AutismKB 2.0

Annotation Detail for ITPR1


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Basic Information Top
Gene Symbol:ITPR1 ( DKFZp313E1334,DKFZp313N1434,INSP3R1,IP3R,IP3R1,SCA15,SCA16 )
Gene Full Name: inositol 1,4,5-triphosphate receptor, type 1
Band: 3p26.1
Quick LinksEntrez ID:3708; OMIM: 147265; Uniprot ID:ITPR1_HUMAN; ENSEMBL ID: ENSG00000150995; HGNC ID: 6180
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04912GnRH signaling pathway
hsa04720Long-term potentiation
hsa04020Calcium signaling pathway
hsa04540Gap junction
hsa04730Long-term depression
hsa04970Salivary secretion
hsa04972Pancreatic secretion
hsa05016Huntington's disease
hsa05010Alzheimer's disease
hsa04971Gastric acid secretion
hsa04114Oocyte meiosis
hsa04070Phosphatidylinositol signaling system
Pathway IDPathway Name
Signaling by GPCR
Diabetes pathways
Signalling by NGF
Hemostasis
Opioid Signalling
Integration of energy metabolism
No data
Pathway IDPathway Name
P00053T cell activation
P04385Histamine H1 receptor mediated signaling pathway
P00019Endothelin signaling pathway
P00042Muscarinic acetylcholine receptor 1 and 3 signaling pathway
P00010B cell activation
P00002Alpha adrenergic receptor signaling pathway
P00047PDGF signaling pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
P00031Inflammation mediated by chemokine and cytokine signaling pathway
P00041Metabotropic glutamate receptor group I pathway
P00057Wnt signaling pathway
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Nervous system diseases
Neurodegenerative diseases
H00063Spinocerebellar ataxia
Desease IDDesease Name
1831Prostate cancer
2055Spinocerebellar ataxias
2206Sicca syndrome
No data
No data
Desease Name
Spinocerebellar ataxia 15
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ITPR1 mRNAaffects expression 21346803
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of ITPR1 proteindecreases activity 16278292
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of ITPR1 mRNAdecreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ITPR1 mRNAaffects expression 21346803
C109986 2-aminoethoxydiphenyl borate 2-aminoethoxydiphenyl borate results in decreased activity of ITPR1 proteindecreases activity 15326217
C002385 3-morpholino-sydnonimine 3-morpholino-sydnonimine results in increased expression of ITPR1 mRNAincreases expression 17241155
C002385 3-morpholino-sydnonimine Cycloheximide inhibits the reaction [3-morpholino-sydnonimine results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 17241155
C002385 3-morpholino-sydnonimine Dactinomycin inhibits the reaction [3-morpholino-sydnonimine results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 17241155
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ITPR1 mRNAaffects expression 21346803
C006014 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate results in decreased activity of ITPR1 proteindecreases activity 15326217
D000079 Acetaldehyde Acetaldehyde results in increased expression of and affects the localization of ITPR1 proteinaffects localization|increases expression 17241155
D000079 Acetaldehyde ITPR1 protein promotes the reaction [Acetaldehyde metabolite results in increased abundance of Calcium]increases abundance|increases reaction 17241155
D000082 Acetaminophen Acetaminophen affects the expression of ITPR1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ITPR1 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ITPR1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ITPR1 mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ITPR1 mRNAincreases expression 20127859
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ITPR1 mRNAdecreases expression 20018196
19150397
C095105 bexarotene bexarotene results in increased expression of ITPR1 mRNAincreases expression 17178900
D002118 Calcium ITPR1 protein promotes the reaction [Acetaldehyde metabolite results in increased abundance of Calcium]increases abundance|increases reaction 17241155
D002118 Calcium ITPR1 protein promotes the reaction [Ethanol metabolite results in increased abundance of Calcium]increases abundance|increases reaction 17241155
D003474 Curcumin Curcumin results in decreased expression of ITPR1decreases expression 18462866
D003513 Cycloheximide Cycloheximide inhibits the reaction [3-morpholino-sydnonimine results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 17241155
D003513 Cycloheximide Cycloheximide inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 17241155
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 11007951
C017160 cypermethrin cypermethrin results in increased activity of ITPR1 proteinincreases activity 16278292
D003609 Dactinomycin Dactinomycin inhibits the reaction [3-morpholino-sydnonimine results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 17241155
