AutismKB 2.0

Annotation Detail for JUP


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:JUP ( ARVD12,CTNNG,DP3,DPIII,PDGB,PKGB )
Gene Full Name: junction plakoglobin
Band: 17q21.2
Quick LinksEntrez ID:3728; OMIM: 173325; Uniprot ID:PLAK_HUMAN; ENSEMBL ID: ENSG00000173801; HGNC ID: 6207
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
Pathway IDPathway Name
Cell junction organization
Pathway IDPathway Name
200105E-cadherin signaling in the nascent adherens junction
Pathway IDPathway Name
P00004Alzheimer disease-presenilin pathway
Pathway IDPathway Name
500120Adherens junctions interactions
Related Diseases/Disorders Top
Desease IDDesease Name
Circulatory system diseases
Cardiac diseases
H00293Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Desease IDDesease Name
1990Skin disease, Genetic
1934Cancer
No data
No data
Desease Name
Arrhythmogenic right ventricular dysplasia, familial, 12
Naxos disease
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C063609 1,2-dimethyl-4-nitrobenzene 1,2-dimethyl-4-nitrobenzene results in increased expression of JUP mRNAincreases expression 19784758
D000082 Acetaminophen Acetaminophen affects the expression of JUP mRNAaffects expression 19784758
D000082 Acetaminophen Acetaminophen results in decreased expression of JUP mRNAdecreases expression 19784758
D000082 Acetaminophen Acetaminophen results in increased expression of JUP mRNAincreases expression 19784758
D000643 Ammonium Chloride Ammonium Chloride results in decreased expression of JUP proteindecreases expression 16483693
C095105 bexarotene bexarotene results in increased expression of JUP mRNAincreases expression 16648578
C006780 bisphenol A bisphenol A results in decreased expression of JUP mRNAdecreases expression 16474171
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of JUP mRNAdecreases expression 15336504
D007631 Chlordecone Chlordecone inhibits the reaction [CDH1 protein binds to JUP protein]affects binding|decreases reaction 11695219
D002713 Chlorine Chlorine results in increased expression of JUP mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of JUP mRNAaffects cotreatment|decreases expression 18636392
D016572 Cyclosporine Cyclosporine results in decreased expression of JUP mRNAdecreases expression 20106945
C014347 decitabine decitabine results in increased expression of JUP mRNAincreases expression 16887905
18974268
C014347 decitabine decitabine results in increased expression of JUP proteinincreases expression 18974268
16887905
C014347 decitabine DNMT3A protein affects the reaction [decitabine results in increased expression of JUP mRNA]affects reaction|increases expression 16887905
C014347 decitabine DNMT3B protein affects the reaction [decitabine results in increased expression of JUP protein]affects reaction|increases expression 16887905
D004041 Dietary Fats Dietary Fats results in increased expression of JUP mRNAincreases expression 18042831
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of JUP mRNAincreases expression 12807726
D004958 Estradiol Estradiol results in decreased expression of JUP mRNAdecreases expression 16474171
D019833 Genistein Genistein results in decreased expression of JUP mRNAdecreases expression 16705744
16474171
C017557 nickel subsulfide nickel subsulfide results in decreased expression of JUP mRNAdecreases expression 12760830
D009578 Nitrobenzenes Nitrobenzenes analog results in increased expression of JUP mRNAincreases expression 19784758
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of JUP mRNAaffects cotreatment|decreases expression 18636392
C041786 palm oil palm oil results in increased expression of JUP mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of JUP mRNAdecreases expression 12807726
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of JUP mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of JUP mRNAdecreases expression 17426115
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in decreased expression of JUP mRNAdecreases expression 16474171
D011374 Progesterone Progesterone affects the expression of JUP mRNAaffects expression 17251523
C065299 S-allylcysteine S-allylcysteine results in increased expression of JUP proteinincreases expression 17155983
C017947 sodium arsenite sodium arsenite results in decreased expression of JUP mRNAdecreases expression 12760830
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of JUP mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of JUP mRNAincreases expression 17586704
17035482
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the localization of and results in decreased expression of JUP proteinaffects localization|decreases expression 12478657
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of JUP mRNAdecreases expression 12478657
D013853 Thioacetamide Thioacetamide results in increased expression of JUP mRNAincreases expression 19784758
C015559 trimellitic anhydride trimellitic anhydride results in decreased expression of JUP mRNAdecreases expression 16141432
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.536195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5311752688 14514962 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.3318287403
MESH:D055371 Acute Lung Injury Chlorine 8.4420601635
MESH:D055371 Acute Lung Injury pirinixic acid 8.4418653653
MESH:D000230 Adenocarcinoma Estradiol 4.2711473722
MESH:D000230 Adenocarcinoma Genistein 4.2711473722
MESH:D000236 Adenoma Diethylnitrosamine 2.726695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 22.9717162532 19061943 18056438 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 22.9717620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 22.9716434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 22.9716835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6717306315 16712894
MESH:D000544 Alzheimer Disease Ozone 2.3915513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000799 Angioedema Acetaminophen 3.6110982225
OMIM:611528 ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 12 marker/mechanism
MESH:D001161 Arteriosclerosis Dietary Fats 3.6615238619
