AutismKB 2.0

Annotation Detail for IVL


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Basic Information Top
Gene Symbol:IVL ( - )
Gene Full Name: involucrin
Band: 1q21.3
Quick LinksEntrez ID:3713; OMIM: 147360; Uniprot ID:INVO_HUMAN; ENSEMBL ID: ENSG00000163207; HGNC ID: 6187
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200044Validated transcriptional targets of AP1 family members Fra1 and Fra2
No data
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Related Diseases/Disorders Top
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Desease IDDesease Name
1712Yersinia infection
2220Dermatitis
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C049325 1,2-dithiol-3-thione 1,2-dithiol-3-thione results in decreased expression of IVL proteindecreases expression 10769631
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IVL mRNAdecreases expression 19933214
C033170 4-bromo-A-23187 4-bromo-A-23187 results in increased expression of IVL mRNAincreases expression 16621454
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in increased expression of IVL mRNAincreases expression 17034753
C041819 4-oxoretinol 4-oxoretinol results in increased expression of IVL mRNAincreases expression 17034753
D000082 Acetaminophen Acetaminophen affects the expression of IVL mRNAaffects expression 17562736
C103303 alitretinoin alitretinoin results in increased expression of IVL mRNAincreases expression 17034753
C004984 apocarotenal apocarotenal results in increased expression of IVL mRNAincreases expression 17034753
C015001 arsenite arsenite results in decreased expression of IVL mRNAdecreases expression 18633435
C015001 arsenite arsenite results in decreased expression of IVL proteindecreases expression 18633435
C015001 arsenite JAG1 protein inhibits the reaction [arsenite results in decreased expression of IVL mRNA]decreases expression|decreases reaction 18633435
C015001 arsenite tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of IVL mRNA]decreases expression|decreases reaction 18633435
D019207 beta Carotene beta Carotene results in increased expression of IVL mRNAincreases expression 17034753
D019256 Cadmium Chloride Cadmium Chloride results in decreased expression of IVL mRNAdecreases expression 20006635
D002118 Calcium Calcium results in increased expression of IVL mRNAincreases expression 10469331
D002118 Calcium NPS R-467 promotes the reaction [Calcium results in increased expression of IVL mRNA]increases expression|increases reaction 10469331
D003474 Curcumin Curcumin inhibits the reaction [MAP3K1 protein results in increased expression of IVL mRNA]decreases reaction|increases expression 17148446
D003474 Curcumin Curcumin inhibits the reaction [PRKCD protein results in increased expression of IVL mRNA]decreases reaction|increases expression 17148446
D003474 Curcumin Curcumin inhibits the reaction [PRKCE protein results in increased expression of IVL mRNA]decreases reaction|increases expression 17148446
D003474 Curcumin Curcumin inhibits the reaction [PRKCH protein results in increased expression of IVL mRNA]decreases reaction|increases expression 17148446
D003474 Curcumin Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA]decreases reaction|increases expression 17148446
D005419 Flavonoids Flavonoids results in decreased expression of IVL mRNAdecreases expression 18035473
D006427 Hemin Hemin results in decreased expression of IVL mRNAdecreases expression 20006635
C015329 lycopene lycopene results in decreased expression of IVL proteindecreases expression 10769631
D009151 Mustard Gas Mustard Gas results in decreased expression of IVL mRNAdecreases expression 15674843
D009538 Nicotine Nicotine results in decreased expression of IVL proteindecreases expression 16011614
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL mRNAdecreases expression 18633435
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of IVL proteindecreases expression 18633435
C111654 NPS R-467 NPS R-467 promotes the reaction [Calcium results in increased expression of IVL mRNA]increases expression|increases reaction 10469331
C026209 oltipraz oltipraz results in decreased expression of IVL proteindecreases expression 10769631
C032208 perilla alcohol perilla alcohol results in decreased expression of IVL proteindecreases expression 10769631
C025299 polyphenols polyphenols results in decreased expression of IVL proteindecreases expression 10769631
C027373 potassium chromate(VI) potassium chromate(VI) results in decreased expression of IVL mRNAdecreases expression 20006635
D020849 Raloxifene Raloxifene affects the expression of IVL mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of IVL mRNAaffects cotreatment|decreases expression 19059307
C407502 Ro 16-9100 Ro 16-9100 results in decreased expression of IVL proteindecreases expression 10769631
C009277 sodium arsenate sodium arsenate results in decreased expression of IVL mRNAdecreases expression 20006635
12727804
11485391
C017947 sodium arsenite sodium arsenite affects the reaction [FOSL1 protein binds to IVL promoter]affects binding|affects reaction 20006635
