AutismKB 2.0

Annotation Detail for ITGB7


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Basic Information Top
Gene Symbol:ITGB7 ( - )
Gene Full Name: integrin, beta 7
Band: 12q13.13
Quick LinksEntrez ID:3695; OMIM: 147559; Uniprot ID:ITB7_HUMAN; ENSEMBL ID: ENSG00000139626; HGNC ID: 6162
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04672Intestinal immune network for IgA production
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa04810Regulation of actin cytoskeleton
hsa04514Cell adhesion molecules (CAMs)
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
Pathway IDPathway Name
Signaling in Immune system
Integrin cell surface interactions
Pathway IDPathway Name
200178Paxillin-independent events mediated by a4b1 and a4b7
200092a4b1 and a4b7 Integrin signaling
200117Paxillin-dependent events mediated by a4b1
200105E-cadherin signaling in the nascent adherens junction
Pathway IDPathway Name
P00034Integrin signalling pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
Pathway IDPathway Name
500004Integrin cell surface interactions
500477Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ITGB7 mRNAaffects expression 17562736
C430898 AGN 194204 AGN 194204 results in increased expression of ITGB7 mRNAincreases expression 16339527
C061133 Am 80 Am 80 results in increased expression of ITGB7 mRNAincreases expression 17229644
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ITGB7 mRNAaffects expression 16483693
D000968 Antimycin A Antimycin A results in increased expression of ITGB7 mRNAincreases expression 19304788
C006632 arsenic trioxide arsenic trioxide results in increased expression of ITGB7 mRNAincreases expression 15761015
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ITGB7 mRNAincreases expression 20064835
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ITGB7 mRNAincreases expression 15766595
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ITGB7 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ITGB7 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITGB7 mRNAaffects cotreatment|increases expression 17942748
D005419 Flavonoids Flavonoids results in decreased expression of ITGB7 mRNAdecreases expression 18035473
C072105 KN 93 KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA]decreases reaction|increases expression 18089838
D020366 Methylmethacrylate Methylmethacrylate results in increased expression of ITGB7 mRNAincreases expression 16916219
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ITGB7 mRNAaffects binding|decreases expression|increases activity 19710929
D012402 Rotenone Rotenone results in increased expression of ITGB7 mRNAincreases expression 19304788
C458525 STO 609 STO 609 results in increased expression of ITGB7 mRNAincreases expression 18755850
D013629 Tamoxifen Tamoxifen affects the expression of ITGB7 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin KN 93 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNA]decreases reaction|increases expression 18089838
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNAincreases expression 18089838
18755850
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITGB7 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ITGB7 mRNAdecreases expression 20159946
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITGB7 mRNAincreases expression 17337447
D014212 Tretinoin Tretinoin results in increased expression of ITGB7 mRNAincreases expression 17218384
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.8115322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.5218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.9611798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9620127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9614692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.636695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7816835633
MESH:D000505 Alopecia Tretinoin 3.5815955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.4415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.1116412693
MESH:D001172 Arthritis, Rheumatoid Am 80 5.0716819260
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.0716292516
MESH:D001249 Asthma Tretinoin 2.3316456186
MESH:D050197 Atherosclerosis Am 80 4.3116484594
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3616935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 21.6216206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 21.6219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 21.6212125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 21.6216206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.3120146248 17474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.3117129689 15324884
MESH:D001943 Breast Neoplasms Tamoxifen 2.3120065188 19221464 19410462 20544844 21152245 19155303 16273361 18815881 21138602 19115204 19103187 19142967 19200415 11161223 20859285 17893378 19059307 18351453 17242785 20135344 19289846 19084267 16873071 19288272 17440819 18855134 18425577 16202921 19066611 18629630 19244106 15668708 16818667 19011961 18997820 15565566 18821012 19189212 20005174 19189210 18984771 17049068 17261762 19487384 20390343
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3116873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5516813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2911589617
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4719066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1316168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.803084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.8011135700 14691202 15553829 15073043 16217749
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.8015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.8016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.801917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.8519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0812490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5220419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 7.1410977129
MESH:D002386 Cataract Tretinoin 7.1417460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5516129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6311677210 16105132 15861022 17681005 17333356 16919318 17110522
MESH:D002779 Cholestasis pirinixic acid 7.6319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.7012621046 8697196 15340226 16354765 15668235
MESH:D002972 Cleft Palate Tretinoin 5.709407595
MESH:D003092 Colitis Tretinoin 3.6617035595
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.1412609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.7310525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7310048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.739211117 10589399 9664655 16925845 9142499 17551590 9125849 14991402 9224671 8800419
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.5216002989 12952375
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.0515213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3219031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4419279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5111529661 12705907 11743745 18071297 11739529 17906064 17562736 19739265 15619225 16781746 19923254 16081117 16485898 12540782 2444490 11461765 10663392 14550746 12153990 11421492 12392966 19085960 18713872 11834606 19420014 19416960 16393943 16227642 10774834 11287661 19370779 14725611 12594235 16109766 19164858 15968718 16177239 17522070 12958197 10915739 14986274
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7311462148
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.8516714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 11.8518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Am 80 15.2716819260
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.2712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.2719031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.6616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.3215700306 16804899
MESH:D016889 Endometrial Neoplasms Tamoxifen 12.3220544844 16202921 19155303 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 12.3216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.989294722 10568697
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.4012903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.7211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.7216938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 18.4215073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 18.4215345470
MESH:D005234 Fatty Liver pirinixic acid 18.4220131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 18.4219224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 8.1215751030 16513791 16534752 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 8.1216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1519069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4920067830
MESH:D005355 Fibrosis Tretinoin 8.4917994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.2216904648
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.9116452187
MESH:D005909 Glioblastoma Tretinoin 2.9817312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.9620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.9611294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 10.9614991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5120558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly pirinixic acid 8.1316221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1316120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.5016870215