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5115570426
MESH:D001249 Asthma Ozone 5.3017854713 16373670
MESH:D001249 Asthma trimellitic anhydride 5.3016141432
MESH:D001321 Autistic Disorder Acetaminophen 1.4418445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.1619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.1612125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 14.1619483382
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6215746008
MESH:D001862 Bone Resorption bisphenol A 3.6611985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1117868700
MESH:D001930 Brain Injuries Progesterone 4.0315665606 15380490 15845082
MESH:D001943 Breast Neoplasms bexarotene 5.6016818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 5.6017123778
MESH:D001943 Breast Neoplasms decitabine 5.6018320071 19208741
MESH:D001943 Breast Neoplasms Dietary Fats 5.6020435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 5.6017474063
MESH:D001943 Breast Neoplasms Estradiol 5.6017289903 17018787 12948864 14630087 16675129 17261762 18497071 19861407
MESH:D001943 Breast Neoplasms Genistein 5.6016873071 17200150 16541309
MESH:D001943 Breast Neoplasms Progesterone 5.6016175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.6020435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.5018315731 17626835 18417511 16777450 14754758 19059883 15516495
MESH:D002100 Cachexia Ozone 4.5116183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2316111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 13.493084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 13.4918056438 16935385 20007298 17173139 18971187 16288022 19107877 20214788 21159647 3084413 17162532 20727157 19383236 10672840 17428255 19052882 16779866 19919837 18978308 17978847 11831363 18210153 18494052 20514400 18665156 16502159 19335982 16878318 16830150 16328049 20524982 19171122 19519916 17761372 16540662 18506893 20935162 17138121 19418558 20512989 16698587 18788625 20432363 17055752 19822196 16569478 18785209 19208518 19701751 19539802 20101231 18393292 20084675 10737359 16681979 18691550 16807293 3581430 19394651
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.4916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.4916924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 13.4917173139 20935162 20007298 6705139 1701930
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.4916507464 17306315 15276417
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 13.4917997003
MESH:D002278 Carcinoma in Situ bisphenol A 4.7617123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1516247446
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.5719215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.5718572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2418670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.1516332659
MESH:D002386 Cataract Acetaminophen 2.4510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.7412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.7417174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.7418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.7420056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.034080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 15.0119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 15.0116835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 15.0118291259
MESH:D002779 Cholestasis Cyclosporine 7.2019486331
MESH:D002779 Cholestasis pirinixic acid 7.2019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0112621046 15340226 15668235 8697196 16354765
MESH:D003110 Colonic Neoplasms decitabine 3.7417616700
MESH:D003110 Colonic Neoplasms Genistein 3.7417182828
MESH:D015179 Colorectal Neoplasms decitabine 2.8518981723
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.8515531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2410048152 15322242 20055451
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5016140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.7620387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.7616647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.7617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2219279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2717187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.4011834606 18071297 16177239 19420014 19416960 12153990 16081117 12540782 12958197 14550746 16781746 10774834 15968718 15619225 17522070 11461765 2444490 10663392 11421492 12392966 16227642 11739529 19739265 11529661 14725611 11743745 16109766 18713872 10915739 16485898 17906064 17562736 12705907 16393943 19085960 12594235 19923254 19164858 14986274 19370779 11287661
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.4019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.4020420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 8.4012963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2918367378
MESH:D004417 Dyspnea Chlorine 4.3920016425
MESH:D004421 Dystonia Phenobarbital 3.791851702
MESH:D004487 Edema pirinixic acid 5.8712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.8711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.5617692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.8819294695
MESH:D004714 Endometrial Hyperplasia Genistein 4.3616402032
MESH:D016889 Endometrial Neoplasms Estradiol 7.0211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 7.0211473722
MESH:D004715 Endometriosis Progesterone 8.2716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.279294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.883659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.643922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.7720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.356401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.037750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.793659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8916302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005218 Fat Necrosis Thioacetamide 5.4916456712
MESH:D005234 Fatty Liver Cyclosporine 17.0719224547