C017947 sodium arsenite sodium arsenite affects the reaction [FOS protein binds to IVL promoter]affects binding|affects reaction 20006635
C017947 sodium arsenite sodium arsenite affects the reaction [JUNB protein binds to IVL promoter]affects binding|affects reaction 20006635
C017947 sodium arsenite sodium arsenite inhibits the reaction [EP300 protein binds to IVL promoter]affects binding|decreases reaction 20006635
C017947 sodium arsenite sodium arsenite results in decreased expression of IVL mRNAdecreases expression 12727804
20006635
11485391
C017947 sodium arsenite sodium arsenite results in decreased expression of IVL proteindecreases expression 20006635
C017947 sodium arsenite sodium arsenite results in increased expression of IVL mRNAincreases expression 19524636
C017947 sodium arsenite sodium arsenite results in increased expression of IVL proteinincreases expression 19524636
18572023
D013629 Tamoxifen ESR2 protein affects the reaction [Tamoxifen results in decreased expression of IVL mRNA]affects reaction|decreases expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of IVL mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of IVL mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen results in decreased expression of IVL mRNAdecreases expression 15590111
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IVL mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IVL mRNAincreases expression 17035482
D013755 Tetradecanoylphorbol Acetate Curcumin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IVL mRNA]decreases reaction|increases expression 17148446
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of IVL mRNAincreases expression 17148446
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of IVL mRNAincreases expression 10866668
D014212 Tretinoin Tretinoin inhibits the reaction [IL1A protein results in increased expression of IVL mRNA]decreases reaction|increases expression 17214633
D014212 Tretinoin Tretinoin results in decreased expression of IVL mRNAdecreases expression 17214633
D014212 Tretinoin Tretinoin results in increased expression of IVL mRNAincreases expression 17034753
16249480
9716179
D014212 Tretinoin Tretinoin results in increased expression of IVL proteinincreases expression 9716179
C101044 tyrphostin AG 1478 tyrphostin AG 1478 inhibits the reaction [arsenite results in decreased expression of IVL mRNA]decreases expression|decreases reaction 18633435
C101044 tyrphostin AG 1478 tyrphostin AG 1478 results in increased expression of IVL proteinincreases expression 18633435
D014580 Ursodeoxycholic Acid Ursodeoxycholic Acid results in decreased expression of IVL proteindecreases expression 10769631
D014638 Vanadates Vanadates results in decreased expression of IVL mRNAdecreases expression 20006635
D014801 Vitamin A Vitamin A results in increased expression of IVL mRNAincreases expression 17034753
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.4915322242 11752688 14514962
MESH:D000015 Abnormalities, Multiple Vitamin A 4.5310992263
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0116835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.5316712894 17306315
MESH:D000419 Albuminuria Raloxifene 4.2517451421 17308373
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7117887948
MESH:D000505 Alopecia Tretinoin 3.3315955085
MESH:D000544 Alzheimer Disease Curcumin 6.2815590663
MESH:D000544 Alzheimer Disease Nicotine 6.2816627626
MESH:D000544 Alzheimer Disease Raloxifene 6.2815800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9211748828
MESH:D000740 Anemia Vitamin A 7.9216960172
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.4816960172
MESH:D000799 Angioedema Acetaminophen 3.4710982225
MESH:D001169 Arthritis, Experimental Tretinoin 2.8516412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 4.4116807698
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4116292516
MESH:D001249 Asthma Mustard Gas 7.3310378619
MESH:D001249 Asthma Tretinoin 7.3316456186
MESH:D001249 Asthma Vitamin A 7.3316732791
MESH:D050197 Atherosclerosis Curcumin 3.1018704882
MESH:D001321 Autistic Disorder Acetaminophen 1.4618445737
MESH:D001327 Autoimmune Diseases Curcumin 4.1319761891
MESH:D001471 Barrett Esophagus Tretinoin 4.0516935849
MESH:D001768 Blister Mustard Gas 4.7919167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.8512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 7.8516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5315746008
MESH:D001930 Brain Injuries Raloxifene 4.1216580743
MESH:D002545 Brain Ischemia beta Carotene 9.4016157235
MESH:D002545 Brain Ischemia Curcumin 9.4016770732
MESH:D001932 Brain Neoplasms Curcumin 3.6217596214
MESH:D001943 Breast Neoplasms alitretinoin 2.7616344269
