AutismKB 2.0

Annotation Detail for ITGB2


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Basic Information Top
Gene Symbol:ITGB2 ( CD18,LAD,LCAMB,LFA-1,MAC-1,MF17,MFI7 )
Gene Full Name: integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Band: 21q22.3
Quick LinksEntrez ID:3689; OMIM: 600065; Uniprot ID:ITB2_HUMAN; ENSEMBL ID: ENSG00000160255; HGNC ID: 6155
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04650Natural killer cell mediated cytotoxicity
hsa04145Phagosome
hsa05416Viral myocarditis
hsa05140Leishmaniasis
hsa05146Amoebiasis
hsa05144Malaria
hsa05150Staphylococcus aureus infection
hsa04810Regulation of actin cytoskeleton
hsa04514Cell adhesion molecules (CAMs)
Pathway IDPathway Name
Hemostasis
Signaling in Immune system
Integrin cell surface interactions
Pathway IDPathway Name
200172HIF-1-alpha transcription factor network
200150CXCR3-mediated signaling events
200117Paxillin-dependent events mediated by a4b1
200108amb2 Integrin signaling
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500305Cell surface interactions at the vascular wall
500004Integrin cell surface interactions
500477Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Related Diseases/Disorders Top
Desease IDDesease Name
H00099Leukocyte adhesion deficiency
Immune system diseases
Primary immunodeficiency
Desease IDDesease Name
1706Thrombophilia
1770Melanoma
1781Rheumatoid arthritis
1804Chronic obstructive airway disease
1809HIV infection
1856Obesity
1902Kidney failure
1904Diabetes mellitus
1909Migraine
1929Pertussis
1954Stroke
1998Enteritis
2053Colon cancer
Desease Name
restenosis
CARDIOVASCULAR
anti-myeloperoxidase subtypes of ANCA-associated systemic vasculitides
reduced risk of restenosis after coronary stenting
No data
Desease Name
Leukocyte adhesion deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C070379 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
C001079 2-(2,6-dioxopiperidin-3-yl)phthalimidine 2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGB2 proteindecreases expression 8538367
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
C029955 2-nitrotoluene 2-nitrotoluene results in increased expression of ITGB2 mRNAincreases expression 16460773
C108123 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
D000082 Acetaminophen Acetaminophen affects the expression of ITGB2 mRNAaffects expression 17562736
C430898 AGN 194204 AGN 194204 results in increased expression of ITGB2 mRNAincreases expression 16339527
C103303 alitretinoin Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGB2 protein]increases expression|increases reaction 15964820
C006632 arsenic trioxide arsenic trioxide results in increased expression of ITGB2 mRNAincreases expression 20458559
D001374 Azacitidine Azacitidine results in decreased expression of ITGB2 mRNAdecreases expression 19194470
C070515 bisindolylmaleimide I bisindolylmaleimide I inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
C006780 bisphenol A bisphenol A results in increased expression of ITGB2 mRNAincreases expression 14555285
C006780 bisphenol A bisphenol A results in increased expression of ITGB2 proteinincreases expression 14555285
C099813 bromochloroacetic acid bromochloroacetic acid results in increased expression of ITGB2 mRNAincreases expression 16460773
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ITGB2 mRNAincreases expression 15056808
D002392 Catechin Catechin inhibits the reaction [S100B protein results in increased expression of ITGB2 mRNA]decreases reaction|increases expression 17103373
D004041 Dietary Fats Dietary Fats results in decreased expression of ITGB2 mRNAdecreases expression 18042831
D004121 Dimethyl Sulfoxide Dimethyl Sulfoxide promotes the reaction [alitretinoin results in increased expression of ITGB2 protein]increases expression|increases reaction 15964820
D009240 N-Formylmethionine Leucyl-Phenylalanine N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 proteinincreases expression 10215738
D009240 N-Formylmethionine Leucyl-Phenylalanine plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]decreases reaction|increases expression 10215738
C031927 hydroquinone hydroquinone results in decreased expression of ITGB2 proteindecreases expression 17464197
C027185 indirubin indirubin results in increased expression of ITGB2 proteinincreases expression 16115123
D007213 Indomethacin Indomethacin results in increased expression of [ITGAM protein binds to ITGB2 protein]affects binding|increases expression 10761979
D007213 Indomethacin ITGB2 protein affects the susceptibility to Indomethacinaffects response to substance 10486359
D007501 Iron Iron deficiency results in increased expression of ITGB2 mRNAincreases expression 20368581
D007529 Isoflavones Isoflavones affects the expression of ITGB2 mRNAaffects expression 16365062
D009151 Mustard Gas Mustard Gas results in increased expression of ITGB2 mRNAincreases expression 18955075
D009151 Mustard Gas Mustard Gas results in increased expression of ITGB2 mRNAincreases expression 18988085
C104820 N-(3-(aminomethyl)benzyl)acetamidine N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
C104820 N-(3-(aminomethyl)benzyl)acetamidine N-(3-(aminomethyl)benzyl)acetamidine inhibits the reaction [ITGB2 protein results in increased activity of RAP2A protein]decreases reaction|increases activity 16963453
D015058 1-Naphthylisothiocyanate ITGB2 protein results in increased susceptibility to 1-Naphthylisothiocyanateincreases response to substance 16614373
D009569 Nitric Oxide Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP1A protein]increases activity|increases reaction 16963453
D009569 Nitric Oxide Nitric Oxide promotes the reaction [ITGB2 protein results in increased activity of RAP2A protein]increases activity|increases reaction 16963453
D009569 Nitric Oxide CSF2 protein promotes the reaction [ITGB2 protein results in increased abundance of Nitric Oxide]increases abundance|increases reaction 8600936
