AutismKB 2.0

Annotation Detail for JAK1


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Basic Information Top
Gene Symbol:JAK1 ( JAK1A,JAK1B,JTK3 )
Gene Full Name: Janus kinase 1
Band: 1p31.3
Quick LinksEntrez ID:3716; OMIM: 147795; Uniprot ID:JAK1_HUMAN; ENSEMBL ID: ENSG00000162434; HGNC ID: 6190
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa04630Jak-STAT signaling pathway
hsa05212Pancreatic cancer
hsa05200Pathways in cancer
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200158IL2 signaling events mediated by STAT5
200124IL6-mediated signaling events
200082IL2-mediated signaling events
200140PDGFR-alpha signaling pathway
200065Signaling events mediated by TCPTP
200099IL2 signaling events mediated by PI3K
200018IL4-mediated signaling events
200110IFN-gamma pathway
200023IL27-mediated signaling events
Pathway IDPathway Name
P00035Interferon-gamma signaling pathway
P00005Angiogenesis
P00047PDGF signaling pathway
P00038JAK/STAT signaling pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
1807Autoimmune disease
1831Prostate cancer
1848Embryoma
2051Leukemia
2052Infection
2053Colon cancer
2118Adenovirus infection
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of JAK1 mRNAincreases expression 19933214
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of JAK1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of JAK1 mRNAaffects expression 17562736
D000638 Amiodarone Amiodarone affects the expression of JAK1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of JAK1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of JAK1 mRNAdecreases expression 19654921
C006632 arsenic trioxide arsenic trioxide results in increased phosphorylation of JAK1 proteinincreases phosphorylation 19951532
D001553 Benzbromarone Benzbromarone affects the expression of JAK1 mRNAaffects expression 19483382
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of JAK1 mRNAdecreases expression 20018196
D002211 Capsaicin Capsaicin results in decreased phosphorylation of and results in decreased activity of JAK1 proteindecreases activity|decreases phosphorylation 17505005
D002994 Clofibrate Clofibrate affects the expression of JAK1 mRNAaffects expression 19483382
D003474 Curcumin Curcumin results in decreased expression of JAK1decreases expression 18462866
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of JAK1 mRNAincreases expression 17654400
C044101 endotoxin, Escherichia coli endotoxin, Escherichia coli results in increased expression of JAK1 mRNAincreases expression 15919760
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of JAK1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of JAK1 mRNAdecreases expression 17942748
16467188
D005001 Ethionine Ethionine affects the expression of JAK1 mRNAaffects expression 19483382
D017313 Fenretinide Fenretinide results in increased expression of JAK1 proteinincreases expression 15059897
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of JAK1 mRNAincreases expression 15919760
C015329 lycopene lycopene results in increased expression of JAK1 mRNAincreases expression 16886892
D008775 Methylprednisolone Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]decreases reaction|increases phosphorylation 11997017
C008493 methylselenic acid methylselenic acid affects the expression of JAK1 mRNAaffects expression 14617803
C008493 methylselenic acid methylselenic acid results in increased expression of JAK1 mRNAincreases expression 18548127
D037742 Nanotubes, Carbon Nanotubes, Carbon results in decreased expression of JAK1 mRNAdecreases expression 15585362
D009853 Omeprazole Omeprazole affects the expression of JAK1 mRNAaffects expression 19483382
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of JAK1 mRNAdecreases expression 17616710
C006253 pirinixic acid pirinixic acid affects the expression of JAK1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil affects the expression of JAK1 mRNAaffects expression 19483382
D012402 Rotenone Rotenone inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of JAK1 protein]decreases reaction|increases activity|increases phosphorylation 15748169
C009277 sodium arsenate sodium arsenate results in increased expression of JAK1 mRNAincreases expression 16882884
C017947 sodium arsenite sodium arsenite results in decreased expression of JAK1 mRNAdecreases expression 12679051
D013629 Tamoxifen Tamoxifen affects the expression of JAK1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of JAK1 mRNAincreases expression 18691609
19933214
D013752 Tetracycline Tetracycline results in increased expression of JAK1 mRNAincreases expression 16917069
D013853 Thioacetamide Thioacetamide affects the expression of JAK1 mRNAaffects expression 19483382
C066075 vanadium pentoxide JAK1 protein affects the reaction [vanadium pentoxide results in increased activity of STAT1 protein]affects reaction|increases activity 18322232
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.2014745880
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 7.5718926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5715322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D058186 Acute Kidney Injury Capsaicin 4.2418460982
MESH:D055371 Acute Lung Injury Lipopolysaccharides 8.0018653653 11850527
MESH:D055371 Acute Lung Injury pirinixic acid 8.0018653653