MESH:D001943 Breast Neoplasms Curcumin 2.7618462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Raloxifene 2.7616912660 17242785 15572757 17952589 17893378 15775269 15758505 17440819 17595753 17261762 16837676 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 2.7619142967 11161223 18629630 19011961 18855134 19084267 16202921 18815881 19289846 20135344 19487384 19189212 19244106 19155303 17049068 17893378 20859285 19115204 19059307 15668708 16818667 15565566 20005174 21152245 18821012 17261762 19066611 19189210 16273361 20544844 17440819 18351453 20390343 19221464 18425577 19103187 18997820 17242785 16873071 19200415 21138602 18984771 20065188 19288272 19410462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.7620435547
MESH:D001943 Breast Neoplasms Tretinoin 2.7616873071 16443354 16166294
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.6012794006
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.7915286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.6017687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 11.7916813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 11.7917377406 17426644
MESH:D002277 Carcinoma Curcumin 7.3318593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.3316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.7816168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.013084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.0117306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.0116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.011917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8518414057
MESH:D002294 Carcinoma, Squamous Cell marker/mechanism 18572023
MESH:D002294 Carcinoma, Squamous Cell Curcumin 9.8718462866
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.8718572023
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 9.8718922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.8716051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.4417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.4417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1616120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.1915775269
MESH:D002386 Cataract Acetaminophen 6.5010977129
MESH:D002386 Cataract Tretinoin 6.5017460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.7419524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2216129372
MESH:D015362 Child Nutrition Disorders Vitamin A 5.1016153327
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8516835633
MESH:D002779 Cholestasis Ursodeoxycholic Acid 8.2016487557
MESH:D002779 Cholestasis Vitamin A 8.2016175620
MESH:D002780 Cholestasis, Intrahepatic Ursodeoxycholic Acid 6.2414728856
MESH:D002822 Choriocarcinoma Tretinoin 4.7816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.9715668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 8.979407595
MESH:D002972 Cleft Palate Vitamin A 8.9716054864
MESH:D003072 Cognition Disorders Raloxifene 4.2615800139
MESH:D003092 Colitis Curcumin 8.4516782535 16804969 18200517
MESH:D003092 Colitis Tretinoin 8.4517035595
MESH:D003103 Coloboma Curcumin 4.2218809619
MESH:D003110 Colonic Neoplasms arsenite 7.7515037631
MESH:D003110 Colonic Neoplasms Curcumin 7.7516340194 19359593
MESH:D003110 Colonic Neoplasms polyphenols 7.7516293270
MESH:D003110 Colonic Neoplasms Vitamin A 7.7516267017 17219422
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7517141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.5418497527
MESH:D019465 Craniofacial Abnormalities sodium arsenate 5.1010525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.1010048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.109142499 10589399 8800419 9224671 9125849 16925845 14991402 17551590 9664655 9211117
MESH:D019465 Craniofacial Abnormalities Vitamin A 5.1010992263
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8517474826
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.3916506275
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.0718403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0717107852
MESH:D003928 Diabetic Nephropathies Curcumin 13.3218204486
MESH:D003928 Diabetic Nephropathies Raloxifene 13.3217451421 17308373 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.3219279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.0311739529 19739265 19164858 11834606 15619225 16081117 18713872 12705907 16485898 16177239 14550746 19085960 16393943 17522070 2444490 11421492 12594235 16227642 12540782 11287661 12153990 16781746 11529661 17906064 12392966 11461765 10774834 18071297 11743745 14986274 19370779 19416960 17562736 16109766 10663392 10915739 19420014 14725611 15968718 12958197 19923254
MESH:D056486 Drug-Induced Liver Injury polyphenols 8.0319370779
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 8.0318186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.0320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4911462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.4316146918
MESH:D004381 Duodenal Ulcer Curcumin 3.7017351913
MESH:D020821 Dystonic Disorders Nicotine 5.5617881519
MESH:C538011 Eales disease Vitamin A 5.249068938
MESH:D004480 Ectromelia Vitamin A 5.4516054864
MESH:D004487 Edema Mustard Gas 13.8311428631 9260866 11402378 11428647