MESH:D005234 Fatty Liver Dietary Fats 17.0717967931 19004024 19551842 18296743
MESH:D005234 Fatty Liver Diethylnitrosamine 17.0721071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 17.0719236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005355 Fibrosis Cyclosporine 13.4212168785 12639820
MESH:D005355 Fibrosis Dietary Fats 13.4218296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.4220067830
MESH:D005739 Gas Poisoning Chlorine 4.7820016425
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.4516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma Genistein 3.1116598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.3419215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.4020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.3718665440 17276928 15929193
MESH:D006505 Hepatitis Thioacetamide 4.0016456712
MESH:D006529 Hepatomegaly Phenobarbital 13.0816109766
MESH:D006529 Hepatomegaly pirinixic acid 13.0816221962 19176532 19772884 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.0815340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8015709030
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D019584 Hot Flashes Estradiol 3.5217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.818697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.5216870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3921332399
MESH:D006943 Hyperglycemia pirinixic acid 2.9920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.4021332399
MESH:D006973 Hypertension Cyclosporine 4.6610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6618670907 18850075
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1815869954
MESH:D007248 Infertility, Male decitabine 6.4117581917
MESH:D007248 Infertility, Male sodium arsenite 6.4115346721 12646999
MESH:D007249 Inflammation Dietary Fats 10.9820412841
MESH:D007249 Inflammation Diethylnitrosamine 10.9818785209
MESH:D007249 Inflammation Progesterone 10.9815869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.9812200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 16.4316393666
MESH:D007333 Insulin Resistance Dietary Fats 16.4311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 16.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.4316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acetaminophen 13.3412587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 13.348314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 13.3415618244
MESH:D007674 Kidney Diseases sodium arsenite 13.3420008137
MESH:D007680 Kidney Neoplasms Cyclosporine 6.6612371664
MESH:D007680 Kidney Neoplasms Estradiol 6.6615610895
MESH:D007938 Leukemia decitabine 6.1519235587 18980019
MESH:D007938 Leukemia Genistein 6.1517468513 18980019
MESH:D007951 Leukemia, Myeloid decitabine 3.8019117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3419387464 18460780 18206229 19010910 18704418 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2318055864
MESH:D008103 Liver Cirrhosis Dietary Fats 10.3118296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 10.3118665156 18407596 18522880 19638242 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 10.3121047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.4217823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.4215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.4212878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 6.4218395095 18458672 16489207 18380797 10677585 15316131 17050028 16248980 16511523 18031379 12085344 18032466 11481614 17355460 17629604 16126171 12531686 11682029 17127702 15288472 12557150 15716488 18615449 15158331 18416461 16343077 15288473 15078482 18263696 17292413 14739098 12891558 16098781 18295389 16097051 15474484 15465738 11172339 15362042 15095483 12679928 18606216 15334695 15075984 12175628
MESH:D008107 Liver Diseases marker/mechanism 19784758
MESH:D008107 Liver Diseases Acetaminophen 8.8912969438 11587558 19460945 12587719 19784758 16610002 19014921 16611625
MESH:D008107 Liver Diseases Diethylnitrosamine 8.8917034775
MESH:D008107 Liver Diseases Phenobarbital 8.8919363144
MESH:D008107 Liver Diseases Thioacetamide 8.8915158337 18374380 16337175
MESH:D017114 Liver Failure, Acute Acetaminophen 8.9817185352 16871587
MESH:D017114 Liver Failure, Acute Thioacetamide 8.9815633222 15313186 12479984 17276928
MESH:D008113 Liver Neoplasms Diethylnitrosamine 13.3019690152 19254457 20492335 19551842 2422723 19499222 21047994 19294768 18978307 18754104 19255062 12771043 10737359 20137499 21167192 18977376 19833225 21278145 21071580 20452335 15885732 12112319 19426721 19812893 19850985 20101389 19996281 18648771 20434301 15175105 9163691 18644402 19090486 19638242 20501860 20118626 19073162 16942905 2862719 20583210 19427195 19642983 20405173 19256749
MESH:D008113 Liver Neoplasms Phenobarbital 13.308742319 21047994 19812893 15975961 19073162 19482888
MESH:D008113 Liver Neoplasms pirinixic acid 13.3020007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 13.3016712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.3016984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.0017174075 2563599 21159647 18775883 18253720 19009564 19126423 18079962 18308698 16267830 17942915 18544905 19004024 19539802 18282651 16842330 18093689 17854601 19519916 18164116 3124819 9362446
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 13.006150874 17172636 1399818 18308698 2563599
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 13.001423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.0012151625
MESH:D008171 Lung Diseases Ozone 7.0119066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 7.0119095001
MESH:D055370 Lung Injury Ozone 3.6320417186
MESH:D008175 Lung Neoplasms bexarotene 6.2917849452
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.2920970405 21163286 20512841 6695378
MESH:D008175 Lung Neoplasms Ozone 6.298597069 7614698
MESH:D008175 Lung Neoplasms sodium arsenite 6.2919931552 17077188 17306315 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.2911884234 19555203
MESH:D008223 Lymphoma decitabine 3.2619470736