D003609 Dactinomycin Dactinomycin inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 17241155
D004642 Emodin Emodin results in decreased expression of ITPR1 mRNAdecreases expression 16045814
D004958 Estradiol ESR2 protein promotes the reaction [Estradiol results in decreased expression of ITPR1 mRNA]decreases expression|increases reaction 19426747
D004958 Estradiol Estradiol results in decreased expression of ITPR1 mRNAdecreases expression 19426747
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ITPR1 mRNA]decreases expression|decreases reaction 19426747
D000431 Ethanol Cycloheximide inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 17241155
D000431 Ethanol Dactinomycin inhibits the reaction [Ethanol results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 17241155
D000431 Ethanol Ethanol results in increased expression of and affects the localization of ITPR1 proteinaffects localization|increases expression 17241155
D000431 Ethanol Ethanol results in increased expression of ITPR1 mRNAincreases expression 17241155
D000431 Ethanol fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]affects localization|decreases reaction|increases expression 17241155
D000431 Ethanol ITPR1 protein promotes the reaction [Ethanol metabolite results in increased abundance of Calcium]increases abundance|increases reaction 17241155
D000431 Ethanol Uric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]affects localization|decreases reaction|increases expression 17241155
D000431 Ethanol xestospongin C inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]affects localization|decreases reaction|increases expression 17241155
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ITPR1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITPR1 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of ITPR1 mRNAdecreases expression 17557909
D005047 Etoposide ITPR1 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005419 Flavonoids Flavonoids results in increased expression of ITPR1 mRNAincreases expression 18035473
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in decreased expression of ITPR1 mRNA]affects reaction|decreases expression 15016801
C010238 fomepizole fomepizole inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]affects localization|decreases reaction|increases expression 17241155
D019833 Genistein Genistein results in increased expression of ITPR1 mRNAincreases expression 18847459
D008727 Methotrexate ITPR1 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C008493 methylselenic acid methylselenic acid results in increased expression of ITPR1 mRNAincreases expression 18548127
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of ITPR1 mRNAdecreases expression 17616710
D019319 Okadaic Acid Okadaic Acid results in increased activity of ITPR1 proteinincreases activity 16278292
C006253 pirinixic acid pirinixic acid results in decreased expression of ITPR1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of ITPR1 mRNAincreases expression 12832660
D011189 Potassium Chloride Potassium Chloride results in increased expression of ITPR1 mRNAincreases expression 16412482
C045950 propiconazole propiconazole results in increased expression of ITPR1 mRNAincreases expression 19363144
D020123 Sirolimus Sirolimus analog results in decreased activity of ITPR1 proteindecreases activity 16278292
D020123 Sirolimus Sirolimus inhibits the reaction [FKBP1A protein binds to ITPR1 protein]affects binding|decreases reaction 16278292
D020123 Sirolimus Sirolimus results in decreased activity of ITPR1 proteindecreases activity 16278292
C025462 sulindac sulfide sulindac sulfide results in decreased expression of ITPR1 mRNAdecreases expression 15767558
D014284 Triiodothyronine Triiodothyronine results in increased expression of ITPR1 mRNAincreases expression 15953391
D013974 Thyroxine Thyroxine results in increased expression of ITPR1 mRNAincreases expression 17403546
D016559 Tacrolimus Tacrolimus inhibits the reaction [FKBP1A protein binds to ITPR1 protein]affects binding|decreases reaction 16278292
D016559 Tacrolimus Tacrolimus results in increased activity of ITPR1 proteinincreases activity 16278292
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol results in decreased expression of ITPR1 mRNA]decreases expression|decreases reaction 19426747
D013629 Tamoxifen Tamoxifen results in increased expression of ITPR1 mRNAincreases expression 19426747
D013629 Tamoxifen Tamoxifen affects the expression of ITPR1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNA]decreases reaction|increases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ITPR1 mRNAincreases expression 20106945
11007951
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ITPR1 mRNAaffects cotreatment|increases expression 17942748