MESH:D000230 Adenocarcinoma arsenic trioxide 6.6211798837 19825857
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.6214692618
MESH:D000230 Adenocarcinoma Fenretinide 6.6210697514
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.6417306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.6416712894 17306315
MESH:D019973 Alcohol-Related Disorders Curcumin 4.7417887948
MESH:D000505 Alopecia Capsaicin 4.4617569567
MESH:D000544 Alzheimer Disease Curcumin 2.5415590663
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6511748828
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.5118218290 20041841 18057881
MESH:D020261 Arsenic Poisoning Arsenic 2.7716251483 12569548 18414634 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.4515885639
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.6516807698
MESH:D050197 Atherosclerosis Arsenic 6.2319371607 12928151
MESH:D050197 Atherosclerosis Curcumin 6.2318704882
MESH:D001281 Atrial Fibrillation Amiodarone 3.6518651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4518445737
MESH:D001327 Autoimmune Diseases Curcumin 4.1619761891
MESH:D001778 Blood Coagulation Disorders Amiodarone 59.5519483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 59.5516206674
MESH:D001778 Blood Coagulation Disorders Benzbromarone 59.5519483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 59.5519483382
MESH:D001778 Blood Coagulation Disorders Ethionine 59.5519483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 59.5519483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 59.5519483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 59.5519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 59.5512125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 59.5519483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5515746008
MESH:D001919 Bradycardia Capsaicin 4.7218207255
MESH:D002545 Brain Ischemia Capsaicin 9.4519211983
MESH:D002545 Brain Ischemia Curcumin 9.4516770732
MESH:D001932 Brain Neoplasms Curcumin 8.1917596214
MESH:D001932 Brain Neoplasms Fenretinide 8.1916187019
MESH:D001943 Breast Neoplasms Curcumin 1.9518462866 19250217 16243823 18593918
MESH:D001943 Breast Neoplasms Fenretinide 1.9516601279
MESH:D001943 Breast Neoplasms Tamoxifen 1.9519289846 18855134 19200415 19155303 19103187 15668708 19066611 17893378 16818667 11161223 20005174 20544844 20390343 19115204 16273361 19189212 20065188 18629630 20859285 19189210 17242785 19084267 18984771 18815881 16873071 18351453 19244106 20135344 18425577 19142967 17440819 19011961 18821012 16202921 19059307 19221464 17261762 15565566 21152245 17049068 18997820 19487384 19288272 19410462 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D001991 Bronchitis vanadium pentoxide 5.8917459161
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0211589617
MESH:D002277 Carcinoma Curcumin 7.4018593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4016835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4017687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1719066611
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 18.6716705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 18.673084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 18.6717306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 18.6715073043 14691202 15553829 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 18.671701930
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 18.6716270382 17159502
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 18.6717306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 18.6716924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 18.6717997003
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.8618414057
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5319014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8212490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 9.9917687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Curcumin 9.9918462866
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 9.9916274795
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.9918572023
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.5318640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.5317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1816120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7715710769 19225199
MESH:D002318 Cardiovascular Diseases Arsenic 3.2215738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.0216973168 18022660
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.7418974383
MESH:D002386 Cataract Acetaminophen 2.3810977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 14.146135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.1420889678
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 14.141399818
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.1419524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.1316154183
MESH:D002637 Chest Pain Omeprazole 4.7615447763
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.6016835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 8.6018291259
MESH:D002779 Cholestasis Ethinyl Estradiol 6.9117681005 17110522 16919318 11677210 16105132 17333356 15861022
MESH:D002779 Cholestasis pirinixic acid 6.9119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9615668235 8697196 16354765 15340226 12621046
