AutismKB 2.0

Annotation Detail for JAG2


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Basic Information Top
Gene Symbol:JAG2 ( HJ2,SER2 )
Gene Full Name: jagged 2
Band: 14q32.33
Quick LinksEntrez ID:3714; OMIM: 602570; Uniprot ID:JAG2_HUMAN; ENSEMBL ID: ENSG00000184916; HGNC ID: 6189
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04330Notch signaling pathway
Pathway IDPathway Name
Signaling by Notch
Pathway IDPathway Name
200013Notch signaling pathway
Pathway IDPathway Name
P00005Angiogenesis
P00045Notch signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of JAG2 mRNAaffects expression 16483693
C015001 arsenite arsenite results in increased expression of JAG2 mRNAincreases expression 18191166
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of JAG2 mRNAdecreases expression 19150397
D002117 Calcitriol Calcitriol results in decreased expression of JAG2 mRNAdecreases expression 16002434
D004317 Doxorubicin Doxorubicin results in decreased expression of JAG2 mRNAdecreases expression 16404146
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of JAG2 mRNAincreases expression 17606305
C025462 sulindac sulfide sulindac sulfide results in increased expression of JAG2 mRNAincreases expression 16184548
D014635 Valproic Acid Valproic Acid results in increased expression of JAG2 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.828875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.1719490988
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Doxorubicin 4.5617418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.5614692618
MESH:D000419 Albuminuria Doxorubicin 4.8321441931
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1318759972
MESH:D000550 Amblyopia Valproic Acid 5.6117688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.7617497229
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Valproic Acid 1.9916609825 17157402 19232924 18985861 18396377 15238991 18940202 17507914 18177632 18316065 17688650 18558336 18775368 20603192 19460635
MESH:D001714 Bipolar Disorder Valproic Acid 3.1820046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.548888407
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.0814601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.0417150277
MESH:D001943 Breast Neoplasms Calcitriol 2.4211237771
MESH:D001943 Breast Neoplasms Doxorubicin 2.4218628466 17369602 16096432 16595493 15136595 18382427 19526202 15993339 15939500 17983394 16264153 16826403 18695136 11325840 17426702 15668708 15692762 16935488 15634643 18234424 16322301 15567936 16115903 15994142
MESH:D002276 Carcinoid Tumor Doxorubicin 5.1916051944
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2516023760 18059187 17876044 16234567
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.5112391285
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2616201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.1011237771
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.106189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.6817007740 17928571 17308081 16612575 16651473 17974986 15476868 16242529 16109756 15811867 17351982 15792986 16731534 17382496 17131338 16278810 16269455 16455267 17329180 17924179 18627295 16952015 17519947 16364871 15505089
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0116243910 17334414
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8820889678
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7820734317
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517681005 11677210 16105132 17110522 16919318 15861022 17333356
MESH:D003110 Colonic Neoplasms arsenite 2.6215037631
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D019465 Craniofacial Abnormalities marker/mechanism 9531541
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.9016575769 8888407 17688650
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.3017416283
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 4.3019641884 1733752
MESH:D004362 Drug Toxicity Doxorubicin 3.8418602426
MESH:D004421 Dystonia Valproic Acid 4.311851702
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 10.0515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 10.0512538720
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6017359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.5318037988
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.4617275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.293922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0420417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.806254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.607750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.403659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1220426865
MESH:D005234 Fatty Liver arsenite 14.6518296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.6515345470
MESH:D005234 Fatty Liver Valproic Acid 14.6519224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.2616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.4118558336 8888407
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.9319069698
MESH:D005355 Fibrosis arsenite 4.3718296743
MESH:D005909 Glioblastoma Doxorubicin 3.4917150277
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6815692506
MESH:D006331 Heart Diseases Doxorubicin 3.6416495754 16144979 16244372 16244371 18006777 16707910 14766674 18674790 16879835 12587719 17875725 17888722 16330681
MESH:D006333 Heart Failure Doxorubicin 3.4817481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.1415692506
MESH:D006689 Hodgkin Disease Doxorubicin 3.6218501091 17606976 15147373
MESH:D006849 Hydrocephalus Valproic Acid 5.2017688650
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007674 Kidney Diseases Doxorubicin 3.1815369732 16775033 15699352
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4016707910
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.5316085563
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1816294345 17596541
MESH:D008103 Liver Cirrhosis arsenite 3.5418296743
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.1516439617 16595196
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 3.1516842330 17085340
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.6417228818
MESH:D008175 Lung Neoplasms arsenite 2.8716809336
MESH:D008175 Lung Neoplasms Doxorubicin 2.8717418594 6189445
MESH:D008223 Lymphoma Doxorubicin 3.6316098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.9917654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.8715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.1715458769
MESH:D008545 Melanoma Doxorubicin 2.3116827129
MESH:D008654 Mesothelioma Doxorubicin 3.1417638057
MESH:D008881 Migraine Disorders Valproic Acid 3.3618765137 18803445
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.7415792986
MESH:D052016 Mucositis Doxorubicin 5.1317415656
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.278888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2817596541
MESH:D009203 Myocardial Infarction Doxorubicin 3.0319429709 15857846
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0318259882
MESH:D009389 Neovascularization, Pathologic arsenite 4.7515738583
MESH:D009401 Nephrosis Doxorubicin 5.0816899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2116889571 15640375
MESH:D009436 Neural Tube Defects Valproic Acid 3.2716359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 3.3715555623
MESH:D012516 Osteosarcoma Doxorubicin 4.3115930896
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D003557 Phyllodes Tumor Doxorubicin 5.5317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.5317638057
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.1720603192
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.1215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.4415754350 16289102 16644109 18247401 12479363
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.4416888761 15897917 16868541 16729912 15749863 18437689
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 4.9211422049 12752131
MESH:D051437 Renal Insufficiency Doxorubicin 4.5317922066
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4419155313
MESH:D012509 Sarcoma Doxorubicin 4.2217710206 15625365 17203757 16767912 18313854 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.5214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.1317846226
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8911738929 16876388 1511512 15475178 3137016 17978042 11044598 14763951
MESH:D012878 Skin Neoplasms Doxorubicin 3.0515692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.8717203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9212833885
MESH:D013576 Syndactyly marker/mechanism 9531541
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.5516010429 17909728
MESH:D014178 Translocation, Genetic Valproic Acid 5.6117262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.863119515
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 2.8417653716
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.958888407
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.6414692618
MESH:D014594 Uterine Neoplasms sulindac sulfide 10.6418645019
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7815869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.5316364871 17334414 17638931 17678736
Pathway ID Pathway Name
KEGG:04330 Notch signaling pathway
REACT:299 Signaling by Notch
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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