C052342 topiramate topiramate results in increased expression of ITPR1 mRNAincreases expression 16979414
D014527 Uric Acid Uric Acid inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]affects localization|decreases reaction|increases expression 17241155
C025643 vinclozolin vinclozolin results in increased expression of ITPR1 mRNAincreases expression 15686871
C511704 xestospongin C xestospongin C inhibits the reaction [Ethanol results in increased expression of and affects the localization of ITPR1 protein]affects localization|decreases reaction|increases expression 17241155
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0514745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 16.437525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 16.4317676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 16.4312039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 16.4315322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 8.8518287403
MESH:D000138 Acidosis Ethanol 8.8511192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4517505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.6718653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 11.9520127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 11.9511473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 11.9514692618
MESH:D000230 Adenocarcinoma Fluorouracil 11.9517638652
MESH:D000230 Adenocarcinoma Genistein 11.9511473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.366695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.2816434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.2816835633
MESH:D000382 Agricultural Workers' Diseases cypermethrin 4.4516487989
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.8215451040 15451039
MESH:D000437 Alcoholism topiramate 4.6517925516 19331489 18552399
MESH:D019973 Alcohol-Related Disorders Curcumin 4.5817887948
MESH:D000544 Alzheimer Disease Curcumin 4.1915590663
MESH:D000544 Alzheimer Disease sulindac sulfide 4.1918759972
MESH:D000740 Anemia Fluorouracil 7.2815504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.2811748828
MESH:D000799 Angioedema Acetaminophen 3.3510982225
MESH:D000853 Anophthalmos Ethanol 4.3415513904
MESH:D001008 Anxiety Disorders Ethanol 7.7311141031
MESH:D001008 Anxiety Disorders vinclozolin 7.7319015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6019183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9911256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.3515885639
MESH:D015210 Arthritis, Gouty Uric Acid 6.2419655406
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.5816807698
MESH:D001172 Arthritis, Rheumatoid Methotrexate 4.5817286800
MESH:D001249 Asthma Acetaldehyde 3.509600491
MESH:D050197 Atherosclerosis Curcumin 3.0218704882
MESH:D001321 Autistic Disorder Acetaminophen 2.3018445737
MESH:D001321 Autistic Disorder Sirolimus 2.3021115397
MESH:D001327 Autoimmune Diseases Curcumin 4.0219761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.3219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.3212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4415746008
MESH:D019046 Bone Marrow Neoplasms Dactinomycin 10.8114601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 10.8114601052
MESH:D002545 Brain Ischemia Curcumin 3.8516770732
MESH:D001932 Brain Neoplasms Curcumin 3.5217596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.3220146248 17474063
MESH:D001943 Breast Neoplasms bexarotene 6.3216344269 16818667
MESH:D001943 Breast Neoplasms Curcumin 6.3216243823 18593918 18462866 19250217
MESH:D001943 Breast Neoplasms Estradiol 6.3212948864 19861407 17289903 17261762 16675129 14630087 17018787 18497071
MESH:D001943 Breast Neoplasms Etoposide 6.3216322251
MESH:D001943 Breast Neoplasms Fluorouracil 6.3218608205 16110121 16595493 18357371 16557594 15136595 19217205
MESH:D001943 Breast Neoplasms Genistein 6.3217200150 16873071 16541309
MESH:D001943 Breast Neoplasms Methotrexate 6.3216978400
MESH:D001943 Breast Neoplasms Tamoxifen 6.3220005174 20135344 19244106 11161223 17242785 19115204 17049068 19142967 19066611 19189210 16873071 19189212 20390343 19084267 19059307 15565566 16273361 15668708 16818667 16202921 17261762 19011961 21152245 20544844 19487384 19221464 18997820 18351453 18629630 17893378 19289846 18815881 21138602 19155303 18821012 18855134 17440819 19410462 19288272 18425577 20065188 19103187 20859285 18984771 19200415
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.3220435547
MESH:D002056 Burns Ethanol 4.1816374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.1716051944
MESH:D002277 Carcinoma Curcumin 11.7318593918