MESH:D003092 Colitis Curcumin 3.8516782535 18200517 16804969
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.5320423518
MESH:D003103 Coloboma Curcumin 4.2518809619
MESH:D003110 Colonic Neoplasms Curcumin 2.4516340194 19359593
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.7120501625
MESH:D015179 Colorectal Neoplasms Fenretinide 2.7117273769
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7817141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.5618497527
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8612609071
MESH:D003371 Cough Capsaicin 4.8310350223
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.6510525206
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.6510525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.6515322242 20055451 10048152
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.6918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7815213294
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0319031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2718249437
MESH:D003882 Dermatomyositis Methylprednisolone 6.0720191521
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.1018403477
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1017107852
MESH:D003928 Diabetic Nephropathies Curcumin 8.1218204486
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.1219279558
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 20.3118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 20.3112153990 11743745 10774834 19416960 19923254 16227642 19370779 14725611 17562736 17522070 19164858 11461765 16485898 11834606 12958197 16081117 18713872 11287661 12594235 17906064 12392966 12705907 16393943 14986274 2444490 16781746 11529661 16177239 19420014 19085960 15619225 18071297 10663392 15968718 14550746 11421492 12540782 10915739 11739529 16109766 19739265
MESH:D056486 Drug-Induced Liver Injury Amiodarone 20.3118218290 15265979
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 20.3117654400
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 20.3118186108
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 20.3120420201
MESH:D056486 Drug-Induced Liver Injury Tetracycline 20.3117522070
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 20.3112963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5111462148
MESH:D004381 Duodenal Ulcer Capsaicin 13.6711535926 10671773
MESH:D004381 Duodenal Ulcer Curcumin 13.6717351913
MESH:D004381 Duodenal Ulcer Omeprazole 13.6717151854 16613094 15991576 21218061
MESH:D050171 Dyslipidemias Clofibrate 3.8216707586
MESH:D004487 Edema pirinixic acid 5.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5618230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.8712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.8719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 2.8219155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.739294722 10568697
MESH:D019446 Endotoxemia endotoxin, Escherichia coli 9.9217637181 18509659
MESH:D019446 Endotoxemia Lipopolysaccharides 9.9217637181 15328337 15821434
MESH:D004935 Esophageal Diseases Capsaicin 5.3619566590
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1420426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.1412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7611564622
MESH:D005218 Fat Necrosis Thioacetamide 5.3716456712
MESH:D005234 Fatty Liver Amiodarone 38.0314986274
MESH:D005234 Fatty Liver arsenic trioxide 38.0315073043
MESH:D005234 Fatty Liver Clofibrate 38.0319224547
MESH:D005234 Fatty Liver Curcumin 38.0319297423
MESH:D005234 Fatty Liver Ethinyl Estradiol 38.0315345470
MESH:D005234 Fatty Liver pirinixic acid 38.0320131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 38.0319224547 14986274
MESH:D005234 Fatty Liver Tetracycline 38.0319224547 16917069
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.0316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D005334 Fever endotoxin, Escherichia coli 8.7816997862
MESH:D005334 Fever Lipopolysaccharides 8.789205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8419069698
MESH:D005355 Fibrosis Curcumin 7.6918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.6920067830
MESH:D005534 Foot Diseases Arsenic 5.216392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9416904648
MESH:D005756 Gastritis Acetaminophen 3.3316983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.3618462866
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3416452187
MESH:D005909 Glioblastoma Capsaicin 10.9018405923
MESH:D005909 Glioblastoma Curcumin 10.9017596214
MESH:D005909 Glioblastoma Fenretinide 10.9016187019
MESH:D018149 Glucose Intolerance sodium arsenate 4.7719446573
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006258 Head and Neck Neoplasms Curcumin 3.4318829502 18462866
MESH:D006356 Heartburn Capsaicin 5.3619566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1511294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.3320558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.0916366002
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.2718665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 3.8916456712
MESH:D006529 Hepatomegaly Amiodarone 12.4915265979
