AutismKB 2.0

Annotation Detail for ITIH1


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Basic Information Top
Gene Symbol:ITIH1 ( H1P,IATIH,IGHEP1,ITIH,MGC126415,SHAP )
Gene Full Name: inter-alpha (globulin) inhibitor H1
Band: 3p21.1
Quick LinksEntrez ID:3697; OMIM: 147270; Uniprot ID:ITIH1_HUMAN; ENSEMBL ID: ENSG00000055957; HGNC ID: 6166
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
Desease Name
bipolar disorder
PSYCH
Desease Name
Bipolar disorder
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ITIH1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ITIH1 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ITIH1 proteinaffects expression 20106945
C006632 arsenic trioxide arsenic trioxide results in increased expression of ITIH1 mRNAincreases expression 20458559
D002118 Calcium Calcium promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
D002122 Calcium Chloride Calcium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
D002330 Carmustine Carmustine results in decreased expression of ITIH1 mRNAdecreases expression 15980968
D016572 Cyclosporine Cyclosporine results in decreased expression of ITIH1 mRNAdecreases expression 20106945
C056933 fumonisin B1 fumonisin B1 results in decreased expression of ITIH1 mRNAdecreases expression 16221962
D008274 Magnesium Magnesium promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
D015636 Magnesium Chloride Magnesium Chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
D008345 Manganese Manganese promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
C025340 manganese chloride manganese chloride promotes the reaction [ITIH1 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
C006253 pirinixic acid pirinixic acid results in decreased expression of ITIH1 mRNAdecreases expression 16221962
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.1718653653
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3019825857 11798837
MESH:D000236 Adenoma Magnesium 4.5717823441
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.5616434500
MESH:D000756 Anemia, Sideroblastic Manganese 11.2116910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 11.2116910769
MESH:D001321 Autistic Disorder Magnesium 3.5816846101
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.1816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1819483382
MESH:D001930 Brain Injuries Magnesium Chloride 6.4210506531
MESH:D001932 Brain Neoplasms Carmustine 4.4416187019
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.3911589617
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.6516705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6512907637 21507988 12619106
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 6.6511135700 14691202 15073043 16217749 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.9719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1712490120
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.706135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.7012371664
MESH:D002779 Cholestasis Cyclosporine 7.8919486331
MESH:D002779 Cholestasis pirinixic acid 7.8919176532
MESH:D003111 Colonic Polyps Magnesium 6.1217823441
MESH:D015179 Colorectal Neoplasms arsenic trioxide 3.0920501625
MESH:D015179 Colorectal Neoplasms Magnesium 3.0917823441
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2512609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8810525206
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.1418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.1418551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1515213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4518249437
MESH:D002658 Developmental Disabilities Magnesium 4.9416846101
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4418551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4421346803 18551238
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 6.4416221962
MESH:D004487 Edema pirinixic acid 2.5312083418
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3212903497
MESH:D005234 Fatty Liver arsenic trioxide 13.3915073043
MESH:D005234 Fatty Liver Cyclosporine 13.3919224547
MESH:D005234 Fatty Liver pirinixic acid 13.3919236843 20131406
MESH:D005355 Fibrosis Cyclosporine 3.2112639820 12168785
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3316904648
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.308708960
MESH:D005909 Glioblastoma Carmustine 7.9016187019
MESH:D005909 Glioblastoma Manganese 7.9017043766
MESH:D006333 Heart Failure pirinixic acid 2.5720558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5015720958
MESH:D006529 Hepatomegaly fumonisin B1 9.0116221962
MESH:D006529 Hepatomegaly pirinixic acid 9.0116221962 19772884 19176532 18467677
MESH:D006943 Hyperglycemia pirinixic acid 3.2320558911
MESH:D006973 Hypertension Cyclosporine 2.1210903974
MESH:D007333 Insulin Resistance pirinixic acid 2.6616306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5415604871
MESH:D007674 Kidney Diseases Cyclosporine 2.3718776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.6316705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.6312371664
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 5.1416316344
MESH:D007938 Leukemia arsenic trioxide 2.8615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8512560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.3916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4714633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.8119077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1516467208 16968895 20471514 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.2517712046 16330433 11468182 17869043 19642359 12018890 15213294 15336539 16891316 15748426 9834237 17217047 16112521 16966277 12712474 11161223 17107899 12679006 19035177 19225113 19075265 16331271 17649720 15622746 16823087
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4216882451
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.877678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 10.879163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms arsenic trioxide 10.8714682389
MESH:D008113 Liver Neoplasms pirinixic acid 10.8720007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.082876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.088603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.0820377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.3915213294
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.5414755239
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5411798837 19825857
MESH:D008275 Magnesium Deficiency Magnesium 6.5317823441
MESH:D020149 Manganese Poisoning Manganese 5.6216568477 16551646 19453300
MESH:D008545 Melanoma Carmustine 2.8712393984
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8816801185
MESH:D008881 Migraine Disorders Magnesium 4.8118803445
MESH:D009069 Movement Disorders Manganese 5.0716551646
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1415949261 19417148 14977855 19549372 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.5816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.7718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.1716882451 16105982
MESH:D009203 Myocardial Infarction pirinixic acid 2.1619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.6318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.637678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0216624393
MESH:D009369 Neoplasms pirinixic acid 1.9717405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3319348381 18481113
MESH:D009410 Nerve Degeneration Manganese 4.3116551646
MESH:D009436 Neural Tube Defects arsenic trioxide 3.1510525206
MESH:D009765 Obesity pirinixic acid 1.8220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.0616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.0616049721
MESH:D010024 Osteoporosis Calcium 3.8117882678
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4219769630 12452020 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5415580305
MESH:D010235 Paraganglioma arsenic trioxide 4.2219927285
MESH:D010300 Parkinson Disease Manganese 3.3911181820
MESH:D020734 Parkinsonian Disorders Manganese 4.5216140633
MESH:D011230 Precancerous Conditions Cyclosporine 3.2712371664
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2719131511
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4119058328
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0216646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9918551238
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.1319014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0415213294
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.4216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.4216049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.4212973940 20435036 12845720 11780464
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.2710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.2710091137
MESH:D014605 Uveitis Cyclosporine 4.081336536
MESH:D014985 Xerophthalmia Cyclosporine 4.5417120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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