AutismKB 2.0

Annotation Detail for ITGB3


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Basic Information Top
Gene Symbol:ITGB3 ( CD61,GP3A,GPIIIa )
Gene Full Name: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Band: 17q21.32
Quick LinksEntrez ID:3690; OMIM: 173470; Uniprot ID:ITB3_HUMAN; ENSEMBL ID: ENSG00000056345; HGNC ID: 6156
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa04145Phagosome
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa04810Regulation of actin cytoskeleton
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Axon guidance
Hemostasis
Integrin cell surface interactions
Pathway IDPathway Name
200033Signaling events mediated by PTP1B
200060Arf6 signaling events
200173Ephrin B reverse signaling
200018IL4-mediated signaling events
200161Signaling events mediated by VEGFR1 and VEGFR2
200042Osteopontin-mediated events
200109Integrins in angiogenesis
200053Nectin adhesion pathway
Pathway IDPathway Name
P00034Integrin signalling pathway
P00011Blood coagulation
Pathway IDPathway Name
500307PECAM1 interactions
500004Integrin cell surface interactions
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Hematologic diseases
H00083Allograft rejection
H00226Glanzmann thrombasthenia
Immune system diseases
Allergies and autoimmune diseases
Desease IDDesease Name
1858Hemorrhagic disorder
1863Aplastic anemia
1904Diabetes mellitus
1918Atherosclerosis
1934Cancer
2002Hemorrhagic fevers, Viral
1954Stroke
1764Purpura, Thrombocytopenic, Idiopathic
1925Pemphigoid, Bullous
2074Asthma
2114Thrombocytopenia
2119Temporal arteritis
2124Autistic disorder
2145Subarachnoid hemorrhage
2146Lupus erythematosus
1912Penile disease
2199Takayasu's arteritis
2255Intermediate coronary syndrome
Desease Name
HEMATOLOGICAL
cardiovascular disease
atherosclerosis, coronary
CARDIOVASCULAR
myocardial infarct
premature myocardial infarction in men.
cancer.
double homozygosity for receptor polymorphisms of platelet GPIa and GPIIIa
heart disease, ischemic
CANCER
PSYCH
stroke, ischemic
Kidney Failure, Chronic
cancer
breast cancer ovarian cancer
Asthma
breast cancer
hypertension
asthma IgE wheezing
allergy
Increased platelet aggregability
lipoprotein
cardiovascular
IMMUNE
peripheral vascular disease
kidney cancer
Resistance in vitro to low-dose aspirin
METABOLIC
Stroke
Myocardial Infarction
aspirin resistance
fracture risk
lung cancer
fetal loss, early
REPRODUCTION
diabetes, type 2
neonatal thrombocytopenia
Glanzmann thrombasthenia
Autism
No data
Desease Name
Glanzmann thrombasthenia, type B
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C001079 2-(2,6-dioxopiperidin-3-yl)phthalimidine 2-(2,6-dioxopiperidin-3-yl)phthalimidine results in decreased expression of ITGB3 proteindecreases expression 8538367
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]affects binding|affects localization|decreases reaction|increases expression 16465378
C426703 3-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid 3-(3-(3-(4,5-dihydroimidazol-2-ylamino)propyloxylisoxazol-5-yl)carbonylamino)-2-(phenylsulfonylamino)propionic acid binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]affects binding|decreases activity 16384862
D000082 Acetaminophen Acetaminophen affects the expression of ITGB3 mRNAaffects expression 17562736
D000244 Adenosine Diphosphate cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]affects binding|decreases reaction|increases expression 18404433
D000244 Adenosine Diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]affects binding|decreases reaction|increases expression 18404433
D000244 Adenosine Diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]affects binding|decreases reaction|increases expression|increases reaction 18404433
C047981 arginyl-glycyl-aspartic acid arginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]affects binding|decreases reaction 16790523
D001241 Aspirin ITGB3 gene polymorphism affects the susceptibility to Aspirinaffects response to substance 17184645
C020711 beryllium sulfate beryllium sulfate results in increased expression of ITGB3 mRNAincreases expression 16314022
C117446 cangrelor cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]affects binding|decreases reaction|increases expression 18404433
C117446 cangrelor N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]affects binding|decreases reaction|increases expression|increases reaction 18404433
C422910 Cilengitide Cilengitide results in decreased activity of [ITGA5 protein binds to ITGB3 protein]affects binding|decreases activity 16729916