MESH:D004487 Edema Raloxifene 13.8315860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.8312711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 13.8311698051 8273558 15177302 9599246 7812673 8113982 16716910
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.6915322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.6918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.0915845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.0919031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 6.6316202921 19155303 20544844 17893378
MESH:D016889 Endometrial Neoplasms Tretinoin 6.6316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7110568697 9294722
MESH:D004890 Erythema Mustard Gas 4.799357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.9311564622
MESH:D005124 Eye Abnormalities Tretinoin 7.939664655 16938888
MESH:D005234 Fatty Liver arsenite 16.1818296743
MESH:D005234 Fatty Liver Curcumin 16.1819297423
MESH:D005234 Fatty Liver Raloxifene 16.1817473493
MESH:D005234 Fatty Liver Tamoxifen 16.1814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1011858732
MESH:D005327 Fetal Resorption Vitamin A 4.9916054864
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8119069698
MESH:D005355 Fibrosis arsenite 18.2518296743
MESH:D005355 Fibrosis Curcumin 18.2518705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.2520067830
MESH:D005355 Fibrosis Tretinoin 18.2517994277
MESH:D005756 Gastritis Acetaminophen 3.3016983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3318462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3116452187
MESH:D005909 Glioblastoma Curcumin 6.4917596214
MESH:D005909 Glioblastoma Tretinoin 6.4917312396
MESH:D018149 Glucose Intolerance sodium arsenate 4.7419446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2210696789
MESH:D006258 Head and Neck Neoplasms Curcumin 7.0618462866 18829502
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.0616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.7816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.1010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.1014991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 10.1010992263 16080930
MESH:D006331 Heart Diseases Raloxifene 3.2811110106
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0111000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.5415340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.6817701891
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.4816863852 16490937 16292552 17436238 15707848 16877224
MESH:D015658 HIV Infections beta Carotene 6.6316960176
MESH:D015658 HIV Infections Vitamin A 6.6316960176
MESH:D006679 HIV Seropositivity Vitamin A 5.2317209195
MESH:D006689 Hodgkin Disease sodium arsenite 2.8512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6718606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 6.6716870215
MESH:D006930 Hyperalgesia Tretinoin 6.6716870215
MESH:D006937 Hypercholesterolemia Curcumin 3.7318704882
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2116778211
MESH:D006962 Hyperparathyroidism, Secondary NPS R-467 6.7115086907
MESH:D006973 Hypertension Raloxifene 4.7415787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7418850075 18670907
MESH:D006986 Hypervitaminosis A Vitamin A 5.7916054864
MESH:D007248 Infertility, Male sodium arsenite 2.7512646999 15346721
MESH:D007249 Inflammation Curcumin 21.2216956363 18403477 17151092
MESH:D007249 Inflammation Flavonoids 21.2217296493
MESH:D007249 Inflammation Mustard Gas 21.229357497 9260866 11428631 8975870 11402378 17524151 16001271 11428620 11428647
MESH:D007249 Inflammation polyphenols 21.2216366677
MESH:D007249 Inflammation Tamoxifen 21.2219457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 21.2212878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 21.227562506 8273558 11698051 7812673 15177302
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0618200517 18596194
MESH:D007410 Intestinal Diseases Tretinoin 3.4117994277
MESH:D007414 Intestinal Neoplasms Curcumin 3.9010783313
MESH:D019586 Intracranial Hypertension Vitamin A 5.4515955940
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.8416580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.8415992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.2716144296
MESH:D007674 Kidney Diseases Acetaminophen 8.9012587719 15629191
MESH:D007674 Kidney Diseases Cadmium Chloride 8.9016962696
MESH:D007674 Kidney Diseases sodium arsenite 8.9020008137
MESH:D007680 Kidney Neoplasms Tamoxifen 2.7518625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.6716316344
MESH:D007889 Leiomyoma Curcumin 10.0318555241
MESH:D007889 Leiomyoma Raloxifene 10.0316973256
MESH:D007938 Leukemia Curcumin 5.8618462866
MESH:D007938 Leukemia Tretinoin 5.8617143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.8816106398
MESH:D007951 Leukemia, Myeloid Tretinoin 3.3719285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0117596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.9116140955 17107899 19029980 17339181 16331271 16891316 16935935 16788101 17506722 17649720 12679006 17712046 17217047 9834237 16766008 17361223 19642359 19075265 15748426 19035177 17368321 17294898 17301526 16823087 19225113