D009569 Nitric Oxide [CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxideincreases abundance|increases expression 8600936
D009569 Nitric Oxide ITGB2 protein results in increased abundance of Nitric Oxideincreases abundance 8600936
D009569 Nitric Oxide [ITGB2 protein results in increased susceptibility to Ozone] which results in increased abundance of Nitric Oxideincreases abundance|increases response to substance 8600936
D009569 Nitric Oxide Ozone promotes the reaction [[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide]increases abundance|increases expression|increases reaction 8600936
D010126 Ozone ITGB2 protein results in increased susceptibility to Ozoneincreases response to substance 8600936
D010126 Ozone [ITGB2 protein results in increased susceptibility to Ozone] which results in increased abundance of Nitric Oxideincreases abundance|increases response to substance 8600936
D010126 Ozone Ozone promotes the reaction [[CSF2 protein results in increased expression of ITGB2 protein] which results in increased abundance of Nitric Oxide]increases abundance|increases expression|increases reaction 8600936
C041786 palm oil palm oil results in decreased expression of ITGB2 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ITGB2 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ITGB2 mRNAdecreases expression 17426115
C047686 plaunotol plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]decreases reaction|increases expression 10215738
D011374 Progesterone Progesterone affects the expression of ITGB2 mRNAaffects expression 17251523
D011794 Quercetin Quercetin inhibits the reaction [S100B protein results in increased expression of ITGB2 mRNA]decreases reaction|increases expression 17103373
C017947 sodium arsenite sodium arsenite results in decreased expression of ITGB2 mRNAdecreases expression 14691202
C416927 SU 6656 SU 6656 inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of ITGB2 mRNAaffects expression 16962184
C024746 tobacco tar tobacco tar results in decreased expression of ITGB2 mRNAdecreases expression 19559774
D014212 Tretinoin CSF3 protein promotes the reaction [Tretinoin results in increased expression of ITGB2 protein]increases expression|increases reaction 18055984
D014212 Tretinoin EP300 protein promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA]increases expression|increases reaction 16581781
D014212 Tretinoin [GABPA protein binds to EP300 protein] promotes the reaction [Tretinoin results in increased expression of ITGB2 mRNA]affects binding|increases expression|increases reaction 16581781
D014212 Tretinoin Tretinoin results in increased expression of ITGB2 mRNAincreases expression 16322068
16581781
D014212 Tretinoin Tretinoin results in increased expression of ITGB2 proteinincreases expression 18055984
C030665 triphenyltin triphenyltin results in increased expression of ITGB2 mRNAincreases expression 12788061
C030665 triphenyltin triphenyltin results in increased expression of ITGB2 proteinincreases expression 12788061
C025643 vinclozolin vinclozolin affects the expression of ITGB2 mRNAaffects expression 19015723
D014807 Vitamin D Vitamin D results in increased expression of ITGB2 mRNAincreases expression 20368581
C009687 wortmannin wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]decreases reaction|increases activity 16963453
C063449 zileuton zileuton results in decreased expression of ITGB2 proteindecreases expression 9738763
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.616734493 473085 3196154 3355362
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.6114514962 11752688 15322242
MESH:D000152 Acne Vulgaris zileuton 5.3120436887
MESH:D055371 Acute Lung Injury pirinixic acid 8.0118653653
MESH:D055371 Acute Lung Injury zileuton 8.0117118201
MESH:D000230 Adenocarcinoma 2-(2,6-dioxopiperidin-3-yl)phthalimidine 6.701933837
MESH:D000230 Adenocarcinoma arsenic trioxide 6.7011798837 19825857
MESH:D000230 Adenocarcinoma Indomethacin 6.7016537180
MESH:D000236 Adenoma Indomethacin 3.1811497255
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.3916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.3916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.2415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.4416712894 17306315
MESH:D000505 Alopecia Isoflavones 8.3817569567
MESH:D000505 Alopecia Tretinoin 8.3815955085
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.2016640825
MESH:D016301 Alveolar Bone Loss Indomethacin 4.9117225004
MESH:D000544 Alzheimer Disease Indomethacin 8.5217627676 15579461
MESH:D000544 Alzheimer Disease Iron 8.5216563566 16640825
MESH:D000544 Alzheimer Disease Nitric Oxide 8.5217556102
MESH:D000544 Alzheimer Disease Ozone 8.5215513908
MESH:D000740 Anemia Iron 7.6216566752 16434484
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.6211748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8317084956
MESH:D018798 Anemia, Iron-Deficiency Iron 4.2517147795 17162259 17375513 16569441 17163184
MESH:D000756 Anemia, Sideroblastic Iron 4.4116910769
MESH:D000799 Angioedema Acetaminophen 3.3810982225
MESH:D001008 Anxiety Disorders vinclozolin 3.2819015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.4210231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.4310388637
MESH:D001145 Arrhythmias, Cardiac Iron 3.9816604332
MESH:D001161 Arteriosclerosis Dietary Fats 3.4515238619
MESH:D018771 Arthralgia Indomethacin 4.712160914
MESH:D001169 Arthritis, Experimental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.219598899
MESH:D001169 Arthritis, Experimental Tretinoin 7.2116412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 6.7211248219
MESH:D001172 Arthritis, Rheumatoid Ozone 6.7215570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.7216292516
MESH:D001249 Asthma Mustard Gas 10.0410378619
MESH:D001249 Asthma Ozone 10.0417854713 16373670
MESH:D001249 Asthma Tretinoin 10.0416456186