MESH:D006930 Hyperalgesia Tretinoin 7.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5316778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.4014722030 12960047
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 11.1116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.1116569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.3115036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Flavonoids 8.1717296493
MESH:D007249 Inflammation Tamoxifen 8.1719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.1712200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.6016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7317994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.8016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.8015992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.1712587719 15629191
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 7.4415003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Tamoxifen 7.4418625569
MESH:D007859 Learning Disorders Diethylstilbestrol 4.0217184923
MESH:D007938 Leukemia arsenic trioxide 6.2715070760
MESH:D007938 Leukemia Tretinoin 6.2717143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.7517077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.2716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.3419077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.3416482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8516467208 19850784 20471514 16968895 17050201
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8516294345 17596541 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Am 80 12.7616819260 16531727
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 12.7611161223 17712046 16966277 12712474 19225113 19035177 12679006 17649720 12018890 9834237 15622746 11468182 17869043 15213294 15748426 17107899 15336539 19075265 17217047 16891316 16331271 16112521 16330433 19642359 16823087
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 12.7617368321 16823087 16935935 17294898 17301526 17649720 17217047 16788101 16331271 17107899 15748426 19642359 16766008 12679006 16140955 17506722 19225113 19035177 19029980 19075265 17712046 17339181 17361223 16891316 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.3116882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.279224671
MESH:D008064 Lipidoses Tamoxifen 3.1217567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.8815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8816248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6219014921 16611625 19460945 16610002 19784758 12587719 12969438 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2017185352 16871587
MESH:D008113 Liver Neoplasms arsenic trioxide 17.7814682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.7820195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 17.7815890375 16712894
MESH:D008113 Liver Neoplasms pirinixic acid 17.7816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 17.7816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.7816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.7120377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.7112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3115213294
MESH:D008175 Lung Neoplasms arsenic trioxide 4.7811798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.7817053015 18816296 20869020 18569708 6695378 20464547 20064080 20135361 18520028
MESH:D008175 Lung Neoplasms Tamoxifen 4.7818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.7819555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.1115166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.4415700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.4916002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7219428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.5914580682 19196722 11731420 19196723 16827153
MESH:D020149 Manganese Poisoning Tamoxifen 4.5219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7717453147
MESH:D008545 Melanoma Tamoxifen 3.2619393235 12393984
MESH:D008545 Melanoma Tretinoin 3.2616752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1515990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008591 Meningomyelocele Tretinoin 4.3916940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009101 Multiple Myeloma Am 80 7.7117229644
MESH:D009101 Multiple Myeloma arsenic trioxide 7.7119417148 19549372 14977855 15949261 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.6418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3116105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.3117596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.9216624393
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5019410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.6811141357
MESH:D009369 Neoplasms Diethylstilbestrol 11.6815313581
MESH:D009369 Neoplasms pirinixic acid 11.6817405874
MESH:D009369 Neoplasms Tretinoin 11.6816594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9719196722 19189210 19200415
MESH:D009410 Nerve Degeneration Rotenone 3.8415790535 17356569 18619942
MESH:D009421 Nervous System Malformations Diethylstilbestrol 16.1711399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.1714600291
MESH:D009421 Nervous System Malformations Tretinoin 16.179125849
MESH:D009436 Neural Tube Defects arsenic trioxide 7.2010525206
MESH:D009436 Neural Tube Defects Tretinoin 7.209142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D010051 Ovarian Neoplasms arsenic trioxide 4.8316624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8316936753
MESH:D010146 Pain Acetaminophen 6.4616870215
MESH:D010146 Pain Tretinoin 6.4616870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.2415580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.2415976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010235 Paraganglioma arsenic trioxide 4.1219927285
MESH:D010300 Parkinson Disease Rotenone 2.9611445065 18191903 11535288 18619942 15451049 16412576 19114014 16140633 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 4.0415795934 15574749 15927086 18197244
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.1414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.6315687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.4517184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4511399792 11118676 11222880 11896295
MESH:D011471 Prostatic Neoplasms AGN 194204 1.9016000583
MESH:D011471 Prostatic Neoplasms Am 80 1.9016289102
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9019131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.9017292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.9017136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9015067354
MESH:D011507 Proteinuria Tretinoin 3.5616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011565 Psoriasis Am 80 4.0716819260
MESH:D011625 Pterygium Tretinoin 4.7616723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0616116481 16283617
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.9216646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.2710029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.2716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.2716467112
MESH:D013088 Spermatocele Diethylstilbestrol 19.9816002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 19.9816709447
MESH:D013088 Spermatocele Tamoxifen 19.9816709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0019457130
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3217007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3220155912 2093021
MESH:D013274 Stomach Neoplasms Tretinoin 3.3217261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.0919014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0917045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.7516051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.9315213294
MESH:D014376 Tuberculosis Tretinoin 3.2016040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.8020435036 12973940 11780464 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.8017053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.8016712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.808653321 16712894 17572228
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.3816175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.3816129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.1414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.3415809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.3414692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5816752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.4016513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.0216761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D009396 Wilms Tumor Tretinoin 3.9316287080
Pathway ID Pathway Name
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:04514 Cell adhesion molecules (CAMs)
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:04672 Intestinal immune network for IgA production
KEGG:04810 Regulation of actin cytoskeleton
REACT:6900 Signaling in Immune system
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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