MESH:D015458 Leukemia, T-Cell Curcumin 4.4116106398
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.639224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.6316054864
MESH:D008064 Lipidoses Tamoxifen 2.8915342952 17567588
MESH:D008103 Liver Cirrhosis arsenite 6.5318296743
MESH:D008103 Liver Cirrhosis Vitamin A 6.5316256175
MESH:D008105 Liver Cirrhosis, Biliary Ursodeoxycholic Acid 4.9112468960
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.0618006644 18705752 17355460
MESH:D008106 Liver Cirrhosis, Experimental oltipraz 8.0616544323
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.0618564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.0612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.0616248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 8.0616248980
MESH:D008107 Liver Diseases Acetaminophen 11.4419460945 16610002 19784758 16611625 12969438 12587719 19014921 11587558
MESH:D008107 Liver Diseases Curcumin 11.4416956363
MESH:D008107 Liver Diseases Hemin 11.4417173083
MESH:D008107 Liver Diseases polyphenols 11.4416698588
MESH:D008107 Liver Diseases Vitamin A 11.4416175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.8016762690
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9216871587 17185352
MESH:D008113 Liver Neoplasms sodium arsenite 6.5516712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 6.5516684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 6.5516984957
MESH:D008114 Liver Neoplasms, Experimental beta Carotene 8.7717113696
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.7712151625
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 8.7717113696
MESH:D008171 Lung Diseases Mustard Gas 11.0618161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 11.0619095001
MESH:D008171 Lung Diseases Vitamin A 11.0616863852
MESH:D008175 Lung Neoplasms alitretinoin 14.3616413115
MESH:D008175 Lung Neoplasms arsenite 14.3616809336
MESH:D008175 Lung Neoplasms beta Carotene 14.3616401635
MESH:D008175 Lung Neoplasms Curcumin 14.3616243823 19359593 18462866
MESH:D008175 Lung Neoplasms Mustard Gas 14.363148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 14.3617306315 17077188 16712894 15276417 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 14.3618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 14.3611884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 14.3611807781
MESH:D008223 Lymphoma Curcumin 3.3318462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3316173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3919428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.4811731420 19196722 14580682 19196723 16827153
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 5.488985016
MESH:D020149 Manganese Poisoning Tamoxifen 4.1719453300
MESH:D008527 Medulloblastoma Tretinoin 2.6317453147
MESH:D008545 Melanoma Curcumin 6.6918462866 17885582
MESH:D008545 Melanoma sodium arsenite 6.6919082730 16487513
MESH:D008545 Melanoma Tamoxifen 6.6912393984 19393235
MESH:D008545 Melanoma Tretinoin 6.6916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8115990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2119513568
MESH:D008569 Memory Disorders Curcumin 3.8117263510
MESH:D008591 Meningomyelocele Tretinoin 4.0616940565
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1815863610
MESH:D009101 Multiple Myeloma Curcumin 10.8119372569
MESH:D009101 Multiple Myeloma Raloxifene 10.8116497877
MESH:D009101 Multiple Myeloma Vitamin A 10.8116374440
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5517962980
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.5318186108
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8717596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7312213967
MESH:D009232 Myxoma Raloxifene 5.1816343187
MESH:D009361 Neoplasm Invasiveness Curcumin 4.0218495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3919410462
MESH:D009369 Neoplasms alitretinoin 17.3716946489
MESH:D009369 Neoplasms beta Carotene 17.3717051425
MESH:D009369 Neoplasms lycopene 17.3717051425
MESH:D009369 Neoplasms Nicotine 17.3716365874
MESH:D009369 Neoplasms sodium arsenite 17.3711559025
MESH:D009369 Neoplasms Tretinoin 17.3716946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3120056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.5912497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.5919189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic arsenite 9.3915738583
MESH:D009389 Neovascularization, Pathologic Nicotine 9.3916365874
MESH:D009397 Nephrocalcinosis NPS R-467 6.7115086907
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.3514600291
MESH:D009421 Nervous System Malformations Tretinoin 8.359125849
MESH:D009423 Nervous System Neoplasms Curcumin 5.2618462866
MESH:D009436 Neural Tube Defects sodium arsenate 15.4418186108 10525206 19446573 11749123
MESH:D009436 Neural Tube Defects sodium arsenite 15.4412854658