MESH:D006529 Hepatomegaly pirinixic acid 12.4918467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 12.4915340226 12621046 16120746
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.7117701891
MESH:D006689 Hodgkin Disease sodium arsenite 2.8812676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7016959395 15340226 16354765 8697196 18606429
MESH:D006930 Hyperalgesia Acetaminophen 7.1516870215
MESH:D006930 Hyperalgesia Capsaicin 7.1517434803 17043245
MESH:D006937 Hypercholesterolemia Amiodarone 8.338137927 9751232
MESH:D006937 Hypercholesterolemia Curcumin 8.3318704882
MESH:D006943 Hyperglycemia pirinixic acid 2.8920558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1617050553
MESH:D006973 Hypertension Arsenic 4.7816076760 11953799 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.2116093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816569931 16945680
MESH:D007037 Hypothyroidism Amiodarone 10.5017991464 18020914
MESH:D007037 Hypothyroidism Propylthiouracil 10.5018031379 8137927
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.8917937319
MESH:D007248 Infertility, Male sodium arsenite 5.8912646999 15346721
MESH:D007249 Inflammation Capsaicin 13.9616956363
MESH:D007249 Inflammation Curcumin 13.9618403477 17151092 16956363
MESH:D007249 Inflammation Lipopolysaccharides 13.969205823 17237260 17255318 12878042 17963957
MESH:D007249 Inflammation Tamoxifen 13.9619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 13.9612200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.0718200517 18596194
MESH:D007333 Insulin Resistance pirinixic acid 2.4116306350
MESH:D007414 Intestinal Neoplasms Curcumin 3.9310783313
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.3217255318
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0316580747
MESH:D007642 Keratosis Arsenic 4.6516930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 5.3112587719 15629191
MESH:D007674 Kidney Diseases sodium arsenite 5.3120008137
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.4816705839
MESH:D007680 Kidney Neoplasms Tamoxifen 6.4818625569
MESH:D007889 Leiomyoma Curcumin 4.2618555241
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.8219248655
MESH:D007938 Leukemia arsenic trioxide 5.9415070760
MESH:D007938 Leukemia Curcumin 5.9418462866
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Methylprednisolone 4.7314551737
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.7612560223 17077332
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 8.7616106398
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.1814633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.4619077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.0816467208 19850784 17050201 16968895 20471514
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.0417339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0419642359 15336539 16112521 16330433 19035177 15622746 9834237 17217047 17107899 12018890 17712046 15748426 12712474 11161223 17649720 16331271 12679006 19225113 19075265 17869043 11468182 16966277 15213294 16823087 16891316
MESH:D015458 Leukemia, T-Cell arsenic trioxide 10.6416882451
MESH:D015458 Leukemia, T-Cell Curcumin 10.6416106398
MESH:D007970 Leukopenia Lipopolysaccharides 4.3615821434
MESH:D007972 Leukoplakia, Oral Fenretinide 5.7016707609
MESH:D008064 Lipidoses Amiodarone 7.1115342952 17567588
MESH:D008064 Lipidoses Tamoxifen 7.1117567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 8.1118705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 8.1112878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.1115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.1118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.1112878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 8.1112679928 18295389 10677585 15095483 14739098 16343077 17050028 17292413 18263696 11682029 18606216 15078482 16489207 17629604 12891558 11172339 12085344 15474484 12175628 18031379 17127702 16248980 18416461 18032466 16511523 18458672 12557150 18380797 12531686 15716488 15334695 15316131 11481614 16126171 16097051 15288472 15075984 17355460 16098781 15158331 15465738 15288473 18395095 18615449 15362042
MESH:D008107 Liver Diseases Acetaminophen 11.5211587558 19460945 16610002 19784758 16611625 12969438 12587719 19014921
MESH:D008107 Liver Diseases Arsenic 11.5211134558
MESH:D008107 Liver Diseases Capsaicin 11.5216956363
MESH:D008107 Liver Diseases Curcumin 11.5216956363
MESH:D008107 Liver Diseases Thioacetamide 11.5218374380 16337175 15158337
MESH:D017114 Liver Failure, Acute Acetaminophen 8.6616871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 8.6617276928 15633222 12479984 15313186
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 19.817678174
MESH:D008113 Liver Neoplasms Arsenic 19.8116368122
MESH:D008113 Liver Neoplasms arsenic trioxide 19.8114682389
MESH:D008113 Liver Neoplasms pirinixic acid 19.8120007298 15890375 16377806
MESH:D008113 Liver Neoplasms sodium arsenite 19.8116712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 19.8116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 19.8116984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 8.562876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 8.5620377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.5612151625
MESH:D008133 Long QT Syndrome Amiodarone 7.3417391786 15350150 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 7.3415213294
