AutismKB 2.0

Annotation Detail for ITIH2


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Basic Information Top
Gene Symbol:ITIH2 ( H2P,SHAP )
Gene Full Name: inter-alpha (globulin) inhibitor H2
Band: 10p14
Quick LinksEntrez ID:3698; OMIM: 146640; Uniprot ID:ITIH2_HUMAN; ENSEMBL ID: ENSG00000151655; HGNC ID: 6167
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1850Herpes
1859Ovarian cancer
1986Eating disorder
1796Labor, Premature
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of ITIH2 mRNAaffects expression 18281256
C013813 4-anisidine 4-anisidine results in increased expression of ITIH2 mRNAincreases expression 12929121
D000082 Acetaminophen Acetaminophen affects the expression of ITIH2 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone results in increased expression of ITIH2 mRNAincreases expression 19774075
D002118 Calcium Calcium promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
D002122 Calcium Chloride Calcium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
D016572 Cyclosporine Cyclosporine results in decreased expression of ITIH2 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in decreased expression of ITIH2 mRNAdecreases expression 15238619
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITIH2 mRNAaffects cotreatment|increases expression 17942748
C029424 hydrazine hydrazine results in increased expression of ITIH2 mRNAincreases expression 15282401
D006918 Hydroxyurea Hydroxyurea results in increased expression of ITIH2 mRNAincreases expression 12929121
D008274 Magnesium Magnesium promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
D015636 Magnesium Chloride Magnesium Chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
D008345 Manganese Manganese promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
C025340 manganese chloride manganese chloride promotes the reaction [ITIH2 protein binds to TNFAIP6 protein]affects binding|increases reaction 16768462
D017239 Paclitaxel Paclitaxel results in increased expression of ITIH2 mRNAincreases expression 12929121
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ITIH2 mRNAaffects binding|decreases expression|increases activity 19710929
C017947 sodium arsenite sodium arsenite affects the expression of ITIH2 mRNAaffects expression 17450228
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ITIH2 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITIH2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7915322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8014692618
MESH:D000236 Adenoma Magnesium 4.5117823441
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.7016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6415276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8516712894 17306315
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000756 Anemia, Sideroblastic Manganese 10.8216910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.8216910769
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.7418218290 20041841 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 9.7015238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.7011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6215885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.8519698954 18651412
MESH:D001321 Autistic Disorder Acetaminophen 2.4318445737
MESH:D001321 Autistic Disorder Magnesium 2.4316846101
MESH:D001778 Blood Coagulation Disorders Amiodarone 14.9519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.9512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001859 Bone Neoplasms Paclitaxel 4.5015867366
MESH:D001930 Brain Injuries Magnesium Chloride 6.2910506531
MESH:D001943 Breast Neoplasms Dietary Fats 1.9320435547
MESH:D001943 Breast Neoplasms Paclitaxel 1.9318323546 18223236 16244791 18234424 16273361 16115903 15136595 11325840
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9320435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.583084413
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 4.5816313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.5815276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.3618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3318670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8715710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.0218974383
MESH:D002386 Cataract Acetaminophen 2.5410977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.5012371664
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 6.5020056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1016835633
MESH:D002779 Cholestasis Cyclosporine 13.0519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.0516105132 15861022 16919318 17110522 11677210 17333356 17681005
MESH:D002779 Cholestasis pirinixic acid 13.0519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0812621046 15340226 15668235 8697196 16354765
MESH:D003111 Colonic Polyps Magnesium 5.9917823441
MESH:D015179 Colorectal Neoplasms Magnesium 3.2817823441
MESH:D015179 Colorectal Neoplasms Paclitaxel 3.2818802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0014669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D002658 Developmental Disabilities Magnesium 4.8616846101
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6517107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.0611529661 16781746 12540782 19085960 14550746 15968718 15619225 19416960 16177239 11287661 16393943 11461765 12392966 17906064 12594235 18071297 19370779 12705907 17562736 14986274 10774834 14725611 19164858 10915739 18713872 12958197 16485898 17522070 11739529 16227642 11743745 11421492 19420014 16081117 2444490 16109766 12153990 11834606 10663392 19739265 19923254
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.0618218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.0620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7111462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4018367378
MESH:D004487 Edema pirinixic acid 6.3312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.3311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8518230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004938 Esophageal Neoplasms Paclitaxel 2.8816481741
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9611564622
MESH:D005234 Fatty Liver Amiodarone 23.9914986274
MESH:D005234 Fatty Liver Cyclosporine 23.9919224547
MESH:D005234 Fatty Liver Dietary Fats 23.9917967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Ethinyl Estradiol 23.9915345470
MESH:D005234 Fatty Liver pirinixic acid 23.9920131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D005355 Fibrosis Cyclosporine 14.3512168785 12639820
