Manganese Poisoning Tamoxifen 19.1619453300
MESH:D019767 Maxillofacial Abnormalities Folic Acid 5.1516832597
MESH:D008545 Melanoma Curcumin 4.4818462866 17885582
MESH:D008545 Melanoma resveratrol 4.4817992120
MESH:D008545 Melanoma Tamoxifen 4.4812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0319513568
MESH:D008569 Memory Disorders Curcumin 3.6417263510
MESH:D008607 Mental Retardation Phenytoin 3.469212184
MESH:D008654 Mesothelioma Atrazine 3.291916698
MESH:D008659 Metabolic Diseases resveratrol 3.8917112576
MESH:D008679 Metaplasia Ozone 4.5510496685
MESH:D008881 Migraine Disorders Magnesium 4.3718803445
MESH:D020326 Migraine without Aura Cyclic AMP 4.6411304026
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.0015863610
MESH:D009069 Movement Disorders Manganese 4.5016551646
MESH:D009101 Multiple Myeloma arsenic trioxide 18.4414977855 19417148 15949261 19549372 11468182
MESH:D009101 Multiple Myeloma Curcumin 18.4419372569
MESH:D009101 Multiple Myeloma Raloxifene 18.4416497877
MESH:D009101 Multiple Myeloma resveratrol 18.4416267019 16490592 17164350 17049120 14749477 17935668
MESH:D009101 Multiple Myeloma Vitamin A 18.4416374440
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.1213678655
MESH:D009134 Muscular Atrophy, Spinal Curcumin 10.5917962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 10.5917962980
MESH:D009135 Muscular Diseases pirinixic acid 2.9716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.1118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.8116882451 16105982
MESH:D009203 Myocardial Infarction Isoproterenol 8.1217052832 19595682 16697266 19172585 16538859 15740881 16584858
MESH:D009203 Myocardial Infarction pirinixic acid 8.1219151258
MESH:D009203 Myocardial Infarction resveratrol 8.1217188708 17125593 16525036 16317513 16456233 17015251
MESH:D017202 Myocardial Ischemia Dobutamine 12.9112447174
MESH:D017202 Myocardial Ischemia resveratrol 12.9117125593 17015251
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 12.9112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 6.8316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 6.8316411023
MESH:D009205 Myocarditis resveratrol 4.2117322642
MESH:D020191 Myoclonic Epilepsies, Progressive Phenytoin 4.9717484760
MESH:D009224 Myotonia Congenita Phenytoin 4.861896199
MESH:D009232 Myxoma Raloxifene 5.0016343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.5318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.537678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 8.6016624393
MESH:D009361 Neoplasm Invasiveness Curcumin 8.6018495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.3119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3119410462
MESH:D009369 Neoplasms beta Carotene 6.8217051425
MESH:D009369 Neoplasms Nicotine 6.8216365874
MESH:D009369 Neoplasms pirinixic acid 6.8217405874
MESH:D009374 Neoplasms, Experimental resveratrol 3.478985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 8.9912497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 8.9919189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 8.5517289903
MESH:D009389 Neovascularization, Pathologic Nicotine 8.5516365874
MESH:D009410 Nerve Degeneration Manganese 3.8516551646
MESH:D009421 Nervous System Malformations Estradiol 7.7411399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 7.7414600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.0718462866
MESH:D009436 Neural Tube Defects arsenic trioxide 14.4110525206
MESH:D009436 Neural Tube Defects Folic Acid 14.4117438019
MESH:D009436 Neural Tube Defects Phenytoin 14.419118846
MESH:D009436 Neural Tube Defects Vitamin A 14.4117400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.8618514411
MESH:D019636 Neurodegenerative Diseases resveratrol 6.8617652729
MESH:D020078 Neurogenic Inflammation resveratrol 3.8917929310
MESH:D009503 Neutropenia Folic Acid 7.9216322990
MESH:D009503 Neutropenia Mustard Gas 7.927688884 16761898
MESH:D009765 Obesity Curcumin 4.0419297423
MESH:D009765 Obesity pirinixic acid 4.0420558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 7.3016049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 7.3016049721
MESH:D010018 Osteomalacia Phenytoin 4.8617016548
MESH:D010024 Osteoporosis Curcumin 6.2318719352
MESH:D010024 Osteoporosis Raloxifene 6.2317882678 19059307 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 8.5317823083 17893378 15579764 15758505
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 8.5317513867
MESH:D010051 Ovarian Neoplasms arsenic trioxide 9.6116624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Curcumin 9.6119020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 9.6119401270
MESH:D010051 Ovarian Neoplasms Progesterone 9.6117393432 16525653
MESH:D010146 Pain Acetaminophen 5.5216870215
MESH:D010146 Pain Phenytoin 5.5215215642
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.7015580305
MESH:D010190 Pancreatic Neoplasms Curcumin 4.7019196508 19401701 17440100
MESH:D010212 Papilloma Hydrogen Peroxide 3.5612065085
MESH:D010235 Paraganglioma arsenic trioxide 3.6619927285
MESH:D010300 Parkinson Disease Atrazine 5.1117218051
MESH:D010300 Parkinson Disease Manganese 5.1111181820
MESH:D020734 Parkinsonian Disorders Manganese 4.0016140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.6912520081
MESH:D010538 Peritonitis Ozone 3.6016369182
MESH:D011014 Pneumonia Ozone 3.8518381685 18929643 18007984
MESH:D011041 Poisoning Mustard Gas 3.3015727166
MESH:D017689 Polydactyly Phenytoin 4.589212184
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0418163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 13.1316679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.1311118676 11222880 11399792 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.1319015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.3918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.3920887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.2819131511
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.2817024972
MESH:D011471 Prostatic Neoplasms Curcumin 2.2811398177 15129424 18156803 18226269 12497104 10851300 18769126