MESH:D001249 Asthma zileuton 10.0417944539 8598621 19214143 10764316 20332717 10181070 9620945
MESH:D001250 Asthma, Exercise-Induced zileuton 5.1410984370
MESH:D001260 Ataxia Telangiectasia Iron 11.5915336622
MESH:D001260 Ataxia Telangiectasia Quercetin 11.5915336622
MESH:D050197 Atherosclerosis Iron 3.4316632123 16640825
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001327 Autoimmune Diseases Quercetin 3.9619761891
MESH:D001424 Bacterial Infections Iron 4.7416640825
MESH:D001471 Barrett Esophagus Tretinoin 3.9716935849
MESH:D001477 Bartter Syndrome Indomethacin 4.5410684365
MESH:D001768 Blister Mustard Gas 4.7019167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 18.6216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 18.6219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 18.6212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 18.6216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3315340226
MESH:D001848 Bone Diseases, Developmental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.823355362
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.8215746008
MESH:D001862 Bone Resorption bisphenol A 3.4611985600
MESH:D001929 Brain Edema Indomethacin 11.3311481608
MESH:D001929 Brain Edema zileuton 11.3319309543
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8717868700
MESH:D001930 Brain Injuries Progesterone 3.8215665606 15380490 15845082
MESH:D002545 Brain Ischemia Indomethacin 3.9712524144
MESH:D001943 Breast Neoplasms alitretinoin 5.2816344269
MESH:D001943 Breast Neoplasms bisphenol A 5.2817123778
MESH:D001943 Breast Neoplasms Dietary Fats 5.2820435547
MESH:D001943 Breast Neoplasms Indomethacin 5.2817401462
MESH:D001943 Breast Neoplasms Nitric Oxide 5.2815631943
MESH:D001943 Breast Neoplasms Progesterone 5.2815562024 17614352 16175315
MESH:D001943 Breast Neoplasms Quercetin 5.2818628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.2820435547
MESH:D001943 Breast Neoplasms Tretinoin 5.2816873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 7.8216777450 18315731 19059883 15516495 14754758 18417511 17626835
MESH:D016535 Bronchial Hyperreactivity zileuton 7.8212654629 12388339 12794006
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5117687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1416813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.9111589617
MESH:D002056 Burns Indomethacin 4.2610459503
MESH:D002100 Cachexia Indomethacin 10.8811239499 15625704 15141370 16537180
MESH:D002100 Cachexia Ozone 10.8816183385
MESH:D002105 Cadmium Poisoning Quercetin 5.0816962696
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.343786805 16227642 16097048 15673190 16011737 15700767 18705752 15721981 16050911 16124888 10355542 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 12.693084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 12.6915553829 14691202 11135700 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 12.6918788625
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 12.6916391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 12.6919519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 12.6916507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 12.691917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.5317123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.2711053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.9018791128 14736730 11352223
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5117234771
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.4119014326
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1517341418
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.7212490120
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 6.7212636206 15482327
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.7218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.7216096774 16051514
MESH:D006332 Cardiomegaly Quercetin 5.9219794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9218670907 18850075 16120746
MESH:D009202 Cardiomyopathies Iron 3.7416640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.2916604332
MESH:D002318 Cardiovascular Diseases Isoflavones 3.8417689850
MESH:D002386 Cataract Acetaminophen 6.3010977129
MESH:D002386 Cataract Tretinoin 6.3017460283
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 5.2714688030
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.1220056578 19524636
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 6.1219559774
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1416129372
MESH:D054506 Chloracne marker/mechanism 17101203
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D002761 Cholangitis 1-Naphthylisothiocyanate 5.7412912871
MESH:D002764 Cholecystitis Indomethacin 4.7111181007
MESH:D002779 Cholestasis 1-Naphthylisothiocyanate 11.7815913567 16629650 18164287 18590720 15500046 12927374 19486331 7624871
MESH:D002779 Cholestasis Nitric Oxide 11.7816919318
MESH:D002779 Cholestasis pirinixic acid 11.7819176532
MESH:D002780 Cholestasis, Intrahepatic 1-Naphthylisothiocyanate 5.3919407337 10220858
MESH:D002822 Choriocarcinoma Tretinoin 4.6916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.0816354765 15340226 15668235 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 5.089407595
MESH:D003092 Colitis Tretinoin 3.2617035595
MESH:D003110 Colonic Neoplasms 2-(2,6-dioxopiperidin-3-yl)phthalimidine 10.051933837
MESH:D003110 Colonic Neoplasms Indomethacin 10.0515625704 11260862 15963497 15637740 15786552 15936596
MESH:D003110 Colonic Neoplasms Iron 10.0516640825
MESH:D003110 Colonic Neoplasms Quercetin 10.0511134977 17148506 19056647 17191121 16640504 19440933 15741050
MESH:D003110 Colonic Neoplasms zileuton 10.0518927292
MESH:D015179 Colorectal Neoplasms arsenic trioxide 5.9220501625
MESH:D015179 Colorectal Neoplasms Azacitidine 5.9219934284
MESH:D015179 Colorectal Neoplasms Indomethacin 5.9212606626 18059344 11197048 17054584