MESH:D002277 Carcinoma Fluorouracil 11.7317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 11.7316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0319066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 20.7716705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 20.7716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 20.773084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 20.7721507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Estradiol 20.7716924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 20.7715289165 18788625 15763234
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 20.7717088986 17045692 18930000 16332177 17971768 16799960
MESH:D006528 Carcinoma, Hepatocellular Genistein 20.7716924424
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 20.7719335982
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 20.7716924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 8.0316247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 8.0318414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 8.0312391285
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.7718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 9.4920419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 9.4918462866
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 9.4916280240 16757204 17066447 18986760
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 9.4919435901
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1917572228
MESH:D006332 Cardiomegaly Ethanol 9.9119332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 9.9116120746 18670907 18850075
MESH:D006332 Cardiomegaly Thyroxine 9.9118093424
MESH:D002310 Cardiomyopathy, Alcoholic Acetaldehyde 5.9810525098
MESH:D002318 Cardiovascular Diseases Genistein 6.7916332659
MESH:D002318 Cardiovascular Diseases Tacrolimus 6.7917703430
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 6.4214694615
MESH:D002386 Cataract Acetaminophen 6.4210977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 9.186135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.1820889678
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.1818566989
MESH:D002659 Child Development Disorders, Pervasive topiramate 3.9015650499
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.7516835633
MESH:D002779 Cholestasis Ethinyl Estradiol 6.5315861022 17681005 17110522 16105132 11677210 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 6.5319176532
MESH:D002971 Cleft Lip Ethanol 3.3215513904
MESH:D002972 Cleft Palate Ethanol 5.2015513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2012621046 15340226 15668235 8697196 16354765
MESH:D003092 Colitis Curcumin 3.7016804969 16782535 18200517
MESH:D003103 Coloboma Curcumin 4.1118809619
MESH:D003110 Colonic Neoplasms Curcumin 5.2419359593 16340194
MESH:D003110 Colonic Neoplasms Fluorouracil 5.2416510598 15001691 17725105 18772588 17172411 17169374 17018589 17016597 16340194 17287894
MESH:D003110 Colonic Neoplasms Genistein 5.2417182828
MESH:D015179 Colorectal Neoplasms Fluorouracil 1.9917695437 16391804 17454858 14970324 15148649 18949393 17401013 18288408 18383874 18448328 16524972 15289873 17255274 17094418 20501625 17016601 18509181 17594712 16282729 18802399 16303861 16331619
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 7.8215095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 7.8214669216 17141729
MESH:D016510 Corneal Neovascularization Curcumin 4.4218497527
MESH:D019465 Craniofacial Abnormalities Ethanol 3.5611873399 19302082 15451040 15451039 15513904 11198716 10194807
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.569562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5615322242 10048152 20055451
MESH:D003456 Cryptorchidism vinclozolin 3.8814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.3118551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.3118551238
MESH:D003550 Cystic Fibrosis Methotrexate 3.8219747007
MESH:D007644 Darier Disease Fluorouracil 4.3016733453
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8919031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003882 Dermatomyositis Methotrexate 4.6620191521
MESH:D003922 Diabetes Mellitus, Type 1 Uric Acid 4.4616506275
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 9.1218403477
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 9.1216647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 9.1217107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 9.1216979414
MESH:D003928 Diabetic Nephropathies Curcumin 12.6618204486
MESH:D003928 Diabetic Nephropathies Estradiol 12.6619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.6619279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 13.0321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 13.0321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 13.0321346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 13.0311421492 11461765 15968718 14986274 17522070 11834606 19370779 16081117 14550746 11287661 2444490 19739265 16485898 12705907 11739529 16781746 11529661 10915739 19923254 16177239 15619225 14725611 12153990 16227642 19164858 18071297 18713872 19085960 16393943 19416960 10663392 12958197 11743745 16109766 12594235 17906064 19420014 17562736 10774834 12392966 12540782
