AutismKB 2.0

Annotation Detail for ITPKB


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Basic Information Top
Gene Symbol:ITPKB ( IP3-3KB,IP3K,IP3K-B,IP3KB,PIG37 )
Gene Full Name: inositol 1,4,5-trisphosphate 3-kinase B
Band: 1q42.12
Quick LinksEntrez ID:3707; OMIM: 147522; Uniprot ID:IP3KB_HUMAN; ENSEMBL ID: ENSG00000143772; HGNC ID: 6179
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
PWY-63621D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
Pathway IDPathway Name
hsa00562Inositol phosphate metabolism
hsa04020Calcium signaling pathway
hsa01100Metabolic pathways
hsa04070Phosphatidylinositol signaling system
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of ITPKB mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ITPKB mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ITPKB mRNAaffects cotreatment|decreases expression 18164116
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITPKB mRNAaffects cotreatment|increases expression 18164116
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in decreased expression of ITPKB mRNAdecreases expression 15912405
D004041 Dietary Fats Dietary Fats results in increased expression of ITPKB mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in decreased expression of ITPKB mRNAdecreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in decreased expression of ITPKB mRNA]decreases expression|decreases reaction 17942915
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ITPKB mRNAaffects cotreatment|decreases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ITPKB mRNAaffects cotreatment|increases expression 18164116
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of ITPKB geneincreases mutagenesis 16724327
C041786 palm oil palm oil results in increased expression of ITPKB mRNAincreases expression 18042831
D014810 Vitamin E Vitamin E results in increased expression of ITPKB mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000236 Adenoma beta-Naphthoflavone 12.0019389873
MESH:D000236 Adenoma Diethylnitrosamine 12.006695378 10737359
MESH:D000236 Adenoma Ethylnitrosourea 12.006695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1816434500 19061943 18056438 17620307 17162532 19052882
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.1515238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0714991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4816436596 16357521 16651633 18412241 15144691
MESH:D001943 Breast Neoplasms Dietary Fats 2.1620435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1617474063
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.933084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 2.9318785209 3084413 19822196 19539802 19418558 10672840 20935162 20727157 20432363 18210153 10737359 17978847 16540662 19919837 17428255 20514400 20524982 16878318 18665156 18506893 21159647 19171122 20007298 16328049 16698587 17761372 18971187 19107877 20084675 17138121 16779866 20214788 19335982 19052882 19394651 16288022 3581430 18393292 18691550 20101231 19519916 17162532 16681979 19383236 16807293 16935385 18056438 18788625 11831363 19208518 16830150 19701751 20512989 17173139 18494052 17055752 18978308 16569478 16502159
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 7.5017174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 7.5016003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.3017160924
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9211461765 14550746 19416960 16485898 12958197 11743745 11421492 18713872 11834606 12392966 16781746 15619225 14725611 11739529 16227642 17562736 15968718 16393943 19085960 19164858 19739265 10663392 16177239 19420014 14986274 19923254 16081117 19370779 17522070 12540782 17906064 12153990 16109766 11529661 11287661 12594235 12705907 10774834 18071297 2444490 10915739
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 3.9219107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Dietary Fats 3.6018367378
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.3018357618
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005234 Fatty Liver Dietary Fats 8.5518296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 8.5521071580 20387270
MESH:D005355 Fibrosis Dietary Fats 3.7818296743
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9516436596
MESH:D005910 Glioma Ethylnitrosourea 3.5616651633 18412241 16357521
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0816080930
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7616490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.8021332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.8321332399
MESH:D007249 Inflammation Dietary Fats 5.4320412841
MESH:D007249 Inflammation Diethylnitrosamine 5.4318785209
MESH:D007251 Influenza, Human Vitamin E 4.5316624496
MESH:D007333 Insulin Resistance Dietary Fats 3.2318457598 11836018
MESH:D007674 Kidney Diseases Acetaminophen 6.3312587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.3312488133
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.1017379185
MESH:D008103 Liver Cirrhosis Dietary Fats 6.9818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9818522880 19638242 18665156 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 4.0519784758 19460945 12587719 19014921 16610002 12969438 11587558 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0517034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4316871587 17185352
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 4.9919389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.9919294768 20118626 18977376 19427195 19426721 19256749 19638242 20501860 15885732 9163691 18644402 19833225 20452335 2862719 20101389 19073162 12112319 20583210 20137499 18978307 19499222 19090486 21278145 2422723 15175105 20405173 12771043 20492335 18648771 10737359 19254457 19642983 18754104 21071580 19690152 16942905 19812893 19996281 19850985 21047994 20434301 19255062 21167192 19551842
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.5418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.543124819 19009564 19126423 18775883 19519916 19539802 18164116 16267830 17174075 21159647 18093689 18079962 9362446 18544905 18253720 18308698 18282651 16842330 17942915 17854601 19004024 2563599
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.6920970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.6917703301 16019985 6695378 16271038
MESH:D008175 Lung Neoplasms Vitamin E 3.6911062179
MESH:D008223 Lymphoma Ethylnitrosourea 4.0815790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.3115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.6310838139 10767621 18041768
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D008579 Meningioma Ethylnitrosourea 6.3017943659
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.643581430 9029167
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6616707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.7017160924 16003739 16651423
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.7618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.7620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D009765 Obesity Dietary Fats 2.3318674790 20132043 19632207 17217161 16723640 21332399 18457598 11836018 20518802
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.3017160924
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2715084515
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4515790496
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.147505956
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D015430 Weight Gain Dietary Fats 3.9216723640
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:00562 Inositol phosphate metabolism
KEGG:01100 Metabolic pathways
KEGG:04070 Phosphatidylinositol signaling system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29976
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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