MESH:D008171 Lung Diseases Amiodarone 6.7612587719
MESH:D008171 Lung Diseases sodium arsenite 6.7619095001
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.1318516814
MESH:D055370 Lung Injury Lipopolysaccharides 3.6821114838
MESH:D008175 Lung Neoplasms Arsenic 9.9717306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 9.9719825857 11798837
MESH:D008175 Lung Neoplasms Curcumin 9.9719359593 18462866 16243823
MESH:D008175 Lung Neoplasms sodium arsenite 9.9715276417 17306315 19931552 16712894 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 9.9718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.9719555203 11884234
MESH:D008175 Lung Neoplasms vanadium pentoxide 9.9712376484
MESH:D008223 Lymphoma Curcumin 3.3518462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.3616173963
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4219428831
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 5.6210697514
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.6219196723 11731420 16827153 14580682 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 4.2019453300
MESH:D008545 Melanoma Curcumin 6.7917885582 18462866
MESH:D008545 Melanoma Fenretinide 6.7916270382
MESH:D008545 Melanoma sodium arsenite 6.7919082730 16487513
MESH:D008545 Melanoma Tamoxifen 6.7919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8415990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008569 Memory Disorders Curcumin 3.8317263510
MESH:D009062 Mouth Neoplasms Fenretinide 4.0616274795
MESH:D009101 Multiple Myeloma arsenic trioxide 10.9014977855 19417148 15949261 11468182 19549372
MESH:D009101 Multiple Myeloma Capsaicin 10.9017505005
MESH:D009101 Multiple Myeloma Curcumin 10.9019372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 4.5817962980
MESH:D009135 Muscular Diseases pirinixic acid 3.1716239165
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.5518186108
MESH:D009181 Mycoses Amiodarone 4.5617974566 12754197
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.9516105982 16882451
MESH:D009203 Myocardial Infarction pirinixic acid 2.0019151258
MESH:D017202 Myocardial Ischemia Arsenic 8.1115371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.1112213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.6916411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.527678174 18551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 9.2516624393
MESH:D009361 Neoplasm Invasiveness Curcumin 9.2518495463
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms Fenretinide 10.5317353921 15958647
MESH:D009369 Neoplasms lycopene 10.5317051425
MESH:D009369 Neoplasms pirinixic acid 10.5317405874
MESH:D009369 Neoplasms sodium arsenite 10.5311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3420056578
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 9.6912497104
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.6919189210 19200415 19196722
MESH:D009395 Nephritis, Interstitial Tetracycline 4.449884423
MESH:D009410 Nerve Degeneration Rotenone 3.6215790535 18619942 17356569
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.8914600291
MESH:D009423 Nervous System Neoplasms Curcumin 5.2818462866
MESH:D009436 Neural Tube Defects Arsenic 15.5716620997
MESH:D009436 Neural Tube Defects arsenic trioxide 15.5710525206
MESH:D009436 Neural Tube Defects sodium arsenate 15.5718186108 11749123 10525206 19446573
MESH:D009436 Neural Tube Defects sodium arsenite 15.5712854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6018514411
MESH:D020078 Neurogenic Inflammation Arsenic 9.9117056641
MESH:D020078 Neurogenic Inflammation Capsaicin 9.9117961222
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.3416303764
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.619802331
MESH:D009765 Obesity Capsaicin 7.0419056576
MESH:D009765 Obesity Curcumin 7.0419297423
MESH:D009765 Obesity pirinixic acid 7.0420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.1416049721
MESH:D010024 Osteoporosis Curcumin 3.2618719352
MESH:D010051 Ovarian Neoplasms Arsenic 13.7817306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.7816624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Curcumin 13.7818462866 19020741
MESH:D010051 Ovarian Neoplasms Fenretinide 13.7816133793
MESH:D010051 Ovarian Neoplasms sodium arsenite 13.7815276417 17306315
MESH:D010146 Pain Acetaminophen 6.1016870215
MESH:D010146 Pain Capsaicin 6.1017084039 17434803 17043245 19081190 18987195 16996476
MESH:D010149 Pain, Postoperative Methylprednisolone 5.8812538197
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.0515580305
MESH:D010190 Pancreatic Neoplasms Curcumin 8.0517440100 19196508 19401701
MESH:D010190 Pancreatic Neoplasms Fenretinide 8.0515580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010235 Paraganglioma arsenic trioxide 3.8519927285
MESH:D010300 Parkinson Disease Rotenone 2.8511535288 18191903 19114014 16140633 11445065 19232380 15451049 16412576 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 3.7815927086 18197244 15574749 15795934
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D010391 Pemphigoid, Bullous Tetracycline 5.0911026799
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.6515371236 6392382 16905509
MESH:D011014 Pneumonia Lipopolysaccharides 4.2112224865 11605937