MESH:D056486 Drug-Induced Liver Injury Ethanol 13.0311566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 13.0320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4011462148
MESH:D004381 Duodenal Ulcer Curcumin 8.2617351913
MESH:D004381 Duodenal Ulcer Tacrolimus 8.2617202747
MESH:D004417 Dyspnea cypermethrin 4.9016487989
MESH:D004487 Edema pirinixic acid 5.1212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.1211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.4118230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.4112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.4119031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.1016402032
MESH:D016889 Endometrial Neoplasms Estradiol 10.5611473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 10.5611473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 10.5616202921 17893378 19155303 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.609294722 10568697
MESH:D004827 Epilepsy topiramate 4.0619148780
MESH:D004833 Epilepsy, Temporal Lobe topiramate 5.7816499746
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.2220426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.2216530937
MESH:D004938 Esophageal Neoplasms Ethanol 12.2216704527
MESH:D004938 Esophageal Neoplasms Fluorouracil 12.2217638652 16337965 16785472 15173087 16481741
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 12.2215547721 15547733 15623463 15878914 15150132 15264214 16704527 16510608 16805852
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6511564622
MESH:D005234 Fatty Liver Curcumin 20.0619297423
MESH:D005234 Fatty Liver Ethanol 20.0616409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.0615345470
MESH:D005234 Fatty Liver pirinixic acid 20.0620131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 20.0614986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.1717920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.9316709447
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.8116946407 15451040 15513904 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9811858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0414745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6919069698
MESH:D005355 Fibrosis Curcumin 12.2618705752
MESH:D005355 Fibrosis Emodin 12.2619474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.2620067830
MESH:D005756 Gastritis Acetaminophen 9.4816983495
MESH:D005756 Gastritis Ethanol 9.4815046732
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.2218462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.4516973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.8016417039
MESH:D005909 Glioblastoma Curcumin 10.2717596214
MESH:D005909 Glioblastoma Genistein 10.2716598420
MESH:D005909 Glioblastoma Okadaic Acid 10.2717312396
MESH:D005910 Glioma Fluorouracil 2.6616145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1010696789
MESH:D006086 Graft vs Host Disease Methotrexate 10.8916518429
MESH:D006086 Graft vs Host Disease Tacrolimus 10.8916376943
MESH:D006130 Growth Disorders Tacrolimus 4.5911041285
MESH:D006258 Head and Neck Neoplasms Curcumin 11.2118829502 18462866
MESH:D006258 Head and Neck Neoplasms Fluorouracil 11.2115102660 15162350 18337622
MESH:D006258 Head and Neck Neoplasms Sirolimus 11.2119435901
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.5410048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.2320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9011000095
MESH:D006505 Hepatitis cypermethrin 4.7016487989
MESH:D006529 Hepatomegaly pirinixic acid 11.7816221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly propiconazole 11.7817178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.7815340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.5617701891
MESH:D006558 Herpes Genitalis Estradiol 4.5315709030
MESH:D006561 Herpes Simplex Etoposide 4.0810809021
MESH:D006689 Hodgkin Disease Etoposide 3.4715147373 18180244 16135485 17606976 16200630
MESH:D019584 Hot Flashes Estradiol 3.2617088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.558697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.5316870215
MESH:D006930 Hyperalgesia Ethanol 6.5318783367
MESH:D006937 Hypercholesterolemia Curcumin 3.6218704882
MESH:D006943 Hyperglycemia pirinixic acid 2.7620558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7118670907 18850075
MESH:D006984 Hypertrophy Sirolimus 4.7919211884
MESH:C537153 Hypomagnesemia primary Tacrolimus 5.6711041285
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3316569931 16945680
MESH:D007022 Hypotension Tacrolimus 4.6711041285