MESH:D011471 Prostatic Neoplasms Estradiol 2.2816740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.2816205645
MESH:D011471 Prostatic Neoplasms Raloxifene 2.2815731164 16220300 16536755
MESH:D011471 Prostatic Neoplasms resveratrol 2.2816731767 17804756 15767336 17675339 17718901 17636462
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.2815067354
MESH:D011472 Prostatitis vinclozolin 4.3918629315
MESH:D011537 Pruritus Mustard Gas 3.5518058305
MESH:D019310 Pseudolymphoma Phenytoin 4.981419762 8603615 12752131
MESH:D011654 Pulmonary Edema Isoproterenol 4.6910903255
MESH:D011656 Pulmonary Emphysema Curcumin 4.0519168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7017894541 10334151 17266442 17720292 17620002
MESH:D011693 Purpura Raloxifene 5.0015770314
MESH:D051437 Renal Insufficiency Folic Acid 4.2515728788
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.0216325855
MESH:D015427 Reperfusion Injury pirinixic acid 9.4319058328
MESH:D015427 Reperfusion Injury resveratrol 9.4317520802 16314181 15827377 17058453 16317513
MESH:D015427 Reperfusion Injury Superoxides 9.4318460982
MESH:D012120 Respiration Disorders Chlorine 4.6518579056
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 7.8218379247 10666014
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 7.8217627322 18339021
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.2516877224
MESH:D012135 Respiratory Sounds Atrazine 3.9911874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3218990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6418045962
MESH:D012509 Sarcoma Curcumin 3.6418462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.4416646077
MESH:D012559 Schizophrenia Folic Acid 2.8116641680
MESH:D012640 Seizures 2,4-dinitrotoluene 11.0218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.0218551238
MESH:D012640 Seizures Nicotine 11.0217873105
MESH:D012640 Seizures Phenytoin 11.023137016 3691417 11044598 9844417 10029267 16876388 15946322 19919933
MESH:D018805 Sepsis Curcumin 3.6218389075
MESH:D012871 Skin Diseases Folic Acid 7.1718709164
MESH:D012871 Skin Diseases Mustard Gas 7.1716961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin A 7.1718709164
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 7.8712065085
MESH:D012878 Skin Neoplasms resveratrol 7.878985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 7.8716192470
MESH:D013088 Spermatocele Tamoxifen 3.7416709447
MESH:D013118 Spinal Cord Diseases Folic Acid 4.9416361298
MESH:D013119 Spinal Cord Injuries Progesterone 9.0515862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.0519457130
MESH:D013262 Stevens-Johnson Syndrome Phenytoin 4.6220235791
MESH:D013272 Stomach Diseases beta Carotene 4.5517638125
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.6217007042
MESH:D013274 Stomach Neoplasms Folic Acid 2.6217171786
MESH:D013276 Stomach Ulcer beta Carotene 6.2212500499
MESH:D013276 Stomach Ulcer Curcumin 6.2216631530 19188055
MESH:D020521 Stroke Folic Acid 7.5516517955
MESH:D020521 Stroke Raloxifene 7.5516837676
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.0016321402
MESH:D013398 Sudden Infant Death Oxygen 5.0012563064
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.2019014326
MESH:D013964 Thyroid Neoplasms Butyrates 6.2017967635
MESH:D013978 Tibial Fractures Estradiol 11.8519048282
MESH:D013978 Tibial Fractures Raloxifene 11.8519048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.3211259349 16720336 16785264
MESH:D014029 Tobacco Use Disorder Nicotine 4.9117979512 18041664 15735609 18305452
MESH:D014062 Tongue Neoplasms resveratrol 3.7316227395
MESH:D016171 Torsades de Pointes arsenic trioxide 8.8715213294
MESH:D016171 Torsades de Pointes Dobutamine 8.8719353679
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 20.3516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 20.3516049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 20.3512973940 20435036 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Cacodylic Acid 20.3515537745
MESH:D001749 Urinary Bladder Neoplasms Curcumin 20.3518593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 20.3517572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 20.3516712894 8653321 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.7218462866
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.1710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.1710091137
MESH:D014581 Urticaria Acetaminophen 2.4810982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 3.6317473185
MESH:D014594 Uterine Neoplasms resveratrol 3.6217044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0412125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.6516837676
MESH:D018487 Ventricular Dysfunction, Left Isoproterenol 8.9018097624
MESH:D018487 Ventricular Dysfunction, Left resveratrol 8.9017488730
MESH:D020257 Ventricular Remodeling Isoproterenol 5.1418097624
MESH:D014802 Vitamin A Deficiency Vitamin A 4.7716960172 16175781 16146918
MESH:D014846 Vulvar Neoplasms Raloxifene 5.0016343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.6915886252
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
KEGG:05100 Bacterial invasion of epithelial cells
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:20676 Cell junction organization
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:05140 Leishmaniasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:05130 Pathogenic Escherichia coli infection
KEGG:05200 Pathways in cancer
KEGG:04145 Phagosome
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05131 Shigellosis
REACT:6900 Signaling in Immune system
KEGG:05222 Small cell lung cancer
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29953
    • No data
    No data
    Releated drug ID Related drug Name
    PA450952phospholipids
    PA448976choline
    PA448478l-arginine
    PA450635nitric oxide
    PA152241909PP2
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00098 - Antithymocyte globulin Immunomodulatory Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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