MESH:D015179 Colorectal Neoplasms Isoflavones 5.9217116718
MESH:D015179 Colorectal Neoplasms Quercetin 5.9218852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6814669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 3.7512609071
MESH:D018352 Coronavirus Infections Indomethacin 5.2517302372
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.4210525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.4210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.429125849 10589399 9142499 17551590 9664655 16925845 14991402 9211117 9224671 8800419
MESH:D003456 Cryptorchidism vinclozolin 3.9114966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.6815213294
MESH:D003665 Decompression Sickness zileuton 5.7618309904
MESH:D015140 Dementia, Vascular Nitric Oxide 5.5017556102
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2018249437
MESH:D003920 Diabetes Mellitus Iron 4.0716640825 16604332
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.3719496084
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.2116506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.1216506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1217107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.0517187935
MESH:D003967 Diarrhea Indomethacin 3.377237001 7907874
MESH:D056486 Drug-Induced Liver Injury 1-Naphthylisothiocyanate 10.3817522070 18289764 20133375 7624871
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 10.3811834606 16393943 16081117 11529661 14986274 19164858 16109766 19370779 16227642 12540782 10915739 17562736 16177239 12153990 12705907 2444490 17522070 10663392 18071297 11739529 19085960 15619225 15968718 10774834 17906064 12594235 11461765 16485898 19416960 14550746 14725611 19420014 19739265 19923254 11287661 12392966 16781746 12958197 11421492 11743745 18713872
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.3821278145 7179309 16227642 7120509 17522070 10092053 4309450 6623471 15968718 6884620 19085960 3732212 9327722 19336974 16177239 3786805 2869522 11566570 7440962 15998439 10915739 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.3820420201
MESH:D056486 Drug-Induced Liver Injury zileuton 10.3817944539
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4211462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6918446180 16133044 18043480 12774134 17190690 16326151
MESH:D004381 Duodenal Ulcer Indomethacin 3.7111595415 17151854 17202747 17045617 11595431 17329845 11991626 11535926 16699067 10671773 17351913
MESH:D050171 Dyslipidemias Dietary Fats 3.1218367378
MESH:D004480 Ectromelia 2-(2,6-dioxopiperidin-3-yl)phthalimidine 6.587940403
MESH:D004487 Edema bisindolylmaleimide I 21.848273558
MESH:D004487 Edema Indomethacin 21.847907874 10653021 16100529 19703484 8985016 7990266 8273558
MESH:D004487 Edema Mustard Gas 21.8411402378 9260866 11428631 11428647
MESH:D004487 Edema pirinixic acid 21.8412083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 21.8411000095 12711302
MESH:D004487 Edema zileuton 21.847990266 11698051 8273558 9831321 7812673 17118201 19703484
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.4015322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.3517692515
MESH:D018159 Endolymphatic Hydrops Dimethyl Sulfoxide 6.1020641076
MESH:D016889 Endometrial Neoplasms Tretinoin 2.8116569247
MESH:D004715 Endometriosis Indomethacin 13.0315652904
MESH:D004715 Endometriosis Progesterone 13.0316134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.039294722 10568697
MESH:D019446 Endotoxemia Indomethacin 9.4918509659
MESH:D019446 Endotoxemia zileuton 9.4915328337
MESH:D004751 Enteritis Indomethacin 4.2816328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.5417980183
MESH:D004802 Eosinophilia Indomethacin 8.0211298111
MESH:D004802 Eosinophilia zileuton 8.0210764316 8621850
MESH:D004890 Erythema Mustard Gas 4.709357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.2812903497
MESH:D004938 Esophageal Neoplasms Indomethacin 4.2811005569
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.7011564622
MESH:D005124 Eye Abnormalities Tretinoin 7.709664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 20.3815073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.3815959796 61145 12631006 16045604 12795759 16239168 17595544 19224547
MESH:D005234 Fatty Liver Dietary Fats 20.3819551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Iron 20.3816640825
MESH:D005234 Fatty Liver pirinixic acid 20.3820131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0111858732
MESH:D005334 Fever Indomethacin 3.7311852909 17627676 10431976
MESH:D005354 Fibrosarcoma Indomethacin 4.4410962813
MESH:D005355 Fibrosis Carbon Tetrachloride 28.7618705752
MESH:D005355 Fibrosis Dietary Fats 28.7618296743
MESH:D005355 Fibrosis Indomethacin 28.7617994277
MESH:D005355 Fibrosis Quercetin 28.7619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 28.7620067830
MESH:D005355 Fibrosis Tretinoin 28.7617994277
MESH:D005499 Folliculitis Indomethacin 4.7111298111
MESH:D005596 Fractures, Closed zileuton 5.3919544365
MESH:D005621 Friedreich Ataxia Iron 4.9816604332 16640825
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.8316904648
MESH:D005756 Gastritis Acetaminophen 9.6116983495
MESH:D005756 Gastritis Indomethacin 9.6115046732
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4816973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8416417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2216452187
MESH:D005909 Glioblastoma Indomethacin 10.2212870263
MESH:D005909 Glioblastoma Quercetin 10.2219804834
MESH:D005909 Glioblastoma Tretinoin 10.2217312396
MESH:D005910 Glioma Indomethacin 5.6616487511 18371953
MESH:D005910 Glioma Quercetin 5.6617643826
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.9211849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1310696789
MESH:D006073 Gout Indomethacin 4.9011248219
MESH:D006261 Headache Nitric Oxide 4.7111554966 11284996