D002996 Clomiphene Clomiphene results in decreased expression of ITGB3 proteindecreases expression 15749485
C055162 clopidogrel ITGB3 gene SNP affects the susceptibility to clopidogrelaffects response to substance 15166949
C055162 clopidogrel ITGB3 gene SNP results in decreased susceptibility to clopidogreldecreases response to substance 19530321
D003474 Curcumin Curcumin inhibits the reaction [F2 protein results in increased expression of ITGB3 protein]decreases reaction|increases expression 18565277
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB3 mRNA]decreases reaction|increases expression 11007951
C472511 dimethylarsinous acid dimethylarsinous acid results in decreased expression of ITGB3 mRNAdecreases expression 16507463
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of ITGB3 mRNAaffects cotreatment|decreases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ITGB3 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ITGB3 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITGB3 mRNAaffects cotreatment|increases expression 17942748
C013038 hydroxyhydroquinone hydroxyhydroquinone results in increased expression of ITGB3 mRNAincreases expression 17572062
D012701 Serotonin ITGB3 gene polymorphism affects the abundance of Serotoninaffects abundance 17203304
16724005
D016729 Leuprolide Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]affects binding|affects localization|decreases reaction|increases expression 17143537
C406082 monomethylarsonous acid monomethylarsonous acid results in decreased expression of ITGB3 mRNAdecreases expression 16507463
C111914 N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]affects binding|decreases reaction|increases expression 18404433
C111914 N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]]affects binding|decreases reaction|increases expression|increases reaction 18404433
C029938 nickel sulfate nickel sulfate results in increased expression of ITGB3 mRNAincreases expression 16780908
D009711 Nucleotides ITGB3 protein affects the reaction [Nucleotides results in increased phosphorylation of MAPK1 protein]affects reaction|increases phosphorylation 17620283
D009711 Nucleotides ITGB3 protein affects the reaction [Nucleotides results in increased phosphorylation of MAPK3 protein]affects reaction|increases phosphorylation 17620283
C006253 pirinixic acid NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of ITGB3 mRNA]decreases expression|increases reaction 17950772
C006253 pirinixic acid pirinixic acid results in decreased expression of ITGB3 mRNAdecreases expression 17950772
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of ITGB3 mRNAaffects cotreatment|decreases expression 17404688
D011374 Progesterone Progesterone results in decreased expression of ITGB3 mRNAdecreases expression 17404688
D011374 Progesterone Progesterone results in increased expression of ITGB3 mRNAincreases expression 16403803
C037219 quinoline quinoline analog binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein]affects binding|decreases activity 16984141
C059514 resveratrol arginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]affects binding|decreases reaction 16790523
C059514 resveratrol [ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK1 protein]affects binding|increases phosphorylation|increases reaction 16790523
C059514 resveratrol [ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of MAPK3 protein]affects binding|increases phosphorylation|increases reaction 16790523
C059514 resveratrol [ITGA5 protein binds to ITGB3 protein] promotes the reaction [resveratrol results in increased phosphorylation of TP53 protein]affects binding|increases phosphorylation|increases reaction 16790523
C059514 resveratrol resveratrol binds to [ITGA5 protein binds to ITGB3 protein]affects binding 16790523
C059514 resveratrol resveratrol binds to ITGB3 proteinaffects binding 16790523
C017947 sodium arsenite sodium arsenite results in decreased expression of ITGB3 mRNAdecreases expression 16507463
C017947 sodium arsenite sodium arsenite results in increased expression of ITGB3 proteinincreases expression 19072884
D013467 Sulindac Sulindac inhibits the reaction [CDKN1A protein results in increased expression of ITGB3 mRNA]decreases reaction|increases expression 15190207
D014284 Triiodothyronine Triiodothyronine binds to [ITGA5 protein binds to ITGB3 protein]affects binding 16384862
D013974 Thyroxine Thyroxine binds to [ITGA5 protein binds to ITGB3 protein]affects binding 16384862
