AutismKB 2.0

Annotation Detail for ITK


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Basic Information Top
Gene Symbol:ITK ( EMT,LYK,MGC126257,MGC126258,PSCTK2 )
Gene Full Name: IL2-inducible T-cell kinase
Band: 5q33.3
Quick LinksEntrez ID:3702; OMIM: 186973; Uniprot ID:ITK_HUMAN; ENSEMBL ID: ENSG00000113263; HGNC ID: 6171
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04062Chemokine signaling pathway
hsa04660T cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200003Fc-epsilon receptor I signaling in mast cells
200098Class I PI3K signaling events
200022TCR signaling in naive CD4+ T cells
No data
Pathway IDPathway Name
500481Generation of second messenger molecules
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1809HIV infection
2074Asthma
No data
No data
Desease Name
Lymphoproliferative syndrome, EBV-associated, autosomal, 1
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C027309 3,4,5,3',4',5'-hexachlorobiphenyl 3,4,5,3',4',5'-hexachlorobiphenyl results in increased expression of ITK mRNAincreases expression 16050139
D000082 Acetaminophen Acetaminophen affects the expression of ITK mRNAaffects expression 17562736
C014949 acetylhydrazine acetylhydrazine results in decreased expression of ITK mRNAdecreases expression 15282401
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ITK mRNAincreases expression 16050139
C029424 hydrazine hydrazine results in decreased expression of ITK mRNAdecreases expression 15282401
D018038 Sodium Selenite Sodium Selenite results in decreased expression of ITK mRNAdecreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0420127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.826695378
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4919183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0017474063 20146248
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1220419170
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1715894690
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0616285004
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0814986274 12594235 16177239 11739529 15968718 19164858 19739265 14550746 11421492 11529661 12958197 19923254 16081117 18713872 16485898 11743745 14725611 12392966 19085960 10663392 16109766 12153990 17522070 17562736 19416960 2444490 11461765 16393943 16227642 19420014 11834606 19370779 12705907 15619225 16781746 10774834 18071297 12540782 10915739 11287661 17906064
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0815131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0716530937
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8020471113
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D007333 Insulin Resistance Sodium Selenite 3.4714714311
MESH:D007674 Kidney Diseases Acetaminophen 2.3612587719 15629191
MESH:D008107 Liver Diseases Acetaminophen 1.6919460945 16610002 19014921 11587558 12969438 16611625 19784758 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 2.1321137059 20195826
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5720464547 18569708 18816296 20135361 20869020 6695378 20064080 17053015 18520028
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.4114737004
OMIM:613011 LYMPHOPROLIFERATIVE SYNDROME, EBV-ASSOCIATED, AUTOSOMAL, 1 marker/mechanism
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4316381670
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3011141357
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.1518760546
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4910029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2817053015
MESH:D014581 Urticaria Acetaminophen 3.3310982225
Pathway ID Pathway Name
KEGG:04062 Chemokine signaling pathway
KEGG:04670 Leukocyte transendothelial migration
REACT:6900 Signaling in Immune system
KEGG:04660 T cell receptor signaling pathway
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB02010 - Staurosporine Enzyme Inhibitors
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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