MESH:D009436 Neural Tube Defects Tretinoin 15.449142499
MESH:D009436 Neural Tube Defects Vitamin A 15.4417400914
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.5818514411
MESH:D009503 Neutropenia Mustard Gas 3.6316761898 7688884
MESH:D009765 Obesity Curcumin 2.6519297423
MESH:D010024 Osteoporosis Calcium 10.7017882678
MESH:D010024 Osteoporosis Curcumin 10.7018719352
MESH:D010024 Osteoporosis Raloxifene 10.7017882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 3.8917823083 15758505 17893378 15579764
MESH:D010051 Ovarian Neoplasms Curcumin 7.2218462866 19020741
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.2217306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 7.2216936753
MESH:D010146 Pain Acetaminophen 5.6216870215
MESH:D010146 Pain Tretinoin 5.6216870215
MESH:D010190 Pancreatic Neoplasms Curcumin 7.9419196508 19401701 17440100
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 7.9415976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 7.9415976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.948330346 12065085 18922899 18404319
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8712520081
MESH:D011041 Poisoning Mustard Gas 3.4615727166
MESH:D017499 Porokeratosis alitretinoin 5.6316144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2118163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8311896295 11118676 11399792 11222880
MESH:D011471 Prostatic Neoplasms Curcumin 1.9312497104 10851300 18156803 18226269 15129424 18769126 11398177
MESH:D011471 Prostatic Neoplasms lycopene 1.9315084515 17337101
MESH:D011471 Prostatic Neoplasms Raloxifene 1.9316220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9316039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9315067354
MESH:D011507 Proteinuria Tretinoin 3.2716636307
MESH:D011537 Pruritus Mustard Gas 3.7318058305
MESH:D011625 Pterygium Tretinoin 4.4216723453
MESH:D011656 Pulmonary Emphysema Curcumin 4.2119168576
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.7817266442 17720292 17894541 17620002 10334151
MESH:D011693 Purpura Raloxifene 5.1815770314
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.6918379247 10666014
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.4316877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.4918990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.7616116481 16283617
MESH:D012509 Sarcoma Curcumin 3.8018462866
MESH:D012640 Seizures Nicotine 3.5617873105
MESH:D018805 Sepsis Curcumin 3.7818389075
MESH:D012871 Skin Diseases Mustard Gas 5.0112880345 15451306 16961503
MESH:D012871 Skin Diseases Vitamin A 5.0118709164
MESH:D012878 Skin Neoplasms marker/mechanism 18572023
MESH:D012878 Skin Neoplasms sodium arsenite 12.1019524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.1016192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 12.108330346 11807781 18404319 8985016 12065085
MESH:D012878 Skin Neoplasms Tretinoin 12.1016467112
MESH:D013088 Spermatocele Tamoxifen 3.9216709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6719457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5112854658
MESH:D013272 Stomach Diseases beta Carotene 4.7317638125
MESH:D013274 Stomach Neoplasms Tretinoin 1.7917261132
MESH:D013276 Stomach Ulcer beta Carotene 6.7512500499
MESH:D013276 Stomach Ulcer Curcumin 6.7519188055 16631530
MESH:D020521 Stroke Raloxifene 3.5316837676
MESH:D013705 Temporomandibular Joint Disorders polyphenols 4.8817997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5312697716
MESH:D013964 Thyroid Neoplasms Tretinoin 2.7516026305 17045167
MESH:D013978 Tibial Fractures Raloxifene 4.8319048282
OMIM:188890 TOBACCO ADDICTION, SUSCEPTIBILITY TO Nicotine 4.4611259349 16785264 16720336
MESH:D014029 Tobacco Use Disorder Nicotine 5.0917979512 18305452 15735609 18041664
MESH:D014062 Tongue Neoplasms Tretinoin 3.4716051514
MESH:D014376 Tuberculosis Tretinoin 3.0016040207
MESH:D001749 Urinary Bladder Neoplasms Curcumin 10.7118593936
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 10.7117572228
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.7117306315 16452187 16712894 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.7116712894 17572228 8653321
MESH:D014565 Urogenital Neoplasms Curcumin 4.9018462866
MESH:D014581 Urticaria Acetaminophen 2.6410982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.3511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.3516129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.2416752155
MESH:D014652 Vascular Diseases sodium arsenite 4.0617056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2212125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8316837676
MESH:D014802 Vitamin A Deficiency Vitamin A 4.9416960172 16175781 16146918
MESH:D014820 Vitiligo Tretinoin 3.7116761959
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1816343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8715886252
MESH:D009396 Wilms Tumor Tretinoin 3.6616287080
No data
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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