D013629 Tamoxifen Tamoxifen affects the expression of ITGB3 mRNAaffects expression 17555576
C087926 tellimagrandin I tellimagrandin I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]decreases reaction|increases expression 14757314
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB3 mRNA]decreases reaction|increases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITGB3 mRNAincreases expression 11007951
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITGB3 mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate tellimagrandin I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB3 protein]decreases reaction|increases expression 14757314
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of ITGB3 proteinincreases expression 10910098
14757314
14769215
C011126 tetraiodothyroacetic acid tetraiodothyroacetic acid binds to [ITGA5 protein binds to ITGB3 protein]affects binding 16384862
C025643 vinclozolin vinclozolin results in decreased expression of ITGB3 mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 11.6814745880
MESH:D000008 Abdominal Neoplasms Tamoxifen 11.6814745880
MESH:D000014 Abnormalities, Drug-Induced 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.80473085 6734493 3355362 3196154
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.8015322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.5417505938
MESH:D054058 Acute Coronary Syndrome clopidogrel 5.6119106084
MESH:D058186 Acute Kidney Injury resveratrol 7.8516538975
MESH:D058186 Acute Kidney Injury Sulindac 7.857897758
MESH:D055371 Acute Lung Injury nickel sulfate 7.9416100012 19131640 12718980 11954676
MESH:D055371 Acute Lung Injury pirinixic acid 7.9418653653
MESH:D000230 Adenocarcinoma 2-(2,6-dioxopiperidin-3-yl)phthalimidine 9.371933837
MESH:D000230 Adenocarcinoma Estradiol 9.3711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.3714692618
MESH:D000230 Adenocarcinoma Sulindac 9.3711910360
MESH:D000236 Adenoma resveratrol 6.4415688382
MESH:D000236 Adenoma Sulindac 6.4410223192
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.5916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.5916835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 4.2619003578 11535846 16460482 11874996 15623613 12394442 17611924
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5016712894 17306315
MESH:D019973 Alcohol-Related Disorders Curcumin 4.6817887948
MESH:D000544 Alzheimer Disease Curcumin 4.1115590663
MESH:D000544 Alzheimer Disease resveratrol 4.1116162502 16183991
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6111748828
MESH:D000799 Angioedema Acetaminophen 3.4410982225
MESH:D001008 Anxiety Disorders vinclozolin 3.3319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.0811256880
MESH:D001169 Arthritis, Experimental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 11.149598899
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.1415885639
MESH:D001169 Arthritis, Experimental resveratrol 11.1417115116
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6416807698
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.3712372130 20485159
MESH:D050197 Atherosclerosis Curcumin 6.1218704882
MESH:D050197 Atherosclerosis resveratrol 6.1217967414 16873680
MESH:D001321 Autistic Disorder marker/mechanism 16721604 17203304 16724005
MESH:D001321 Autistic Disorder Acetaminophen 2.5018445737
MESH:D001321 Autistic Disorder Leuprolide 2.5017187010
MESH:D001321 Autistic Disorder Serotonin 2.5018361446 17157402 18062943 19221690 15132762 18405062 8570775
MESH:D001327 Autoimmune Diseases Curcumin 4.1119761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.6019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.6012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3915340226
MESH:D001848 Bone Diseases, Developmental 2-(2,6-dioxopiperidin-3-yl)phthalimidine 7.963355362
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9615746008
MESH:D001913 Bowen's Disease Sulindac 4.9511207687
MESH:D001919 Bradycardia Serotonin 5.088112388
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.9417868700
MESH:D001930 Brain Injuries Progesterone 3.8715665606 15380490 15845082
MESH:D002545 Brain Ischemia Curcumin 9.0116770732
MESH:D002545 Brain Ischemia resveratrol 9.0117600658
MESH:D001932 Brain Neoplasms Aspirin 8.0615481559
MESH:D001932 Brain Neoplasms Curcumin 8.0617596214
MESH:D001943 Breast Neoplasms Aspirin 4.3615161893
MESH:D001943 Breast Neoplasms Curcumin 4.3618593918 18462866 19250217 16243823
MESH:D001943 Breast Neoplasms Estradiol 4.3614630087 12948864 19861407 17289903 17018787 18497071 17261762 16675129