MESH:D002534 Hypoxia, Brain marker/mechanism 17285299
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0112013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.5517937319
MESH:D007248 Infertility, Male vinclozolin 5.5516467254
MESH:D007249 Inflammation Curcumin 9.7418403477 16956363 17151092
MESH:D007249 Inflammation Flavonoids 9.7417296493
MESH:D007249 Inflammation Tamoxifen 9.7419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.7412200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0018596194 18200517
MESH:D007299 Insect Bites and Stings cypermethrin 5.4815189238
MESH:D007333 Insulin Resistance Estradiol 6.1016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.1016306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.8010783313
MESH:D007569 Jaw Abnormalities Ethanol 8.6715513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.6716580747
MESH:D007674 Kidney Diseases Acetaminophen 8.5212587719 15629191
MESH:D007674 Kidney Diseases Estradiol 8.5215618244
MESH:D007674 Kidney Diseases Tacrolimus 8.5211041285
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 19.1416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 19.1416705839
MESH:D007680 Kidney Neoplasms Estradiol 19.1415610895
MESH:D007680 Kidney Neoplasms Fluorouracil 19.1416985049
MESH:D007680 Kidney Neoplasms Tamoxifen 19.1418625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.5516316344
MESH:D007805 Language Development Disorders Methotrexate 4.659562676
MESH:D007859 Learning Disorders Ethanol 3.7415451040
MESH:D007889 Leiomyoma Curcumin 4.1218555241
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9.1712970779
MESH:D007938 Leukemia Curcumin 9.1718462866
MESH:D007938 Leukemia Genistein 9.1718980019 17468513
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.7716106398
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Emodin 8.7717077332
MESH:D015458 Leukemia, T-Cell Curcumin 4.3016106398
MESH:D007984 Leydig Cell Tumor vinclozolin 4.2416417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.4617676605
MESH:D008064 Lipidoses Tamoxifen 2.8017567588 15342952
MESH:D008103 Liver Cirrhosis Ethanol 6.1915289165
MESH:D008103 Liver Cirrhosis Methotrexate 6.1914986274
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.6118295389
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 14.1318006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental Emodin 14.1315288473
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.1314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 14.1318166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 14.1317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.1315474484
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 14.1317050028
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.1318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.1312878042
MESH:D008107 Liver Diseases Acetaminophen 8.2619014921 12587719 12969438 16610002 19460945 11587558 19784758 16611625
MESH:D008107 Liver Diseases Curcumin 8.2616956363
MESH:D008107 Liver Diseases cypermethrin 8.2615991261
MESH:D008107 Liver Diseases propiconazole 8.2619363144
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.1817347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 2.8116871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 22.277678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 22.279163691 15890375 2125692 18177683
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 22.2721137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 22.2717045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms pirinixic acid 22.2720007298 15890375 16377806
MESH:D008113 Liver Neoplasms propiconazole 22.2719028983
MESH:D008113 Liver Neoplasms Tamoxifen 22.2716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 22.2716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 11.572876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 11.578603461
MESH:D008114 Liver Neoplasms, Experimental propiconazole 11.5717178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 11.5712151625
MESH:D017563 Lung Diseases, Interstitial Methotrexate 4.5318516814
MESH:D008175 Lung Neoplasms Acetaldehyde 11.6217372256
MESH:D008175 Lung Neoplasms Aflatoxin B1 11.6214755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 11.6218816296 20064080 18569708 18520028 20464547 6695378 20869020 17053015 20135361
MESH:D008175 Lung Neoplasms bexarotene 11.6217849452
MESH:D008175 Lung Neoplasms Curcumin 11.6219359593 16243823 18462866
MESH:D008175 Lung Neoplasms Fluorouracil 11.6215246190
MESH:D008175 Lung Neoplasms Tamoxifen 11.6218625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 11.6219555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.3015086387
MESH:D008223 Lymphoma Curcumin 10.7318462866
MESH:D008223 Lymphoma Etoposide 10.7312854902 12556972
