AutismKB 2.0

Annotation Detail for ITIH4


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Basic Information Top
Gene Symbol:ITIH4 ( DKFZp686G21125,H4P,IHRP,ITIHL1,PK120 )
Gene Full Name: inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
Band: 3p21.1
Quick LinksEntrez ID:3700; OMIM: 600564; Uniprot ID:ITIH4_HUMAN; ENSEMBL ID: ENSG00000055955,ENSG00000243696; HGNC ID: 6169
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1956Cystitis
Desease Name
hypercholesterolemia
cholesterol
METABOLIC
No data
Desease Name
Hypercholesterolemia, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ITIH4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ITIH4 mRNAaffects expression 21346803
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ITIH4 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of ITIH4 mRNAaffects expression 19483382
D001553 Benzbromarone Benzbromarone affects the expression of ITIH4 mRNAaffects expression 19483382
C032036 bromobenzene bromobenzene results in decreased expression of ITIH4 mRNAdecreases expression 12628495
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of ITIH4 mRNAincreases expression 16239168
D002994 Clofibrate Clofibrate affects the expression of ITIH4 mRNAaffects expression 19483382
D016572 Cyclosporine Cyclosporine results in decreased expression of ITIH4 mRNAdecreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ITIH4 mRNAincreases expression 17010207
D004958 Estradiol Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of ITIH4 mRNA]decreases reaction|increases expression 16977382
D004958 Estradiol Estradiol results in increased expression of ITIH4 mRNAincreases expression 17010207
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ITIH4 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITIH4 mRNAaffects cotreatment|increases expression 17942748
D005001 Ethionine Ethionine affects the expression of ITIH4 mRNAaffects expression 19483382
C056933 fumonisin B1 fumonisin B1 results in decreased expression of ITIH4 mRNAdecreases expression 16221962
C039281 furan furan results in decreased expression of ITIH4 mRNAdecreases expression 15120968
D007657 Ketone Bodies Ketone Bodies results in decreased expression of ITIH4 mRNAdecreases expression 16807920
D008070 Lipopolysaccharides Estradiol inhibits the reaction [Lipopolysaccharides results in increased expression of ITIH4 mRNA]decreases reaction|increases expression 16977382
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of ITIH4 mRNAincreases expression 16977382
D008727 Methotrexate Methotrexate results in increased expression of ITIH4 mRNAincreases expression 15120968
C474055 octylphenol octylphenol results in increased expression of ITIH4 mRNAincreases expression 17010207
D009853 Omeprazole Omeprazole affects the expression of ITIH4 mRNAaffects expression 19483382
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ITIH4 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ITIH4 mRNAdecreases expression 20059764
16221962
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ITIH4 mRNA]decreases expression|increases reaction 20059764
C006253 pirinixic acid pirinixic acid affects the expression of ITIH4 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of ITIH4 mRNAaffects expression 19483382
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITIH4 mRNAaffects cotreatment|increases expression 17942748
D013853 Thioacetamide Thioacetamide affects the expression of ITIH4 mRNAaffects expression 19483382
D015215 Zidovudine [Zidovudine co-treated with IFNA1 protein] results in increased expression of ITIH4 mRNAaffects cotreatment|increases expression 20370541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 7.9512039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.9515322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7517505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.649612607
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.4511850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 8.4518653653
MESH:D000230 Adenocarcinoma Estradiol 4.0511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.0514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.2616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2616835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.3015469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7811748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6418218290 18057881 20041841
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5515885639
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.0517286800
MESH:D001281 Atrial Fibrillation Amiodarone 3.7619698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 54.9819483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 54.9819483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 54.9819483382
MESH:D001778 Blood Coagulation Disorders Ethionine 54.9819483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 54.9819483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 54.9819483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 54.9819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 54.9812125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 54.9819483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6015340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6415746008
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9617129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 1.9617289903 14630087 12948864 17261762 19861407 16675129 18497071 17018787
MESH:D001943 Breast Neoplasms Methotrexate 1.9616978400
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5916227642 15700767 15673190 15721981 16097048 10355542 16124888 16011737 16050911 18705752 16192424 3786805
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.3816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.3816705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.3812619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 16.381701930
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.3818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 16.3816924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.3816924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 16.3817997003
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2616120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8315710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8918974383
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.976135515
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.971399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.9712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.9718566989
MESH:D002637 Chest Pain Omeprazole 4.9115447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.0116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 9.0118291259
MESH:D002779 Cholestasis Cyclosporine 12.5319486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.5316919318 17110522 16105132 17333356 11677210 15861022 17681005
MESH:D002779 Cholestasis pirinixic acid 12.5319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0312621046 8697196 15668235 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9014669216 17141729