MESH:D001943 Breast Neoplasms Progesterone 4.3616175315 15562024 17614352
MESH:D001943 Breast Neoplasms resveratrol 4.3617534123 17651959 16393696
MESH:D001943 Breast Neoplasms Sulindac 4.3616642371
MESH:D001943 Breast Neoplasms Tamoxifen 4.3619103187 20135344 18821012 18351453 18425577 19155303 20065188 17893378 19288272 19410462 16818667 11161223 19289846 19189212 17242785 19011961 20859285 19084267 18997820 19142967 17440819 18629630 19059307 16202921 16873071 15668708 21152245 18855134 20005174 15565566 19066611 19115204 19200415 18815881 18984771 21138602 19244106 19189210 16273361 19221464 17049068 20544844 17261762 20390343 19487384
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.3620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0716111702
MESH:D002277 Carcinoma Curcumin 7.2618593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.2616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 10.423084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.4216924424
MESH:D006528 Carcinoma, Hepatocellular quinoline 10.42598648
MESH:D006528 Carcinoma, Hepatocellular resveratrol 10.4216227395 19321006
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 10.4216507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.4216924424
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2016675471
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8318414057
MESH:D002294 Carcinoma, Squamous Cell Curcumin 9.8118462866
MESH:D002294 Carcinoma, Squamous Cell resveratrol 9.8116227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.8118572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 9.8118922899
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3418850075 18670907 16120746
MESH:D006332 Cardiomegaly Thyroxine 6.3418093424
MESH:D002318 Cardiovascular Diseases clopidogrel 7.0820180610
MESH:D002318 Cardiovascular Diseases resveratrol 7.0815458977
MESH:D002386 Cataract Acetaminophen 2.3510977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.7818566989
MESH:D002471 Cell Transformation, Neoplastic monomethylarsonous acid 9.7819716837
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.7820056578 19524636
MESH:D002659 Child Development Disorders, Pervasive marker/mechanism 21254450
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.0221254450
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.7717110522 16105132 15861022 16919318 17333356 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 6.7719176532
MESH:D021081 Chronobiology Disorders Serotonin 6.2917157402
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9315340226 15668235 8697196 12621046 16354765
MESH:D003092 Colitis Curcumin 8.5216782535 18200517 16804969
MESH:D003092 Colitis resveratrol 8.5216474422
MESH:D003103 Coloboma Curcumin 4.2018809619
MESH:D003110 Colonic Neoplasms 2-(2,6-dioxopiperidin-3-yl)phthalimidine 10.231933837
MESH:D003110 Colonic Neoplasms Aspirin 10.2312411196
MESH:D003110 Colonic Neoplasms Curcumin 10.2319359593 16340194
MESH:D003110 Colonic Neoplasms resveratrol 10.2316338953
MESH:D003110 Colonic Neoplasms Sulindac 10.2312458338 12902858
MESH:D015179 Colorectal Neoplasms Aspirin 3.4717047198
MESH:D015179 Colorectal Neoplasms resveratrol 3.4716550006
MESH:D015179 Colorectal Neoplasms Sulindac 3.4718059344 10666051 11076880 11197048
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7317141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.5118497527
MESH:D003327 Coronary Disease resveratrol 3.5016507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 3.9714966744
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9819031437
MESH:D017449 Dermatitis, Allergic Contact nickel sulfate 3.3111298694 16823706 16780908
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2418249437
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.4516873680
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.0418403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0417107852
MESH:D003928 Diabetic Nephropathies Curcumin 18.7318204486
MESH:D003928 Diabetic Nephropathies Estradiol 18.7319279558
MESH:D003928 Diabetic Nephropathies resveratrol 18.7316286809
MESH:D003928 Diabetic Nephropathies Tamoxifen 18.7319279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.1117187935
MESH:D003930 Diabetic Retinopathy Sulindac 4.8012861449 17621415
MESH:D003967 Diarrhea Serotonin 4.408112388 11488427 10446763