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.8511118676 11399792 11222880 11896295
MESH:D017096 Prion Diseases Tetracycline 5.0710903871
MESH:D011471 Prostatic Neoplasms Arsenic 2.3716140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.3719131511
MESH:D011471 Prostatic Neoplasms Curcumin 2.3718769126 11398177 15129424 18226269 18156803 12497104 10851300
MESH:D011471 Prostatic Neoplasms Fenretinide 2.3717024972
MESH:D011471 Prostatic Neoplasms lycopene 2.3715084515 17337101
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.3716205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.3716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3715067354
MESH:D011507 Proteinuria Arsenic 3.6921343184
MESH:D011537 Pruritus Ethinyl Estradiol 2.9815861022 16919318
MESH:D011656 Pulmonary Emphysema Curcumin 4.2319168576
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7212832656 12490602 11597910
MESH:D015427 Reperfusion Injury Capsaicin 6.2618460982 19211983
MESH:D015427 Reperfusion Injury pirinixic acid 6.2619058328
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.7218379247 10666014
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.5110835634
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012162 Retinal Degeneration Fenretinide 4.1516303925
MESH:D012509 Sarcoma Curcumin 3.8218462866
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6416646077
MESH:D012640 Seizures 2,6-dinitrotoluene 2.3218551238
MESH:D018805 Sepsis Curcumin 3.8018389075
MESH:D012772 Shock, Septic endotoxin, Escherichia coli 5.2918063050
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.7418724381
MESH:D012871 Skin Diseases Arsenic 2.6616353154 19834688 16759981 6392382 18709164 17548696 17453740 17050553 17938729 15952646 16702368
MESH:D012878 Skin Neoplasms Arsenic 12.2617976673 19538983 17029826 15504454 17050553 16251483
MESH:D012878 Skin Neoplasms Fenretinide 12.2616467112
MESH:D012878 Skin Neoplasms sodium arsenite 12.2619524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.2616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 10.4116709447
MESH:D013088 Spermatocele Tamoxifen 10.4116709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.7019457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5412854658
MESH:D013272 Stomach Diseases Omeprazole 4.2718545984
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8517007042
MESH:D013276 Stomach Ulcer Amiodarone 10.4618087811
MESH:D013276 Stomach Ulcer Curcumin 10.4616631530 19188055
MESH:D013276 Stomach Ulcer Omeprazole 10.4617977527 18237397 16755016 15991576 10750652 11906479
MESH:D013610 Tachycardia Amiodarone 3.9711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.8719225199
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.3817997062
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 4.6015864552
MESH:D013921 Thrombocytopenia Lipopolysaccharides 3.8715821434
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.8715669648
MESH:D013959 Thyroid Diseases Amiodarone 10.9019731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.9012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.6019014326
MESH:D013964 Thyroid Neoplasms Propylthiouracil 6.6015710170
MESH:D013971 Thyrotoxicosis Amiodarone 4.5318020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 9.1311989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 9.1315213294
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 22.0016049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 22.0019322015 18640142 11144890 15987713 17976673 17306315 19429237
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 22.0012845720 20435036 11780464 12973940
MESH:D001749 Urinary Bladder Neoplasms Curcumin 22.0018593936
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 22.0016720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 22.0016712894 16452187 17306315 11723127
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 22.0016712894 8653321 17572228
MESH:D014565 Urogenital Neoplasms Curcumin 4.9218462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.9810091137
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 8.7616154183
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.7611813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.9814692618
MESH:D014652 Vascular Diseases Arsenic 10.7117056641
MESH:D014652 Vascular Diseases sodium arsenite 10.7117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2414671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
Pathway ID Pathway Name
KEGG:05160 Hepatitis C
KEGG:04630 Jak-STAT signaling pathway
KEGG:05140 Leishmaniasis
KEGG:05162 Measles
KEGG:04380 Osteoclast differentiation
KEGG:05212 Pancreatic cancer
KEGG:05200 Pathways in cancer
REACT:6900 Signaling in Immune system
KEGG:05145 Toxoplasmosis
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29988
    • No data
    Releated disease ID Related disease Name
    PA443624Carcinoma, Renal Cell
    PA443450Asthma
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA164749376interferon alfacon-1
    PA164749238exenatide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04716 - 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE
    DB08183 - 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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