MESH:D019465 Craniofacial Abnormalities Methotrexate 2.699562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6920055451 10048152 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3712952375 16002989
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.2618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.2618551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.0719747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3418249437
MESH:D003882 Dermatomyositis Methotrexate 4.9420191521
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2519279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 21.2521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 21.2518551238 21346803
MESH:D056486 Drug-Induced Liver Injury Amiodarone 21.2515265979 18218290
MESH:D056486 Drug-Induced Liver Injury bromobenzene 21.2512628495 10092053
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 21.259327722 3732212 16177239 19336974 2869522 15027814 16227642 10092053 10915739 7179309 21278145 15998439 7440962 7120509 19085960 11566570 17522070 6623471 4309450 3786805 15968718 6884620
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 21.2516221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 21.2520420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 21.2512963478
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.7711462148
MESH:D004362 Drug Toxicity Zidovudine 7.7715040536
MESH:D004381 Duodenal Ulcer Omeprazole 4.1516613094 17151854 21218061 15991576
MESH:D050171 Dyslipidemias Clofibrate 3.9316707586
MESH:D004487 Edema pirinixic acid 5.9712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7116714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.0112538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.5016402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.1315700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 7.1319148513 11473722 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.869294722 10568697
MESH:D019446 Endotoxemia Lipopolysaccharides 4.2015821434 17637181 15328337
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8711564622
MESH:D005218 Fat Necrosis Thioacetamide 5.5316456712
MESH:D005234 Fatty Liver Amiodarone 34.3214986274
MESH:D005234 Fatty Liver Carbon Tetrachloride 34.3216239168 15959796 19224547 12631006 17595544 12795759 61145 16045604
MESH:D005234 Fatty Liver Clofibrate 34.3219224547
MESH:D005234 Fatty Liver Cyclosporine 34.3219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 34.3215345470
MESH:D005234 Fatty Liver pirinixic acid 34.3220131406 19236843
MESH:D005234 Fatty Liver Zidovudine 34.3218299183
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.5416002989 16611131 15751030 16513791 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2711858732
MESH:D005334 Fever Lipopolysaccharides 3.859205823 11852909
MESH:D005355 Fibrosis Carbon Tetrachloride 13.6118705752
MESH:D005355 Fibrosis Cyclosporine 13.6112639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.6120067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.038708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4010696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.9616518429
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2310048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4220558911
MESH:D006402 Hematologic Diseases Zidovudine 4.5312579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2315720958
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.2216366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1611000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.4018665440 15929193 17276928
MESH:D006505 Hepatitis Carbon Tetrachloride 8.8719110552 19900420
MESH:D006505 Hepatitis Thioacetamide 8.8716456712
MESH:D006529 Hepatomegaly Amiodarone 19.1615265979
MESH:D006529 Hepatomegaly fumonisin B1 19.1616221962
MESH:D006529 Hepatomegaly pirinixic acid 19.1616221962 18467677 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.1615340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8415709030
MESH:D015658 HIV Infections Zidovudine 3.3911698656 11363243 20032539 17358032 11141242
MESH:D019584 Hot Flashes Estradiol 3.5617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8515340226 16354765 8697196 16959395 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3416899240
MESH:D006937 Hypercholesterolemia Amiodarone 3.708137927 9751232
OMIM:143890 HYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT marker/mechanism
MESH:D006943 Hyperglycemia pirinixic acid 3.0220558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2514722030 12960047
MESH:D006973 Hypertension Cyclosporine 4.7010903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7018670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9015338365
MESH:D007021 Hypospadias Diethylstilbestrol 10.6116002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.6116569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.9817991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.9818031379 8137927
MESH:D007246 Infertility Diethylstilbestrol 4.1715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.3617937319
MESH:D007249 Inflammation Lipopolysaccharides 4.7517237260 9205823 12878042 17255318 17963957
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.7512878042 12200463
MESH:D007333 Insulin Resistance Estradiol 6.7916627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.7916306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.4517255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2515604871
MESH:D007674 Kidney Diseases Cyclosporine 5.578314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.5715618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 27.0916705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 27.0916705839
MESH:D007680 Kidney Neoplasms Cyclosporine 27.0912371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 27.0915003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 27.0915610895
MESH:D007680 Kidney Neoplasms Zidovudine 27.0912579204
MESH:D007805 Language Development Disorders Methotrexate 4.929562676
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8717184923
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.9419248655
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.2420370541
MESH:D007970 Leukopenia Lipopolysaccharides 4.5115821434
MESH:D008064 Lipidoses Amiodarone 3.3715342952 17567588
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.5816943688 17174718 11408273 11903743 16239168 17334410 16221502 17157831 21278145
MESH:D008103 Liver Cirrhosis Methotrexate 6.5814986274
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.4217900296 17557913 17766677 17922224 16027843 15338365 14716833 12546737 18420326 16015684 15123356 12898905 18205269 14512876 18166357 18156304 18481824 14748882 17565644 12666154 16011737 15730626 16116963 14620537 18705752 15673190 15057751 17714472 18263696 18277467 17976157 17805973 18317297 14716496 17721639 15370692 18395095 17823541 17944888 18395914 12632512 17525996 16192424 15876570 17631135 18006644 10355542 12632514 15996030 15818738 18279442 17869086 18429990 18418968 15052691 16638106 12741479 18472094 12609069 17708605 14724832 18376398 15893842 15931870 16033810 17761835 15650968 16248980 16097048 12389079 20821823 15925388 12586293 12649538 18339082 18251166 15362042 16136751 11481614 17698563 15959796 18412020 13678700 18054572 18187930 12445421 12958196 12445418 12667390 17481882 18472332 18210741 17640975