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.1416485898 11834606 19923254 11421492 14986274 19416960 10774834 14725611 2444490 16109766 19420014 11461765 12153990 15968718 12540782 19085960 15619225 17522070 12594235 12958197 12392966 19739265 10663392 17906064 16393943 16781746 18713872 11287661 19370779 10915739 14550746 16227642 17562736 18071297 19164858 16177239 11529661 16081117 11739529 12705907 11743745
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.1420420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4711462148
MESH:D004381 Duodenal Ulcer Curcumin 3.6817351913
MESH:D004480 Ectromelia 2-(2,6-dioxopiperidin-3-yl)phthalimidine 6.647940403
MESH:D004487 Edema Aspirin 22.5217259670
MESH:D004487 Edema pirinixic acid 22.5212083418
MESH:D004487 Edema resveratrol 22.528985016
MESH:D004487 Edema Serotonin 22.5218841975
MESH:D004487 Edema Tetrachlorodibenzodioxin 22.5212711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 22.5215177302 9599246 16716910 11698051 8273558 8113982 7812673
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5015322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 18.8612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 18.8617692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 18.8617872969
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 18.8619031437
MESH:D016889 Endometrial Neoplasms Estradiol 6.5218566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.5219155303 16202921 20544844 17893378
MESH:D004715 Endometriosis Progesterone 13.3816134523
MESH:D004715 Endometriosis Sulindac 13.3815652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 13.3810568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.4617923197
MESH:D004938 Esophageal Neoplasms Sulindac 3.0312235107
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7211564622
MESH:D005234 Fatty Liver Curcumin 15.8919297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.8915345470
MESH:D005234 Fatty Liver pirinixic acid 15.8920131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 15.8914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0711858732
MESH:D018221 Fibromatosis, Abdominal Sulindac 11.6414745880
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 11.6414745880
MESH:D018222 Fibromatosis, Aggressive Sulindac 10.3319069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.3319069698
MESH:D005355 Fibrosis Curcumin 7.5218705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.5220067830
MESH:D005756 Gastritis Acetaminophen 3.2716983495
MESH:D005764 Gastroesophageal Reflux Sulindac 4.6411910360
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3118462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5416973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9016417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.2816452187
MESH:D005909 Glioblastoma Aspirin 6.7812870263
MESH:D005909 Glioblastoma Curcumin 6.7817596214
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1910696789
MESH:D006261 Headache Aspirin 4.5615240983
MESH:D006258 Head and Neck Neoplasms Curcumin 3.3918829502 18462866
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.2920558911
MESH:D006390 Hemangioendothelioma quinoline 5.50598648
MESH:D006394 Hemangiosarcoma quinoline 4.64598648
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9811000095
MESH:D006529 Hepatomegaly pirinixic acid 6.9916221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 6.9915340226 16120746 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6517701891
MESH:D006558 Herpes Genitalis Estradiol 4.6315709030
MESH:D006561 Herpes Simplex resveratrol 3.7916876885
MESH:D006689 Hodgkin Disease sodium arsenite 2.8312676792
MESH:D019584 Hot Flashes Estradiol 3.3517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6415340226 16959395 8697196 16354765 18606429
MESH:D012001 Hyperacusis Aspirin 5.3615240983
MESH:D006930 Hyperalgesia Acetaminophen 2.3916870215
MESH:D006937 Hypercholesterolemia Curcumin 8.2218704882
MESH:D006937 Hypercholesterolemia resveratrol 8.2217188708
MESH:D006943 Hyperglycemia pirinixic acid 2.8420558911
MESH:D006949 Hyperlipidemias resveratrol 3.6716873680
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7518670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.9617488730
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 10.2015869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.2017600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1012013081
MESH:D007248 Infertility, Male Clomiphene 13.9719371211
MESH:D007248 Infertility, Male Ethinyl Estradiol 13.9717937319
MESH:D007248 Infertility, Male sodium arsenite 13.9712646999 15346721
MESH:D007248 Infertility, Male vinclozolin 13.9716467254