MESH:D005355 Fibrosis Dietary Fats 14.3518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.3520067830
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6216452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.168708960
MESH:D005909 Glioblastoma Manganese 3.8717043766
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3011294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3615720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 20.2316109766
MESH:D006529 Hepatomegaly Amiodarone 20.2315265979
MESH:D006529 Hepatomegaly pirinixic acid 20.2318467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 20.2312621046 15340226 16120746
MESH:D006689 Hodgkin Disease sodium arsenite 3.1012676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916959395 18606429 16354765 15340226 8697196
MESH:D006930 Hyperalgesia Acetaminophen 2.6516870215
MESH:D006937 Hypercholesterolemia Amiodarone 8.969751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 8.9621332399
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5521332399
MESH:D006973 Hypertension Cyclosporine 4.8610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.8618670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.4517991464 18020914
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4917937319
MESH:D007248 Infertility, Male sodium arsenite 6.4912646999 15346721
MESH:D007249 Inflammation Dietary Fats 4.8020412841
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.8012200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 7.1018457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.1016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3915604871
MESH:D007674 Kidney Diseases Acetaminophen 9.7812587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 9.788314463 10903974 18776723
MESH:D007674 Kidney Diseases sodium arsenite 9.7820008137
MESH:D007680 Kidney Neoplasms Cyclosporine 2.6812371664
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.9916316344
MESH:D007951 Leukemia, Myeloid Hydroxyurea 4.9516532439
MESH:D008064 Lipidoses Amiodarone 3.4615342952 17567588
MESH:D008080 Liposarcoma Paclitaxel 4.7617353645
MESH:D008103 Liver Cirrhosis Dietary Fats 2.8418296743
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1112878042
MESH:D008107 Liver Diseases Acetaminophen 1.6119014921 16610002 19460945 12587719 12969438 11587558 19784758 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.1817185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 7.2115890375 20007298 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 7.2116712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.2116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.5317391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 7.3712587719
MESH:D008171 Lung Diseases sodium arsenite 7.3719095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.4218516814
MESH:D008175 Lung Neoplasms sodium arsenite 2.2817306315 19931552 16712894 17077188 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.2811884234 19555203
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.0314749477
MESH:D008275 Magnesium Deficiency Magnesium 6.3817823441
MESH:D020149 Manganese Poisoning Manganese 5.4619453300 16568477 16551646
MESH:D008545 Melanoma Paclitaxel 3.5412025231 12040289 16342250
MESH:D008545 Melanoma sodium arsenite 3.5416487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7316801185
MESH:D008881 Migraine Disorders Magnesium 4.7218803445
MESH:D009069 Movement Disorders Manganese 4.9516551646
MESH:D009101 Multiple Myeloma Paclitaxel 3.6414749477
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009181 Mycoses Amiodarone 4.8517974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.2315867366
MESH:D009369 Neoplasms pirinixic acid 4.8317405874
MESH:D009369 Neoplasms sodium arsenite 4.8311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6020056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3917954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2318481113 19348381
MESH:D009410 Nerve Degeneration Manganese 4.2216551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1514600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1012854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8118514411
MESH:D009765 Obesity Dietary Fats 4.3818674790 21332399 20518802 17217161 20132043 19632207 16723640 11836018 18457598
MESH:D009765 Obesity pirinixic acid 4.3820558911
MESH:D010014 Osteolysis Paclitaxel 4.9215867366
MESH:D010024 Osteoporosis Calcium 3.7417882678
MESH:D010051 Ovarian Neoplasms Paclitaxel 5.0511161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.0515276417 17306315
MESH:D010146 Pain Acetaminophen 2.3416870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010300 Parkinson Disease Manganese 3.3511181820
MESH:D020734 Parkinsonian Disorders Manganese 4.4116140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1612371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Paclitaxel 3.5416729912 17172428 17136230 16356831
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.5416039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.2516919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8312832656 12490602 11597910
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.0218724381
MESH:D012878 Skin Neoplasms sodium arsenite 5.4918572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4916192470
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8916709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7412854658
MESH:D013274 Stomach Neoplasms Paclitaxel 2.4418396642 18506536
MESH:D013276 Stomach Ulcer Amiodarone 3.2618087811
MESH:D013610 Tachycardia Amiodarone 4.2211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.1319225199
MESH:D024801 Tauopathies Paclitaxel 4.7516930453
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Amiodarone 11.8719731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.8712697716
MESH:D013971 Thyrotoxicosis Amiodarone 4.8018020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.1317467628 11989578
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 2.4817306315 11723127 16712894 16452187
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7111813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014605 Uveitis Cyclosporine 3.931336536
MESH:D014652 Vascular Diseases sodium arsenite 4.3617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D015430 Weight Gain Dietary Fats 3.6816723640
MESH:D014985 Xerophthalmia Cyclosporine 4.3917120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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