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.4214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.4212878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 8.4218031379 18416461 15288472 16489207 15716488 11481614 18458672 17127702 15095483 12679928 18380797 15362042 16248980 14739098 15474484 18615449 18032466 18395095 17292413 12557150 11172339 12175628 12891558 15288473 17629604 18263696 11682029 15075984 17355460 12531686 16126171 17050028 15078482 15465738 15316131 15334695 15158331 16511523 16343077 16098781 18295389 12085344 18606216 10677585 16097051
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.1316964402 16246199 17285989 15830285 15720792
MESH:D008107 Liver Diseases Thioacetamide 4.1316337175 18374380 15158337
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2516899240 14706259
MESH:D017114 Liver Failure, Acute Thioacetamide 9.2515633222 12479984 15313186 17276928
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 17.047678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 17.042125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 17.0419294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 17.0416712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 17.0416377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.0416984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 13.132876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 13.138603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.1315583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.1312151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4417391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.2512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 10.9018516814
MESH:D017563 Lung Diseases, Interstitial Methotrexate 10.9018516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.8221114838
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.3614755239
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3619555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 3.3618800350
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9615166399
MESH:D008223 Lymphoma Diethylstilbestrol 7.4815700306
MESH:D008223 Lymphoma Methotrexate 7.4817352296
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3216002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.4416891317 11807958 11408345 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.2919453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5916801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.6517358032
MESH:D052016 Mucositis Methotrexate 5.0917488658
MESH:D009135 Muscular Diseases pirinixic acid 3.3216239165
MESH:D009181 Mycoses Amiodarone 4.7117974566 12754197
MESH:D009203 Myocardial Infarction pirinixic acid 2.0719151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7716810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7716411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.7118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.7118551238 7678174
MESH:D009369 Neoplasms Diethylstilbestrol 4.7315313581
MESH:D009369 Neoplasms pirinixic acid 4.7317405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2517954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1218481113 19348381
MESH:D009421 Nervous System Malformations Diethylstilbestrol 15.3111399458
MESH:D009421 Nervous System Malformations Estradiol 15.3116427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.3114600291
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.759802331
MESH:D009765 Obesity pirinixic acid 1.7720558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.3312819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.3316049721
MESH:D010051 Ovarian Neoplasms Estradiol 2.1619401270
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5111578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0612520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9814722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4815687265 16977796
MESH:D011014 Pneumonia Lipopolysaccharides 4.3612224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3718163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0612371664
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.9317184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.9311896295 11118676 11222880 11399792
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7120887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3917136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 3.3916740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.1215861022 16919318
MESH:D011565 Psoriasis Cyclosporine 5.6916882103
MESH:D011565 Psoriasis Methotrexate 5.6917410198
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7812490602 11597910 12832656
MESH:D051437 Renal Insufficiency Methotrexate 4.5217352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.6110835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6518990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.4418551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.4418551238
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8918724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9616192470
MESH:D013088 Spermatocele Diethylstilbestrol 11.0716709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 11.0716709447
MESH:D013272 Stomach Diseases Omeprazole 4.4218545984
MESH:D013274 Stomach Neoplasms Zidovudine 2.4717696246
MESH:D013276 Stomach Ulcer Amiodarone 7.0118087811
MESH:D013276 Stomach Ulcer Omeprazole 7.0110750652 17977527 16755016 18237397 11906479 15991576
MESH:D013576 Syndactyly Methotrexate 4.859562676
MESH:D013610 Tachycardia Amiodarone 4.1111238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0119225199
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.0015821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9915669648
MESH:D013959 Thyroid Diseases Amiodarone 11.4119731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.4112697716
MESH:D013964 Thyroid Neoplasms Propylthiouracil 3.5415710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.6718020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.4919048282
MESH:D016171 Torsades de Pointes Amiodarone 4.0017467628 11989578
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.9116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.9116049721
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 7.9116712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.3510091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.3510091137
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.8716175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9814652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.8615809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8614692618
MESH:D014605 Uveitis Cyclosporine 3.791336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 10.5116513791 16002989
MESH:D014625 Vaginal Neoplasms Zidovudine 10.5112579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0615886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2517120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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