MESH:D007249 Inflammation Curcumin 20.9718403477 17151092 16956363
MESH:D007249 Inflammation Progesterone 20.9715869954
MESH:D007249 Inflammation resveratrol 20.9716366677
MESH:D007249 Inflammation Sulindac 20.973291741
MESH:D007249 Inflammation Tamoxifen 20.9719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 20.9712878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 20.9715177302 7812673 7562506 8273558 11698051
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0418200517 18596194
MESH:D007251 Influenza, Human resveratrol 4.1416624496
MESH:D007333 Insulin Resistance Estradiol 6.3316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.3316306350
MESH:D007414 Intestinal Neoplasms Curcumin 8.9910783313
MESH:D007414 Intestinal Neoplasms Sulindac 8.9910223192 12584176 10213222 12351151 12628509 12663524
MESH:D007417 Intestinal Polyps Sulindac 4.6211245490 12394442
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.9816580747
MESH:D007674 Kidney Diseases Acetaminophen 8.6915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 8.6915618244
MESH:D007674 Kidney Diseases sodium arsenite 8.6920008137
MESH:D007680 Kidney Neoplasms Estradiol 6.3415610895
MESH:D007680 Kidney Neoplasms Tamoxifen 6.3418625569
MESH:D007889 Leiomyoma Curcumin 4.2118555241
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 6.1912970779
MESH:D007938 Leukemia Curcumin 6.1918462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8516106398
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.3216087638
MESH:D015458 Leukemia, T-Cell Curcumin 4.3916106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3416417039
MESH:D017880 Limb Deformities, Congenital 2-(2,6-dioxopiperidin-3-yl)phthalimidine 5.266734493 3355362
MESH:D008064 Lipidoses Tamoxifen 2.8717567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.9712468960
MESH:D008106 Liver Cirrhosis, Experimental arginyl-glycyl-aspartic acid 10.0315547672
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 10.0318705752 18006644 17355460
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 10.0314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Nucleotides 10.0315465738
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 10.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 10.0318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 10.0312878042
MESH:D008107 Liver Diseases Acetaminophen 5.9912969438 11587558 19784758 16610002 19014921 12587719 19460945 16611625
MESH:D008107 Liver Diseases Curcumin 5.9916956363
MESH:D008107 Liver Diseases Sulindac 5.9914986274 16867024
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9016871587 17185352
MESH:D008113 Liver Neoplasms pirinixic acid 12.5120007298 16377806 15890375
MESH:D008113 Liver Neoplasms resveratrol 12.5119321006 19812893 19073162 20405173
MESH:D008113 Liver Neoplasms sodium arsenite 12.5116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 12.5116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.5116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 1.8712151625
MESH:D008171 Lung Diseases sodium arsenite 2.9119095001
MESH:D008175 Lung Neoplasms Curcumin 7.8216243823 19359593 18462866
MESH:D008175 Lung Neoplasms sodium arsenite 7.8219931552 17306315 15276417 16712894 17077188
MESH:D008175 Lung Neoplasms Sulindac 7.8215713900 19359593
MESH:D008175 Lung Neoplasms Tamoxifen 7.8218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8211884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 7.8211807781
MESH:D008223 Lymphoma Curcumin 3.3118462866
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9417088997
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.5514749477
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3116173963
MESH:D015674 Mammary Neoplasms, Animal resveratrol 8.6915688416
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 8.6919428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 16.1111408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 16.1111408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 16.118985016 11606380
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 16.1116827153 14580682 19196723 11731420 19196722
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 16.118985016
MESH:D020149 Manganese Poisoning Estradiol 11.3119453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.3119453300
MESH:D008545 Melanoma Curcumin 8.9317885582 18462866
MESH:D008545 Melanoma resveratrol 8.9317992120
MESH:D008545 Melanoma sodium arsenite 8.9319082730 16487513