MESH:D008223 Lymphoma Methotrexate 10.7317352296
MESH:D016399 Lymphoma, T-Cell Curcumin 4.2216173963
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6711161223
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2819428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 11.6519196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.6511408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 11.6512929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.6514580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Estradiol 10.9919453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.9919453300
MESH:D008545 Melanoma Curcumin 4.7018462866 17885582
MESH:D008545 Melanoma Sirolimus 4.7019282848
MESH:D008545 Melanoma Tamoxifen 4.7012393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6915990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0919513568
MESH:D008569 Memory Disorders Curcumin 8.2217263510
MESH:D008569 Memory Disorders Ethanol 8.2218411066 15451040
MESH:D008881 Migraine Disorders topiramate 4.2318803445 16942474 18765137 18759728
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 12.3416381670
MESH:D009062 Mouth Neoplasms Fluorouracil 12.3416757204 18986760
MESH:D009062 Mouth Neoplasms Sirolimus 12.3419435901
MESH:D052016 Mucositis Methotrexate 4.7917488658
MESH:D009101 Multiple Myeloma Curcumin 3.1719372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.4317962980
MESH:D009135 Muscular Diseases pirinixic acid 3.0316239165
MESH:D009203 Myocardial Infarction Genistein 4.9317141266
MESH:D009203 Myocardial Infarction pirinixic acid 4.9319151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6312213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.9916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 11.9917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.9916411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.7318551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.737678174 18551238
MESH:D009361 Neoplasm Invasiveness Curcumin 3.9118495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.3419393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3419410462
MESH:D009369 Neoplasms Benzo(a)pyrene 6.7111141357
MESH:D009369 Neoplasms Fluorouracil 6.7118600527 16928823 18239605
MESH:D009369 Neoplasms pirinixic acid 6.7117405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 15.4519196722
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 15.4512497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 15.4519189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2517289903
MESH:D009421 Nervous System Malformations Estradiol 13.6911399458 16427766
MESH:D009421 Nervous System Malformations Genistein 13.6916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.6914600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.1318462866
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.4518514411
MESH:D019636 Neurodegenerative Diseases Tacrolimus 7.4515081597
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.1016436463
MESH:D009765 Obesity Curcumin 4.1219297423
MESH:D009765 Obesity pirinixic acid 4.1220558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 12.7116049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 12.7116049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 12.7114694615
MESH:D010024 Osteoporosis Calcium 10.2017882678
MESH:D010024 Osteoporosis Curcumin 10.2018719352
MESH:D010024 Osteoporosis Genistein 10.2019401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.6416169203
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9.8916211241
MESH:D010051 Ovarian Neoplasms Curcumin 9.8918462866 19020741
MESH:D010051 Ovarian Neoplasms Estradiol 9.8919401270
MESH:D010051 Ovarian Neoplasms Genistein 9.8919005980
MESH:D010146 Pain Acetaminophen 2.0116870215
MESH:D010190 Pancreatic Neoplasms Curcumin 10.7817440100 19401701 19196508
MESH:D010190 Pancreatic Neoplasms Ethanol 10.7812384795
MESH:D010190 Pancreatic Neoplasms Etoposide 10.7819003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 10.7819003803 16929163 16500647 15113037
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2411578682
MESH:D010300 Parkinson Disease Sirolimus 3.5519682553
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7512520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1018163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 7.8711222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 7.8718042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.4518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4520887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17199135
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3117292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.3112497104 18769126 11398177 10851300 18156803 18226269 15129424