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.8815482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.8816096774
MESH:D034381 Hearing Loss Dimethyl Sulfoxide 4.7920641076
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.7011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 5.7014991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.2520558911
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 4.6813678655
MESH:D006432 Hemochromatosis Iron 4.1616640825 17053826 16574947 16604332 17255318 17236123
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9311000095
MESH:D006486 Hemosiderosis Iron 4.7516604332
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1615633222
MESH:D006505 Hepatitis 1-Naphthylisothiocyanate 8.2318590720
MESH:D006505 Hepatitis Carbon Tetrachloride 8.2319110552 19900420
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2515135802
MESH:D006525 Hepatitis, Viral, Human Iron 5.0116640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.5017182432
MESH:D006529 Hepatomegaly Iron 17.1416890145
MESH:D006529 Hepatomegaly pirinixic acid 17.1419176532 16221962 18467677 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 17.1415340226 12621046 16120746
MESH:D006529 Hepatomegaly zileuton 17.148661344
MESH:D015658 HIV Infections Iron 3.4316597321
MESH:D006689 Hodgkin Disease sodium arsenite 2.7812676792
MESH:D019584 Hot Flashes Isoflavones 4.5217290160 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5818606429 15340226 16959395 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 11.0016870215
MESH:D006930 Hyperalgesia Indomethacin 11.0012727271
MESH:D006930 Hyperalgesia Tretinoin 11.0016870215
MESH:D034321 Hyperamylasemia Indomethacin 5.2517883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0816899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.1921332399
MESH:D006940 Hyperemia Indomethacin 11.2112524144
MESH:D006940 Hyperemia Nitric Oxide 11.2111156591
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1216778211
MESH:D006943 Hyperglycemia pirinixic acid 13.6120558911
MESH:D006943 Hyperglycemia Quercetin 13.6111834736 18262572
MESH:D006943 Hyperglycemia triphenyltin 13.6110522495
MESH:D020138 Hyperhomocysteinemia Catechin 4.5917292331
MESH:D006949 Hyperlipidemias Dietary Fats 7.9521332399
MESH:D006949 Hyperlipidemias Indomethacin 7.9517546600
MESH:D006968 Hypersensitivity, Delayed indirubin 5.4711275354
MESH:D006973 Hypertension Quercetin 4.5918356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5918850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.6415338365
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 7.8015838368
MESH:D006976 Hypertension, Pulmonary zileuton 7.8014726295
MESH:D015228 Hypertriglyceridemia triphenyltin 5.5610522495
MESH:D007006 Hypogonadism Iron 4.0816640825
MESH:D007037 Hypothyroidism Iron 4.6416640825
MESH:D007077 Ileal Diseases Indomethacin 4.5610574470 18306037
MESH:D007079 Ileitis Indomethacin 4.9010651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.9116133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.3715869954
MESH:D020244 Infarction, Middle Cerebral Artery zileuton 10.3719309543
MESH:D007246 Infertility triphenyltin 5.5915205045
MESH:D007248 Infertility, Male sodium arsenite 5.8212646999 15346721
MESH:D007248 Infertility, Male vinclozolin 5.8216467254
MESH:D007249 Inflammation bisindolylmaleimide I 20.408273558
MESH:D007249 Inflammation Dietary Fats 20.4020412841
MESH:D007249 Inflammation Indomethacin 20.407812673 3291741 12568917
MESH:D007249 Inflammation Mustard Gas 20.408975870 16001271 17524151 9357497 11428620 11402378 11428631 11428647 9260866
MESH:D007249 Inflammation Progesterone 20.4015869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.4012200463 12878042
MESH:D007249 Inflammation zileuton 20.408960868 18295198 18059327 7812673 18309904 17118201 9831321 8621850
MESH:D015212 Inflammatory Bowel Diseases zileuton 3.9615339030
MESH:D007251 Influenza, Human Quercetin 4.0516624496
MESH:D007333 Insulin Resistance bisphenol A 10.5716393666
MESH:D007333 Insulin Resistance Dietary Fats 10.5711836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 10.5716306350
MESH:D007410 Intestinal Diseases Indomethacin 19.9117329856 18236018 15831440 15610444 11713966 10210152 11686837 17994277 11855677
MESH:D007410 Intestinal Diseases N-(3-(aminomethyl)benzyl)acetamidine 19.9111713966
MESH:D007410 Intestinal Diseases Nitric Oxide 19.9111574821 11713966 10210152
MESH:D007410 Intestinal Diseases Tretinoin 19.9117994277
MESH:D019586 Intracranial Hypertension Indomethacin 4.9115241188
MESH:D019189 Iron Metabolism Disorders Iron 4.6217163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5816580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.5815992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.5610574470 18306037 16133968
MESH:D007627 Keloid Quercetin 4.5117086741
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.1816144296
MESH:D007674 Kidney Diseases Acetaminophen 12.2415629191 12587719
MESH:D007674 Kidney Diseases Indomethacin 12.2417190690
MESH:D007674 Kidney Diseases Quercetin 12.2416962696
MESH:D007674 Kidney Diseases sodium arsenite 12.2420008137
MESH:D007896 Leishmaniasis Nitric Oxide 4.2817218153
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5410320625 12228301 11703811
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17.1712970779
MESH:D007938 Leukemia arsenic trioxide 17.1715070760
MESH:D007938 Leukemia Azacitidine 17.1719148494
MESH:D007938 Leukemia Quercetin 17.1717468513
MESH:D007938 Leukemia Tretinoin 17.1717143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.3912560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.8516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 12.2914633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 12.2910785260 16572323 15631656
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive zileuton 12.2919503090 19823023