MESH:D008545 Melanoma Sulindac 8.9316642371
MESH:D008545 Melanoma Tamoxifen 8.9312393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.1819513568
MESH:D008569 Memory Disorders Curcumin 3.7817263510
MESH:D008659 Metabolic Diseases resveratrol 4.0217112576
MESH:D008881 Migraine Disorders Aspirin 3.7915240983
MESH:D009101 Multiple Myeloma Curcumin 6.6419372569
MESH:D009101 Multiple Myeloma resveratrol 6.6416490592 16267019 17049120 17164350 14749477 17935668
MESH:D009134 Muscular Atrophy, Spinal Curcumin 11.1017962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 11.1017962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1216239165
MESH:D009203 Myocardial Infarction Aspirin 8.5712692751
MESH:D009203 Myocardial Infarction pirinixic acid 8.5719151258
MESH:D009203 Myocardial Infarction resveratrol 8.5717188708 16317513 16525036 16456233 17015251 17125593
MESH:D017202 Myocardial Ischemia resveratrol 7.9817015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 7.9812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.2516810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.2516411023
MESH:D009205 Myocarditis resveratrol 4.3617322642
MESH:D009325 Nausea Aspirin 4.8115240983
MESH:D009361 Neoplasm Invasiveness Curcumin 9.8418495463
MESH:D009361 Neoplasm Invasiveness Leuprolide 9.8417143537
MESH:D009362 Neoplasm Metastasis clopidogrel 8.9111875746
MESH:D009362 Neoplasm Metastasis quinoline 8.91598648
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.9119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3819410462
MESH:D009369 Neoplasms pirinixic acid 4.2817405874
MESH:D009369 Neoplasms sodium arsenite 4.2811559025
MESH:D009374 Neoplasms, Experimental resveratrol 7.958985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.9520056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.5112497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.5119189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3417289903
MESH:D009421 Nervous System Malformations Estradiol 8.2211399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.2214600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.2318462866
MESH:D009436 Neural Tube Defects sodium arsenite 2.8912854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 12.3318514411
MESH:D019636 Neurodegenerative Diseases resveratrol 12.3317652729
MESH:D019636 Neurodegenerative Diseases Sulindac 12.3317266991 16850258
MESH:D020078 Neurogenic Inflammation resveratrol 4.0417929310
MESH:D009765 Obesity Curcumin 4.2319297423
MESH:D009765 Obesity pirinixic acid 4.2320558911
MESH:D010003 Osteoarthritis Aspirin 3.827009135
MESH:D010024 Osteoporosis Curcumin 3.2318719352
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.8917513867
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13.5416211241
MESH:D010051 Ovarian Neoplasms Curcumin 13.5419020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 13.5419401270
MESH:D010051 Ovarian Neoplasms Progesterone 13.5416525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.5417306315 15276417
MESH:D010146 Pain Acetaminophen 9.6216870215
MESH:D010146 Pain Aspirin 9.626995502 6363464
MESH:D010146 Pain Sulindac 9.623291741
MESH:D010190 Pancreatic Neoplasms Curcumin 7.9917440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Sulindac 7.9911504793 16820089
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.9915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3211578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.9118922899 12065085 18404319 8330346
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8512520081
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.1511156591
MESH:D020795 Photophobia Aspirin 5.3615240983
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1818163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 14.0016679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.0011222880 11399792 11118676 11896295
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 14.0018042343 19015723 18220299
MESH:D011469 Prostatic Diseases vinclozolin 4.5418220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5320887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 16158739
MESH:D011471 Prostatic Neoplasms Cilengitide 2.0416729916
MESH:D011471 Prostatic Neoplasms Curcumin 2.0411398177 12497104 18156803 15129424 10851300 18226269 18769126
MESH:D011471 Prostatic Neoplasms Estradiol 2.0416740699
MESH:D011471 Prostatic Neoplasms Leuprolide 2.0417143537
MESH:D011471 Prostatic Neoplasms resveratrol 2.0415767336 17675339 17718901 17636462 16731767 17804756