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9211161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 13.1219196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 13.1217203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 13.1214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 13.1217203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.2519453300
MESH:D008545 Melanoma decitabine 3.3216505122 17785578
MESH:D008545 Melanoma sodium arsenite 3.3219082730 16487513
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D008679 Metaplasia Ozone 4.8710496685
MESH:D009101 Multiple Myeloma decitabine 3.1918172295
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.2519157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Genistein 5.3617141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.3619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.1716810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.1717141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.1716411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2517484760
MESH:C538346 Naxos disease marker/mechanism
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.483581430 9029167
MESH:D009369 Neoplasms decitabine 7.6217925555 19116145 19470736
MESH:D009369 Neoplasms pirinixic acid 7.6217405874
MESH:D009369 Neoplasms sodium arsenite 7.6211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4420056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.5519196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0919348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 21.6416427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 21.6416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 21.6416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 21.6414600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.0012854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.5718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.5720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8920387270
MESH:D009765 Obesity Dietary Fats 4.2420518802 21332399 18457598 17217161 19632207 20132043 16723640 18674790 11836018
MESH:D009765 Obesity pirinixic acid 4.2420558911
MESH:D010018 Osteomalacia Phenobarbital 4.1317016548
MESH:D010024 Osteoporosis Genistein 3.1119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8716169203
MESH:D010049 Ovarian Diseases bisphenol A 4.7611985600
MESH:D010051 Ovarian Neoplasms decitabine 14.2019331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 14.2019401270
MESH:D010051 Ovarian Neoplasms Genistein 14.2019005980
MESH:D010051 Ovarian Neoplasms Progesterone 14.2016525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 14.2015276417 17306315
MESH:D010146 Pain Acetaminophen 2.2116870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.1719294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.1716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.1716965848
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3116702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D010538 Peritonitis Ozone 3.9116369182
MESH:D011014 Pneumonia Ozone 4.1718381685 18929643 18007984
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 14.1612371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 14.162563599
MESH:D011230 Precancerous Conditions Phenobarbital 14.162563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.7510548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.7511222880 11896295 11399792 11118676
MESH:D055728 Primary Myelofibrosis decitabine 4.5017616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.8720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.8720887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms bisphenol A 1.9016740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms Genistein 1.9016925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.9015721890
MESH:D011471 Prostatic Neoplasms S-allylcysteine 1.9017155983
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9016039940
MESH:D019310 Pseudolymphoma Phenobarbital 4.2612752131
MESH:D011565 Psoriasis Cyclosporine 2.1516882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5610548101
MESH:D011658 Pulmonary Fibrosis S-allylcysteine 4.7116614485
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D012120 Respiration Disorders Chlorine 4.9818579056
MESH:D012130 Respiratory Hypersensitivity trimellitic anhydride 4.7220219652
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.1919155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012640 Seizures Phenobarbital 2.553137016 4039156 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 4.596407741
MESH:D012878 Skin Neoplasms sodium arsenite 8.8218572023 19524636
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 8.828532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.8216192470
MESH:D013119 Spinal Cord Injuries Progesterone 4.0516503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6212854658
MESH:D013274 Stomach Neoplasms decitabine 2.4719037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.4718456281
MESH:D019966 Substance-Related Disorders bisphenol A 3.7616045194 16684133
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6712697716
MESH:D013964 Thyroid Neoplasms decitabine 11.0217967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.027505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.021399818
MESH:D013978 Tibial Fractures Estradiol 4.4519048282
MESH:D014202 Tremor Chlordecone 5.746175765
MESH:D001749 Urinary Bladder Neoplasms decitabine 4.9519087683 17616700
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 4.9516452187 17306315 11723127 16712894
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.5711813266
MESH:D014591 Uterine Diseases bisphenol A 4.7814652134
MESH:D014604 Uveal Neoplasms decitabine 4.6817785578
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REACT:20676 Cell junction organization
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30009
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    PA445062Neoplasms
    PA443632Cardiomyopathy, Dilated
    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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