MESH:D011471 Prostatic Neoplasms Estradiol 2.3116740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.3117172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.3119082440 18626508
MESH:D011471 Prostatic Neoplasms Genistein 2.3116925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.3116205645
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3115067354
MESH:D011472 Prostatitis vinclozolin 4.4518629315
MESH:D011537 Pruritus Ethinyl Estradiol 2.8316919318 15861022
MESH:D011565 Psoriasis Methotrexate 3.2517410198
MESH:D011656 Pulmonary Emphysema Curcumin 4.1019168576
MESH:D012004 Rectal Neoplasms Fluorouracil 3.6018722050 15538739 16160472 18286688
MESH:D051437 Renal Insufficiency Methotrexate 4.2417352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.1319058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.5818379247 10666014
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3718990726
MESH:D012220 Rhinitis Acetaldehyde 4.3317050345
MESH:D012509 Sarcoma Curcumin 3.6918462866
MESH:D012512 Sarcoma, Ewing's Dactinomycin 9.3214601052
MESH:D012512 Sarcoma, Ewing's Etoposide 9.3214601052
MESH:D012640 Seizures 2,4-dinitrotoluene 11.3818551238
MESH:D012640 Seizures 2,6-dinitrotoluene 11.3818551238
MESH:D012640 Seizures Ethanol 11.389754883
MESH:D012640 Seizures topiramate 11.3816499746
MESH:D018805 Sepsis Curcumin 3.6818389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.1510029692 19755658
MESH:D012878 Skin Neoplasms Okadaic Acid 8.1512628509
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.1516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 9.9116709447
MESH:D013088 Spermatocele Tamoxifen 9.9116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.5519457130
MESH:D020754 Spinocerebellar Ataxias marker/mechanism
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.262093021 20155912
MESH:D013274 Stomach Neoplasms Ethanol 4.2618456281
MESH:D013274 Stomach Neoplasms Fluorouracil 4.2617522103 17172411 16424979 19015929 18396642 16951190 19084572 18567086 15786421 17498489
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.2617575124 12958204
MESH:D013276 Stomach Ulcer Curcumin 6.1319188055 16631530
MESH:D013276 Stomach Ulcer Ethanol 6.1317918041 9211565 16755016 9562338 11906479 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.839754883
MESH:D013576 Syndactyly Methotrexate 4.579562676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1711994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7415669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.7212697716
MESH:D013959 Thyroid Diseases Thyroxine 10.7219910387
MESH:D013978 Tibial Fractures Estradiol 4.1919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.5716280240
MESH:D014402 Tuberous Sclerosis Sirolimus 5.1021115397 18495876
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.5216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 13.5216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.5217053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 13.5218593936
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 13.5216712894 8653321 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.7818462866
MESH:D014570 Urologic Diseases cypermethrin 5.3716487989
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.3710091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.3710091137
MESH:D014581 Urticaria Acetaminophen 2.5310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.4616803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.1614692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 8.1618645019
MESH:D014605 Uveitis Sirolimus 5.141336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1012125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7515886252
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
KEGG:04020 Calcium signaling pathway
REACT:15380 Diabetes pathways
KEGG:04540 Gap junction
KEGG:04971 Gastric acid secretion
KEGG:04724 Glutamatergic synapse
KEGG:04912 GnRH signaling pathway
REACT:604 Hemostasis
KEGG:05016 Huntington's disease
REACT:1505 Integration of energy metabolism
KEGG:04730 Long-term depression
KEGG:04720 Long-term potentiation
KEGG:04114 Oocyte meiosis
REACT:15295 Opioid Signalling
KEGG:04972 Pancreatic secretion
KEGG:04070 Phosphatidylinositol signaling system
KEGG:04745 Phototransduction - fly
KEGG:04970 Salivary secretion
REACT:14797 Signaling by GPCR
REACT:11061 Signalling by NGF
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29978
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449855heparin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03401 - D-Myo-Inositol-1,4,5-Triphosphate
    DB04077 - Glycerol Solvents;Cryoprotective Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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