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0416039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0415067354
MESH:D011472 Prostatitis vinclozolin 4.5418629315
MESH:D011537 Pruritus Ethinyl Estradiol 2.9216919318 15861022
MESH:D011656 Pulmonary Emphysema Curcumin 4.1919168576
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.1816325855
MESH:D015427 Reperfusion Injury pirinixic acid 5.9019058328
MESH:D015427 Reperfusion Injury resveratrol 5.9015827377 16314181 17058453 16317513 17520802
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.6710666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4618990726
MESH:D012170 Retinal Vein Occlusion clopidogrel 5.7419371211
MESH:D012220 Rhinitis Aspirin 4.0412372130
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7118045962
MESH:D012509 Sarcoma Curcumin 3.7818462866
MESH:D018805 Sepsis Curcumin 3.7518389075
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.8812269725
MESH:D012871 Skin Diseases monomethylarsonous acid 3.2717431481
MESH:D012878 Skin Neoplasms resveratrol 12.008985016 15837718
MESH:D012878 Skin Neoplasms sodium arsenite 12.0018572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.0016192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.008330346 11807781 18404319 12065085 8985016
MESH:D013088 Spermatocele Ethinyl Estradiol 10.2216709447
MESH:D013088 Spermatocele Tamoxifen 10.2216709447
MESH:D013119 Spinal Cord Injuries Progesterone 9.5616503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.5619457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4912854658
MESH:D013276 Stomach Ulcer Curcumin 3.1619188055 16631530
MESH:D020521 Stroke Aspirin 4.0716403987
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1416321402
MESH:D013915 Thrombasthenia marker/mechanism
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.2611994571
MESH:D013927 Thrombosis Aspirin 8.1017672075
MESH:D013927 Thrombosis Ethinyl Estradiol 8.1015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.0412697716
MESH:D013959 Thyroid Diseases Thyroxine 11.0419910387
MESH:D013978 Tibial Fractures Estradiol 4.2819048282
MESH:D014062 Tongue Neoplasms resveratrol 3.8716227395
MESH:D001749 Urinary Bladder Neoplasms Curcumin 10.6418593936
MESH:D001749 Urinary Bladder Neoplasms monomethylarsonous acid 10.6420375083
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.6417306315 11723127 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.6416712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 4.8718462866
MESH:D014581 Urticaria Acetaminophen 7.7010982225
MESH:D014581 Urticaria Aspirin 7.7020485159 10982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 8.4317473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.4311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 13.9814692618
MESH:D014594 Uterine Neoplasms resveratrol 13.9817044934
MESH:D014594 Uterine Neoplasms Sulindac 13.9818645019
MESH:D014652 Vascular Diseases sodium arsenite 4.0317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1915869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.9217488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8515886252
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REACT:18266 Axon guidance
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:04640 Hematopoietic cell lineage
REACT:604 Hemostasis
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:04380 Osteoclast differentiation
KEGG:04145 Phagosome
KEGG:04810 Regulation of actin cytoskeleton
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA205
    • Releated gene ID Related gene Name
    PA205ITGB3
    Releated disease ID Related disease Name
    PA443796Coronary Artery Disease
    PA443797Coronary Disease
    PA445843Thrombasthenia
    PA443450Asthma
    PA444417Hemorrhage
    PA445019Myocardial Infarction
    PA444645Ischemia
    PA446145Myocardial Reperfusion Injury
    PA445204Ovarian Neoplasms
    Releated drug ID Related drug Name
    PA449053clopidogrel
    PA448478l-arginine
    PA450635nitric oxide
    PA130619705orbofiban
    PA448497aspirin
    PA451089pravastatin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00054 antagonist Abciximab Anticoagulants;Antiplatelet Agents
    DB00063 - Eptifibatide Anticoagulants;Antiplatelet Agents;Platelet Aggregation Inhibitors
    DB00098 - Antithymocyte globulin Immunomodulatory Agents
    DB00775 antagonist Tirofiban Platelet Aggregation Inhibitors;Fibrinolytic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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