MESH:D007951 Leukemia, Myeloid arsenic trioxide 13.7419077051
MESH:D007951 Leukemia, Myeloid Azacitidine 13.7419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 13.7416932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 10.6316467208 20471514 16968895 19850784 17050201
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 10.6317596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 10.6318360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 10.6316294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute Vitamin D 10.6320368581
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.7719299654
MESH:D015473 Leukemia, Promyelocytic, Acute marker/mechanism 16764927
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 6.6212679006 15213294 17869043 16891316 16330433 16823087 16112521 17107899 15622746 19075265 16966277 12712474 16331271 17712046 12018890 19642359 15336539 17649720 11161223 9834237 17217047 11468182 15748426 19035177 19225113
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 6.6219075265 9834237 19642359 17506722 17294898 16140955 17712046 12679006 17649720 16331271 17107899 16766008 16823087 17217047 16788101 15748426 17361223 19225113 17339181 17368321 16891316 16935935 19035177 19029980 17301526
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.9216882451
OMIM:116920 LEUKOCYTE ADHESION DEFICIENCY, TYPE I marker/mechanism
MESH:D007964 Leukocytosis Indomethacin 4.9116537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2517980183
MESH:D020961 Lewy Body Disease Iron 4.9816563566
MESH:D007984 Leydig Cell Tumor vinclozolin 4.2816417039
MESH:D017880 Limb Deformities, Congenital 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.866734493 3355362
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.869224671
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2511479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 9.6111408273 17334410 21278145 16943688 11903743 16221502 16239168 17157831 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 9.6118296743
MESH:D008103 Liver Cirrhosis Iron 9.6116640825
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 9.8317869086 18429990 16248980 15650968 18395914 12667390 15338365 10355542 12666154 12958196 17481882 15996030 12389079 17721639 18376398 14724832 18210741 18263696 17708605 15052691 18472332 12586293 16097048 15959796 17557913 18418968 12649538 18205269 15673190 12741479 15818738 11481614 17823541 17640975 12445418 17976157 12898905 18156304 16015684 20821823 17761835 18279442 15931870 15123356 18472094 16011737 18251166 17766677 18054572 18317297 16638106 16116963 12632514 18187930 16136751 18339082 12546737 16027843 15925388 13678700 17805973 15362042 14716496 12445421 18006644 17525996 14748882 17565644 15370692 17631135 18277467 16192424 17714472 12632512 14512876 15876570 17922224 15893842 15730626 18705752 14620537 12609069 17698563 18166357 18412020 17944888 18481824 14716833 16033810 18395095 15057751 18420326 17900296
MESH:D008106 Liver Cirrhosis, Experimental Dimethyl Sulfoxide 9.8311682029
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 9.8318194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 9.8315474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 9.8312741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 9.8312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 9.8318397230 16248980
MESH:D008107 Liver Diseases 1-Naphthylisothiocyanate 5.8117184895
MESH:D008107 Liver Diseases Acetaminophen 5.8112587719 19014921 11587558 19460945 16610002 19784758 16611625 12969438
MESH:D008107 Liver Diseases Carbon Tetrachloride 5.8116246199 15830285 17285989 16964402 15720792
MESH:D008108 Liver Diseases, Alcoholic Iron 4.5616737972 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 3.7215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 8.1016871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 8.1016899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 18.9614682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 18.9619294768
MESH:D008113 Liver Neoplasms Iron 18.9620302851 16640825
MESH:D008113 Liver Neoplasms pirinixic acid 18.9615890375 20007298 16377806
MESH:D008113 Liver Neoplasms Quercetin 18.9618980244
MESH:D008113 Liver Neoplasms sodium arsenite 18.9615276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.9616984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 11.7320377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 11.7312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Quercetin 11.7319519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.7312151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0015213294
MESH:D008171 Lung Diseases Mustard Gas 10.6018702808 18161513
MESH:D008171 Lung Diseases Ozone 10.6019066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 10.6019095001
MESH:D055370 Lung Injury Nitric Oxide 8.0311395602
MESH:D055370 Lung Injury Ozone 8.0320417186
MESH:D008175 Lung Neoplasms alitretinoin 16.3816413115
MESH:D008175 Lung Neoplasms arsenic trioxide 16.3819825857 11798837
MESH:D008175 Lung Neoplasms Azacitidine 16.3821224363
MESH:D008175 Lung Neoplasms Indomethacin 16.3811053908 11497255 16537180
MESH:D008175 Lung Neoplasms Iron 16.3816640825
MESH:D008175 Lung Neoplasms Mustard Gas 16.383148597 8781369
MESH:D008175 Lung Neoplasms Ozone 16.387614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 16.3816280456
MESH:D008175 Lung Neoplasms sodium arsenite 16.3817306315 15276417 16712894 17077188 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 16.3819555203 11884234
MESH:D008223 Lymphoma Nitric Oxide 3.9616166326
MESH:D008268 Macular Degeneration Iron 3.7216640825
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.5817203775 11408345
MESH:D008527 Medulloblastoma Tretinoin 2.5917453147
MESH:D008545 Melanoma sodium arsenite 3.0416487513 19082730
MESH:D008545 Melanoma Tretinoin 3.0416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1219513568
MESH:D008591 Meningomyelocele Tretinoin 3.9816940565
MESH:D008679 Metaplasia Ozone 4.6410496685
MESH:D008881 Migraine Disorders Indomethacin 7.0311903285
MESH:D008881 Migraine Disorders Nitric Oxide 7.0311701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.6811304026 14659530
MESH:D009006 Monosomy Azacitidine 5.6219299654
MESH:D009062 Mouth Neoplasms Indomethacin 3.6412636206
MESH:D009101 Multiple Myeloma arsenic trioxide 6.5219417148 11468182 15949261 19549372 14977855
MESH:D009101 Multiple Myeloma Azacitidine 6.5219549372 18443271
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.2117086897
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 6.2213678655
MESH:D009135 Muscular Diseases pirinixic acid 3.0616239165
MESH:D009181 Mycoses Iron 5.0116640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.2118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 10.8516105982 16882451
MESH:D009190 Myelodysplastic Syndromes Azacitidine 10.8519805378 17611569 18720364 17596541
MESH:D009190 Myelodysplastic Syndromes Tretinoin 10.8517596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.0419151258
MESH:D009203 Myocardial Infarction Quercetin 5.0419595682
MESH:D017202 Myocardial Ischemia Iron 7.9716604332
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.9712213967
MESH:D015428 Myocardial Reperfusion Injury Iron 12.3016604332
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.3016411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 12.3019207477
MESH:D009298 Nasal Polyps zileuton 5.7610665187
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.5316624393
MESH:D009362 Neoplasm Metastasis Indomethacin 2.9711053908 11239499 16537180
MESH:D009369 Neoplasms alitretinoin 13.1916946489
MESH:D009369 Neoplasms pirinixic acid 13.1917405874
MESH:D009369 Neoplasms Quercetin 13.1915185748
MESH:D009369 Neoplasms sodium arsenite 13.1911559025
MESH:D009369 Neoplasms Tretinoin 13.1916594593 16946489
MESH:D009374 Neoplasms, Experimental Indomethacin 7.8115625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.8120056578
MESH:D009404 Nephrotic Syndrome Iron 4.1317178036
MESH:D009421 Nervous System Malformations bisphenol A 13.8816427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.8814600291
MESH:D009421 Nervous System Malformations Tretinoin 13.889125849
MESH:D009436 Neural Tube Defects arsenic trioxide 10.3910525206
MESH:D009436 Neural Tube Defects sodium arsenite 10.3912854658
MESH:D009436 Neural Tube Defects Tretinoin 10.399142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.0518514411
MESH:D019636 Neurodegenerative Diseases Indomethacin 12.0512349958
MESH:D019636 Neurodegenerative Diseases Iron 12.0517296847 16604332
MESH:D020078 Neurogenic Inflammation Quercetin 3.9417929310
MESH:D009503 Neutropenia Mustard Gas 3.5616761898 7688884
MESH:D009765 Obesity Dietary Fats 3.9920518802 21332399 20132043 17217161 18457598 18674790 16723640 11836018 19632207
MESH:D009765 Obesity pirinixic acid 3.9920558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.716374098
MESH:D010003 Osteoarthritis Indomethacin 7.047009135
MESH:D010003 Osteoarthritis Iron 7.0416640825
MESH:D010024 Osteoporosis Iron 10.6316640825 16648989
MESH:D010024 Osteoporosis Isoflavones 10.6316562857
MESH:D010024 Osteoporosis Vitamin D 10.6317882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 3.8019495926
MESH:D010049 Ovarian Diseases bisphenol A 4.5311985600
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16.7516211241
MESH:D010051 Ovarian Neoplasms arsenic trioxide 16.7516624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Progesterone 16.7516525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 16.7519005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 16.7515276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 16.7516936753
MESH:D010146 Pain Acetaminophen 13.1716870215
MESH:D010146 Pain Indomethacin 13.1717440234 13679232 3291741 17627676
MESH:D010146 Pain Tretinoin 13.1716870215
MESH:D010146 Pain zileuton 13.1715935457
MESH:D010149 Pain, Postoperative Indomethacin 4.2212538197 18702446
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 7.6115580305
MESH:D010190 Pancreatic Neoplasms Quercetin 7.6116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.6115976015
MESH:D010195 Pancreatitis Indomethacin 3.5115028970 17883296
MESH:D010212 Papilloma Iron 4.0412065085
MESH:D010235 Paraganglioma arsenic trioxide 3.7419927285
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2516537180
MESH:D020447 Parasomnias Iron 5.5517352947
MESH:D010300 Parkinson Disease Iron 3.1416563566 16640825
MESH:D020734 Parkinsonian Disorders Indomethacin 3.7312349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2511903285
MESH:D010382 Peliosis Hepatis 1-Naphthylisothiocyanate 12.2520133375
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 12.2512520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6911148446
MESH:D010518 Periodontitis Indomethacin 4.4517225004
MESH:D010538 Peritonitis Ozone 9.0816369182
MESH:D010538 Peritonitis zileuton 9.0817371808
MESH:D010900 Pituitary Diseases Iron 5.2116604332
MESH:D011014 Pneumonia Ozone 3.9418929643 18007984 18381685
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 4.8818573544
MESH:D011041 Poisoning Iron 7.6116604332
MESH:D011041 Poisoning Mustard Gas 7.6115727166
MESH:D017499 Porokeratosis alitretinoin 5.5416144296
MESH:D017119 Porphyria Cutanea Tarda Iron 9.5916640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.5918163543
MESH:D011230 Precancerous Conditions Quercetin 3.6019056647
MESH:D011225 Pre-Eclampsia Iron 4.0716640825
MESH:D047928 Premature Birth Indomethacin 4.6817000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 13.6310548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 13.6311222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 13.6319015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.4818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.8020887781
MESH:D011471 Prostatic Neoplasms AGN 194204 2.0316000583
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.0319131511
MESH:D011471 Prostatic Neoplasms Azacitidine 2.0318324645
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0316740699
MESH:D011471 Prostatic Neoplasms Isoflavones 2.0317571952 17374662 16365062 17219775
MESH:D011471 Prostatic Neoplasms Quercetin 2.0314715546 17292933
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0316039940
MESH:D011472 Prostatitis vinclozolin 4.4818629315
MESH:D011507 Proteinuria Indomethacin 7.9511849393
MESH:D011507 Proteinuria Tretinoin 7.9516636307
MESH:D011528 Protozoan Infections Iron 5.5516640825
MESH:D011537 Pruritus Mustard Gas 8.6918058305
MESH:D011537 Pruritus zileuton 8.6917827870 19657356
MESH:D011625 Pterygium Tretinoin 4.3416723453
MESH:D011629 Puberty, Precocious bisphenol A 4.3310548101
MESH:D011654 Pulmonary Edema zileuton 4.9618309904
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7410334151 17894541 17620002 17266442 17720292
MESH:D015427 Reperfusion Injury pirinixic acid 6.1419058328
MESH:D015427 Reperfusion Injury zileuton 6.1415266012 9865762
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4118990726
MESH:D012148 Restless Legs Syndrome Iron 4.2116930377
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6816283617 16116481
MESH:D012220 Rhinitis zileuton 4.4520332717
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6818045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.5316646077
MESH:D012554 Schistosomiasis japonica Quercetin 5.0816862918
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.019673227
MESH:D012852 Sinusitis zileuton 5.0610665187
MESH:D012871 Skin Diseases Mustard Gas 2.5912880345 16961503 15451306
MESH:D012878 Skin Neoplasms Iron 11.7112065085
MESH:D012878 Skin Neoplasms sodium arsenite 11.7118572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.7116192470
MESH:D012878 Skin Neoplasms Tretinoin 11.7116467112
MESH:D020181 Sleep Apnea, Obstructive zileuton 5.4119118273
MESH:D013119 Spinal Cord Injuries Progesterone 9.9015862959 16503802
MESH:D013119 Spinal Cord Injuries zileuton 9.9018059327
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4412854658
MESH:D013272 Stomach Diseases Indomethacin 9.7017638125 10215738 16184426 10486359 18209964 15038085 10192188 17207306 18545984 15472012 16113693 17160473 16280098
MESH:D013272 Stomach Diseases plaunotol 9.7010215738
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.1517007042
MESH:D013274 Stomach Neoplasms Indomethacin 3.1515609394
MESH:D013274 Stomach Neoplasms Tretinoin 3.1517261132
MESH:D013276 Stomach Ulcer Indomethacin 6.5011145282 12077510 12500499 15138204 16169175 17977527 16934674 11906479 12787963 10878458 17654042 18543354 18726076 16150113 11595431 10423059 18209962 17918041 18181030 1323529 15255614 16631530 17657623 17135157 11595415 10750652 16252198 16397915 18193104 17627676 11523592 16755016 12467913 15104355 18087811 17895592 12498302 18431645 18299717 11729361 14567935 18237397
MESH:D013276 Stomach Ulcer Nitric Oxide 6.5015138204
MESH:D019966 Substance-Related Disorders bisphenol A 3.5316045194 16684133
MESH:D013398 Sudden Infant Death Iron 4.9916640825
MESH:D013921 Thrombocytopenia 1-Naphthylisothiocyanate 4.3620133375
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.4412697716
MESH:D013964 Thyroid Neoplasms 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine 14.3716940797
MESH:D013964 Thyroid Neoplasms arsenic trioxide 14.3719014326
MESH:D013964 Thyroid Neoplasms Indomethacin 14.3718791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 14.3716026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.3916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.5115213294
MESH:D014376 Tuberculosis Iron 7.2116597321
MESH:D014376 Tuberculosis Tretinoin 7.2116040207
MESH:D014456 Ulcer Indomethacin 4.4410574470 17380554
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 7.2620435036 11780464 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Quercetin 7.2616720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.2616452187 16712894 11723127 17306315
MESH:D014581 Urticaria Acetaminophen 2.5610982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.1011813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.1016129372
MESH:D014591 Uterine Diseases bisphenol A 4.5414652134
MESH:D014604 Uveal Neoplasms Tretinoin 4.1516752155
MESH:D014652 Vascular Diseases sodium arsenite 3.9717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1312125929
MESH:D014820 Vitiligo Tretinoin 3.6316761959
MESH:D014839 Vomiting Indomethacin 4.2811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7815886252
MESH:D015430 Weight Gain Dietary Fats 3.3616723640
MESH:D009396 Wilms Tumor Tretinoin 3.5816287080
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04514 Cell adhesion molecules (CAMs)
REACT:604 Hemostasis
REACT:13552 Integrin cell surface interactions
KEGG:05140 Leishmaniasis
KEGG:04670 Leukocyte transendothelial migration
KEGG:05144 Malaria
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04145 Phagosome
KEGG:04810 Regulation of actin cytoskeleton
KEGG:05323 Rheumatoid arthritis
REACT:6900 Signaling in Immune system
KEGG:05150 Staphylococcus aureus infection
KEGG:05152 Tuberculosis
KEGG:05416 Viral myocarditis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29955
    • No data
    Releated disease ID Related disease Name
    PA445019Myocardial Infarction
    PA443434Arthritis, Rheumatoid
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA133950441hmg coa reductase inhibitors
    PA450952phospholipids
    PA10004adalimumab
    PA450428methotrexate
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00641 other Vytorin Anticholesteremic Agents;Antilipemic Agents;Hydroxymethylglutaryl-CoA Reductase Inhibitors
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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